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-Structure paper
Title | The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors. |
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Journal, issue, pages | J. Biol. Chem., Vol. 290, Page 19681-19696, Year 2015 |
Publish date | Mar 26, 2015 (structure data deposition date) |
Authors | Wood, E.R. / Bledsoe, R. / Chai, J. / Daka, P. / Deng, H. / Ding, Y. / Harris-Gurley, S. / Kryn, L.H. / Nartey, E. / Nichols, J. ...Wood, E.R. / Bledsoe, R. / Chai, J. / Daka, P. / Deng, H. / Ding, Y. / Harris-Gurley, S. / Kryn, L.H. / Nartey, E. / Nichols, J. / Nolte, R.T. / Prabhu, N. / Rise, C. / Sheahan, T. / Shotwell, J.B. / Smith, D. / Tai, V. / Taylor, J.D. / Tomberlin, G. / Wang, L. / Wisely, B. / You, S. / Xia, B. / Dickson, H. |
External links | J. Biol. Chem. / PubMed:26055709 |
Methods | X-ray diffraction |
Resolution | 1.78 - 1.8 Å |
Structure data | PDB-4z0v: PDB-4z2b: |
Chemicals | ChemComp-MG: ChemComp-GOL: ChemComp-HOH: ChemComp-SO4: ChemComp-EDO: ChemComp-TRS: ChemComp-4LC: |
Source |
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Keywords | HYDROLASE / PDE12 2'-5'A EEP nuclease / Hydrolase/Hydrolase Inhibitor / PDE12 2'-5'A EEP nuclease Inhibitor complex / Hydrolase-Hydrolase Inhibitor complex |