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-Structure paper
Title | Property- and structure-guided discovery of a tetrahydroindazole series of interleukin-2 inducible T-cell kinase inhibitors. |
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Journal, issue, pages | J. Med. Chem., Vol. 57, Page 5714-5727, Year 2014 |
Publish date | Mar 3, 2014 (structure data deposition date) |
Authors | Burch, J.D. / Lau, K. / Barker, J.J. / Brookfield, F. / Chen, Y. / Eigenbrot, C. / Ellebrandt, C. / Ismaili, M.H. / Johnson, A. / Kordt, D. ...Burch, J.D. / Lau, K. / Barker, J.J. / Brookfield, F. / Chen, Y. / Eigenbrot, C. / Ellebrandt, C. / Ismaili, M.H. / Johnson, A. / Kordt, D. / MacKinnon, C.H. / McEwan, P.A. / Ortwine, D.F. / Stein, D.B. / Wang, X. / Winkler, D. / Yuen, P.W. / Zhang, Y. / Zarrin, A.A. / Pei, Z. |
External links | J. Med. Chem. / PubMed:24918870 |
Methods | X-ray diffraction |
Resolution | 1.71 - 2.8 Å |
Structure data | PDB-4pqn: PDB-4prj: |
Chemicals | ChemComp-2W6: ChemComp-P4G: ChemComp-HOH: ChemComp-2VU: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / protein kinase / phospho-transfer / TRANSFERASE-TRANSFERASE INHIBITOR complex |