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TitleHepatitis C virus E2 envelope glycoprotein core structure.
Journal, issue, pagesScience, Vol. 342, Issue 6162, Page 1090-1094, Year 2013
Publish dateNov 29, 2013
AuthorsLeopold Kong / Erick Giang / Travis Nieusma / Rameshwar U Kadam / Kristin E Cogburn / Yuanzi Hua / Xiaoping Dai / Robyn L Stanfield / Dennis R Burton / Andrew B Ward / Ian A Wilson / Mansun Law /
PubMed AbstractHepatitis C virus (HCV), a Hepacivirus, is a major cause of viral hepatitis, liver cirrhosis, and hepatocellular carcinoma. HCV envelope glycoproteins E1 and E2 mediate fusion and entry into host ...Hepatitis C virus (HCV), a Hepacivirus, is a major cause of viral hepatitis, liver cirrhosis, and hepatocellular carcinoma. HCV envelope glycoproteins E1 and E2 mediate fusion and entry into host cells and are the primary targets of the humoral immune response. The crystal structure of the E2 core bound to broadly neutralizing antibody AR3C at 2.65 angstroms reveals a compact architecture composed of a central immunoglobulin-fold β sandwich flanked by two additional protein layers. The CD81 receptor binding site was identified by electron microscopy and site-directed mutagenesis and overlaps with the AR3C epitope. The x-ray and electron microscopy E2 structures differ markedly from predictions of an extended, three-domain, class II fusion protein fold and therefore provide valuable information for HCV drug and vaccine design.
External linksScience / PubMed:24288331 / PubMed Central
MethodsEM (single particle) / X-ray diffraction
Resolution2.645 - 20.0 Å
Structure data

EMDB-5759:
Hepatitis C Virus E2 Envelope Glycoprotein Core Structure
Method: EM (single particle) / Resolution: 16.0 Å

EMDB-5760:
Hepatitis C Virus E2 Envelope Glycoprotein Core Structure
Method: EM (single particle) / Resolution: 20.0 Å

EMDB-5761:
Hepatitis C Virus E2 Envelope Glycoprotein Core Structure
Method: EM (single particle) / Resolution: 19.0 Å

PDB-4mwf:
Structure of Hepatitis C Virus Envelope Glycoprotein E2 core bound to broadly neutralizing antibody AR3C
Method: X-RAY DIFFRACTION / Resolution: 2.645 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose / N-Acetylglucosamine

Source
  • Hepatitis C virus
  • homo sapiens (human)
  • hepatitis c virus (isolate h)
KeywordsIMMUNE SYSTEM / Immunoglobulin Fold / HCV E2

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