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-Structure paper
タイトル | Hepatitis C virus E2 envelope glycoprotein core structure. |
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ジャーナル・号・ページ | Science, Vol. 342, Issue 6162, Page 1090-1094, Year 2013 |
掲載日 | 2013年11月29日 |
著者 | Leopold Kong / Erick Giang / Travis Nieusma / Rameshwar U Kadam / Kristin E Cogburn / Yuanzi Hua / Xiaoping Dai / Robyn L Stanfield / Dennis R Burton / Andrew B Ward / Ian A Wilson / Mansun Law / |
PubMed 要旨 | Hepatitis C virus (HCV), a Hepacivirus, is a major cause of viral hepatitis, liver cirrhosis, and hepatocellular carcinoma. HCV envelope glycoproteins E1 and E2 mediate fusion and entry into host ...Hepatitis C virus (HCV), a Hepacivirus, is a major cause of viral hepatitis, liver cirrhosis, and hepatocellular carcinoma. HCV envelope glycoproteins E1 and E2 mediate fusion and entry into host cells and are the primary targets of the humoral immune response. The crystal structure of the E2 core bound to broadly neutralizing antibody AR3C at 2.65 angstroms reveals a compact architecture composed of a central immunoglobulin-fold β sandwich flanked by two additional protein layers. The CD81 receptor binding site was identified by electron microscopy and site-directed mutagenesis and overlaps with the AR3C epitope. The x-ray and electron microscopy E2 structures differ markedly from predictions of an extended, three-domain, class II fusion protein fold and therefore provide valuable information for HCV drug and vaccine design. |
リンク | Science / PubMed:24288331 / PubMed Central |
手法 | EM (単粒子) / X線回折 |
解像度 | 2.645 - 20.0 Å |
構造データ | EMDB-5759: EMDB-5760: EMDB-5761: PDB-4mwf: |
化合物 | ChemComp-NAG: |
由来 |
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キーワード | IMMUNE SYSTEM (免疫系) / Immunoglobulin Fold / HCV E2 |