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-Structure paper
Title | Discovery of novel irreversible inhibitors of interleukin (IL)-2-inducible tyrosine kinase (Itk) by targeting cysteine 442 in the ATP pocket. |
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Journal, issue, pages | J. Biol. Chem., Vol. 288, Page 28195-28206, Year 2013 |
Publish date | May 2, 2013 (structure data deposition date) |
![]() | Harling, J.D. / Deakin, A.M. / Campos, S. / Grimley, R. / Chaudry, L. / Nye, C. / Polyakova, O. / Bessant, C.M. / Barton, N. / Somers, D. ...Harling, J.D. / Deakin, A.M. / Campos, S. / Grimley, R. / Chaudry, L. / Nye, C. / Polyakova, O. / Bessant, C.M. / Barton, N. / Somers, D. / Barrett, J. / Graves, R.H. / Hanns, L. / Kerr, W.J. / Solari, R. |
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Methods | X-ray diffraction |
Resolution | 2.18 Å |
Structure data | ![]() PDB-4kio: |
Chemicals | ![]() ChemComp-G5K: ![]() ChemComp-G6K: ![]() ChemComp-SO4: ![]() ChemComp-GOL: ![]() ChemComp-HOH: |
Source |
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![]() | Transferase/Transferase inhibitor / ![]() |