The wwPDB has reviewed the representation of peptide-like antibiotic and inhibitor molecules in the PDB archive. As a result, a new reference dictionary has been created to help define and represent these biologically interesting molecules.
This Biologically Interesting molecule Reference Dictionary (BIRD) contains chemical descriptions, sequence and linkage information, and functional and classification information as taken from the core structures and from external resources. PDB entries containing these molecules will be annotated using this dictionary, and will contain a corresponding BIRD ID code only in the PDBx-formatted file.
BIRD will be available on the wwPDB FTP server adjacent to the Chemical Component Dictionary.
The use of BIRD will greatly improve the consistency of peptide-like antibiotic and inhibitor molecules in the PDB.
These data reflect the wwPDB's continuing commitment to providing accurate and detailed data to users worldwide.
The 2012 Nobel Prize in Chemistry was awarded jointly to Robert J. Lefkowitz and Brian K. Kobilka for studies of G-protein-coupled receptors. The PDB holds many GPCRs, such as Kobilka's groundbreaking structure of the2 adrenergic receptor-Gs protein complex ( 3sn6 ).