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4OBR	Crystal structure of human alpha-L-iduronidase complex with alpha-L-iduronic acid Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-L-iduronidase, ... Authors: Bie, H.Y, Yin, J, He, X, Kermode, A.R, James, M.N.G. Deposit date: 2014-01-07 Release date: 2015-01-14 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.46 Å) Cite: Crystal structure of human alpha-L-iduronidase complex with alpha-L-iduronic acid To be Published
8QJ2	Structure of active state MC4R in complex with a potent ligand mimicking nanobody Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... Authors: Busch, A, Jaakola, V.-P, Masiulis, S. Deposit date: 2023-09-12 Release date: 2024-09-25 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structure of active state MC4R in complex with a potent ligand mimicking nanobody To Be Published
7QU1	Machupo virus GP1 glycoprotein in complex with Fab fragment of antibody MAC1 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab MAC1 heavy chain, Fab MAC1 light chain, ... Authors: Ng, W.M, Sahin, M, Krumm, S.A, Seow, J, Zeltina, A, Harlos, K, Paesen, G, Pinschewer, D.D, Doores, K.J, Bowden, T.A. Deposit date: 2022-01-17 Release date: 2022-02-09 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Contrasting Modes of New World Arenavirus Neutralization by Immunization-Elicited Monoclonal Antibodies. Mbio, 13, 2022
1AG5	THE SOLUTION STRUCTURE OF AN AFLATOXIN B1 EPOXIDE ADDUCT AT THE N7 POSITION OF GUANINE OPPOSITE AN ADENINE IN THE COMPLEMENTARY STRAND OF AN OLIGODEOXYNUCLEOTIDE DUPLEX, NMR, MINIMIZED AVERAGE STRUCTURE Descriptor: 8,9-DIHYDRO-9-HYDROXY-AFLATOXIN B1, DNA (5'-D(*CP*CP*AP*TP*CP*GP*AP*TP*CP*C)-3'), DNA (5'-D(*GP*GP*AP*TP*CP*AP*GP*AP*TP*GP*G)-3') Authors: Johnson, D.S, Stone, M.P. Deposit date: 1997-04-01 Release date: 1997-09-17 Last modified: 2024-04-10 Method: SOLUTION NMR Cite: Refined solution structure of 8,9-dihydro-8-(N7-guanyl)-9-hydroxyaflatoxin B1 opposite CpA in the complementary strand of an oligodeoxynucleotide duplex as determined by 1H NMR. Biochemistry, 34, 1995
6PZW	CryoEM derived model of NA-22 Fab in complex with N9 Shanghai2 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, NA-22 fragment antigen binding heavy chain, ... Authors: Ward, A.B, Turner, H.L, Zhu, X. Deposit date: 2019-08-01 Release date: 2019-12-04 Last modified: 2023-04-05 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies. Cell Host Microbe, 26, 2019
6Q1Z	Crystal structure of human 1G04 Fab in complex with influenza virus neuraminidase from A/Hunan/02650/2016 (H7N9) Descriptor: 1G04 Fab IgG1 heavy chain, 1G04 Fab kappa light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Zhu, X, Wilson, I.A. Deposit date: 2019-08-06 Release date: 2019-10-23 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.446 Å) Cite: Broadly protective human antibodies that target the active site of influenza virus neuraminidase. Science, 366, 2019
1AFZ	SOLUTION NMR STRUCTURE OF AN 11 BASE-PAIR OLIGONUCLEOTIDE FROM THE HUMAN N-RAS PROTOONCOGENE ENCODING FOR AMINO ACIDS 11-13 OF P21, MINIMIZED AVERAGE STRUCTURE Descriptor: DNA (5'-D(*CP*AP*CP*CP*AP*CP*CP*TP*GP*CP*C)-3'), DNA (5'-D(*GP*GP*CP*AP*GP*GP*TP*GP*GP*TP*G)-3') Authors: Zegar, I.S, Stone, M.P. Deposit date: 1997-03-18 Release date: 1997-08-20 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Solution structure of an oligodeoxynucleotide containing the human N-ras codon 12 sequence refined from 1H NMR using molecular dynamics restrained by nuclear Overhauser effects. Chem.Res.Toxicol., 9, 1996
7QBC	Structure of the GPCR dimer Ste2 in the inactive-like state bound to agonist Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha factor pheromone, CHOLESTEROL HEMISUCCINATE, ... Authors: Velazhahan, V, Tate, C.G. Deposit date: 2021-11-18 Release date: 2022-03-16 Last modified: 2022-04-06 Method: ELECTRON MICROSCOPY (3.53 Å) Cite: Activation mechanism of the class D fungal GPCR dimer Ste2. Nature, 603, 2022
6PZD	Crystal structure of the neuraminidase stabilization mutant Y169aH from A/Shanghai/2/2013 (H7N9) Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Zhu, X, Wilson, I.A. Deposit date: 2019-07-31 Release date: 2019-12-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.12 Å) Cite: Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies. Cell Host Microbe, 26, 2019
7QB9	Structure of the ligand-free GPCR dimer Ste2 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Pheromone alpha factor receptor Authors: Velazhahan, V, Tate, C.G. Deposit date: 2021-11-18 Release date: 2022-03-16 Last modified: 2022-04-06 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Activation mechanism of the class D fungal GPCR dimer Ste2. Nature, 603, 2022
7QBI	Structure of the GPCR dimer Ste2 in the active-like state bound to agonist Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha factor pheromone, CHOLESTEROL HEMISUCCINATE, ... Authors: Velazhahan, V, Tate, C.G. Deposit date: 2021-11-19 Release date: 2022-03-16 Last modified: 2022-04-06 Method: ELECTRON MICROSCOPY (3.46 Å) Cite: Activation mechanism of the class D fungal GPCR dimer Ste2. Nature, 603, 2022
7QA8	Structure of the GPCR dimer Ste2 bound to an antagonist Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, HIS-ALA-LEU-GLN-LEU-LYS-PRO-GLY-GLN-PRO-NLE-TYR, ... Authors: Velazhahan, V, Tate, C.G. Deposit date: 2021-11-16 Release date: 2022-03-16 Last modified: 2022-04-06 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Activation mechanism of the class D fungal GPCR dimer Ste2. Nature, 603, 2022
1A6I	TET REPRESSOR, CLASS D VARIANT Descriptor: TETRACYCLINE REPRESSOR PROTEIN CLASS D Authors: Orth, P, Cordes, F, Schnappinger, D, Hillen, W, Saenger, W, Hinrichs, W. Deposit date: 1998-02-25 Release date: 1999-03-02 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Conformational changes of the Tet repressor induced by tetracycline trapping. J.Mol.Biol., 279, 1998
7QNE	Cryo-EM structure of human full-length synaptic alpha1beta3gamma2 GABA(A)R in complex with Ro15-4513 and megabody Mb38 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... Authors: Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R. Deposit date: 2021-12-20 Release date: 2022-04-13 Last modified: 2022-05-04 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Differential assembly diversifies GABA A receptor structures and signalling. Nature, 604, 2022
6PZE	Crystal structure of human NA-45 Fab in complex with neuraminidase Y169aH mutant from A/Shanghai/2/2013 (H7N9) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, NA-45 FAB HEAVY CHAIN, ... Authors: Zhu, X, Wilson, I.A. Deposit date: 2019-07-31 Release date: 2019-12-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies. Cell Host Microbe, 26, 2019
1BHG	HUMAN BETA-GLUCURONIDASE AT 2.6 A RESOLUTION Descriptor: BETA-GLUCURONIDASE, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Authors: Jain, S, Drendel, W.B. Deposit date: 1996-03-04 Release date: 1997-09-17 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.53 Å) Cite: Structure of human beta-glucuronidase reveals candidate lysosomal targeting and active-site motifs. Nat.Struct.Biol., 3, 1996
6PZF	Crystal structure of human NA-63 Fab in complex with neuraminidase from A/Hunan/02650/2016(H7N9) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... Authors: Zhu, X, Wilson, I.A. Deposit date: 2019-07-31 Release date: 2019-12-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies. Cell Host Microbe, 26, 2019
1BFO	CAMPATH-1G IGG2B RAT MONOCLONAL FAB Descriptor: CAMPATH-1G ANTIBODY Authors: Cheetham, G.M.T, Hale, G, Waldmann, H, Bloomer, A.C. Deposit date: 1998-05-20 Release date: 1999-03-16 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal structures of a rat anti-CD52 (CAMPATH-1) therapeutic antibody Fab fragment and its humanized counterpart. J.Mol.Biol., 284, 1998
6PV9	Human PD-L1 bound to a macrocyclic peptide which blocks the PD-1/PD-L1 interaction Descriptor: Programmed cell death 1 ligand 1, macrocyclic peptide Authors: Appleby, T.C, Lad, L, Gross, M.L. Deposit date: 2019-07-19 Release date: 2020-01-01 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2 Å) Cite: Protein Footprinting and X-ray Crystallography Reveal the Interaction of PD-L1 and a Macrocyclic Peptide. Biochemistry, 59, 2020
6PZZ	CryoEM derived model of NA-80 Fab in complex with N9 Shanghai2 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, NA-80 fragment antibody heavy chain, ... Authors: Ward, A.B, Turner, H.L, Zhu, X. Deposit date: 2019-08-01 Release date: 2019-12-04 Last modified: 2023-04-05 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies. Cell Host Microbe, 26, 2019
6PXH	Crystal Structure of MERS-CoV S1-NTD bound with G2 Fab Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DIHYDROFOLIC ACID, ... Authors: Wang, N, McLellan, J.S. Deposit date: 2019-07-26 Release date: 2019-09-25 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD. Cell Rep, 28, 2019
1CZ8	VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH AN AFFINITY MATURED ANTIBODY Descriptor: HEAVY CHAIN OF NEUTRALIZING ANTIBODY, LIGHT CHAIN OF NEUTRALIZING ANTIBODY, SULFATE ION, ... Authors: Chen, Y, Wiesmann, C, Fuh, G, Li, B, Christinger, H.W, McKay, P, de Vos, A.M, Lowman, H.B. Deposit date: 1999-09-01 Release date: 2000-03-20 Last modified: 2017-04-05 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen. J.Mol.Biol., 293, 1999
9DJ9	HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) in distinct apo form Descriptor: Dual specificity protein phosphatase 3 Authors: Keedy, D.A, Lemberikman, A.M, Isiorho, E.A, Aleshin, A.E, Wu, J, Lambert, L.J, Cosford, N.D.P, Tautz, L. Deposit date: 2024-09-06 Release date: 2024-09-25 Method: X-RAY DIFFRACTION (1.924 Å) Cite: Fragment Screening Platform and Discovery of Novel Fragment Binders of the VHR Phosphatase, a Drug Target for Sepsis and Septic Shock To Be Published
7QUO	FimH lectin domain in complex with oligomannose-6 Descriptor: FimH, NICKEL (II) ION, SULFATE ION, ... Authors: Bouckaert, J, Bourenkov, G.P. Deposit date: 2022-01-18 Release date: 2023-02-01 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural insights into a cooperative switch between one and two FimH bacterial adhesins binding pauci- and high-mannose type N-glycan receptors J.Biol.Chem., 299, 2023
1B38	HUMAN CYCLIN-DEPENDENT KINASE 2 Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PROTEIN (CELL DIVISION PROTEIN KINASE 2) Authors: Brown, N.R, Noble, M.E.M, Lawrie, A.M, Morris, M.C, Tunnah, P, Divita, G, Johnson, L.N, Endicott, J.A. Deposit date: 1998-12-17 Release date: 1998-12-23 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2 Å) Cite: Effects of phosphorylation of threonine 160 on cyclin-dependent kinase 2 structure and activity. J.Biol.Chem., 274, 1999

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