6P6V
| HCV NS3/4A protease domain of genotype 5a in complex with glecaprevir | Descriptor: | (3aR,7S,10S,12R,21E,24aR)-7-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclop ropyl]-20,20-difluoro-5,8-dioxo-2,3,3a,5,6,7,8,11,12,20,23,24a-dodecahydro-1H,10H-9,12-methanocyclopenta[18,19][1,10,17, 3,6]trioxadiazacyclononadecino[11,12-b]quinoxaline-10-carboxamide, 1,2-ETHANEDIOL, ... | Authors: | Timm, J, Schiffer, C.A. | Deposit date: | 2019-06-04 | Release date: | 2020-06-10 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Molecular mechanism of pan-genotypic HCV NS3/4A protease inhibition by glecaprevir and characterization of genotype-specific structural differences To Be Published
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6P6T
| HCV NS3/4A protease domain of genotype 4a in complex with glecaprevir | Descriptor: | (3aR,7S,10S,12R,21E,24aR)-7-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclop ropyl]-20,20-difluoro-5,8-dioxo-2,3,3a,5,6,7,8,11,12,20,23,24a-dodecahydro-1H,10H-9,12-methanocyclopenta[18,19][1,10,17, 3,6]trioxadiazacyclononadecino[11,12-b]quinoxaline-10-carboxamide, Non-structural protein 4A,Serine protease NS3, ... | Authors: | Timm, J, Schiffer, C.A. | Deposit date: | 2019-06-04 | Release date: | 2020-06-10 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Molecular mechanism of pan-genotypic HCV NS3/4A protease inhibition by glecaprevir and characterization of genotype-specific structural differences To Be Published
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1KSQ
| NMR Study of the Third TB Domain from Latent Transforming Growth Factor-beta Binding Protein-1 | Descriptor: | LATENT TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN 1 | Authors: | Lack, J, O'leary, J.M, Knott, V, Yuan, X, Rifkin, D.B, Handford, P.A, Downing, A.K. | Deposit date: | 2002-01-14 | Release date: | 2003-08-26 | Last modified: | 2021-11-03 | Method: | SOLUTION NMR | Cite: | Solution Structure of the Third TB Domain from LTBP1 Provides Insight into Assembly
of the Large Latent Complex that Sequesters Latent TGF-beta. J.Mol.Biol., 334, 2003
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3FCR
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6D0A
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3WZF
| Crystal structure of human cytoplasmic aspartate aminotransferase | Descriptor: | Aspartate aminotransferase, cytoplasmic | Authors: | Jiang, X, Chang, H, Zhou, Y, Chen, L, Yang, Q. | Deposit date: | 2014-09-24 | Release date: | 2015-10-07 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.991 Å) | Cite: | Recombinant expression, purification and Preliminary crystallographic studies of human cytoplasmic aspartate aminotransferase To be Published
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3GJU
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2EH6
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3F65
| The F4 fimbrial chaperone FaeE does not self-cap its interactive surfaces | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Chaperone protein faeE, PHOSPHATE ION | Authors: | Van Molle, I, Moonens, K, Buts, L, Garcia-Pino, A, Wyns, L, De Greve, H, Bouckaert, J. | Deposit date: | 2008-11-05 | Release date: | 2009-05-19 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | The F4 fimbrial chaperone FaeE is stable as a monomer that does not require self-capping of its pilin-interactive surfaces Acta Crystallogr.,Sect.D, 65, 2009
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2E54
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3FFR
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1Q71
| The structure of microcin J25 is a threaded sidechain-to-backbone ring structure and not a head-to-tail cyclized backbone | Descriptor: | microcin J25 | Authors: | Rosengren, K.J, Clark, R, Daly, N.L, Goransson, U, Jones, A, Craik, D.J. | Deposit date: | 2003-08-14 | Release date: | 2003-12-16 | Last modified: | 2012-12-12 | Method: | SOLUTION NMR | Cite: | Microcin J25 has a threaded sidechain-to-backbone ring structure and not a head-to-tail cyclized backbone. J.Am.Chem.Soc., 125, 2003
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1XZ4
| Intersubunit Interactions Associated with Tyr42alpha Stabilize the Quaternary-T Tetramer but are not Major Quaternary Constraints in Deoxyhemoglobin: alphaY42A deoxyhemoglobin no-salt | Descriptor: | Hemoglobin alpha chain, Hemoglobin beta chain, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Kavanaugh, J.S, Rogers, P.H, Arnone, A, Hui, H.L, Wierzba, A, DeYoung, A, Kwiatkowski, L.D, Noble, R.W, Juszczak, L.J, Peterson, E.S, Friedman, J.M. | Deposit date: | 2004-11-11 | Release date: | 2004-11-30 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Intersubunit interactions associated with tyr42alpha stabilize the quaternary-T tetramer but are not major quaternary constraints in deoxyhemoglobin Biochemistry, 44, 2005
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5HXL
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2D5Y
| Aspartate Aminotransferase Mutant MC With Isovaleric Acid | Descriptor: | Aspartate aminotransferase, ISOVALERIC ACID, PYRIDOXAL-5'-PHOSPHATE | Authors: | Tanaka, Y, Nakagawa, N, Tada, H, Yano, T, Masui, R, Kuramitsu, S. | Deposit date: | 2005-11-08 | Release date: | 2006-11-14 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | The Structures of Aspartate Aminotransferase with Mutations of Non-Active-Site Residues To be Published
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2D7Y
| Aspartate Aminotransferase Mutant MA | Descriptor: | Aspartate aminotransferase, PYRIDOXAL-5'-PHOSPHATE | Authors: | Tanaka, Y, Nakagawa, N, Tada, H, Yano, T, Masui, R, Kuramitsu, S. | Deposit date: | 2005-11-30 | Release date: | 2006-11-14 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (2.66 Å) | Cite: | The Structures of Aspartate Aminotransferase with Mutations of Non-Active-Site Residues To be Published
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5HYC
| Structure based function annotation of a hypothetical protein MGG_01005 related to the development of rice blast fungus | Descriptor: | Cytoplasmic dynein 1 intermediate chain 2, Uncharacterized protein | Authors: | Liu, J, Li, G, Huang, J, Peng, Y.-l. | Deposit date: | 2016-02-01 | Release date: | 2017-02-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure based function-annotation of hypothetical protein MGG_01005 from Magnaporthe oryzae reveals it is the dynein light chain orthologue of dynlt1/3. Sci Rep, 8, 2018
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2D7Z
| Aspartate Aminotransferase Mutant MAB Complexed with Maleic Acid | Descriptor: | Aspartate aminotransferase, MALEIC ACID, PYRIDOXAL-5'-PHOSPHATE | Authors: | Tanaka, Y, Nakagawa, N, Tada, H, Yano, T, Masui, R, Kuramitsu, S. | Deposit date: | 2005-11-30 | Release date: | 2006-11-14 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | The Structures of Aspartate Aminotransferase with Mutations of Non-Active-Site Residues To be Published
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2D65
| Aspartate Aminotransferase Mutant MABC | Descriptor: | Aspartate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION | Authors: | Tanaka, Y, Nakagawa, N, Tada, H, Yano, T, Masui, R, Kuramitsu, S. | Deposit date: | 2005-11-09 | Release date: | 2006-11-14 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The Structures of Aspartate Aminotransferase with Mutations of Non-Active-Site Residues To be Published
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2D66
| Aspartate Aminotransferase Mutant MAB | Descriptor: | Aspartate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION | Authors: | Tanaka, Y, Nakagawa, N, Tada, H, Yano, T, Masui, R, Kuramitsu, S. | Deposit date: | 2005-11-09 | Release date: | 2006-11-14 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | The Structures of Aspartate Aminotransferase with Mutations of Non-Active-Site Residues To be Published
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4PLJ
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1FIP
| THE STRUCTURE OF FIS MUTANT PRO61ALA ILLUSTRATES THAT THE KINK WITHIN THE LONG ALPHA-HELIX IS NOT DUE TO THE PRESENCE OF THE PROLINE RESIDUE | Descriptor: | FACTOR FOR INVERSION STIMULATION (FIS), UNKNOWN PEPTIDE, POSSIBLY PART OF THE UNOBSERVED RESIDUES IN ENTITY 1 | Authors: | Yuan, H.S, Wang, S.S, Yang, W.-Z, Finkel, S.E, Johnson, R.C. | Deposit date: | 1994-09-26 | Release date: | 1995-02-14 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The structure of Fis mutant Pro61Ala illustrates that the kink within the long alpha-helix is not due to the presence of the proline residue. J.Biol.Chem., 269, 1994
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3BMW
| Cyclodextrin glycosyl transferase from Thermoanerobacterium thermosulfurigenes EM1 mutant S77P complexed with a maltoheptaose inhibitor | Descriptor: | 6-AMINO-4-HYDROXYMETHYL-CYCLOHEX-4-ENE-1,2,3-TRIOL, CALCIUM ION, CHLORIDE ION, ... | Authors: | Rozeboom, H.J, van Oosterwijk, N, Dijkstra, B.W. | Deposit date: | 2007-12-13 | Release date: | 2008-05-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Elimination of competing hydrolysis and coupling side reactions of a cyclodextrin glucanotransferase by directed evolution. Biochem.J., 413, 2008
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3BMV
| Cyclodextrin glycosyl transferase from Thermoanerobacterium thermosulfurigenes EM1 mutant S77P | Descriptor: | CALCIUM ION, Cyclomaltodextrin glucanotransferase, GLYCEROL, ... | Authors: | Rozeboom, H.J, van Oosterwijk, N, Dijkstra, B.W. | Deposit date: | 2007-12-13 | Release date: | 2008-05-27 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Elimination of competing hydrolysis and coupling side reactions of a cyclodextrin glucanotransferase by directed evolution. Biochem.J., 413, 2008
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2D64
| Aspartate Aminotransferase Mutant MABC With Isovaleric Acid | Descriptor: | Aspartate aminotransferase, ISOVALERIC ACID, PYRIDOXAL-5'-PHOSPHATE | Authors: | Tanaka, Y, Nakagawa, N, Tada, H, Yano, T, Masui, R, Kuramitsu, S. | Deposit date: | 2005-11-09 | Release date: | 2006-11-14 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | The Structures of Aspartate Aminotransferase with Mutations of Non-Active-Site Residues To be Published
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