6VY7
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5CO5
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6CEI
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5YCB
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5YCC
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7VRX
| Pad-1 in the absence of substrate | Descriptor: | Aminotransferase, SULFATE ION | Authors: | Choi, M, Rhee, S. | Deposit date: | 2021-10-25 | Release date: | 2022-04-20 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.96634674 Å) | Cite: | Structural and biochemical basis for the substrate specificity of Pad-1, an indole-3-pyruvic acid aminotransferase in auxin homeostasis. J.Struct.Biol., 214, 2022
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2M61
| NMR and Mass Spectrometric Studies of M-2 Branch Mini-M Conotoxins from Indian Cone Snails | Descriptor: | Conotoxin Ar1446 | Authors: | Sarma, S.P, Rajesh, R.P, Kumar, G.S, Sudarslal, S, Sabareesh, V, Gowd, K.H, Gupta, K, Krishnan, K.S, Balaram, P. | Deposit date: | 2013-03-18 | Release date: | 2014-04-16 | Method: | SOLUTION NMR | Cite: | NMR and Mass Spectrometric Studies of M-2 Branch Mini-M Conotoxins from Indian Cone Snails To be Published
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6WCI
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7NZY
| Crystal structure of human Casein Kinase I delta in complex with CGS-15943 | Descriptor: | 9-chloranyl-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine, Casein kinase I isoform delta, MALONATE ION, ... | Authors: | Pichlo, C, Baumann, U. | Deposit date: | 2021-03-24 | Release date: | 2022-10-05 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Phenotypic Discovery of Triazolo[1,5- c ]quinazolines as a First-In-Class Bone Morphogenetic Protein Amplifier Chemotype. J.Med.Chem., 65, 2022
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5C6U
| Rv3722c aminotransferase from Mycobacterium tuberculosis | Descriptor: | Aminotransferase, CHLORIDE ION, PHOSPHATE ION, ... | Authors: | OSIPIUK, J, Hatzos-Skintges, C, Jedrzejczak, R, Babnigg, G, Sacchettini, J, JOACHIMIAK, A, Midwest Center for Structural Genomics (MCSG), Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI) | Deposit date: | 2015-06-23 | Release date: | 2015-07-15 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Rv3722c aminotransferase from Mycobacterium tuberculosis. to be published
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6WFM
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8CNR
| Hybrid Cluster Protein from the thermophilic methanogen Methanothermococcus thermolithotrophicus as isolated in a reduced state at 1.45-A resolution | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, 1,2-ETHANEDIOL, 2-ETHOXYETHANOL, ... | Authors: | Lemaire, O.N, Wagner, T. | Deposit date: | 2023-02-24 | Release date: | 2023-04-19 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structural and biochemical elucidation of class I hybrid cluster protein natively extracted from a marine methanogenic archaeon. Front Microbiol, 14, 2023
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8CNS
| The Hybrid Cluster Protein from the thermophilic methanogen Methanothermococcus thermolithotrophicus in a mixed redox state after soaking with hydroxylamine, at 1.36-A resolution. | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, 1,2-ETHANEDIOL, 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, ... | Authors: | Lemaire, O.N, Wagner, T. | Deposit date: | 2023-02-24 | Release date: | 2023-04-19 | Last modified: | 2023-06-07 | Method: | X-RAY DIFFRACTION (1.36 Å) | Cite: | Structural and biochemical elucidation of class I hybrid cluster protein natively extracted from a marine methanogenic archaeon. Front Microbiol, 14, 2023
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6XEP
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6T97
| Trypanothione Reductase from Leismania infantum in complex with TRL190 | Descriptor: | 4-[1-[4-[4-(2-phenylethyl)-1,3-thiazol-2-yl]-3-(2-piperidin-4-ylethoxy)phenyl]-1,2,3-triazol-4-yl]butan-1-amine, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | Authors: | Carriles, A, Hermoso, J.A. | Deposit date: | 2019-10-26 | Release date: | 2020-11-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Scaffold hopping identifies new triazole-and triazolium-based inhibitors of Leishmania infantum Trypanothione Reductase with potent and selective antileishmanial activity To Be Published
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3NYS
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4CC1
| Notch ligand, Jagged-1, contains an N-terminal C2 domain | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Chilakuri, C.R, Sheppard, D, Ilagan, M.X.G, Holt, L.R, Abbott, F, Liang, S, Kopan, R, Handford, P.A, Lea, S.M. | Deposit date: | 2013-10-17 | Release date: | 2013-11-27 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.84 Å) | Cite: | Structural Analysis Uncovers Lipid-Binding Properties of Notch Ligands Cell Rep., 5, 2013
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6PNL
| Structure of Epimerase Mth375 from the thermophilic pseudomurein-containing methanogen Methanothermobacter thermautotrophicus | Descriptor: | 1,2-ETHANEDIOL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION, ... | Authors: | Carbone, V, Schofield, L.R, Sutherland-Smith, A.J, Ronimus, R.S. | Deposit date: | 2019-07-02 | Release date: | 2020-07-08 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Structure of a UDP-GALE 4-epimerase (Mth375) from the thermophilic pseudomurein-containing methanogen Methanothermobacter thermautotrophicus To Be Published
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6PMH
| Structure of Epimerase Mth375 from the thermophilic pseudomurein-containing methanogen Methanothermobacter thermautotrophicus | Descriptor: | ADENOSINE MONOPHOSPHATE, CHLORIDE ION, GLYCEROL, ... | Authors: | Carbone, V, Schofield, L.R, Sutherland-Smith, A.J, Ronimus, R.S. | Deposit date: | 2019-07-01 | Release date: | 2020-07-08 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of a UDP-GALE 4-epimerase (Mth375) from the thermophilic pseudomurein-containing methanogen Methanothermobacter thermautotrophicus To Be Published
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5MEG
| Manganese-substituted Cyanothece lipoxygenase 2 (Mn-CspLOX2) | Descriptor: | Arachidonate 15-lipoxygenase, CHLORIDE ION, ETHANOL, ... | Authors: | Newie, J, Neumann, P, Werner, M, Mata, R.A, Ficner, R, Feussner, I. | Deposit date: | 2016-11-14 | Release date: | 2017-05-31 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Lipoxygenase 2 from Cyanothece sp. controls dioxygen insertion by steric shielding and substrate fixation. Sci Rep, 7, 2017
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6HND
| Crystal structure of the aromatic aminotransferase Aro9 from C. Albicans | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Aromatic-amino-acid:2-oxoglutarate transaminase, POTASSIUM ION, ... | Authors: | Kiliszek, A, Rzad, K, Rypniewski, W, Milewski, S, Gabriel, I. | Deposit date: | 2018-09-14 | Release date: | 2019-02-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Crystal structures of aminotransferases Aro8 and Aro9 from Candida albicans and structural insights into their properties. J.Struct.Biol., 205, 2019
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6HNV
| Crystal structure of aminotransferase Aro9 from C. Albicans with ligands | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINOHEXANEDIOIC ACID, 2-OXOADIPIC ACID, ... | Authors: | Kiliszek, A, Rzad, K, Rypniewski, W, Milewski, S, Gabriel, I. | Deposit date: | 2018-09-17 | Release date: | 2019-02-20 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structures of aminotransferases Aro8 and Aro9 from Candida albicans and structural insights into their properties. J.Struct.Biol., 205, 2019
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5M2V
| Structure of GluK1 ligand-binding domain (S1S2) in complex with (2S,4R)-4-(2-carboxyphenoxy)pyrrolidine-2-carboxylic acid at 3.18 A resolution | Descriptor: | (2~{S},4~{R})-4-(2-carboxyphenoxy)pyrrolidine-2-carboxylic acid, CHLORIDE ION, Glutamate receptor ionotropic, ... | Authors: | Frydenvang, K, Kastrup, J.S, Kristensen, C.M. | Deposit date: | 2016-10-13 | Release date: | 2017-01-11 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.18 Å) | Cite: | Design and Synthesis of a Series of l-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid. J. Med. Chem., 60, 2017
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6WCT
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4CBZ
| Notch ligand, Jagged-1, contains an N-terminal C2 domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTEIN JAGGED-1, alpha-L-fucopyranose | Authors: | Chilakuri, C.R, Sheppard, D, Ilagan, M.X.G, Holt, L.R, Abbott, F, Liang, S, Kopan, R, Handford, P.A, Lea, S.M. | Deposit date: | 2013-10-17 | Release date: | 2013-11-27 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural Analysis Uncovers Lipid-Binding Properties of Notch Ligands Cell Rep., 5, 2013
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