2KBO
| Structure, interaction, and real-time monitoring of the enzymatic reaction of wild type APOBEC3G | Descriptor: | DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION | Authors: | Furukawa, A, Nagata, T, Matsugami, A, Habu, Y, Sugiyama, R, Hayashi, F, Kobayashi, N, Yokoyama, S, Takaku, H, Katahira, M. | Deposit date: | 2008-12-04 | Release date: | 2009-02-03 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structure, interaction and real-time monitoring of the enzymatic reaction of wild-type APOBEC3G Embo J., 28, 2009
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2YBM
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2KK1
| Solution structure of C-terminal Domain of Tyrosine-protein kinase ABL2 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) target HR5537A | Descriptor: | Tyrosine-protein kinase ABL2 | Authors: | Liu, G, Wang, D, Nwosu, C, Owens, L, Xiao, R, Liu, J, Baran, M.C, Swapna, G, Acton, T.B, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2009-06-14 | Release date: | 2009-08-11 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | NMR structure of F-actin-binding domain of Arg/Abl2 from Homo sapiens. Proteins, 78, 2010
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2KOM
| Solution structure of humar Par-3b PDZ2 (residues 451-549) | Descriptor: | Partitioning defective 3 homolog | Authors: | Volkman, B.F, Tyler, R.C, Peterson, F.C, Center for Eukaryotic Structural Genomics (CESG) | Deposit date: | 2009-09-24 | Release date: | 2009-11-10 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Rapid, robotic, small-scale protein production for NMR screening and structure determination. Protein Sci., 19, 2010
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2KGI
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2WM9
| Structure of the complex between DOCK9 and Cdc42. | Descriptor: | CELL DIVISION CONTROL PROTEIN 42 HOMOLOG, DEDICATOR OF CYTOKINESIS PROTEIN 9, GLYCEROL | Authors: | Yang, J, Roe, S.M, Barford, D. | Deposit date: | 2009-06-30 | Release date: | 2009-09-22 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Activation of Rho Gtpases by Dock Exchange Factors is Mediated by a Nucleotide Sensor. Science, 325, 2009
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2WQO
| STRUCTURE OF NEK2 BOUND TO THE AMINOPYRIDINE CCT241950 | Descriptor: | 4-[2-AMINO-5-(3,4,5-TRIMETHOXYPHENYL)PYRIDIN-3-YL]BENZOIC ACID, CHLORIDE ION, SERINE/THREONINE-PROTEIN KINASE NEK2 | Authors: | Mas-Droux, C, Bayliss, R. | Deposit date: | 2009-08-24 | Release date: | 2009-12-08 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.167 Å) | Cite: | An Autoinhibitory Tyrosine Motif in the Cell-Cycle- Regulated Nek7 Kinase is Released Through Binding of Nek9. Mol.Cell, 36, 2009
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3DY4
| Crystal structure of yeast 20S proteasome in complex with spirolactacystin | Descriptor: | Omuralide, open form, Proteasome component C1, ... | Authors: | Groll, M, Balskus, E, Jacobsen, E. | Deposit date: | 2008-07-25 | Release date: | 2008-11-04 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural analysis of spiro beta-lactone proteasome inhibitors. J.Am.Chem.Soc., 130, 2008
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2YBJ
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3E1Z
| Crystal structure of the parasite protesase inhibitor chagasin in complex with papain | Descriptor: | ACETIC ACID, Chagasin, FORMIC ACID, ... | Authors: | Redzynia, I, Bujacz, G, Bujacz, A, Ljunggren, A, Abrahamson, M, Jaskolski, M. | Deposit date: | 2008-08-05 | Release date: | 2009-01-27 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Crystal structure of the parasite inhibitor chagasin in complex with papain allows identification of structural requirements for broad reactivity and specificity determinants for target proteases. Febs J., 276, 2009
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2WIP
| STRUCTURE OF CDK2-CYCLIN A COMPLEXED WITH 8-ANILINO-1-METHYL-4,5-DIHYDRO- 1H-PYRAZOLO[4,3-H] QUINAZOLINE-3-CARBOXYLIC ACID | Descriptor: | 1-methyl-8-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylic acid, CELL DIVISION PROTEIN KINASE 2, CYCLIN-A2, ... | Authors: | Brasca, M.G, Amboldi, N, Ballinari, D, Cameron, A.D, Casale, E, Cervi, G, Colombo, M, Colotta, F, Croci, V, Dalessio, R, Fiorentini, F, Isacchi, A, Mercurio, C, Moretti, W, Panzeri, A, Pastori, W, Pevarello, P, Quartieri, F, Roletto, F, Traquandi, G, Vianello, P, Vulpetti, A, Ciomei, M. | Deposit date: | 2009-05-14 | Release date: | 2009-07-28 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Identification of N,1,4,4-Tetramethyl-8-{[4-(4-Methylpiperazin-1-Yl)Phenyl]Amino}-4,5-Dihydro-1H-Pyrazolo[4,3-H]Quinazoline-3-Carboxamide (Pha-848125), a Potent, Orally Available Cyclin Dependent Kinase Inhibitor. J.Med.Chem., 52, 2009
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3DM6
| Beta-secretase 1 complexed with statine-based inhibitor | Descriptor: | 5-[[(2S)-2-[[(3R,4S)-5-(3,5-difluorophenoxy)-3-hydroxy-4-[[3-(methyl-methylsulfonyl-amino)-5-[[(1R)-1-phenylethyl]carbamoyl]phenyl]carbonylamino]pentanoyl]amino]-3-methyl-butanoyl]amino]benzene-1,3-dicarboxylic acid, Beta-secretase 1, ISOPROPYL ALCOHOL | Authors: | Lindberg, J, Borkakoti, N, Nystrom, S. | Deposit date: | 2008-06-30 | Release date: | 2008-12-16 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Design, synthesis and SAR of potent statine-based BACE-1 inhibitors: exploration of P1 phenoxy and benzyloxy residues Bioorg.Med.Chem., 16, 2008
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2KDD
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2KBI
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2KBW
| Solution Structure of human Mcl-1 complexed with human Bid_BH3 peptide | Descriptor: | BH3-interacting domain death agonist, Induced myeloid leukemia cell differentiation protein Mcl-1 | Authors: | Liu, Q, Moldoveanu, T, Sprules, T, Matta-Camacho, E, Mansur-Azzam, N, Gehring, K. | Deposit date: | 2008-12-09 | Release date: | 2009-12-15 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Apoptotic regulation by MCL-1 through heterodimerization. J.Biol.Chem., 285, 2010
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3BIU
| Human thrombin-in complex with UB-THR10 | Descriptor: | (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentylamino)ethanoyl)pyrrolidine-2-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, Hirudin, ... | Authors: | Gerlach, C, Smolinski, M, Steuber, H, Sotriffer, C.A, Heine, A, Hangauer, D.G, Klebe, G. | Deposit date: | 2007-12-01 | Release date: | 2007-12-25 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Thermodynamic Inhibition Profile of a Cyclopentyl and a Cyclohexyl Derivative towards Thrombin: The Same but for Different Reasons Angew.Chem.Int.Ed.Engl., 46, 2007
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2K6T
| Solution structure of the relaxin-like factor | Descriptor: | Insulin-like 3 A chain, Insulin-like 3 B chain | Authors: | Bullesbach, E.E, Hass, M.A.S, Jensen, M.R, Hansen, D.F, Kristensen, S.M, Schwabe, C, Led, J.J. | Deposit date: | 2008-07-23 | Release date: | 2008-12-16 | Last modified: | 2022-03-16 | Method: | SOLUTION NMR | Cite: | Solution structure of a conformationally restricted fully active derivative of the human relaxin-like factor Biochemistry, 47, 2008
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2W96
| Crystal Structure of CDK4 in complex with a D-type cyclin | Descriptor: | CELL DIVISION PROTEIN KINASE 4, G1/S-SPECIFIC CYCLIN-D1, GLYCEROL | Authors: | Day, P.J, Cleasby, A, Tickle, I.J, Reilly, M.O, Coyle, J.E, Holding, F.P, McMenamin, R.L, Yon, J, Chopra, R, Lengauer, C, Jhoti, H. | Deposit date: | 2009-01-21 | Release date: | 2009-03-10 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin. Proc.Natl.Acad.Sci.USA, 106, 2009
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2K7P
| Filamin A Ig-like domains 16-17 | Descriptor: | Filamin-A | Authors: | Heikkinen, O.K, Kilpelainen, I, Koskela, H, Permi, P, Heikkinen, S, Ylanne, J. | Deposit date: | 2008-08-19 | Release date: | 2009-07-07 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Atomic structures of two novel immunoglobulin-like domain pairs in the actin cross-linking protein filamin J.Biol.Chem., 284, 2009
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3B5R
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2W2V
| Rac2 (G12V) in complex with GTPgS | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2 | Authors: | Opaleye, O, Bunney, T.D, Roe, S.M, Pearl, L.H. | Deposit date: | 2008-11-04 | Release date: | 2009-05-05 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Insights Into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2. Mol.Cell, 34, 2009
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2KKF
| Solution structure of MLL CXXC domain in complex with palindromic CPG DNA | Descriptor: | 5'-D(*CP*CP*CP*TP*GP*CP*GP*CP*AP*GP*GP*G)-3', Histone-lysine N-methyltransferase HRX, ZINC ION | Authors: | Cierpicki, T, Riesbeck, J.E, Grembecka, J.E, Lukasik, S.M, Popovic, R, Omonkowska, M, Shultis, D.S, Zeleznik-Le, N.J, Bushweller, J.H. | Deposit date: | 2009-06-18 | Release date: | 2009-12-08 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia. Nat.Struct.Mol.Biol., 17, 2010
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3DHK
| Bisphenylic Thrombin Inhibitors | Descriptor: | Hirudin variant-1, SODIUM ION, Thrombin heavy chain, ... | Authors: | Baum, B, Heine, A, Klebe, G. | Deposit date: | 2008-06-18 | Release date: | 2009-05-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin J.Mol.Biol., 391, 2009
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3DJA
| Crystal Structure of cpaf solved with MAD | Descriptor: | Protein CT_858 | Authors: | Chai, J, Huang, Z. | Deposit date: | 2008-06-22 | Release date: | 2009-01-13 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural basis for activation and inhibition of the secreted chlamydia protease CPAF Cell Host Microbe, 4, 2008
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3BAG
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