1O86
 
 | | Crystal Structure of Human Angiotensin Converting Enzyme in complex with lisinopril. | | Descriptor: | ANGIOTENSIN CONVERTING ENZYME, CHLORIDE ION, GLYCINE, ... | | Authors: | Natesh, R, Schwager, S.L.U, Sturrock, E.D, Acharya, K.R. | | Deposit date: | 2002-11-25 | | Release date: | 2003-02-07 | | Last modified: | 2013-03-06 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structure of the Human Angiotensin-Converting Enzyme-Lisinopril Complex
Nature, 421, 2003
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1O8A
 | | Crystal Structure of Human Angiotensin Converting Enzyme (Native). | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ANGIOTENSIN CONVERTING ENZYME, ... | | Authors: | Natesh, R, Schwager, S.L.U, Sturrock, E.D, Acharya, K.R. | | Deposit date: | 2002-11-26 | | Release date: | 2003-02-07 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of the human angiotensin-converting enzyme-lisinopril complex.
Nature, 421, 2003
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1UZF
 | | Complex of the anti-hypertensive drug captopril an the human testicular angiotensin I-converting enzyme | | Descriptor: | 1-(3-MERCAPTO-2-METHYL-PROPIONYL)-PYRROLIDINE-2-CARBOXYLIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ANGIOTENSIN CONVERTING ENZYME, ... | | Authors: | Natesh, R, Schwager, S.L.U, Evans, H.R, Sturrock, E.D, Acharya, K.R. | | Deposit date: | 2004-03-11 | | Release date: | 2004-07-16 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural Details on the Binding of Antihypertensive Drugs Captopril and Enalaprilat to Human Testicular Angiotensin I-Converting Enzyme
Biochemistry, 43, 2004
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1UZE
 | | Complex of the anti-hypertensive drug enalaprilat and the human testicular angiotensin I-converting enzyme | | Descriptor: | 1-((2S)-2-{[(1S)-1-CARBOXY-3-PHENYLPROPYL]AMINO}PROPANOYL)-L-PROLINE, ANGIOTENSIN CONVERTING ENZYME, CHLORIDE ION, ... | | Authors: | Natesh, R, Schwager, S.L.U, Evans, H.R, Sturrock, E.D, Acharya, K.R. | | Deposit date: | 2004-03-11 | | Release date: | 2004-07-16 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | Structural Details on the Binding of Antihypertensive Drugs Captopril and Enalaprilat to Human Testicular Angiotensin I-Converting Enzyme
Biochemistry, 43, 2004
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2IUL
 | | Human tACE g13 mutant | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ANGIOTENSIN-CONVERTING ENZYME, ... | | Authors: | Watermeyer, J.M, Sewell, B.T, Natesh, R, Corradi, H.R, Acharya, K.R, Sturrock, E.D. | | Deposit date: | 2006-06-06 | | Release date: | 2006-10-25 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Structure of Testis Ace Glycosylation Mutants and Evidence for Conserved Domain Movement.
Biochemistry, 45, 2006
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2IUX
 | | Human tACE mutant g1234 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ANGIOTENSIN-CONVERTING ENZYME, ... | | Authors: | Watermeyer, J.M, Swell, B.T, Natesh, R, Corradi, H.R, Acharya, K.R, Sturrock, E.D. | | Deposit date: | 2006-06-07 | | Release date: | 2006-10-25 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure of Testis Ace Glycosylation Mutants and Evidence for Conserved Domain Movement.
Biochemistry, 45, 2006
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2C6N
 | | Structure of human somatic angiontensin-I converting enzyme N domain with lisinopril | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | | Authors: | Corradi, H.R, Schwager, S.L.U, Nichinda, A, Sturrock, E.D, Acharya, K.R. | | Deposit date: | 2005-11-10 | | Release date: | 2006-03-15 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structure of the N domain of human somatic angiotensin I-converting enzyme provides a structural basis for domain-specific inhibitor design.
J. Mol. Biol., 357, 2006
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2OC2
 | | Structure of testis ACE with RXPA380 | | Descriptor: | Angiotensin-converting enzyme, somatic isoform, CHLORIDE ION, ... | | Authors: | Corradi, H.R, Anthony, C.S, Schwager, S.L, Redelinghuys, P, Georgiadis, D, Dive, V, Acharya, K.R, Sturrock, E.D. | | Deposit date: | 2006-12-20 | | Release date: | 2007-05-22 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | The structure of testis angiotensin-converting enzyme in complex with the C domain-specific inhibitor RXPA380.
Biochemistry, 46, 2007
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3NXQ
 | | Angiotensin Converting Enzyme N domain glycsoylation mutant (Ndom389) in complex with RXP407 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, CHLORIDE ION, ... | | Authors: | Anthony, C.S, Corradi, H.R, Schwager, S.L.U, Redelinghuys, P, Georgiadis, D, Dive, V, Acharya, K.R, Sturrock, E.D. | | Deposit date: | 2010-07-14 | | Release date: | 2010-09-08 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | The N domain of human angiotensin-I-converting enzyme: the role of N-glycosylation and the crystal structure in complex with an N domain-specific phosphinic inhibitor, RXP407.
J.Biol.Chem., 285, 2010
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3L3N
 | | Testis ACE co-crystal structure with novel inhibitor lisW | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, CHLORIDE ION, ... | | Authors: | Watermeyer, J.M, Kroger, W.L, O'Neil, H.G, Sewell, B.T, Sturrock, E.D. | | Deposit date: | 2009-12-17 | | Release date: | 2010-04-28 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Characterization of domain-selective inhibitor binding in angiotensin-converting enzyme using a novel derivative of lisinopril.
Biochem.J., 428, 2010
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3BKL
 | | Testis ACE co-crystal structure with ketone ACE inhibitor kAW | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | | Authors: | Watermeyer, J.M, Kroger, W.L, O'Neill, H.G, Sewell, B.T, Sturrock, E.D. | | Deposit date: | 2007-12-07 | | Release date: | 2008-06-10 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.18 Å) | | Cite: | Probing the basis of domain-dependent inhibition using novel ketone inhibitors of Angiotensin-converting enzyme
Biochemistry, 47, 2008
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3BKK
 | | Tesis ACE co-crystal structure with ketone ACE inhibitor kAF | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, ... | | Authors: | Watermeyer, J.M, Kroger, W.L, O'Neill, H.G, Sewell, B.T, Sturrock, E.D. | | Deposit date: | 2007-12-07 | | Release date: | 2008-06-10 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.17 Å) | | Cite: | Probing the basis of domain-dependent inhibition using novel ketone inhibitors of Angiotensin-converting enzyme
Biochemistry, 47, 2008
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4UFA
 | | Crystal structure of the Angiotensin-1 converting enzyme N-domain in complex with Ac-SD | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ANGIOTENSIN-CONVERTING ENZYME, ... | | Authors: | Masuyer, G, Douglas, R.G, Sturrock, E.D, Acharya, K.R. | | Deposit date: | 2015-03-16 | | Release date: | 2015-10-07 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural Basis of Ac-Sdkp Hydrolysis by Angiotensin-I Converting Enzyme
Sci.Rep., 5, 2015
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4UFB
 | | Crystal structure of the Angiotensin-1 converting enzyme N-domain in complex with Lys-Pro | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ANGIOTENSIN-CONVERTING ENZYME, CHLORIDE ION, ... | | Authors: | Masuyer, G, Douglas, R.G, Sturrock, E.D, Acharya, K.R. | | Deposit date: | 2015-03-16 | | Release date: | 2015-10-07 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural Basis of Ac-Sdkp Hydrolysis by Angiotensin-I Converting Enzyme
Sci.Rep., 5, 2015
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7Z70
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7Z6Z
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2C6F
 | | Structure of human somatic angiontensin-I converting enzyme N domain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | | Authors: | Corradi, H.R, Schwager, S.L.U, Nichinda, A, Sturrock, E.D, Acharya, K.R. | | Deposit date: | 2005-11-09 | | Release date: | 2006-11-08 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (3.01 Å) | | Cite: | Crystal Structure of the N Domain of Human Somatic Angiotensin I-Converting Enzyme Provides a Structural Basis for Domain-Specific Inhibitor Design.
J.Mol.Biol., 357, 2006
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8QHL
 | | Human Angiotensin-1 converting enzyme N-domain in complex with the lactotripeptide VPP | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, ... | | Authors: | Gregory, K.S, Cozier, G.E, Acharya, K.R. | | Deposit date: | 2023-09-08 | | Release date: | 2023-11-22 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural insights into the inhibitory mechanism of angiotensin-I-converting enzyme by the lactotripeptides IPP and VPP.
Febs Lett., 598, 2024
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8QFX
 | | Human Angiotensin-1 converting enzyme N-domain in complex with the lactotripeptide IPP | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Gregory, K.S, Acharya, K.R, Cozier, G.E. | | Deposit date: | 2023-09-05 | | Release date: | 2023-11-22 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structural insights into the inhibitory mechanism of angiotensin-I-converting enzyme by the lactotripeptides IPP and VPP.
Febs Lett., 598, 2024
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6ZPQ
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6ZPT
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6ZPU
 | | Crystal structure of Angiotensin-1 converting enzyme C-domain with inserted symmetry molecule C-terminus. | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | | Authors: | Cozier, G.E, Acharya, K.R. | | Deposit date: | 2020-07-09 | | Release date: | 2020-10-28 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Angiotensin-converting enzyme open for business: structural insights into the subdomain dynamics.
Febs J., 288, 2021
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2XY9
 | | Human Angiotensin converting enzyme in complex with phosphinic tripeptide | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETATE ION, ... | | Authors: | Akif, M, Schwager, S.L, Anthony, C.S, Czarny, B, Beau, F, Dive, V, Sturrock, E.D, Acharya, K.R. | | Deposit date: | 2010-11-16 | | Release date: | 2011-05-11 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.97 Å) | | Cite: | Novel Mechanism of Inhibition of Human Angiotensin-I-Converting Enzyme (Ace) by a Highly Specific Phosphinic Tripeptide.
Biochem.J., 436, 2011
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2XYD
 | | human Angiotenisn converting enzyme N-domain in complex with Phosphinic tripeptide | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ANGIOTENSIN-CONVERTING ENZYME, CHLORIDE ION, ... | | Authors: | Akif, M, Schwager, S.L, Anthony, C.S, Czarny, B, Beau, F, Dive, V, Sturrock, E.D, Acharya, K.R. | | Deposit date: | 2010-11-17 | | Release date: | 2011-05-11 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Novel Mechanism of Inhibition of Human Angiotensin-I-Converting Enzyme (Ace) by a Highly Specific Phosphinic Tripeptide.
Biochem.J., 436, 2011
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2YDM
 | | Structural characterization of angiotensin-I converting enzyme in complex with a selenium analogue of captopril | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ANGIOTENSIN CONVERTING ENZYME, CHLORIDE ION, ... | | Authors: | Akif, M, Masuyer, G, Schwager, S.L.U, Bhuyan, B.J, Mugesh, G, Sturrock, E.D, Acharya, K.R. | | Deposit date: | 2011-03-22 | | Release date: | 2011-09-14 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.44 Å) | | Cite: | Structural Characterization of Angiotensin-I Converting Enzyme in Complex with a Selenium Analogue of Captopril
FEBS J., 278, 2011
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