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PDB: 106 results

1CFI
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NMR STRUCTURE OF CALCIUM ION-BOUND GAMMA-CARBOXY-GLUTAMIC ACID-RICH DOMAIN OF FACTOR IX
Descriptor: COAGULATION FACTOR IX
Authors:Freedman, S.J, Furie, B.C, Furie, B, Baleja, J.D.
Deposit date:1995-04-26
Release date:1996-06-20
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Structure of the calcium ion-bound gamma-carboxyglutamic acid-rich domain of factor IX.
Biochemistry, 34, 1995
1CFH
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STRUCTURE OF THE METAL-FREE GAMMA-CARBOXYGLUTAMIC ACID-RICH MEMBRANE BINDING REGION OF FACTOR IX BY TWO-DIMENSIONAL NMR SPECTROSCOPY
Descriptor: COAGULATION FACTOR IX, FORMIC ACID
Authors:Freedman, S.J, Furie, B.C, Furie, B, Baleja, J.D.
Deposit date:1995-02-26
Release date:1995-07-10
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Structure of the metal-free gamma-carboxyglutamic acid-rich membrane binding region of factor IX by two-dimensional NMR spectroscopy.
J.Biol.Chem., 270, 1995
1NL0
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Crystal structure of human factor IX Gla domain in complex of an inhibitory antibody, 10C12
Descriptor: CALCIUM ION, SULFATE ION, anti-factor IX antibody, ...
Authors:Huang, M, Furie, B.C, Furie, B.
Deposit date:2003-01-06
Release date:2004-01-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of the Calcium-stabilized Human Factor IX Gla Domain Bound to a Conformation-specific Anti-factor IX Antibody.
J.Biol.Chem., 279, 2004
1MGX
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COAGULATION FACTOR, MG(II), NMR, 7 STRUCTURES (BACKBONE ATOMS ONLY)
Descriptor: COAGULATION FACTOR IX
Authors:Freedman, S.J, Furie, B.C, Furie, B, Baleja, J.D.
Deposit date:1995-06-21
Release date:1996-11-08
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Identification of the phospholipid binding site in the vitamin K-dependent blood coagulation protein factor IX.
J.Biol.Chem., 271, 1996
3JTC
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BU of 3jtc by Molmil
Importance of Mg2+ in the Ca2+-Dependent Folding of the gamma-Carboxyglutamic Acid Domains of Vitamin K-Dependent clotting and anticlotting Proteins
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Endothelial protein C receptor, ...
Authors:Bajaj, S.P, Vadivel, K, Agah, S, Cascio, D, Krishnaswamy, S, Esmon, C, Padmanabhan, K.
Deposit date:2009-09-11
Release date:2011-04-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural and Functional Studies of gamma-Carboxyglutamic Acid Domains of Factor VIIa and Activated Protein C: Role of Magnesium at Physiological Calcium.
J.Mol.Biol., 425, 2013
1LQV
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Crystal structure of the Endothelial protein C receptor with phospholipid in the groove in complex with Gla domain of protein C.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Endothelial protein C receptor, ...
Authors:Oganesyan, V, Oganesyan, N, Terzyan, S, Dongfeng, Q, Dauter, Z, Esmon, N.L, Esmon, C.T.
Deposit date:2002-05-13
Release date:2002-06-19
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The crystal structure of the endothelial protein C receptor and a bound phospholipid.
J.Biol.Chem., 277, 2002
6C2W
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BU of 6c2w by Molmil
Crystal structure of human prothrombin mutant S101C/A470C
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Prothrombin, ...
Authors:Chinnaraj, M, Chen, Z, Pelc, L, Grese, Z, Bystranowska, D, Di Cera, E, Pozzi, N.
Deposit date:2018-01-09
Release date:2018-02-28
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (4.12 Å)
Cite:Structure of prothrombin in the closed form reveals new details on the mechanism of activation.
Sci Rep, 8, 2018
8UF7
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Cryo-EM structure of POmAb, a Type-I anti-prothrombin antiphospholipid antibody, bound to kringle-1 of human prothrombin
Descriptor: POmAb Heavy Chain, POmAb Light Chain, Prothrombin
Authors:Kumar, S, Summers, B, Basore, K, Pozzi, N.
Deposit date:2023-10-03
Release date:2024-02-14
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structure and functional basis of prothrombin recognition by a Type-I anti-prothrombin antiphospholipid antibody.
Blood, 2024
8EOK
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Structure of the C3bB proconvertase in complex with lufaxin and factor Xa
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Activated factor Xa heavy chain, Complement C3 beta chain, ...
Authors:Andersen, J.F, Lei, H.
Deposit date:2022-10-03
Release date:2023-08-30
Method:ELECTRON MICROSCOPY (3.53 Å)
Cite:A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism.
Blood, 141, 2023
6R2W
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BU of 6r2w by Molmil
Crystal structure of the super-active FVIIa variant VYT in complex with tissue factor
Descriptor: CALCIUM ION, Coagulation factor VII, N-acetyl-D-phenylalanyl-N-[(2S,3S)-6-carbamimidamido-1-chloro-2-hydroxyhexan-3-yl]-L-phenylalaninamide, ...
Authors:Sorensen, A.B, Svensson, L.A, Gandhi, P.S.
Deposit date:2019-03-19
Release date:2019-12-11
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Beating tissue factor at its own game: Design and properties of a soluble tissue factor-independent coagulation factor VIIa.
J.Biol.Chem., 295, 2020
4IBL
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BU of 4ibl by Molmil
Rubidium Sites in Blood Coagulation Factor VIIa
Descriptor: BENZAMIDINE, CALCIUM ION, CHLORIDE ION, ...
Authors:Vadivel, K, Schmidt, A, Cascio, D, Padmanabhan, K, Bajaj, S.P.
Deposit date:2012-12-08
Release date:2014-04-16
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of human factor VIIa-soluble tissue factor with calcium, magnesium and rubidium
Acta Crystallogr.,Sect.D, D77, 2021
3ELA
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BU of 3ela by Molmil
Crystal structure of active site inhibited coagulation factor VIIA mutant in complex with soluble tissue factor
Descriptor: CALCIUM ION, Coagulation factor VIIA heavy chain, Coagulation factor VIIA light chain, ...
Authors:Bjelke, J.R, Fodje, M, Svensson, L.A.
Deposit date:2008-09-21
Release date:2008-11-04
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mechanism of the Ca2+-induced enhancement of the intrinsic factor VIIa activity
J.Biol.Chem., 283, 2008
6BJR
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BU of 6bjr by Molmil
Crystal structure of prothrombin mutant S101C/A470C
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Prothrombin, ...
Authors:Chinnaraj, M, Chen, Z, Pelc, L, Grese, Z, Bystranowska, D, Di Cera, E, Pozzi, N.
Deposit date:2017-11-06
Release date:2018-06-27
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (6 Å)
Cite:Structure of prothrombin in the closed form reveals new details on the mechanism of activation.
Sci Rep, 8, 2018
6M3C
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BU of 6m3c by Molmil
hAPC-h1573 Fab complex
Descriptor: Vitamin K-dependent protein C heavy chain, Vitamin K-dependent protein C light chain, h1573 Fab H chain, ...
Authors:Wang, X, Wang, D, Zhao, X, Egner, U.
Deposit date:2020-03-03
Release date:2020-07-08
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia.
Nat Commun, 11, 2020
4BXS
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BU of 4bxs by Molmil
Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Lechtenberg, B.C, Murray-Rust, T.A, Johnson, D.J.D, Adams, T.E, Krishnaswamy, S, Camire, R.M, Huntington, J.A.
Deposit date:2013-07-15
Release date:2013-07-31
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.32 Å)
Cite:Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis.
Blood, 122, 2013
6M3B
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BU of 6m3b by Molmil
hAPC-c25k23 Fab complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Vitamin K-dependent protein C heavy chain, Vitamin K-dependent protein C light chain, ...
Authors:Wang, X, Li, L, Zhao, X, Egner, U.
Deposit date:2020-03-03
Release date:2020-07-08
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia.
Nat Commun, 11, 2020
7TPP
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BU of 7tpp by Molmil
Cryo-em structure of human prothrombin:prothrombinase at 4.1 Angstrom resolution
Descriptor: Activated factor Xa heavy chain, Coagulation factor Va, Factor X light chain, ...
Authors:Di Cera, E, Ruben, E.A.
Deposit date:2022-01-25
Release date:2022-05-04
Last modified:2022-06-29
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Cryo-EM structure of the prothrombin-prothrombinase complex.
Blood, 139, 2022
7TPQ
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BU of 7tpq by Molmil
Cryo-em structure of human prothrombinase on a nanodisc at 5.3 Angstrom resolution
Descriptor: Activated factor Xa heavy chain, Coagulation factor Va, Factor X light chain
Authors:Di Cera, E, Ruben, E.A.
Deposit date:2022-01-25
Release date:2022-05-04
Last modified:2022-06-29
Method:ELECTRON MICROSCOPY (5.3 Å)
Cite:Cryo-EM structure of the prothrombin-prothrombinase complex.
Blood, 139, 2022
4BXW
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BU of 4bxw by Molmil
Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis
Descriptor: COAGULATION FACTOR V, FACTOR XA, GLYCEROL, ...
Authors:Lechtenberg, B.C, Murray-Rust, T.A, Johnson, D.J.D, Adams, T.E, Krishnaswamy, S, Camire, R.M, Huntington, J.A.
Deposit date:2013-07-16
Release date:2013-07-31
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis.
Blood, 122, 2013
5EDK
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BU of 5edk by Molmil
Crystal structure of prothrombin deletion mutant residues 146-167 ( Form II ).
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, ...
Authors:Pozzi, N, Chen, Z, Di Cera, E.
Deposit date:2015-10-21
Release date:2016-01-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.214 Å)
Cite:How the Linker Connecting the Two Kringles Influences Activation and Conformational Plasticity of Prothrombin.
J.Biol.Chem., 291, 2016
5EDM
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BU of 5edm by Molmil
Crystal structure of prothrombin deletion mutant residues 154-167 ( Form I )
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ...
Authors:Pozzi, N, Chen, Z, Di Cera, E.
Deposit date:2015-10-21
Release date:2016-01-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:How the Linker Connecting the Two Kringles Influences Activation and Conformational Plasticity of Prothrombin.
J.Biol.Chem., 291, 2016
4O03
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BU of 4o03 by Molmil
Crystal structure of Ca2+ bound prothrombin deletion mutant residues 146-167
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Prothrombin
Authors:Pozzi, N, Chen, Z, Shropshire, D.B, Pelc, L.A, Di Cera, E.
Deposit date:2013-12-13
Release date:2014-05-21
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (3.38 Å)
Cite:The linker connecting the two kringles plays a key role in prothrombin activation.
Proc.Natl.Acad.Sci.USA, 111, 2014
4NZQ
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BU of 4nzq by Molmil
Crystal structure of Ca2+-free prothrombin deletion mutant residues 146-167
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Prothrombin
Authors:Pozzi, N, Chen, Z, Shropshire, D.B, Pelc, L.A, Di Cera, E.
Deposit date:2013-12-12
Release date:2014-05-21
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.807 Å)
Cite:The linker connecting the two kringles plays a key role in prothrombin activation.
Proc.Natl.Acad.Sci.USA, 111, 2014
3TH4
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BU of 3th4 by Molmil
Mg2+ Is Required for Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors At Physiological Ca2+
Descriptor: CALCIUM ION, CHLORIDE ION, Coagulation factor VII heavy chain, ...
Authors:Vadivel, K, Agah, S, Cascio, D, Padmanabhan, K, Bajaj, S.P.
Deposit date:2011-08-18
Release date:2012-08-22
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mg2+ Is Required for Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors At Physiological Ca2+
To be Published
3TH3
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BU of 3th3 by Molmil
Mg2+ Is Required for Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors At Physiological Ca2+
Descriptor: CALCIUM ION, CHLORIDE ION, Coagulation factor VII heavy chain, ...
Authors:Vadivel, K, Agah, S, Cascio, D, Padmanabhan, K, Bajaj, S.P.
Deposit date:2011-08-18
Release date:2012-08-22
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mg2+ Is Required for Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors At Physiological Ca2+
To be Published

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