8HCE
| Crystal structure of mTREX1-CMP complex | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, AMMONIUM ION, CYTIDINE-5'-MONOPHOSPHATE, ... | Authors: | Hsiao, Y.Y, Huang, K.W, Wu, C.Y. | Deposit date: | 2022-11-01 | Release date: | 2023-11-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.501 Å) | Cite: | Molecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids. Nucleic Acids Res., 51, 2023
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8HCF
| Crystal structure of mTREX1-UMP complex | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, SULFATE ION, Three-prime repair exonuclease 1, ... | Authors: | Hsiao, Y.Y, Huang, K.W, Wu, C.Y. | Deposit date: | 2022-11-01 | Release date: | 2023-11-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Molecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids. Nucleic Acids Res., 51, 2023
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5YWT
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3MXM
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8HCG
| Crystal structure of mTREX1-dAMP complex | Descriptor: | 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, MAGNESIUM ION, PENTAETHYLENE GLYCOL, ... | Authors: | Hsiao, Y.Y, Huang, K.W, Wu, C.Y. | Deposit date: | 2022-11-01 | Release date: | 2023-11-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.799 Å) | Cite: | Molecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids. Nucleic Acids Res., 51, 2023
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6W10
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3MXJ
| Crystal Structure of the mTREX1 Apoprotein | Descriptor: | Three prime repair exonuclease 1 | Authors: | Bailey, S.L, Hollis, T. | Deposit date: | 2010-05-07 | Release date: | 2011-05-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | X-ray Crystal Structures of TREX1 3' Exonuclease Autoimmune Disease Mutants To be Published
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8HCD
| Crystal structure of mTREX1-DNA product complex (dNMP) | Descriptor: | 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, COBALT (II) ION, ... | Authors: | Hsiao, Y.Y, Huang, K.W, Wu, C.Y. | Deposit date: | 2022-11-01 | Release date: | 2023-11-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Molecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids. Nucleic Acids Res., 51, 2023
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8HCC
| Crystal structure of mTREX1-RNA product complex (AMP) | Descriptor: | ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, SODIUM ION, ... | Authors: | Hsiao, Y.Y, Huang, K.W, Wu, C.Y. | Deposit date: | 2022-11-01 | Release date: | 2023-11-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Molecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids. Nucleic Acids Res., 51, 2023
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8HCH
| Crystal structure of mTREX1-Uridine complex | Descriptor: | MAGNESIUM ION, Three-prime repair exonuclease 1, URIDINE | Authors: | Hsiao, Y.Y, Huang, K.W, Wu, C.Y. | Deposit date: | 2022-11-01 | Release date: | 2023-11-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Molecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids. Nucleic Acids Res., 51, 2023
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5YWS
| Crystal structure of TREX1 in complex with a Y structured DNA | Descriptor: | A STEM LOOP DNA WITH Y-STRUCTURAL TERMINAL, MAGNESIUM ION, Three-prime repair exonuclease 1 | Authors: | Hsiao, Y.Y. | Deposit date: | 2017-11-30 | Release date: | 2018-05-23 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for overhang excision and terminal unwinding of DNA duplexes by TREX1 PLoS Biol., 16, 2018
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2IOC
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3B6O
| Structure of TREX1 in complex with a nucleotide and an inhibitor ion (lithium) | Descriptor: | LITHIUM ION, THYMIDINE-5'-PHOSPHATE, Three prime repair exonuclease 1 | Authors: | Brucet, M, Querol-Audi, J, Fita, I, Celada, A. | Deposit date: | 2007-10-29 | Release date: | 2008-09-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural and biochemical studies of TREX1 inhibition by metals. Identification of a new active histidine conserved in DEDDh exonucleases. Protein Sci., 17, 2008
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2OA8
| Crystal Structure of mTREX1 with ssDNA | Descriptor: | 5'-D(*GP*AP*CP*G)-3', CALCIUM ION, Three prime repair exonuclease 1 | Authors: | de Silva, U, Hollis, T. | Deposit date: | 2006-12-15 | Release date: | 2007-02-20 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The Crystal Structure of TREX1 Explains the 3' Nucleotide Specificity and Reveals a Polyproline II Helix for Protein Partnering. J.Biol.Chem., 282, 2007
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7U8Y
| TREX1 Structural Studies Capture Small Molecule Inhibition and Implicate Novel DNA Dynamics | Descriptor: | ALIZARIN RED, MANGANESE (II) ION, Three-prime repair exonuclease 1 | Authors: | Hemphill, W.O, Harvey, S.E, Simpson, S.R, Smalley, T.L, Salsbury, F.R, Perrino, F.W, Hollis, T. | Deposit date: | 2022-03-09 | Release date: | 2023-03-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | TREX1 Structural Studies Capture Small Molecule Inhibition and Implicate Novel DNA Dynamics to be published
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3U3Y
| Mouse TREX1 D200H mutant | Descriptor: | 1,4-BUTANEDIOL, 5'-D(*GP*AP*CP*G)-3', CALCIUM ION, ... | Authors: | Bailey, S.L, Harvey, S, Perrino, F.W, Hollis, T. | Deposit date: | 2011-10-06 | Release date: | 2011-12-28 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease. Dna Repair, 11, 2012
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5YWV
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3B6P
| Structure of TREX1 in complex with a nucleotide and inhibitor ions (sodium and zinc) | Descriptor: | SODIUM ION, THYMIDINE-5'-PHOSPHATE, Three prime repair exonuclease 1, ... | Authors: | Brucet, M, Querol-Audi, J, Fita, I, Celada, A. | Deposit date: | 2007-10-29 | Release date: | 2008-09-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural and biochemical studies of TREX1 inhibition by metals. Identification of a new active histidine conserved in DEDDh exonucleases. Protein Sci., 17, 2008
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3U6F
| Mouse TREX1 D200N mutant | Descriptor: | 1,4-BUTANEDIOL, 5'-D(*GP*AP*CP*G)-3', MAGNESIUM ION, ... | Authors: | Bailey, S.L, Harvey, S, Perrino, F.W, Hollis, T. | Deposit date: | 2011-10-12 | Release date: | 2011-12-28 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease. Dna Repair, 11, 2012
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2O4G
| Structure of TREX1 in complex with a nucleotide | Descriptor: | MAGNESIUM ION, THYMIDINE-5'-PHOSPHATE, Three prime repair exonuclease 1 | Authors: | Brucet, M, Macias, M.J, Fita, I, Celada, A. | Deposit date: | 2006-12-04 | Release date: | 2007-03-13 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structure of the dimeric exonuclease TREX1 in complex with DNA displays a proline-rich binding site for WW Domains. J.Biol.Chem., 282, 2007
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3MXI
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4YNQ
| TREX1-dsDNA complex | Descriptor: | DNA (24-MER), DNA (5'-D(P*GP*TP*GP*CP*TP*GP*AP*CP*GP*TP*CP*AP*GP*CP*AP*CP*GP*AP*CP*G)-3'), MAGNESIUM ION, ... | Authors: | Fye, J.M, Harvey, S, Perrino, F.W, Hollis, T. | Deposit date: | 2015-03-10 | Release date: | 2015-05-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease. Proc.Natl.Acad.Sci.USA, 112, 2015
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5YWU
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2O4I
| Structure of TREX1 in complex with DNA | Descriptor: | 5'-D(*GP*CP*TP*AP*GP*GP*CP*AP*GP*GP*AP*AP*CP*CP*CP*CP*TP*CP*CP*TP*CP*CP*CP*CP*T)-3', Three prime repair exonuclease 1 | Authors: | Brucet, M, Macias, M.J, Fita, I, Celada, A. | Deposit date: | 2006-12-04 | Release date: | 2007-03-13 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structure of the dimeric exonuclease TREX1 in complex with DNA displays a proline-rich binding site for WW Domains. J.Biol.Chem., 282, 2007
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