6ONA
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9BJM
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![BU of 9bjm by Molmil](/molmil-images/mine/9bjm) | Crystal Structure of Inhibitor 5c in Complex with Prefusion RSV F Glycoprotein | Descriptor: | 1'-{[5-chloro-1-(4,4,4-trifluorobutyl)-1H-1,3-benzimidazol-2-yl]methyl}-1-(methanesulfonyl)spiro[azetidine-3,3'-indol]-2'(1'H)-one, Prefusion RSV F (DS-CAV1),Envelope glycoprotein | Authors: | Shaffer, P.L, Milligan, C, Abeywickrema, P. | Deposit date: | 2024-04-25 | Release date: | 2024-07-10 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Spiro-Azetidine Oxindoles as Long-Acting Injectables for Pre-Exposure Prophylaxis against Respiratory Syncytial Virus Infections. J.Med.Chem., 67, 2024
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6VKE
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![BU of 6vke by Molmil](/molmil-images/mine/6vke) | Crystal Structure of Inhibitor JNJ-40012665 in Complex with Prefusion RSV F Glycoprotein | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 4-(5-chloro-2-{[1-(3,4-dimethoxyphenyl)-2-oxo-1,2-dihydro-3H-imidazo[4,5-c]pyridin-3-yl]methyl}-1H-indol-1-yl)butanenitrile, CHLORIDE ION, ... | Authors: | McLellan, J.S. | Deposit date: | 2020-01-20 | Release date: | 2020-05-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Discovery of 3-({5-Chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one (JNJ-53718678), a Potent and Orally Bioavailable Fusion Inhibitor of Respiratory Syncytial Virus. J.Med.Chem., 63, 2020
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6G9I
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![BU of 6g9i by Molmil](/molmil-images/mine/6g9i) | Crystal structure of Ebolavirus glycoprotein in complex with clomipramine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(3-CHLORO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE, Envelope glycoprotein,Envelope glycoprotein, ... | Authors: | Zhao, Y, Ren, J, Fry, E.E, Xiao, J, Townsend, A.R, Stuart, D.I. | Deposit date: | 2018-04-10 | Release date: | 2018-05-23 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Structures of Ebola Virus Glycoprotein Complexes with Tricyclic Antidepressant and Antipsychotic Drugs. J. Med. Chem., 61, 2018
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6A0Z
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![BU of 6a0z by Molmil](/molmil-images/mine/6a0z) | Crystal structure of broadly neutralizing antibody 13D4 bound to H5N1 influenza hemagglutinin, HA head region | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody 13D4, Fab Heavy Chain, ... | Authors: | Li, S, Li, T. | Deposit date: | 2018-06-06 | Release date: | 2018-06-20 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.329 Å) | Cite: | Structural Basis for the Broad, Antibody-Mediated Neutralization of H5N1 Influenza Virus. J. Virol., 92, 2018
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5KWW
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![BU of 5kww by Molmil](/molmil-images/mine/5kww) | Crystal Structure of Inhibitor JNJ-53718678 In Complex with Prefusion RSV F Glycoprotein | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[[5-chloranyl-1-(3-methylsulfonylpropyl)indol-2-yl]methyl]-1-[2,2,2-tris(fluoranyl)ethyl]imidazo[4,5-c]pyridin-2-one, ... | Authors: | McLellan, J.S, Battles, M.B, Arnoult, E, Roymans, D, Langedijk, J.P. | Deposit date: | 2016-07-19 | Release date: | 2017-08-02 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor. Nat Commun, 8, 2017
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6VKD
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![BU of 6vkd by Molmil](/molmil-images/mine/6vkd) | Crystal Structure of Inhibitor JNJ-36689282 in Complex with Prefusion RSV F Glycoprotein | Descriptor: | 1-cyclopropyl-3-({1-[3-(methylsulfonyl)propyl]-1H-pyrrolo[3,2-c]pyridin-2-yl}methyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one, CHLORIDE ION, Prefusion RSV F (DS-Cav1), ... | Authors: | McLellan, J.S. | Deposit date: | 2020-01-20 | Release date: | 2020-05-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Discovery of 3-({5-Chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one (JNJ-53718678), a Potent and Orally Bioavailable Fusion Inhibitor of Respiratory Syncytial Virus. J.Med.Chem., 63, 2020
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6VKC
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![BU of 6vkc by Molmil](/molmil-images/mine/6vkc) | Crystal Structure of Inhibitor JNJ-36811054 in Complex with Prefusion RSV F Glycoprotein | Descriptor: | 3-{[5-chloro-1-(4,4,4-trifluorobutyl)-1H-imidazo[4,5-b]pyridin-2-yl]methyl}-1-cyclopropyl-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one, CHLORIDE ION, D(-)-TARTARIC ACID, ... | Authors: | McLellan, J.S. | Deposit date: | 2020-01-20 | Release date: | 2020-05-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Discovery of 3-({5-Chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one (JNJ-53718678), a Potent and Orally Bioavailable Fusion Inhibitor of Respiratory Syncytial Virus. J.Med.Chem., 63, 2020
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7ZRV
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![BU of 7zrv by Molmil](/molmil-images/mine/7zrv) | cryo-EM structure of omicron spike in complex with de novo designed binder, full map | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Envelope glycoprotein, ... | Authors: | Pablo, G, Sarah, W, Alexandra, V.H, Anthony, M, Andreas, S, Zander, H, Dongchun, N, Shuguang, T, Freyr, S, Casper, G, Priscilla, T, Alexandra, T, Stephane, R, Sandrine, G, Jane, M, Aaron, P, Zepeng, X, Yan, C, Pu, H, George, G, Elisa, O, Beat, F, Didier, T, Henning, S, Michael, B, Bruno, E.C. | Deposit date: | 2022-05-05 | Release date: | 2023-03-08 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | De novo design of protein interactions with learned surface fingerprints. Nature, 617, 2023
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7AD1
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![BU of 7ad1 by Molmil](/molmil-images/mine/7ad1) | Cryo-EM structure of a prefusion stabilized SARS-CoV-2 Spike (D614N, R682S, R685G, A892P, A942P and V987P)(One up trimer) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Envelope glycoprotein,Spike glycoprotein,Envelope glycoprotein,SARS-CoV-2 S protein | Authors: | Rutten, L, Renault, L.L.R, Juraszek, J, Langedijk, J.P.M. | Deposit date: | 2020-09-14 | Release date: | 2020-11-04 | Last modified: | 2021-01-27 | Method: | ELECTRON MICROSCOPY (2.92 Å) | Cite: | Stabilizing the closed SARS-CoV-2 spike trimer. Nat Commun, 12, 2021
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8HFX
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![BU of 8hfx by Molmil](/molmil-images/mine/8hfx) | Cryo-EM structure of SARS-CoV-2 Omicron BA.1 spike protein in complex with white-tailed deer ACE2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, ... | Authors: | Han, P, Meng, Y.M, Qi, J.X. | Deposit date: | 2022-11-13 | Release date: | 2023-08-30 | Last modified: | 2023-10-25 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Structural basis of white-tailed deer, Odocoileus virginianus , ACE2 recognizing all the SARS-CoV-2 variants of concern with high affinity. J.Virol., 97, 2023
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7QTI
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![BU of 7qti by Molmil](/molmil-images/mine/7qti) | SARS-CoV-2 S Omicron Spike B.1.1.529 - 3-P2G3 and 1-P5C3 Fabs (Global) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, P2G3 Heavy Chain, ... | Authors: | Ni, D, Lau, K, Turelli, P, Fenwick, C, Perez, L, Pojer, F, Stahlberg, H, Pantaleo, G, Trono, D. | Deposit date: | 2022-01-14 | Release date: | 2022-08-03 | Last modified: | 2022-09-07 | Method: | ELECTRON MICROSCOPY (3.04 Å) | Cite: | Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeys. Nat Microbiol, 7, 2022
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5U68
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![BU of 5u68 by Molmil](/molmil-images/mine/5u68) | |
6W16
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![BU of 6w16 by Molmil](/molmil-images/mine/6w16) | |
7L7F
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![BU of 7l7f by Molmil](/molmil-images/mine/7l7f) | |
7FJN
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![BU of 7fjn by Molmil](/molmil-images/mine/7fjn) | Cryo-EM structure of South African (B.1.351) SARS-CoV-2 spike glycoprotein in complex with two T6 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Envelope glycoprotein, T6 heavy chain, ... | Authors: | Wang, X, Zhang, L, Zhang, S, Liang, Q. | Deposit date: | 2021-08-04 | Release date: | 2022-04-27 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | RBD trimer mRNA vaccine elicits broad and protective immune responses against SARS-CoV-2 variants. Iscience, 25, 2022
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6OUS
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![BU of 6ous by Molmil](/molmil-images/mine/6ous) | Structure of fusion glycoprotein from human respiratory syncytial virus | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F1 fused with Fibritin trimerization domain, Fusion glycoprotein F2, ... | Authors: | Su, H.P. | Deposit date: | 2019-05-05 | Release date: | 2019-10-30 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein. Nat Commun, 10, 2019
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7MPG
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7KC1
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6DC5
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![BU of 6dc5 by Molmil](/molmil-images/mine/6dc5) | RSV prefusion F in complex with AM22 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Jones, H.G, McLellan, J.S. | Deposit date: | 2018-05-04 | Release date: | 2019-07-10 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Alternative conformations of a major antigenic site on RSV F. Plos Pathog., 15, 2019
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6DC3
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![BU of 6dc3 by Molmil](/molmil-images/mine/6dc3) | RSV prefusion F bound to RSD5 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab RSD5-Germline Heavy Chain, Fab RSD5-Germline Light Chain, ... | Authors: | Battles, M.B, McLellan, J.S, Jones, H.J. | Deposit date: | 2018-05-04 | Release date: | 2019-07-10 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.501 Å) | Cite: | Alternative conformations of a major antigenic site on RSV F. Plos Pathog., 15, 2019
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6CXC
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![BU of 6cxc by Molmil](/molmil-images/mine/6cxc) | 3.9A Cryo-EM structure of murine antibody bound at a novel epitope of respiratory syncytial virus fusion protein | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0, Envelope glycoprotein chimera, ... | Authors: | Xie, Q, Wang, Z, Chen, X, Ni, F, Ma, J, Wang, Q. | Deposit date: | 2018-04-02 | Release date: | 2019-07-31 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structure basis of neutralization by a novel site II/IV antibody against respiratory syncytial virus fusion protein. Plos One, 14, 2019
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5I08
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![BU of 5i08 by Molmil](/molmil-images/mine/5i08) | Prefusion structure of a human coronavirus spike protein | Descriptor: | Spike glycoprotein,Foldon chimera | Authors: | Kirchdoerfer, R.N, Cottrell, C.A, Wang, N, Pallesen, J, Yassine, H.M, Turner, H.L, Corbett, K.S, Graham, B.S, McLellan, J.S, Ward, A.B. | Deposit date: | 2016-02-03 | Release date: | 2016-03-02 | Last modified: | 2020-04-22 | Method: | ELECTRON MICROSCOPY (4.04 Å) | Cite: | Pre-fusion structure of a human coronavirus spike protein. Nature, 531, 2016
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6APD
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![BU of 6apd by Molmil](/molmil-images/mine/6apd) | Crystal structure of RSV F bound by AM22 and the infant antibody ADI-19425 | Descriptor: | AM22 Fab Heavy Chain,IGH@ protein, AM22 Fab Light Chain,Uncharacterized protein, Fusion glycoprotein F0,Envelope glycoprotein, ... | Authors: | Wrapp, D, McLellan, J.S. | Deposit date: | 2017-08-17 | Release date: | 2018-03-21 | Last modified: | 2020-01-01 | Method: | X-RAY DIFFRACTION (4.1 Å) | Cite: | Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation. Immunity, 48, 2018
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6CNV
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![BU of 6cnv by Molmil](/molmil-images/mine/6cnv) | INFLUENZA B/BRISBANE HEMAGGLUTININ FAB CR9115 SD84H COMPLEX | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CR9114 Fab heavy chain, ... | Authors: | Luo, J, Obmolova, G. | Deposit date: | 2018-03-09 | Release date: | 2018-11-14 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (4.1 Å) | Cite: | Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin. Science, 362, 2018
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