4M1C
| Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Amyloid-Beta (1-40) | Descriptor: | Amyloid beta A4 protein, Fab-bound IDE, heavy chain, ... | Authors: | McCord, L.M, Liang, W, Farcasanu, M, Scherpelz, K, Meredith, S.C, Koide, S, Tang, W.J. | Deposit date: | 2013-08-02 | Release date: | 2014-08-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.5007 Å) | Cite: | Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Amyloid-Beta (1-40) To be Published
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8AZT
| Type II amyloid-beta 42 filaments from high-spin supernatants of aqueous extracts from Alzheimer's disease brains | ABeta42 | Descriptor: | Amyloid-beta precursor protein | Authors: | Yang, Y, Stern, M.A, Meunier, L.A, Liu, W, Cai, Y.Q, Ericsson, M, Liu, L, Selkoe, J.D, Goedert, M, Scheres, H.W.S. | Deposit date: | 2022-09-06 | Release date: | 2022-11-02 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Abundant A beta fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer's disease brains. Neuron, 111, 2023
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8KF6
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8OWJ
| Lipidic amyloid-beta(1-40) fibril - polymorph L2-L2 | Descriptor: | Amyloid-beta A4 protein | Authors: | Frieg, B, Han, M, Giller, K, Dienemann, C, Riedel, D, Becker, S, Andreas, L.B, Griesinger, C, Schroeder, G.F. | Deposit date: | 2023-04-28 | Release date: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.75 Å) | Cite: | Cryo-EM structures of lipidic fibrils of amyloid-beta (1-40). Nat Commun, 15, 2024
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8OWE
| Lipidic amyloid-beta(1-40) fibril - polymorph L2-L3 | Descriptor: | Amyloid-beta A4 protein | Authors: | Frieg, B, Han, M, Giller, K, Dienemann, C, Riedel, D, Becker, S, Andreas, L.B, Griesinger, C, Schroeder, G.F. | Deposit date: | 2023-04-27 | Release date: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.75 Å) | Cite: | Cryo-EM structures of lipidic fibrils of amyloid-beta (1-40). Nat Commun, 15, 2024
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8SEL
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8OL6
| Murine type II Abeta fibril from tgAPPSwe mouse | Descriptor: | Amyloid-beta protein 42 | Authors: | Zielinski, M, Peralta Reyes, F.S, Gremer, L, Schemmert, S, Frieg, B, Willuweit, A, Donner, L, Elvers, M, Nilsson, L.N.G, Syvanen, S, Sehlin, D, Ingelsson, M, Willbold, D, Schroeder, G.F. | Deposit date: | 2023-03-30 | Release date: | 2023-11-29 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-EM of A beta fibrils from mouse models find tg-APP ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease. Nat.Neurosci., 26, 2023
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8OWK
| Lipidic amyloid-beta(1-40) fibril - polymorph L3-L3 | Descriptor: | Amyloid-beta A4 protein | Authors: | Frieg, B, Han, M, Giller, K, Dienemann, C, Riedel, D, Becker, S, Andreas, L.B, Griesinger, C, Schroeder, G.F. | Deposit date: | 2023-04-28 | Release date: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.86 Å) | Cite: | Cryo-EM structures of lipidic fibrils of amyloid-beta (1-40). Nat Commun, 15, 2024
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5OQV
| Near-atomic resolution fibril structure of complete amyloid-beta(1-42) by cryo-EM | Descriptor: | Amyloid beta A4 protein | Authors: | Gremer, L, Schoelzel, D, Schenk, C, Reinartz, E, Labahn, J, Ravelli, R, Tusche, M, Lopez-Iglesias, C, Hoyer, W, Heise, H, Willbold, D, Schroeder, G.F. | Deposit date: | 2017-08-14 | Release date: | 2017-09-13 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Fibril structure of amyloid-beta (1-42) by cryo-electron microscopy. Science, 358, 2017
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8OLQ
| DI3 Abeta fibril from tg-SwDI mouse | Descriptor: | Amyloid-beta protein 42 | Authors: | Zielinski, M, Peralta Reyes, F.S, Gremer, L, Schemmert, S, Frieg, B, Willuweit, A, Donner, L, Elvers, M, Nilsson, L.N.G, Syvanen, S, Sehlin, D, Ingelsson, M, Willbold, D, Schroeder, G.F. | Deposit date: | 2023-03-30 | Release date: | 2023-11-29 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Cryo-EM of A beta fibrils from mouse models find tg-APP ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease. Nat.Neurosci., 26, 2023
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8OLG
| DI2 Abeta fibril from tg-SwDI mouse | Descriptor: | Amyloid-beta protein 42 | Authors: | Zielinski, M, Peralta Reyes, F.S, Gremer, L, Schemmert, S, Frieg, B, Willuweit, A, Donner, L, Elvers, M, Nilsson, L.N.G, Syvanen, S, Sehlin, D, Ingelsson, M, Willbold, D, Schroeder, G.F. | Deposit date: | 2023-03-30 | Release date: | 2023-11-29 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Cryo-EM of A beta fibrils from mouse models find tg-APP ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease. Nat.Neurosci., 26, 2023
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6SHS
| Abeta fibril (Morphology I) | Descriptor: | Amyloid-beta precursor protein | Authors: | Kollmer, M, Fandrich, M. | Deposit date: | 2019-08-08 | Release date: | 2019-11-06 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Cryo-EM structure and polymorphism of A beta amyloid fibrils purified from Alzheimer's brain tissue. Nat Commun, 10, 2019
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5AEF
| Electron cryo-microscopy of an Abeta(1-42)amyloid fibril | Descriptor: | AMYLOID BETA A4 PROTEIN | Authors: | Schmidt, M, Rohou, A, Lasker, K, Yadav, J.K, Schiene-Fischer, C, Fandrich, M, Grigorieff, N. | Deposit date: | 2015-08-29 | Release date: | 2015-10-14 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (5 Å) | Cite: | Peptide Dimer Structure in an Abeta(1-42) Fibril Visualized with Cryo-Em Proc.Natl.Acad.Sci.USA, 112, 2015
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2M4J
| 40-residue beta-amyloid fibril derived from Alzheimer's disease brain | Descriptor: | Amyloid beta A4 protein | Authors: | Lu, J, Qiang, W, Meredith, S.C, Yau, W, Schweiters, C.D, Tycko, R. | Deposit date: | 2013-02-05 | Release date: | 2013-09-25 | Last modified: | 2024-05-15 | Method: | SOLID-STATE NMR | Cite: | Molecular Structure of beta-Amyloid Fibrils in Alzheimer's Disease Brain Tissue. Cell(Cambridge,Mass.), 154, 2013
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7B3J
| Dynamic complex between all-D-enantiomeric peptide D3 with wild-type amyloid precursor protein 672-726 fragment (amyloid beta 1-55) | Descriptor: | D3 all D-enantimeric peptide, Isoform L-APP677 of Amyloid-beta precursor protein | Authors: | Bocharov, E.V, Volynsky, P.E, Okhrimenko, I.S, Urban, A.S. | Deposit date: | 2020-12-01 | Release date: | 2021-01-13 | Last modified: | 2021-12-08 | Method: | SOLUTION NMR | Cite: | All - d - Enantiomeric Peptide D3 Designed for Alzheimer's Disease Treatment Dynamically Interacts with Membrane-Bound Amyloid-beta Precursors. J.Med.Chem., 64, 2021
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6YHF
| Solution NMR Structure of APP TMD | Descriptor: | Amyloid-beta precursor protein | Authors: | Silber, M, Muhle-Goll, C. | Deposit date: | 2020-03-29 | Release date: | 2020-12-09 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase. Acs Chem Neurosci, 11, 2020
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2BP4
| Zinc-binding domain of Alzheimer's disease amyloid beta-peptide in TFE-water (80-20) solution | Descriptor: | AMYLOID BETA A4 PROTEIN | Authors: | Zirah, S, Kozin, S.A, Mazur, A.K, Blond, A, Cheminant, M, Segalas-Milazzo, I, Debey, P, Rebuffat, S. | Deposit date: | 2005-04-18 | Release date: | 2005-04-21 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural Changes of Region 1-16 of the Alzheimer Disease Amyloid Beta-Peptide Upon Zinc Binding and in Vitro Aging. J.Biol.Chem., 281, 2006
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6YHP
| Solution NMR Structure of APP V44M mutant TMD | Descriptor: | Amyloid-beta precursor protein V44M mutant | Authors: | Silber, M, Muhle-Goll, C. | Deposit date: | 2020-03-30 | Release date: | 2020-12-09 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase. Acs Chem Neurosci, 11, 2020
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6YHX
| Solution NMR Structure of APP I45T mutant TMD | Descriptor: | Amyloid-beta precursor protein I45T mutant | Authors: | Silber, M, Muhle-Goll, C. | Deposit date: | 2020-03-31 | Release date: | 2020-12-09 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase. Acs Chem Neurosci, 11, 2020
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6YHO
| Solution NMR Structure of APP G38P mutant TM | Descriptor: | Amyloid-beta precursor protein G38P mutant | Authors: | Silber, M, Muhle-Goll, C. | Deposit date: | 2020-03-30 | Release date: | 2020-12-09 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase. Acs Chem Neurosci, 11, 2020
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2BEG
| 3D Structure of Alzheimer's Abeta(1-42) fibrils | Descriptor: | Amyloid beta A4 protein | Authors: | Luhrs, T, Ritter, C, Adrian, M, Riek-Loher, D, Bohrmann, B, Dobeli, H, Schubert, D, Riek, R. | Deposit date: | 2005-10-24 | Release date: | 2005-11-22 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | 3D structure of Alzheimer's amyloid-{beta}(1-42) fibrils. Proc.Natl.Acad.Sci.Usa, 102, 2005
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6YHI
| Solution NMR Structure of APP G38L mutant TMD | Descriptor: | Amyloid-beta precursor protein G38L mutant | Authors: | Silber, M, Muhle-Goll, C. | Deposit date: | 2020-03-30 | Release date: | 2020-12-09 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase. Acs Chem Neurosci, 11, 2020
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6SZF
| Solution structure of the amyloid beta-peptide (1-42) | Descriptor: | Amyloid-beta precursor protein | Authors: | Grimaldi, M, Santoro, A, Stillitano, I, Buonocore, M, D'Ursi, A.M. | Deposit date: | 2019-10-02 | Release date: | 2020-10-14 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Exploring the Early Stages of the Amyloid A beta (1-42) Peptide Aggregation Process: An NMR Study. Pharmaceuticals, 14, 2021
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2MXU
| 42-Residue Beta Amyloid Fibril | Descriptor: | Amyloid beta A4 protein | Authors: | Xiao, Y, Ma, B, McElheny, D, Parthasarathy, S, Long, F, Hoshi, M, Nussinov, R, Ishii, Y. | Deposit date: | 2015-01-14 | Release date: | 2015-05-06 | Last modified: | 2024-05-01 | Method: | SOLID-STATE NMR | Cite: | A beta (1-42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease. Nat.Struct.Mol.Biol., 22, 2015
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1AMC
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