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PDB: 18 results

1SFQ
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Fast form of thrombin mutant R(77a)A bound to PPACK
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, SODIUM ION, ...
Authors:Pineda, A.O, Carrell, C.J, Bush, L.A, Prasad, S, Caccia, S, Chen, Z.W, Mathews, F.S, Di Cera, E.
Deposit date:2004-02-20
Release date:2004-06-08
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Molecular dissection of na+ binding to thrombin.
J.Biol.Chem., 279, 2004
3QDZ
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Crystal structure of the human thrombin mutant D102N in complex with the extracellular fragment of human PAR4.
Descriptor: Proteinase-activated receptor 4, Thrombin heavy chain, Thrombin light chain
Authors:Gandhi, P, Chen, Z, Appelbaum, E, Zapata, F, Di Cera, E.
Deposit date:2011-01-19
Release date:2011-06-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis of thrombin-protease-receptor interactions
IUBMB LIFE, 63, 2011
1SG8
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Crystal structure of the procoagulant fast form of thrombin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, thrombin
Authors:Pineda, A.O, Carrell, C.J, Bush, L.A, Prasad, S, Caccia, S, Chen, Z.W, Mathews, F.S, Di Cera, E.
Deposit date:2004-02-23
Release date:2004-06-08
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular dissection of na+ binding to thrombin.
J.Biol.Chem., 279, 2004
1SGI
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Crystal structure of the anticoagulant slow form of thrombin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, thrombin
Authors:Pineda, A.O, Carrell, C.J, Bush, L.A, Prasad, S, Caccia, S, Chen, Z.W, Mathews, F.S, Di Cera, E.
Deposit date:2004-02-23
Release date:2004-06-08
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular dissection of na+ binding to thrombin.
J.Biol.Chem., 279, 2004
1SHH
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Slow form of Thrombin Bound with PPACK
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, thrombin
Authors:Pineda, A.O, Carrell, C.J, Bush, L.A, Prasad, S, Caccia, S, Chen, Z.W, Mathews, F.S, Di Cera, E.
Deposit date:2004-02-25
Release date:2004-06-08
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Molecular dissection of na+ binding to thrombin.
J.Biol.Chem., 279, 2004
3LU9
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Crystal structure of human thrombin mutant S195A in complex with the extracellular fragment of human PAR1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Proteinase-activated receptor 1, ...
Authors:Gandhi, P.S, Chen, Z, Di Cera, E.
Deposit date:2010-02-17
Release date:2010-03-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of thrombin bound to the uncleaved extracellular fragment of PAR1.
J.Biol.Chem., 285, 2010
2OCV
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BU of 2ocv by Molmil
Structural basis of Na+ activation mimicry in murine thrombin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Thrombin
Authors:Marino, F, Chen, Z, Ergenekan, C.E, Bush, L.A, Mathews, F.S, Di Cera, E.
Deposit date:2006-12-21
Release date:2007-04-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis of na+ activation mimicry in murine thrombin.
J.Biol.Chem., 282, 2007
2PGQ
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Human thrombin mutant C191A-C220A in complex with the inhibitor PPACK
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, Thrombin heavy chain, ...
Authors:Bush-Pelc, L.A, Marino, F, Chen, Z, Pineda, A.O, Mathews, F.S, Di Cera, E.
Deposit date:2007-04-10
Release date:2007-07-17
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Important role of the cys-191 cys-220 disulfide bond in thrombin function and allostery
J.Biol.Chem., 282, 2007
2PGB
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BU of 2pgb by Molmil
Inhibitor-free human thrombin mutant C191A-C220A
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Prothrombin, SULFATE ION
Authors:Bush-Pelc, L.A, Marino, F, Chen, Z, Pineda, A.O, Mathews, F.S, Di Cera, E.
Deposit date:2007-04-09
Release date:2007-07-17
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Important role of the cys-191 cys-220 disulfide bond in thrombin function and allostery
J.Biol.Chem., 282, 2007
6P9U
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Crystal structure of human thrombin mutant W215A
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Prothrombin, ZINC ION
Authors:Pelc, L.A, Koester, S.K, Chen, Z, Di Cera, E.
Deposit date:2019-06-10
Release date:2019-09-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Residues W215, E217 and E192 control the allosteric E*-E equilibrium of thrombin.
Sci Rep, 9, 2019
3BEF
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BU of 3bef by Molmil
Crystal structure of thrombin bound to the extracellular fragment of PAR1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Proteinase-activated receptor 1, Prothrombin
Authors:Gandhi, P.S, Bah, A, Chen, Z, Mathews, F.S, Di Cera, E.
Deposit date:2007-11-17
Release date:2008-01-01
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural identification of the pathway of long-range communication in an allosteric enzyme.
Proc.Natl.Acad.Sci.Usa, 105, 2008
5JDU
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BU of 5jdu by Molmil
Crystal structure for human thrombin mutant D189A
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GLYCEROL, ...
Authors:Pozzi, N, Chen, Z, Di Cera, E.
Deposit date:2016-04-17
Release date:2016-07-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Loop Electrostatics Asymmetry Modulates the Preexisting Conformational Equilibrium in Thrombin.
Biochemistry, 55, 2016
4MLF
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BU of 4mlf by Molmil
Crystal structure for the complex of thrombin mutant D102N and hirudin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, Hirudin variant-1, ...
Authors:Vogt, A.D, Pozzi, N, Chen, Z, Di Cera, E.
Deposit date:2013-09-06
Release date:2013-09-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Essential role of conformational selection in ligand binding.
Biophys.Chem., 186C, 2014
4RKJ
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BU of 4rkj by Molmil
Crystal structure of thrombin mutant S195T (free form)
Descriptor: GLYCEROL, POTASSIUM ION, Thrombin heavy chain, ...
Authors:Pelc, A.L, Chen, Z, Gohara, D.W, Vogt, A.D, Pozzi, N, Di Cera, E.
Deposit date:2014-10-13
Release date:2015-03-11
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Why ser and not thr brokers catalysis in the trypsin fold.
Biochemistry, 54, 2015
4RKO
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BU of 4rko by Molmil
Crystal structure of thrombin mutant S195T bound with PPACK
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ...
Authors:Pelc, A.L, Chen, Z, Gohara, D.W, Vogt, A.D, Pozzi, N, Di Cera, E.
Deposit date:2014-10-13
Release date:2015-03-11
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Why ser and not thr brokers catalysis in the trypsin fold.
Biochemistry, 54, 2015
3S7K
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BU of 3s7k by Molmil
Structure of thrombin mutant Y225P in the E form
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, POTASSIUM ION, Prothrombin
Authors:Niu, W, Chen, Z, Gandhi, P, Vogt, A, Pozzi, N, Pele, L.A, Zapata, F, Di Cera, E.
Deposit date:2011-05-26
Release date:2011-07-06
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystallographic and Kinetic Evidence of Allostery in a Trypsin-like Protease.
Biochemistry, 50, 2011
3BV9
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Structure of Thrombin Bound to the Inhibitor FM19
Descriptor: FM19 inhibitor, GLYCEROL, IODIDE ION, ...
Authors:Nieman, M.T, Burke, F, Warnock, M, Zhou, Y, Sweigert, J, Chen, A, Ricketts, D, Lucchesi, B.R, Chen, Z, Di Cera, E, Hilfinger, J, Mosberg, H.I, Schmaier, A.H.
Deposit date:2008-01-05
Release date:2008-03-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Thrombostatin FM compounds: direct thrombin inhibitors - mechanism of action in vitro and in vivo.
J.Thromb.Haemost., 6, 2008
3R3G
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BU of 3r3g by Molmil
Structure of human thrombin with residues 145-150 of murine thrombin.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, Thrombin Heavy Chain, ...
Authors:Pozzi, N, Chen, R, Chen, Z, Bah, A, Di Cera, E.
Deposit date:2011-03-15
Release date:2011-05-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Rigidification of the autolysis loop enhances Na(+) binding to thrombin.
Biophys.Chem., 159, 2011

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PDB entries from 2024-03-27

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