9BQC
 
 | | Human Topoisomerase 2 Beta ATPase domain bound to obex 5c and non-hydrolyzable ATP analog AMPPNP | | Descriptor: | 8-(3,4-dihydroquinoline-1(2H)-carbonyl)-7-(2-hydroxyethoxy)-4-propyl-2H-1-benzopyran-2-one, DNA topoisomerase 2-beta, MAGNESIUM ION, ... | | Authors: | Cong, A.T.Q, Austin, C.A, Kubes, J, Karabanovich, G, Melnikova, I, Lencova, O, Kollarova, P, Piskackova, H.B, Kerestes, V, Applova, L, Arrouye, L, Alvey, J.A, Paluncic, J, Witter, T.L, Jirkovska, A, Kunes, J, Sterbova, P, Sterba, M, Simunek, T, Roh, J, Schellenberg, M.J. | | Deposit date: | 2024-05-09 | | Release date: | 2025-06-25 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Topobexin targets the Topoisomerase II ATPase domain for beta isoform-selective inhibition and anthracycline cardioprotection.
Nat Commun, 16, 2025
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9BQ7
 | | Human Topoisomerase 2 Alpha ATPase domain bound to BNS22 and non-hydrolyzable ATP analog AMPPNP | | Descriptor: | 8-(3,4-dihydroquinoline-1(2H)-carbonyl)-5,7-dimethoxy-4-propyl-2H-1-benzopyran-2-one, CHLORIDE ION, DNA topoisomerase 2-alpha, ... | | Authors: | Cong, A.T.Q, Austin, C.A, Kubes, J, Karabanovich, G, Melnikova, I, Lencova, O, Kollarova, P, Piskackova, H.B, Kerestes, V, Applova, L, Arrouye, L, Alvey, J.A, Paluncic, J, Witter, T.L, Jirkovska, A, Kunes, J, Sterbova, P, Sterba, M, Simunek, T, Roh, J, Schellenberg, M.J. | | Deposit date: | 2024-05-09 | | Release date: | 2025-06-25 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Topobexin targets the Topoisomerase II ATPase domain for beta isoform-selective inhibition and anthracycline cardioprotection.
Nat Commun, 16, 2025
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9BQB
 | | Human Topoisomerase 2 Alpha ATPase domain bound to topobexin and non-hydrolyzable ATP analog AMPPNP | | Descriptor: | 8-(3,4-dihydroquinoline-1(2H)-carbonyl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-4-propyl-2H-1-benzopyran-2-one, CHLORIDE ION, DNA topoisomerase 2-alpha, ... | | Authors: | Cong, A.T.Q, Austin, C.A, Kubes, J, Karabanovich, G, Melnikova, I, Lencova, O, Kollarova, P, Piskackova, H.B, Kerestes, V, Applova, L, Arrouye, L, Alvey, J.A, Paluncic, J, Witter, T.L, Jirkovska, A, Kunes, J, Sterbova, P, Sterba, M, Simunek, T, Roh, J, Schellenberg, M.J. | | Deposit date: | 2024-05-09 | | Release date: | 2025-06-25 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Topobexin targets the Topoisomerase II ATPase domain for beta isoform-selective inhibition and anthracycline cardioprotection.
Nat Commun, 16, 2025
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9BQ9
 | | Human Topoisomerase 2 Alpha ATPase domain bound to obex 5c and non-hydrolyzable ATP analog AMPPNP | | Descriptor: | 8-(3,4-dihydroquinoline-1(2H)-carbonyl)-7-(2-hydroxyethoxy)-4-propyl-2H-1-benzopyran-2-one, CHLORIDE ION, DNA topoisomerase 2-alpha, ... | | Authors: | Cong, A.T.Q, Kubes, J, Karabanovich, G, Melnikova, I, Lencova, O, Kollarova, P, Piskackova, H.B, Kerestes, V, Applova, L, Arrouye, L, Alvey, J.A, Paluncic, J, Witter, T.L, Jirkovska, A, Kunes, J, Sterbova, P, Austin, C.A, Sterba, M, Simunek, T, Roh, J, Schellenberg, M.J. | | Deposit date: | 2024-05-09 | | Release date: | 2025-06-25 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Topobexin targets the Topoisomerase II ATPase domain for beta isoform-selective inhibition and anthracycline cardioprotection.
Nat Commun, 16, 2025
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9BQD
 | | Human Topoisomerase 2 Beta ATPase domain bound to topobexin and non-hydrolyzable ATP analog AMPPNP | | Descriptor: | 8-(3,4-dihydroquinoline-1(2H)-carbonyl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-4-propyl-2H-1-benzopyran-2-one, DNA topoisomerase 2-beta, MAGNESIUM ION, ... | | Authors: | Cong, A.T.Q, Austin, C.A, Kubes, J, Karabanovich, G, Melnikova, I, Lencova, O, Kollarova, P, Piskackova, H.B, Kerestes, V, Applova, L, Arrouye, L, Alvey, J.A, Paluncic, J, Witter, T.L, Jirkovska, A, Kunes, J, Sterbova, P, Sterba, M, Simunek, T, Roh, J, Schellenberg, M.J. | | Deposit date: | 2024-05-09 | | Release date: | 2025-06-25 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Topobexin targets the Topoisomerase II ATPase domain for beta isoform-selective inhibition and anthracycline cardioprotection.
Nat Commun, 16, 2025
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9BQ6
 | | Human Topoisomerase 2 Alpha ATPase domain bound to non-hydrolyzable ATP analog AMPPNP | | Descriptor: | DNA topoisomerase 2-alpha, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Paluncic, J, Witter, T.L, Kubes, J, Karabanovich, G, Cong, A.T.Q, Melnikova, I, Lencova, O, Kollarova, P, Piskackova, H.B, Kerestes, V, Applova, L, Arrouye, L, Alvey, J.A, Jirkovska, A, Kunes, J, Austin, C.A, Sterbova, P, Sterba, M, Simunek, T, Roh, J, Schellenberg, M.J. | | Deposit date: | 2024-05-09 | | Release date: | 2025-06-25 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Topobexin targets the Topoisomerase II ATPase domain for beta isoform-selective inhibition and anthracycline cardioprotection.
Nat Commun, 16, 2025
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9BQ8
 | | Human Topoisomerase 2 Beta ATPase domain bound to non-hydrolyzable ATP analog AMPPNP | | Descriptor: | DNA topoisomerase 2-beta, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Cong, A.T.Q, Austin, C.A, Kubes, J, Karabanovich, G, Melnikova, I, Lencova, O, Kollarova, P, Piskackova, H.B, Kerestes, V, Applova, L, Arrouye, L, Alvey, J.A, Paluncic, J, Witter, T.L, Jirkovska, A, Kunes, J, Sterbova, P, Sterba, M, Simunek, T, Roh, J, Schellenberg, M.J. | | Deposit date: | 2024-05-09 | | Release date: | 2025-06-25 | | Method: | X-RAY DIFFRACTION (1.25 Å) | | Cite: | Topobexin targets the Topoisomerase II ATPase domain for beta isoform-selective inhibition and anthracycline cardioprotection.
Nat Commun, 16, 2025
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9BQA
 | | Human Topoisomerase 2 Beta ATPase domain bound to BNS22 and non-hydrolyzable ATP analog AMPPNP | | Descriptor: | 8-(3,4-dihydroquinoline-1(2H)-carbonyl)-5,7-dimethoxy-4-propyl-2H-1-benzopyran-2-one, DNA topoisomerase 2-beta, GLYCEROL, ... | | Authors: | Cong, A.T.Q, Austin, C.A, Kubes, J, Karabanovich, G, Melnikova, I, Lencova, O, Kollarova, P, Piskackova, H.B, Kerestes, V, Applova, L, Arrouye, L, Alvey, J.A, Paluncic, J, Witter, T.L, Jirkovska, A, Kunes, J, Sterbova, P, Sterba, M, Simunek, T, Roh, J, Schellenberg, M.J. | | Deposit date: | 2024-05-09 | | Release date: | 2025-06-25 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Topobexin targets the Topoisomerase II ATPase domain for beta isoform-selective inhibition and anthracycline cardioprotection.
Nat Commun, 16, 2025
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