3VD7
| E. coli (lacZ) beta-galactosidase (N460S) in complex with galactotetrazole | Descriptor: | (5R, 6S, 7S, ... | Authors: | Wheatley, R.W, Kappelhoff, J.C, Hahn, J.N, Dugdale, M.L, Dutkoski, M.J, Tamman, S.D, Fraser, M.E, Huber, R.E. | Deposit date: | 2012-01-04 | Release date: | 2012-04-11 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.87 Å) | Cite: | Substitution for Asn460 cripples {beta}-galactosidase (Escherichia coli) by increasing substrate affinity and decreasing transition state stability. Arch.Biochem.Biophys., 521, 2012
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3VEB
| Crystal Structure of Matp-matS | Descriptor: | 5'-D(*AP*CP*GP*TP*GP*AP*CP*AP*AP*TP*GP*TP*CP*AP*CP*G)-3', 5'-D(*TP*CP*GP*TP*GP*AP*CP*AP*TP*TP*GP*TP*CP*AP*CP*G)-3', CALCIUM ION, ... | Authors: | Schumacher, M.A. | Deposit date: | 2012-01-07 | Release date: | 2012-11-21 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Molecular basis for a protein-mediated DNA-bridging mechanism that functions in condensation of the E. coli chromosome. Mol.Cell, 48, 2012
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4GIT
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3VDB
| E. coli (lacZ) beta-galactosidase (N460T) in complex with galactonolactone | Descriptor: | Beta-galactosidase, D-galactonolactone, DIMETHYL SULFOXIDE, ... | Authors: | Wheatley, R.W, Kappelhoff, J.C, Hahn, J.N, Dugdale, M.L, Dutkoski, M.J, Tamman, S.D, Fraser, M.E, Huber, R.E. | Deposit date: | 2012-01-04 | Release date: | 2012-04-11 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Substitution for Asn460 cripples {beta}-galactosidase (Escherichia coli) by increasing substrate affinity and decreasing transition state stability. Arch.Biochem.Biophys., 521, 2012
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4GJ4
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5ABS
| CRYSTAL STRUCTURE OF THE C-TERMINAL COILED-COIL DOMAIN OF CIN85 IN SPACE GROUP P321 | Descriptor: | SH3 DOMAIN-CONTAINING KINASE-BINDING PROTEIN 1, ZINC ION | Authors: | Wong, L, Habeck, M, Griesinger, C, Becker, S. | Deposit date: | 2015-08-07 | Release date: | 2016-07-13 | Last modified: | 2019-02-06 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | The Adaptor Protein Cin85 Assembles Intracellular Signaling Clusters for B Cell Activation. Sci.Signal., 9, 2016
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3VH4
| Crystal structure of Atg7CTD-Atg8-MgATP complex | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Autophagy-related protein 8, MAGNESIUM ION, ... | Authors: | Noda, N.N, Satoo, K, Inagaki, F. | Deposit date: | 2011-08-23 | Release date: | 2011-09-21 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structural basis of Atg8 activation by a homodimeric E1, Atg7. Mol.Cell, 44, 2011
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5ADJ
| Structure of bovine endothelial nitric oxide synthase heme domain in complex with 7-((3-(2-(Methylamino)ethyl)phenoxy)methyl)quinolin-2- amine | Descriptor: | 5,6,7,8-TETRAHYDROBIOPTERIN, 7-[[3-[2-(methylamino)ethyl]phenoxy]methyl]quinolin-2-amine, ACETATE ION, ... | Authors: | Li, H, Poulos, T.L. | Deposit date: | 2015-08-20 | Release date: | 2015-10-28 | Last modified: | 2015-11-25 | Method: | X-RAY DIFFRACTION (2.217 Å) | Cite: | Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase. J.Med.Chem., 58, 2015
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3VHO
| Y61-gg insertion mutant of Tm-Cellulase 12A | Descriptor: | Endo-1,4-beta-glucanase | Authors: | Cheng, Y.-S, Ko, T.-P, Guo, R.-T, Liu, J.-R. | Deposit date: | 2011-08-30 | Release date: | 2012-07-11 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Enhanced activity of Thermotoga maritima cellulase 12A by mutating a unique surface loop Appl.Microbiol.Biotechnol., 95, 2012
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4FYC
| Structural and functional characterizations of a thioredoxin-fold protein from Helicobacter pylori | Descriptor: | TETRAETHYLENE GLYCOL, Thiol:disulfide interchange protein (DsbC) | Authors: | Yoon, J.Y, Kim, J, Lee, S.J, Im, H.N, Kim, H.S, Yoon, H, An, D.R, Kim, J.Y, Kim, S, Han, B.W, Suh, S.W. | Deposit date: | 2012-07-04 | Release date: | 2013-05-08 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Structural and functional characterization of HP0377, a thioredoxin-fold protein from Helicobacter pylori Acta Crystallogr.,Sect.D, 69, 2013
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5OID
| Complex Trichoplax STIL-NTD:human CEP85 coiled coil domain 4 | Descriptor: | Centrosomal protein of 85 kDa, Putative uncharacterized protein | Authors: | van Breugel, M. | Deposit date: | 2017-07-18 | Release date: | 2018-04-18 | Last modified: | 2018-05-09 | Method: | X-RAY DIFFRACTION (4.6 Å) | Cite: | Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly. Nat Commun, 9, 2018
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5O1V
| Crystal structure of WNK3 kinase domain in a monophosphorylated apo state (A-loop swapped) | Descriptor: | 1,2-ETHANEDIOL, Serine/threonine-protein kinase WNK3 | Authors: | Pinkas, D.M, Bufton, J.C, Kupinska, K, Wang, D, Fairhead, M, Kopec, J, Sethi, R, Dixon-Clarke, S.E, Chalk, R, Berridge, G, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A, Structural Genomics Consortium (SGC) | Deposit date: | 2017-05-19 | Release date: | 2017-06-28 | Last modified: | 2019-10-16 | Method: | X-RAY DIFFRACTION (1.723 Å) | Cite: | Crystal structure of WNK3 kinase domain in a monophosphorylated apo state (A-loop swapped) To Be Published
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4FZZ
| Exonuclease X in complex with 5' overhanging duplex DNA | Descriptor: | DNA (5'-D(*GP*TP*CP*AP*TP*TP*GP*TP*GP*GP*AP*TP*CP*CP*GP*AP*G)-3'), Exodeoxyribonuclease 10, SODIUM ION | Authors: | Wang, T, Sun, H, Cheng, F, Bi, L, Jiang, T. | Deposit date: | 2012-07-08 | Release date: | 2013-07-03 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Recognition and processing of double-stranded DNA by ExoX, a distributive 3'-5' exonuclease Nucleic Acids Res., 41, 2013
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5O26
| Crystal structure of WNK3 kinase domain in a diphosphorylated state and in complex with AMP-PNP/Mg2+ | Descriptor: | 1,2-ETHANEDIOL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Pinkas, D.M, Bufton, J.C, Newman, J.A, Kopec, J, Borkowska, O, Chalk, R, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A. | Deposit date: | 2017-05-19 | Release date: | 2017-06-28 | Last modified: | 2019-10-16 | Method: | X-RAY DIFFRACTION (2.379 Å) | Cite: | Crystal structure of WNK3 kinase domain in a diphosphorylated state and in complex with AMP-PNP/Mg2+ To Be Published
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4ZY4
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3VPE
| Crystal Structure of Metallo-beta-Lactamase SMB-1 | Descriptor: | ACETATE ION, GLYCEROL, Metallo-beta-lactamase, ... | Authors: | Wachino, J, Yamaguchi, Y, Mori, S, Arakawa, Y, Shibayama, K. | Deposit date: | 2012-02-29 | Release date: | 2013-02-13 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural Insights into the Subclass B3 Metallo-beta-Lactamase SMB-1 and the Mode of Inhibition by the Common Metallo- -Lactamase Inhibitor Mercaptoacetate Antimicrob.Agents Chemother., 57, 2013
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4G0J
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3VRG
| The crystal structure of hemoglobin from woolly mammoth in the met form | Descriptor: | Hemoglobin subunit alpha, Hemoglobin subunit beta/delta hybrid, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Noguchi, H, Campbell, K.L, Ho, C, Park, S.-Y, Tame, J.R.H. | Deposit date: | 2012-04-09 | Release date: | 2012-11-07 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structures of haemoglobin from woolly mammoth in liganded and unliganded states. Acta Crystallogr.,Sect.D, 68, 2012
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5O5Q
| X-ray crystal structure of RapZ from Escherichia coli (P3221 space group) | Descriptor: | RNase adapter protein RapZ, SULFATE ION | Authors: | Gonzalez, G.M, Durica-Mitic, S, Hardwick, S.W, Moncrieffe, M, Resch, M, Neumann, P, Ficner, R, Gorke, B, Luisi, B.F. | Deposit date: | 2017-06-02 | Release date: | 2017-08-30 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Structural insights into RapZ-mediated regulation of bacterial amino-sugar metabolism. Nucleic Acids Res., 45, 2017
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3VRJ
| HLA-B*57:01-LTTKLTNTNI in complex with abacavir | Descriptor: | 10-mer peptide, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... | Authors: | Vivian, J.P, Illing, P.T, McCluskey, J, Rossjohn, J. | Deposit date: | 2012-04-11 | Release date: | 2012-05-30 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Immune self-reactivity triggered by drug-modified HLA-peptide repertoire Nature, 486, 2012
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4ZZM
| Human ERK2 in complex with an irreversible inhibitor | Descriptor: | 7-ethylsulfonyl-N-(oxan-4-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-amine, MITOGEN-ACTIVATED PROTEIN KINASE 1, SULFATE ION | Authors: | Ward, R.A, Colclough, N, Challinor, M, Debreczeni, J.E, Eckersley, K, Fairley, G, Feron, L, Flemington, V, Graham, M.A, Greenwood, R, Hopcroft, P, Howard, T.D, James, M, Jones, C.D, Jones, C.R, Renshaw, J, Roberts, K, Snow, L, Tonge, M, Yeung, K. | Deposit date: | 2015-04-10 | Release date: | 2015-05-27 | Last modified: | 2015-08-26 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of Erk1/2. J.Med.Chem., 58, 2015
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4G33
| Crystal Structure of a Phospholipid-Lipoxygenase Complex from Pseudomonas aeruginosa at 2.0 A (C2221) | Descriptor: | (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradec-5-enoyloxy)propyl (11Z)-octadec-11-enoate, 15S-LIPOXYGENASE, FE (II) ION, ... | Authors: | Carpena, X, Garreta, A, Val-Moraes, S.P, Garcia-Fernandez, Q, Fita, I. | Deposit date: | 2012-07-13 | Release date: | 2013-11-06 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Structure and interaction with phospholipids of a prokaryotic lipoxygenase from Pseudomonas aeruginosa. Faseb J., 27, 2013
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3VW4
| Crystal structure of the DNA-binding domain of ColE2-P9 Rep in complex with the replication origin | Descriptor: | DNA (5'-D(P*AP*AP*TP*GP*AP*GP*AP*CP*CP*AP*GP*AP*TP*AP*AP*GP*CP*CP*TP*TP*AP*TP*C)-3'), DNA (5'-D(P*GP*AP*TP*AP*AP*GP*GP*CP*TP*TP*AP*TP*CP*TP*GP*GP*TP*CP*TP*CP*AP*TP*T)-3'), Rep, ... | Authors: | Itou, H, Yagura, M, Itoh, T, Shirakihara, Y. | Deposit date: | 2012-07-31 | Release date: | 2013-07-31 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural Basis for Replication Origin Unwinding by An Initiator-Primase of Plasmid ColE2-P9: Duplex DNA Unwinding by A Single Protein J.Biol.Chem., 290, 2015
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4G4B
| Room temperature X-ray diffraction study of cisplatin binding to HEWL in DMSO media with NAG after 7 months of crystal storage | Descriptor: | CHLORIDE ION, Cisplatin, DIMETHYL SULFOXIDE, ... | Authors: | Tanley, S.W.M, Schreurs, A.M.M, Kroon-Batenburg, L.M.J, Helliwell, J.R. | Deposit date: | 2012-07-16 | Release date: | 2012-11-07 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Room-temperature X-ray diffraction studies of cisplatin and carboplatin binding to His15 of HEWL after prolonged chemical exposure. Acta Crystallogr.,Sect.F, 68, 2012
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4G4G
| Crystal structure of recombinant glucuronoyl esterase from Sporotrichum thermophile determined at 1.55 A resolution | Descriptor: | 1,2-ETHANEDIOL, 4-O-methyl-glucuronoyl methylesterase, GLYCEROL | Authors: | Charavgi, M.D, Dimarogona, M, Topakas, E, Christakopoulos, P, Chrysina, E.D. | Deposit date: | 2012-07-16 | Release date: | 2013-01-02 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | The structure of a novel glucuronoyl esterase from Myceliophthora thermophila gives new insights into its role as a potential biocatalyst. Acta Crystallogr.,Sect.D, 69, 2013
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