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4TJV	Crystal structure of protease-associated domain of Arabidopsis vacuolar sorting receptor 1 Descriptor: IODIDE ION, Vacuolar-sorting receptor 1 Authors: Luo, F, Fong, Y.H, Jiang, L.W, Wong, K.B. Deposit date: 2014-05-25 Release date: 2014-12-10 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.651 Å) Cite: How vacuolar sorting receptor proteins interact with their cargo proteins: crystal structures of apo and cargo-bound forms of the protease-associated domain from an Arabidopsis vacuolar sorting receptor. Plant Cell, 26, 2014
4TLK	Crystal Structure of Human Transthyretin Ser85Pro/Glu92Pro Mutant Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, SODIUM ION, ... Authors: Saelices, L, Cascio, D, Sawaya, M, Eisenberg, D.S. Deposit date: 2014-05-30 Release date: 2015-10-21 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.44 Å) Cite: Uncovering the Mechanism of Aggregation of Human Transthyretin. J.Biol.Chem., 290, 2015
4TQH	Human transthyretin (TTR) complexed with 3-(9H-fluoren-9-ylideneaminooxy)ethanoic acid Descriptor: 1,2-ETHANEDIOL, Transthyretin, [(9H-fluoren-9-ylideneamino)oxy]acetic acid Authors: Ciccone, L, Nencetti, S, Rossello, A, Orlandini, E, Stura, E.A. Deposit date: 2014-06-11 Release date: 2015-06-24 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.511 Å) Cite: X-ray crystal structure and activity of fluorenyl-based compounds as transthyretin fibrillogenesis inhibitors. J Enzyme Inhib Med Chem, 2015
4TQI	Human transthyretin (TTR) complexed with 3-(9H-fluoren-9-ylideneaminooxy)propanoic acid in a dual binding mode Descriptor: (2S)-3-[(9H-fluoren-9-ylideneamino)oxy]-2-methylpropanoic acid, GLYCEROL, Transthyretin Authors: Stura, E.A, Ciccone, L, Nencetti, S, Rossello, A, Orlandini, E. Deposit date: 2014-06-11 Release date: 2015-06-24 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.25 Å) Cite: X-ray crystal structure and activity of fluorenyl-based compounds as transthyretin fibrillogenesis inhibitors. J Enzyme Inhib Med Chem, 2015
6E6Z	Structure of Wild Type Human Transthyretin in Complex with Tafamidis Descriptor: 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid, Transthyretin Authors: Chung, K, Saelices, L, Sawaya, M.R, Cascio, D, Eisenberg, D. Deposit date: 2018-07-25 Release date: 2019-07-31 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structural Variants of Transthyretin To Be Published
6E77	Structure of Human Transthyretin Asp38Ala Mutant in Complex with Tafamidis Descriptor: 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid, Transthyretin Authors: Saelices, L, Chung, K, Sawaya, M.R, Cascio, D, Eisenberg, D. Deposit date: 2018-07-25 Release date: 2019-07-31 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural Variants of Transthyretin To Be Published
4TNE	Crystal Structure of Human Transthyretin Thr119Tyr Mutant Descriptor: GLYCEROL, Transthyretin Authors: Saelices, L, Cascio, D, Sawaya, M, Eisenberg, D.S. Deposit date: 2014-06-03 Release date: 2015-10-21 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Uncovering the Mechanism of Aggregation of Human Transthyretin. J.Biol.Chem., 290, 2015
4TQ8	Dual binding mode for 3-(9H-fluoren-9-ylideneaminooxy)propanoic acid binding to Human transthyretin (TTR) Descriptor: 1,2-ETHANEDIOL, 3-[(9H-fluoren-9-ylideneamino)oxy]propanoic acid, Transthyretin Authors: Ciccone, L, Orlandini, E, Nencetti, S, Rossello, A, Stura, E.A. Deposit date: 2014-06-10 Release date: 2015-06-24 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.52 Å) Cite: X-ray crystal structure and activity of fluorenyl-based compounds as transthyretin fibrillogenesis inhibitors. J Enzyme Inhib Med Chem, 2015
4TLS	Crystal Structure of Human Transthyretin Glu92Pro Mutant Descriptor: GLYCEROL, PHOSPHATE ION, SODIUM ION, ... Authors: Saelices, L, Cascio, D, Sawaya, M, Eisenberg, D.S. Deposit date: 2014-05-30 Release date: 2015-10-21 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Uncovering the Mechanism of Aggregation of Human Transthyretin. J.Biol.Chem., 290, 2015
4TM9	Crystal Structure of Human Transthyretin Thr119Trp Mutant Descriptor: Transthyretin Authors: Saelices, L, Cascio, D, Sawaya, M, Eisenberg, D.S. Deposit date: 2014-05-31 Release date: 2015-10-21 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Uncovering the Mechanism of Aggregation of Human Transthyretin. J.Biol.Chem., 290, 2015
6E70	Structure of Wild Type Human Transthyretin in Complex with Diflunisal Descriptor: 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID, CALCIUM ION, Transthyretin Authors: Chung, K, Saelices, L, Sawaya, M.R, Cascio, D, Eisenberg, D. Deposit date: 2018-07-25 Release date: 2019-07-31 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.992 Å) Cite: Structural Variants of Transthyretin To Be Published
4U9C	STRUCTURE OF THE LBPB N-LOBE FROM NEISSERIA MENINGITIDIS Descriptor: Lactoferrin-binding protein B Authors: Brooks, C.L, Arutyunova, E, Lemieux, M.J. Deposit date: 2014-08-05 Release date: 2014-10-22 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.995 Å) Cite: The structure of lactoferrin-binding protein B from Neisseria meningitidis suggests roles in iron acquisition and neutralization of host defences. Acta Crystallogr.,Sect.F, 70, 2014
5TZL	Structure of transthyretin in complex with the kinetic stabilizer 201 Descriptor: 4-(7-chloro-1,3-benzoxazol-2-yl)-2,6-diiodophenol, Transthyretin Authors: Connelly, S, Mortenson, D.E, Choi, S, Wilson, I.A, Powers, E.T, Kelly, J.W, Johnson, S.M. Deposit date: 2016-11-21 Release date: 2017-06-28 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors. Bioorg. Med. Chem. Lett., 27, 2017
5U49	Wild-type Transthyretin in complex with 5-[(1E)-2-(2-Chloro-4-hydroxyphenyl)ethenyl]-1,3-benzenediol Descriptor: 5-[(E)-2-(2-chloro-4-hydroxyphenyl)ethenyl]benzene-1,3-diol, Transthyretin Authors: Windsor, I.W, Smith, T.P, Raines, R.T, Forest, K.T. Deposit date: 2016-12-03 Release date: 2017-09-27 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.22 Å) Cite: Stilbene Boronic Acids Form a Covalent Bond with Human Transthyretin and Inhibit Its Aggregation. J. Med. Chem., 60, 2017
5U4E	Wild-type Transthyretin in complex with 3-[(1E)-2-(2-Chloro-4-boronic acid)ethenyl]benzoic Acid Descriptor: 3-[(E)-2-(4-borono-2-chlorophenyl)ethenyl]benzoic acid, Transthyretin Authors: Windsor, I.W, Smith, T.P, Raines, R.T, Forest, K.T. Deposit date: 2016-12-03 Release date: 2017-09-27 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Stilbene Boronic Acids Form a Covalent Bond with Human Transthyretin and Inhibit Its Aggregation. J. Med. Chem., 60, 2017
5U4D	Wild-type Transthyretin in complex with 3-[(1E)-2-(2-Chloro-4-hydroxyphenyl)ethenyl]benzoic Acid Descriptor: 3-[(E)-2-(2-chloro-4-hydroxyphenyl)ethenyl]benzoic acid, Transthyretin Authors: Windsor, I.W, Smith, T.P, Raines, R.T, Forest, K.T. Deposit date: 2016-12-03 Release date: 2017-09-27 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Stilbene Boronic Acids Form a Covalent Bond with Human Transthyretin and Inhibit Its Aggregation. J. Med. Chem., 60, 2017
8VE4	Unliganded human transthyretin in the frayed conformation Descriptor: Transthyretin Authors: Basanta, B, Nugroho, K, Yan, N, Kline, G.M, Tsai, F.J, Wu, M, Kelly, J.W, Lander, G.C. Deposit date: 2023-12-18 Release date: 2024-06-05 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: The conformational landscape of human transthyretin revealed by cryo-EM To Be Published
8VE0	Human transthyretin covalently modified with A2-derived stilbene in the compressed conformation Descriptor: 3-(dimethylamino)-5-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzoic acid, Transthyretin Authors: Basanta, B, Nugroho, K, Yan, N, Kline, G.M, Tsai, F.J, Wu, M, Kelly, J.W, Lander, G.C. Deposit date: 2023-12-18 Release date: 2024-01-31 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: The conformational landscape of human transthyretin revealed by cryo-EM To Be Published
8W1N	Structure of transthyretin pathogenic mutation A120S Descriptor: Transthyretin Authors: Ferguson, J.A, Stanfield, R.L, Wright, P.E. Deposit date: 2024-02-16 Release date: 2024-02-28 Last modified: 2024-08-28 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Mispacking of the F87 sidechain drives aggregation-promoting conformational fluctuations in the subunit interfaces of the transthyretin tetramer. Protein Sci., 33, 2024
8W2W	Structure of transthyretin synthetic mutation A120L Descriptor: Transthyretin Authors: Yang, K, Sun, X, Ferguson, J.A, Stanfield, R.L, Wright, P.E. Deposit date: 2024-02-21 Release date: 2024-02-28 Last modified: 2024-08-28 Method: X-RAY DIFFRACTION (2.07 Å) Cite: Mispacking of the F87 sidechain drives aggregation-promoting conformational fluctuations in the subunit interfaces of the transthyretin tetramer. Protein Sci., 33, 2024
8VJX	Structure of Human Neurolysin in complex with bradykinin peptide Descriptor: Bradykinin, Neurolysin, mitochondrial, ... Authors: Shi, K, Aihara, H. Deposit date: 2024-01-08 Release date: 2024-08-21 Method: X-RAY DIFFRACTION (2.89 Å) Cite: Structural basis of divergent substrate recognition and inhibition of human neurolysin. Sci Rep, 14, 2024
8VJU	Structure of Human Neurolysin in complex with dynorphin A13 peptide Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Dynorphin A(1-13), ... Authors: Shi, K, Aihara, H. Deposit date: 2024-01-08 Release date: 2024-08-21 Method: X-RAY DIFFRACTION (1.99 Å) Cite: Structural basis of divergent substrate recognition and inhibition of human neurolysin. Sci Rep, 14, 2024
8VJV	Structure of Human Neurolysin in complex with dynorphin A8(1-8) peptide Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Dynorphin A(1-8), ... Authors: Shi, K, Aihara, H. Deposit date: 2024-01-08 Release date: 2024-08-21 Method: X-RAY DIFFRACTION (2.12 Å) Cite: Structural basis of divergent substrate recognition and inhibition of human neurolysin. Sci Rep, 14, 2024
8UN7	Single particle analysis of recombinant human MFAP4 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Microfibril-associated glycoprotein 4 Authors: Wozny, M.W, Nelea, V. Deposit date: 2023-10-18 Release date: 2024-05-22 Method: ELECTRON MICROSCOPY (3.55 Å) Cite: Microfibril-associated glycoprotein 4 forms octamers that mediate interactions with elastogenic proteins and cells. Nat Commun, 15, 2024
8VE3	Unliganded human transthyretin in the compressed conformation Descriptor: Transthyretin Authors: Basanta, B, Nugroho, K, Yan, N, Kline, G.M, Tsai, F.J, Wu, M, Kelly, J.W, Lander, G.C. Deposit date: 2023-12-18 Release date: 2024-06-05 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: The conformational landscape of human transthyretin revealed by cryo-EM To Be Published

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