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9BCU	Cryo-EM structure of Thermococcus kodakarensis FttA-dependent transcription pre-termination complex containing 52 nt RNA Descriptor: DNA-directed RNA polymerase subunit A", DNA-directed RNA polymerase subunit A', DNA-directed RNA polymerase subunit B, ... Authors: You, L, Ebright, R.H. Deposit date: 2024-04-09 Release date: 2024-07-31 Method: ELECTRON MICROSCOPY (2.2 Å) Cite: Structural basis of archaeal FttA-dependent transcription termination To Be Published
9BCT	Cryo-EM structure of Thermococcus kodakarensis FttA-dependent transcription pre-termination complex containing 44 nt RNA Descriptor: DNA-directed RNA polymerase subunit A", DNA-directed RNA polymerase subunit A', DNA-directed RNA polymerase subunit B, ... Authors: You, L, Ebright, R.H. Deposit date: 2024-04-09 Release date: 2024-07-31 Method: ELECTRON MICROSCOPY (2.5 Å) Cite: Structural basis of archaeal FttA-dependent transcription termination To Be Published
9BCM	Crystal structure of the glycosyltransferase UGT95A1 Descriptor: Glycosyltransferase Authors: Pereira, J.H, Sirirungruang, S, Shih, P.M, Adams, P.D. Deposit date: 2024-04-09 Release date: 2024-08-07 Last modified: 2024-09-04 Method: X-RAY DIFFRACTION (2.36 Å) Cite: Structural and biochemical basis for regiospecificity of the flavonoid glycosyltransferase UGT95A1. J.Biol.Chem., 300, 2024
9BCG	Myeloid cell leukemia-1 (Mcl-1) complexed with compound Descriptor: 7-[(4R,5S,6P)-7-chloro-10-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-4-methyl-1-oxo-6-(1,3,5-trimethyl-1H-pyrazol-4-yl)-3,4-dihydropyrazino[1,2-a]indol-2(1H)-yl]-4,5-dimethoxy-1-methyl-1H-indole-2-carboxylic acid, Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose Authors: Zhao, B, Fesik, S.W. Deposit date: 2024-04-09 Release date: 2024-08-07 Last modified: 2024-09-11 Method: X-RAY DIFFRACTION (1.898 Å) Cite: Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent In Vivo Activities in Mouse Models of Hematological and Solid Tumors. J.Med.Chem., 67, 2024
9BCB	Crystal structure of human cellular retinol binding protein 3 in complex with C11 TopFluor MG Descriptor: 1-[11-(dipyrrometheneboron difluoride)undecanoyl]-rac-glycerol, GLYCEROL, Retinol-binding protein 5 Authors: Golczak, M. Deposit date: 2024-04-08 Release date: 2024-04-17 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Interactom of cellular retinol binding protein 3. To Be Published
9BC7	HCN1 M305L holo Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 Authors: Kim, E.D, Nimigean, C.M. Deposit date: 2024-04-08 Release date: 2024-07-31 Last modified: 2024-08-21 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants. Nature, 632, 2024
9BC6	HCN1 M305L with propofol Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2,6-BIS(1-METHYLETHYL)PHENOL, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 Authors: Kim, E.D, Nimigean, C.M. Deposit date: 2024-04-07 Release date: 2024-07-31 Last modified: 2024-08-21 Method: ELECTRON MICROSCOPY (2.5 Å) Cite: Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants. Nature, 632, 2024
9BC4	Transglutaminase 2 - Intermediate State Descriptor: CALCIUM ION, GLYCEROL, HB-225 (gluten peptidomimetic TG2 inhibitor), ... Authors: Sewa, A.S, Mathews, I.I, Khosla, C. Deposit date: 2024-04-07 Release date: 2024-07-03 Last modified: 2024-07-17 Method: X-RAY DIFFRACTION (1.84 Å) Cite: Structural and mechanistic analysis of Ca 2+ -dependent regulation of transglutaminase 2 activity using a Ca 2+ -bound intermediate state. Proc.Natl.Acad.Sci.USA, 121, 2024
9BC3	Transglutaminase 2 - Alternate state Descriptor: CALCIUM ION, HB-225 (gluten peptidomimetic TG2 inhibitor), Protein-glutamine gamma-glutamyltransferase 2 Authors: Mathews, I.I, Sewa, A.S, Khosla, C. Deposit date: 2024-04-07 Release date: 2024-07-03 Last modified: 2024-07-17 Method: X-RAY DIFFRACTION (2.52 Å) Cite: Structural and mechanistic analysis of Ca 2+ -dependent regulation of transglutaminase 2 activity using a Ca 2+ -bound intermediate state. Proc.Natl.Acad.Sci.USA, 121, 2024
9BC2	Transglutaminase 2 - Open State Descriptor: CHLORIDE ION, HB-225 (gluten peptidomimetic TG2 inhibitor), Protein-glutamine gamma-glutamyltransferase 2, ... Authors: Mathews, I.I, Sewa, A, Khosla, C. Deposit date: 2024-04-07 Release date: 2024-07-03 Last modified: 2024-07-17 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Structural and mechanistic analysis of Ca 2+ -dependent regulation of transglutaminase 2 activity using a Ca 2+ -bound intermediate state. Proc.Natl.Acad.Sci.USA, 121, 2024
9BBM	PHF filament generated from 4E-Tau(297-407) under neutral Mg2+ condition Descriptor: Isoform Tau-F of Microtubule-associated protein tau Authors: Duan, P, El Mammeri, N. Deposit date: 2024-04-06 Release date: 2024-05-08 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Milligram-scale assembly and NMR fingerprint of tau fibrils adopting the Alzheimer's disease fold. J.Biol.Chem., 300, 2024
9BBL	THF filament generated from 4E-Tau(297-407) under neutral Mg2+ condition Descriptor: Isoform Tau-F of Microtubule-associated protein tau Authors: Duan, P, El Mammeri, N. Deposit date: 2024-04-06 Release date: 2024-05-08 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (2.5 Å) Cite: Milligram-scale assembly and NMR fingerprint of tau fibrils adopting the Alzheimer's disease fold. J.Biol.Chem., 300, 2024
9BBI	Co-crystal structure of human DDB1 bound to fragment UB028669 Descriptor: 3-([1,3]oxazolo[4,5-b]pyridin-2-yl)aniline, DNA damage-binding protein 1, L(+)-TARTARIC ACID, ... Authors: Zeng, H, Dong, A, Frommlet, A, Seitova, A, Loppnau, P, Ackloo, S, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) Deposit date: 2024-04-05 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Co-crystal structure of human DDB1 bound to fragment UB028669 To be published
9BBH	Co-crystal structure of human DDB1 bound to fragment UB028670 Descriptor: 1,2-ETHANEDIOL, 4-methoxy-1H-indole, DNA damage-binding protein 1, ... Authors: Zeng, H, Dong, A, Frommlet, A, Seitova, A, Loppnau, P, Ackloo, S, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) Deposit date: 2024-04-05 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (2 Å) Cite: Co-crystal structure of human DDB1 bound to fragment UB028670 To be published
9BBG	Co-crystal structure of human DDB1 bound to fragment UB028671 Descriptor: 1,2-ETHANEDIOL, 1H-indol-6-amine, DNA damage-binding protein 1, ... Authors: Zeng, H, Dong, A, Frommlet, A, Seitova, A, Loppnau, P, Ackloo, S, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) Deposit date: 2024-04-05 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Co-crystal structure of human DDB1 bound to fragment UB028671 To be published
9BBE	Co-crystal structure of human DDB1 bound to fragment UB028668 Descriptor: 5-(4-methoxyphenyl)-3-[(3S)-pyrrolidin-3-yl]-1,2,4-oxadiazole, DNA damage-binding protein 1, L(+)-TARTARIC ACID, ... Authors: Zeng, H, Dong, A, Frommlet, A, Seitova, A, Loppnau, P, Ackloo, S, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) Deposit date: 2024-04-05 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (2 Å) Cite: Co-crystal structure of human DDB1 bound to fragment UB028668 To be published
9BBB	Human CYP3A4 bound to an inhibitor Descriptor: Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, cobicistat Authors: Sevrioukova, I.F. Deposit date: 2024-04-05 Release date: 2024-07-03 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Interaction of CYP3A4 with the inhibitor cobicistat: Structural and mechanistic insights and comparison with ritonavir to be published
9BB7	Backbone Modification in the GA Module of Protein PAB: ACPC residues at positions 5 and 39, beta3 residue at position 26 Descriptor: Peptostreptococcal albumin-binding protein Authors: Lin, Y, Horne, W.S. Deposit date: 2024-04-05 Release date: 2024-06-05 Last modified: 2024-08-21 Method: SOLUTION NMR Cite: Backbone Modification in a Protein Hydrophobic Core. Chemistry, 30, 2024
9BB6	Backbone Modification in the GA Module of Protein PAB: ACPC residues at positions 5 and 13, beta3 residue at position 9 Descriptor: Peptostreptococcal albumin-binding protein Authors: Lin, Y, Horne, W.S. Deposit date: 2024-04-05 Release date: 2024-06-05 Last modified: 2024-08-21 Method: SOLUTION NMR Cite: Backbone Modification in a Protein Hydrophobic Core. Chemistry, 30, 2024
9BB5	Backbone Modification in the GA Module of Protein PAB: ACPC residues at positions 22 and 26 Descriptor: Peptostreptococcal albumin-binding protein Authors: Lin, Y, Horne, W.S. Deposit date: 2024-04-05 Release date: 2024-06-05 Last modified: 2024-08-21 Method: SOLUTION NMR Cite: Backbone Modification in a Protein Hydrophobic Core. Chemistry, 30, 2024
9BB4	Backbone Modification in the GA Module of Protein PAB: beta3-residues at positions 23 and 26 Descriptor: Peptostreptococcal albumin-binding protein Authors: Lin, Y, Horne, W.S. Deposit date: 2024-04-05 Release date: 2024-06-05 Last modified: 2024-08-21 Method: SOLUTION NMR Cite: Backbone Modification in a Protein Hydrophobic Core. Chemistry, 30, 2024
9BB3	Backbone Modification in the GA Module of Protein PAB: beta3-residues at positions 22 and 26 Descriptor: Peptostreptococcal albumin-binding protein Authors: Lin, Y, Horne, W.S. Deposit date: 2024-04-05 Release date: 2024-06-05 Last modified: 2024-08-21 Method: SOLUTION NMR Cite: Backbone Modification in a Protein Hydrophobic Core. Chemistry, 30, 2024
9BB2	Backbone Modification in the GA Module of Protein PAB: beta3-residues at positions 20 and 24 Descriptor: Peptostreptococcal albumin-binding protein Authors: Lin, Y, Horne, W.S. Deposit date: 2024-04-05 Release date: 2024-06-05 Last modified: 2024-08-21 Method: SOLUTION NMR Cite: Backbone Modification in a Protein Hydrophobic Core. Chemistry, 30, 2024
9BB1	Backbone Modification in the GA Module of Protein PAB: Wild-type Sequence Descriptor: Peptostreptococcal albumin-binding protein Authors: Lin, Y, Horne, W.S. Deposit date: 2024-04-05 Release date: 2024-06-05 Last modified: 2024-08-21 Method: SOLUTION NMR Cite: Backbone Modification in a Protein Hydrophobic Core. Chemistry, 30, 2024
9BAZ	CryoEM structure of DIM2-HP1 complex Descriptor: DNA (cytosine-5-)-methyltransferase, Heterochromatin protein one, S-ADENOSYL-L-HOMOCYSTEINE, ... Authors: Song, J, Shao, Z. Deposit date: 2024-04-05 Release date: 2024-07-24 Method: ELECTRON MICROSCOPY (2.76 Å) Cite: CryoEM structure of DIM2-HP1 complex To Be Published

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