PDB: 95574 resultsInfo pagesStatus searchChemie searchBIRD

---

8V9M	Human Ornithine Aminotransferase cocrystallized with its inhibitor, (R)-3-amino-5,5-difluorocyclohex-1-ene-1-carboxylic acid. Descriptor: 3-fluoro-5-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]benzoic acid, GLYCEROL, Ornithine aminotransferase, ... Authors: Vargas, A.L, Devitt, A, Kaley, N, Silverman, R, Liu, D. Deposit date: 2023-12-08 Release date: 2024-05-08 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (1.61 Å) Cite: Design, Synthesis, and Mechanistic Studies of ( R )-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase. Acs Chem.Biol., 19, 2024
2Z1Z	Crystal structure of LL-Diaminopimelate Aminotransferase from Arabidopsis thaliana complexed with L-malate ion Descriptor: D-MALATE, LL-diaminopimelate aminotransferase, PYRIDOXAL-5'-PHOSPHATE Authors: Watanabe, N, Cherney, M.M, van Belkum, M.J, Marcus, S.L, Flegel, M.D, Clay, M.D, Deyholos, M.K, Vederas, J.C, James, M.N.G. Deposit date: 2007-05-16 Release date: 2007-07-17 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structure of LL-diaminopimelate aminotransferase from Arabidopsis thaliana: a recently discovered enzyme in the biosynthesis of L-lysine by plants and Chlamydia J.Mol.Biol., 371, 2007
2Z20	Crystal structure of LL-Diaminopimelate Aminotransferase from Arabidopsis thaliana Descriptor: GLYCEROL, LL-diaminopimelate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, ... Authors: Watanabe, N, Cherney, M.M, van Belkum, M.J, Marcus, S.L, Flegel, M.D, Clay, M.D, Deyholos, M.K, Vederas, J.C, James, M.N.G. Deposit date: 2007-05-17 Release date: 2007-07-17 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal structure of LL-diaminopimelate aminotransferase from Arabidopsis thaliana: a recently discovered enzyme in the biosynthesis of L-lysine by plants and Chlamydia J.Mol.Biol., 371, 2007
1SPA	ROLE OF ASP222 IN THE CATALYTIC MECHANISM OF ESCHERICHIA COLI ASPARTATE AMINOTRANSFERASE: THE AMINO ACID RESIDUE WHICH ENHANCES THE FUNCTION OF THE ENZYME-BOUND COENZYME PYRIDOXAL 5'-PHOSPHATE Descriptor: ASPARTATE AMINOTRANSFERASE, N-METHYL-4-DEOXY-4-AMINO-PYRIDOXAL-5-PHOSPHATE Authors: Hinoue, Y, Yano, T, Metzler, D.E, Miyahara, I, Hirotsu, K, Kagamiyama, H. Deposit date: 1993-01-26 Release date: 1993-10-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2 Å) Cite: Role of Asp222 in the catalytic mechanism of Escherichia coli aspartate aminotransferase: the amino acid residue which enhances the function of the enzyme-bound coenzyme pyridoxal 5'-phosphate. Biochemistry, 31, 1992
2V3U	Structure of the ligand-binding core of the ionotropic glutamate receptor-like GluRdelta2 in complex with D-serine Descriptor: CHLORIDE ION, D-SERINE, GLUTAMATE RECEPTOR DELTA-2 SUBUNIT, ... Authors: Naur, P, Vestergaard, B, Gajhede, M, Kastrup, J.S. Deposit date: 2007-06-22 Release date: 2007-08-07 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.74 Å) Cite: Ionotropic Glutamate-Like Receptor {Delta}2 Binds D-Serine and Glycine. Proc.Natl.Acad.Sci.USA, 104, 2007
1BQA	ASPARTATE AMINOTRANSFERASE P195A MUTANT Descriptor: ASPARTATE AMINOTRANSFERASE Authors: Malashkevich, V.N, Jansonius, J.N. Deposit date: 1998-08-13 Release date: 1999-05-11 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Functional and structural analysis of cis-proline mutants of Escherichia coli aspartate aminotransferase. Biochemistry, 38, 1999
1BQD	ASPARTATE AMINOTRANSFERASE P138A/P195A DOUBLE MUTANT Descriptor: ASPARTATE AMINOTRANSFERASE Authors: Malashkevich, V.N, Jansonius, J.N. Deposit date: 1998-08-14 Release date: 1999-05-11 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Functional and structural analysis of cis-proline mutants of Escherichia coli aspartate aminotransferase. Biochemistry, 38, 1999
1B4X	ASPARTATE AMINOTRANSFERASE FROM E. COLI, C191S MUTATION, WITH BOUND MALEATE Descriptor: ASPARTATE AMINOTRANSFERASE, MALEIC ACID, PYRIDOXAL-5'-PHOSPHATE Authors: Jeffery, C.J, Gloss, L.M, Petsko, G.A, Ringe, D. Deposit date: 1998-12-30 Release date: 2000-10-27 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.45 Å) Cite: The role of residues outside the active site: structural basis for function of C191 mutants of Escherichia coli aspartate aminotransferase. Protein Eng., 13, 2000
2HHF	X-ray crystal structure of oxidized human mitochondrial branched chain aminotransferase (hBCATm) Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Branched-chain-amino-acid aminotransferase, mitochondrial, ... Authors: Yennawar, N.H, Hutson, S.M. Deposit date: 2006-06-28 Release date: 2006-10-24 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Human Mitochondrial Branched Chain Aminotransferase Isozyme: STRUCTURAL ROLE OF THE CXXC CENTER IN CATALYSIS. J.Biol.Chem., 281, 2006
3R3L	Structure of NP protein from Lassa AV strain Descriptor: MANGANESE (II) ION, Nucleoprotein, ZINC ION Authors: Perbandt, M, Brunotte, L, Gunther, S, Betzel, C. Deposit date: 2011-03-16 Release date: 2011-09-14 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.449 Å) Cite: Structure of the Lassa virus nucleoprotein revealed by X-ray crystallography, small-angle X-ray scattering, and electron microscopy. J.Biol.Chem., 286, 2011
3DC1	Crystal structure of kynurenine aminotransferase II complex with alpha-ketoglutarate Descriptor: 2-OXOGLUTARIC ACID, GLYCEROL, Kynurenine/alpha-aminoadipate aminotransferase mitochondrial Authors: Han, Q, Cai, T, Tagle, D.A, Robinson, H, Li, J. Deposit date: 2008-06-03 Release date: 2008-07-29 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II Biosci.Rep., 28, 2008
2JDX	CRYSTAL STRUCTURE OF HUMAN L-ARGININE:GLYCINE AMIDINOTRANSFERASE, DELETIONMUTANT ATDELTAM302 Descriptor: PROTEIN (L-ARGININE:GLYCINE AMIDINOTRANSFERASE) Authors: Fritsche, E, Humm, A, Huber, R. Deposit date: 1998-10-12 Release date: 1999-02-09 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.9 Å) Cite: The ligand-induced structural changes of human L-Arginine:Glycine amidinotransferase. A mutational and crystallographic study. J.Biol.Chem., 274, 1999
1H1C	Histidinol-phosphate aminotransferase (HisC) from Thermotoga maritima Descriptor: HISTIDINOL-PHOSPHATE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE Authors: Vega, M.C, Fernandez, F.J, Wilmanns, M. Deposit date: 2002-07-08 Release date: 2004-03-19 Last modified: 2019-07-24 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Structural Studies of the Catalytic Reaction Pathway of a Hyperthermophilic Histidinol-Phosphate Aminotransferase J.Biol.Chem., 279, 2004
2DAB	L201A MUTANT OF D-AMINO ACID AMINOTRANSFERASE COMPLEXED WITH PYRIDOXAL-5'-PHOSPHATE Descriptor: D-AMINO ACID AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE Authors: Sugio, S, Kashima, A, Kishimoto, K, Peisach, D, Petsko, G.A, Ringe, D, Yoshimura, T, Esaki, N. Deposit date: 1997-11-30 Release date: 1998-06-03 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structures of L201A mutant of D-amino acid aminotransferase at 2.0 A resolution: implication of the structural role of Leu201 in transamination. Protein Eng., 11, 1998
1AKB	STRUCTURAL BASIS FOR THE CATALYTIC ACTIVITY OF ASPARTATE AMINOTRANSFERASE K258H LACKING ITS PYRIDOXAL-5'-PHOSPHATE-BINDING LYSINE RESIDUE Descriptor: 2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYLENE)-AMINO]-SUCCINIC ACID, ASPARTATE AMINOTRANSFERASE Authors: Malashkevich, V.N, Jansonius, J.N. Deposit date: 1994-02-28 Release date: 1994-07-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis for the catalytic activity of aspartate aminotransferase K258H lacking the pyridoxal 5'-phosphate-binding lysine residue. Biochemistry, 34, 1995
1G7X	ASPARTATE AMINOTRANSFERASE ACTIVE SITE MUTANT N194A/R292L/R386L Descriptor: ASPARTATE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE Authors: Mizuguchi, H, Hayashi, H, Okada, K, Miyahara, I, Hirotsu, K, Kagamiyama, H. Deposit date: 2000-11-15 Release date: 2000-11-29 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Strain is more important than electrostatic interaction in controlling the pKa of the catalytic group in aspartate aminotransferase. Biochemistry, 40, 2001
1AKA	STRUCTURAL BASIS FOR THE CATALYTIC ACTIVITY OF ASPARTATE AMINOTRANSFERASE K258H LACKING ITS PYRIDOXAL-5'-PHOSPHATE-BINDING LYSINE RESIDUE Descriptor: ASPARTATE AMINOTRANSFERASE, PHOSPHATE ION, PYRIDOXAL-5'-PHOSPHATE Authors: Malashkevich, V.N, Jansonius, J.N. Deposit date: 1994-02-28 Release date: 1994-07-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural basis for the catalytic activity of aspartate aminotransferase K258H lacking the pyridoxal 5'-phosphate-binding lysine residue. Biochemistry, 34, 1995
1AKC	Structural basis for the catalytic activity of aspartate aminotransferase K258H lacking its pyridoxal-5'-phosphate-binding lysine residue Descriptor: 4-[(1,3-DICARBOXY-PROPYLAMINO)-METHYL]-3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDINIUM, ASPARTATE AMINOTRANSFERASE Authors: Malashkevich, V.N, Jansonius, J.N. Deposit date: 1994-02-28 Release date: 1994-07-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis for the catalytic activity of aspartate aminotransferase K258H lacking the pyridoxal 5'-phosphate-binding lysine residue. Biochemistry, 34, 1995
1G7W	ASPARTATE AMINOTRANSFERASE ACTIVE SITE MUTANT N194A/R386L Descriptor: ASPARTATE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE Authors: Mizuguchi, H, Hayashi, H, Okada, K, Miyahara, I, Hirotsu, K, Kagamiyama, H. Deposit date: 2000-11-15 Release date: 2000-11-29 Last modified: 2021-10-27 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Strain is more important than electrostatic interaction in controlling the pKa of the catalytic group in aspartate aminotransferase. Biochemistry, 40, 2001
3RBS	Crystal structure of the myomesin domains 10 and 11 Descriptor: BETA-MERCAPTOETHANOL, Myomesin-1, NITRATE ION Authors: Chatziefthimiou, S.D, Pinotsis, N, Wilmanns, M. Deposit date: 2011-03-29 Release date: 2012-03-07 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Superhelical architecture of the Myosin filament-linking protein myomesin with unusual elastic properties. Plos Biol., 10, 2012
1ASM	CRYSTAL STRUCTURES OF ESCHERICHIA COLI ASPARTATE AMINOTRANSFERASE IN TWO CONFORMATIONS: COMPARISON OF AN UNLIGANDED OPEN AND TWO LIGANDED CLOSED FORMS Descriptor: ASPARTATE AMINOTRANSFERASE, MALEIC ACID, PYRIDOXAL-5'-PHOSPHATE Authors: Jaeger, J, Jansonius, J.N. Deposit date: 1993-09-16 Release date: 1994-01-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Crystal structures of Escherichia coli aspartate aminotransferase in two conformations. Comparison of an unliganded open and two liganded closed forms. J.Mol.Biol., 239, 1994
2EGY	Crystal structure of LysN, alpha-aminoadipate aminotransferase (substrate free form), from Thermus thermophilus HB27 Descriptor: Alpha-aminodipate aminotransferase, PYRIDOXAL-5'-PHOSPHATE Authors: Tomita, T, Miyazaki, T, Miyagawa, T, Fushinobu, S, Kuzuyama, T, Nishiyama, M. Deposit date: 2007-03-02 Release date: 2008-03-04 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.67 Å) Cite: Crystal structure of LysN, alpha-aminoadipate aminotransferase, from Thermus thermophilus HB27 To be Published
1ASN	CRYSTAL STRUCTURES OF ESCHERICHIA COLI ASPARTATE AMINOTRANSFERASE IN TWO CONFORMATIONS: COMPARISON OF AN UNLIGANDED OPEN AND TWO LIGANDED CLOSED FORMS Descriptor: ASPARTATE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION Authors: Jaeger, J, Jansonius, J.N. Deposit date: 1993-09-16 Release date: 1994-01-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structures of Escherichia coli aspartate aminotransferase in two conformations. Comparison of an unliganded open and two liganded closed forms. J.Mol.Biol., 239, 1994
1ASL	CRYSTAL STRUCTURES OF ESCHERICHIA COLI ASPARTATE AMINOTRANSFERASE IN TWO CONFORMATIONS: COMPARISON OF AN UNLIGANDED OPEN AND TWO LIGANDED CLOSED FORMS Descriptor: 2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-2-METHYL-SUCCINIC ACID, ASPARTATE AMINOTRANSFERASE Authors: Jaeger, J, Jansonius, J.N. Deposit date: 1993-09-16 Release date: 1994-01-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal structures of Escherichia coli aspartate aminotransferase in two conformations. Comparison of an unliganded open and two liganded closed forms. J.Mol.Biol., 239, 1994
1IX6	Aspartate Aminotransferase Active Site Mutant V39F Descriptor: Aspartate Aminotransferase, PYRIDOXAL-5'-PHOSPHATE Authors: Hayashi, H, Mizuguchi, H, Miyahara, I, Nakajima, Y, Hirotsu, K, Kagamiyama, H. Deposit date: 2002-06-14 Release date: 2002-07-03 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Conformational change in aspartate aminotransferase on substrate binding induces strain in the catalytic group and enhances catalysis J.BIOL.CHEM., 278, 2003

<19202122232425262728293031323334>