PDB: 161444 resultsInfo pagesStatus searchChemie searchBIRD

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8Q7M	Tau - AD-MIA7 (tau intermediate amyloid) Descriptor: Isoform Tau-D of Microtubule-associated protein tau Authors: Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. Deposit date: 2023-08-16 Release date: 2023-08-30 Last modified: 2024-01-24 Method: ELECTRON MICROSCOPY (3.26 Å) Cite: Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
8Q8D	Tau - AD-LIA6 (tau intermediate amyloid) Descriptor: Isoform Tau-D of Microtubule-associated protein tau Authors: Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. Deposit date: 2023-08-18 Release date: 2023-08-30 Last modified: 2024-01-24 Method: ELECTRON MICROSCOPY (3.04 Å) Cite: Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
8Q8C	Tau - AD-MIA10 (intermediate amyloid) Descriptor: Isoform Tau-D of Microtubule-associated protein tau Authors: Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. Deposit date: 2023-08-18 Release date: 2023-09-06 Last modified: 2024-01-24 Method: ELECTRON MICROSCOPY (1.92 Å) Cite: Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
8Q9F	Tau - CTE-LIA3 (tau intermediate amyloid) Descriptor: Isoform Tau-D of Microtubule-associated protein tau Authors: Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. Deposit date: 2023-08-20 Release date: 2023-09-06 Last modified: 2024-01-17 Method: ELECTRON MICROSCOPY (1.91 Å) Cite: Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
8Q9G	Tau - CTE-LIA5 (tau intermediate amyloid) Descriptor: Isoform Tau-D of Microtubule-associated protein tau Authors: Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. Deposit date: 2023-08-20 Release date: 2023-09-06 Last modified: 2024-01-17 Method: ELECTRON MICROSCOPY (2.65 Å) Cite: Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
8Q9J	Tau - CTE-LIA7 (tau intermediate amyloid) Descriptor: Isoform Tau-D of Microtubule-associated protein tau Authors: Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. Deposit date: 2023-08-20 Release date: 2023-09-06 Last modified: 2024-01-17 Method: ELECTRON MICROSCOPY (2.96 Å) Cite: Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
8Q9K	Tau - CTE-LIA13 (tau intermediate amyloid) Descriptor: Isoform Tau-D of Microtubule-associated protein tau Authors: Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. Deposit date: 2023-08-20 Release date: 2023-09-06 Last modified: 2024-01-17 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
8Q9M	Tau - CTE-type I (tau intermediate amyloid) Descriptor: Isoform Tau-D of Microtubule-associated protein tau Authors: Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. Deposit date: 2023-08-20 Release date: 2023-09-06 Last modified: 2024-01-17 Method: ELECTRON MICROSCOPY (2.65 Å) Cite: Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
8Q7L	Tau - AD-MIA6 (tau intermediate amyloid) Descriptor: Isoform Tau-D of Microtubule-associated protein tau Authors: Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. Deposit date: 2023-08-16 Release date: 2023-08-30 Last modified: 2024-01-24 Method: ELECTRON MICROSCOPY (2.82 Å) Cite: Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
8Q9L	Tau - CTE-LIA14 (tau intermediate amyloid) Descriptor: Isoform Tau-D of Microtubule-associated protein tau Authors: Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. Deposit date: 2023-08-20 Release date: 2023-09-06 Last modified: 2024-01-17 Method: ELECTRON MICROSCOPY (2.76 Å) Cite: Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
8Q9I	Tau - CTE-LIA6 (tau intermediate amyloid) Descriptor: Isoform Tau-D of Microtubule-associated protein tau Authors: Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. Deposit date: 2023-08-20 Release date: 2023-09-06 Last modified: 2024-01-17 Method: ELECTRON MICROSCOPY (2.56 Å) Cite: Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
8Q9O	CTE tau intermediate amyloid (LIA-17) Descriptor: Isoform Tau-D of Microtubule-associated protein tau Authors: Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. Deposit date: 2023-08-20 Release date: 2023-09-06 Last modified: 2024-01-17 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
8Q88	Tau - AD-LIA2 (tau intermediate amyloid) Descriptor: Isoform Tau-D of Microtubule-associated protein tau Authors: Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. Deposit date: 2023-08-18 Release date: 2023-08-30 Last modified: 2024-01-24 Method: ELECTRON MICROSCOPY (2.95 Å) Cite: Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
8QCP	Tau - AD-LIA8 (tau intermediate amyloid) Descriptor: Isoform Tau-D of Microtubule-associated protein tau Authors: Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. Deposit date: 2023-08-28 Release date: 2023-09-06 Last modified: 2024-01-24 Method: ELECTRON MICROSCOPY (3.21 Å) Cite: Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
8Q7P	Tau - AD-MIA8 (intermediate amyloid) Descriptor: Isoform Tau-D of Microtubule-associated protein tau Authors: Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. Deposit date: 2023-08-16 Release date: 2023-08-30 Last modified: 2024-01-24 Method: ELECTRON MICROSCOPY (3.28 Å) Cite: Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
8QCR	Tau - CTE-MIA12 (tau intermediate amyloid) Descriptor: Isoform Tau-D of Microtubule-associated protein tau Authors: Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. Deposit date: 2023-08-28 Release date: 2023-09-06 Last modified: 2024-01-17 Method: ELECTRON MICROSCOPY (2.75 Å) Cite: Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
8Q97	Tau - CTE-MIA9 (tau intermediate amyloid) Descriptor: Isoform Tau-D of Microtubule-associated protein tau Authors: Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. Deposit date: 2023-08-20 Release date: 2023-09-20 Last modified: 2024-01-17 Method: ELECTRON MICROSCOPY (2.99 Å) Cite: Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
7DHJ	The co-crystal structure of SARS-CoV-2 main protease with the peptidomimetic inhibitor (S)-2-cinnamamido-N-((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)pent-4-ynamide Descriptor: (2~{S})-~{N}-[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]-2-[[(~{E})-3-phenylprop-2-enoyl]amino]pent-4-ynamide, 3C-like proteinase Authors: Shang, L.Q, Wang, H, Deng, W.L, Xing, S, Wang, Y.X. Deposit date: 2020-11-15 Release date: 2021-11-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.962 Å) Cite: The structure-based design of peptidomimetic inhibitors against SARS-CoV-2 3C like protease as Potent anti-viral drug candidate. Eur.J.Med.Chem., 238, 2022
7DGB	The co-crystal structure of SARS-CoV-2 main protease with (S)-2-cinnamamido-4-methyl-N-((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)pentanamide Descriptor: (2~{S})-4-methyl-~{N}-[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]-2-[[(~{E})-3-phenylprop-2-enoyl]amino]pentanamide, 3C-like proteinase Authors: Shang, L.Q, Wang, H. Deposit date: 2020-11-11 Release date: 2021-11-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.678 Å) Cite: The structure-based design of peptidomimetic inhibitors against SARS-CoV-2 3C like protease as Potent anti-viral drug candidate. Eur.J.Med.Chem., 238, 2022
7DGH	The co-crystal structure of SARS-CoV-2 main protease with peptidomimetic inhibitor N-((S)-3-methyl-1-(((S)-4-methyl-1-oxo-1-(((S)-1-oxo-3-((S)-2-oxopiperidin-3-yl)propan-2-yl)amino)pentan-2-yl)amino)-1-oxobutan-2-yl)-2-naphthamide Descriptor: 3C-like proteinase, ~{N}-[(2~{S})-3-methyl-1-[[(2~{S})-4-methyl-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepiperidin-3-yl]propan-2-yl]amino]pentan-2-yl]amino]-1-oxidanylidene-butan-2-yl]naphthalene-2-carboxamide Authors: Shang, L.Q, Wang, H. Deposit date: 2020-11-11 Release date: 2021-11-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.968 Å) Cite: The structure-based design of peptidomimetic inhibitors against SARS-CoV-2 3C like protease as Potent anti-viral drug candidate. Eur.J.Med.Chem., 238, 2022
7DGF	The co-crystal structure of SARS-CoV-2 main protease with peptidomimetic inhibitor (S)-2-cinnamamido-N-((S)-1-oxo-3-((S)-2-oxopiperidin-3-yl)propan-2-yl)hexanamide Descriptor: (2~{S})-~{N}-[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepiperidin-3-yl]propan-2-yl]-2-[[(~{E})-3-phenylprop-2-enoyl]amino]hexanamide, 3C-like proteinase Authors: Shang, L.Q, Wang, H. Deposit date: 2020-11-11 Release date: 2021-11-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.639 Å) Cite: The structure-based design of peptidomimetic inhibitors against SARS-CoV-2 3C like protease as Potent anti-viral drug candidate. Eur.J.Med.Chem., 238, 2022
7DGG	The co-crystal structure of SARS-CoV-2 main protease with (S)-2-cinnamamido-N-((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)hexanamide Descriptor: (2~{S})-~{N}-[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]-2-[[(~{E})-3-phenylprop-2-enoyl]amino]hexanamide, 3C-like proteinase Authors: Shang, L.Q, Wang, H. Deposit date: 2020-11-11 Release date: 2021-11-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.004 Å) Cite: The structure-based design of peptidomimetic inhibitors against SARS-CoV-2 3C like protease as Potent anti-viral drug candidate. Eur.J.Med.Chem., 238, 2022
7DGI	The co-crystal structure of SARS-CoV-2 main protease with peptidomimetic inhibitor N-((S)-3-methyl-1-(((S)-4-methyl-1-oxo-1-(((S)-1-oxo-3-((S)-2-oxopiperidin-3-yl)propan-2-yl)amino)pentan-2-yl)amino)-1-oxobutan-2-yl)-4-nitrobenzamide Descriptor: 3C-like proteinase, ~{N}-[(2~{S})-3-methyl-1-[[(2~{S})-4-methyl-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepiperidin-3-yl]propan-2-yl]amino]pentan-2-yl]amino]-1-oxidanylidene-butan-2-yl]-4-nitro-benzamide Authors: Shang, L.Q, Wang, H. Deposit date: 2020-11-11 Release date: 2021-11-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.898 Å) Cite: The structure-based design of peptidomimetic inhibitors against SARS-CoV-2 3C like protease as Potent anti-viral drug candidate. Eur.J.Med.Chem., 238, 2022
4JQ8	Crystal structure of EGFR kinase domain in complex with compound 4b Descriptor: Epidermal growth factor receptor, N-[3-(4-{[(1S)-2-hydroxy-1-phenylethyl]amino}-6-phenylfuro[2,3-d]pyrimidin-5-yl)phenyl]-N~3~,N~3~-dimethyl-beta-alaninamide Authors: Peng, Y.H, Wu, J.S. Deposit date: 2013-03-20 Release date: 2013-06-19 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.83 Å) Cite: Protein Kinase Inhibitor Design by Targeting the Asp-Phe-Gly (DFG) Motif: The Role of the DFG Motif in the Design of Epidermal Growth Factor Receptor Inhibitors J.Med.Chem., 56, 2013
4JR3	Crystal structure of EGFR kinase domain in complex with compound 3g Descriptor: Epidermal growth factor receptor, N-[3-(4-{[(1S)-2-hydroxy-1-phenylethyl]amino}-6-phenylfuro[2,3-d]pyrimidin-5-yl)phenyl]acetamide Authors: Peng, Y.H, Wu, J.S. Deposit date: 2013-03-21 Release date: 2013-06-19 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Protein Kinase Inhibitor Design by Targeting the Asp-Phe-Gly (DFG) Motif: The Role of the DFG Motif in the Design of Epidermal Growth Factor Receptor Inhibitors J.Med.Chem., 56, 2013

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