PDB: 1147 resultsInfo pagesStatus searchChemie searchBIRD

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7F4A	Crystal structure of Taf14 YEATS domain in complex with H3K9bz peptide Descriptor: Histone H3, Transcription initiation factor TFIID subunit 14 Authors: Wang, D, Yan, F, Yong, C. Deposit date: 2021-06-18 Release date: 2022-03-16 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2 Å) Cite: Global profiling of regulatory elements in the histone benzoylation pathway. Nat Commun, 13, 2022
7JJH	Crystal structure of the unliganded tandem bromodomain (BD1, BD2) of human TAF1 Descriptor: 1,2-ETHANEDIOL, Transcription initiation factor TFIID subunit 1 Authors: Karim, M.R, Schonbrunn, E. Deposit date: 2020-07-25 Release date: 2021-01-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain. J.Med.Chem., 65, 2022
2C9O	3D Structure of the human RuvB-like helicase RuvBL1 Descriptor: ADENOSINE-5'-DIPHOSPHATE, RUVB-LIKE 1 Authors: Matias, P.M, Gorynia, S, Donner, P, Carrondo, M.A. Deposit date: 2005-12-14 Release date: 2006-10-23 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structure of the human AAA+ protein RuvBL1. J. Biol. Chem., 281, 2006
7JJG	Crystal structure of the second bromodomain (BD2) of human TAF1 bound to ATR kinase inhibitor AZ20 Descriptor: 1,2-ETHANEDIOL, 4-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole, GLYCEROL, ... Authors: Karim, M.R, Schonbrunn, E. Deposit date: 2020-07-25 Release date: 2021-07-28 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain. J.Med.Chem., 65, 2022
7JTC	Crystal structure of the second bromodomain (BD2) of human TAF1 bound to ZS1-322 Descriptor: 1,2-ETHANEDIOL, 1-{6-[(3R)-3-methylmorpholin-4-yl]-2-(methylsulfanyl)pyrimidin-4-yl}cyclopropane-1-sulfonimidoamide, Transcription initiation factor TFIID subunit 1 Authors: Karim, M.R, Schonbrunn, E. Deposit date: 2020-08-17 Release date: 2021-08-25 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Crystal structure of the second bromodomain (BD2) of human TAF1 bound to ZS1-322 To Be Published
7JSP	Crystal structure of the second bromodomain (BD2) of human TAF1 bound to ATR kinase inhibitor AZD6738 Descriptor: 1,2-ETHANEDIOL, 4-(4-{1-[(R)-amino(hydroxy)methyl-lambda~4~-sulfanyl]cyclopropyl}-6-[(3R)-3-methylmorpholin-4-yl]pyrimidin-2-yl)-1H-pyrrolo[2,3-b]pyridine, SULFATE ION, ... Authors: Karim, M.R, Schonbrunn, E. Deposit date: 2020-08-15 Release date: 2021-08-25 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain. J.Med.Chem., 65, 2022
7K0D	Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to mTORC1/2 inhibitor AZD3147 Descriptor: N-(4-{4-[1-(cyclopropylsulfonyl)cyclopropyl]-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl}phenyl)-N'-(2-hydroxyethyl)thiourea, Transcription initiation factor TFIID subunit 1 Authors: Karim, M.R, Schonbrunn, E. Deposit date: 2020-09-04 Release date: 2021-09-22 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain. J.Med.Chem., 65, 2022
7K0U	Crystal structure of the second bromodomain (BD2) of human TAF1 bound to PLK1 kinase inhibitor BI2536 Descriptor: 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, Transcription initiation factor TFIID subunit 1 Authors: Karim, M.R, Schonbrunn, E. Deposit date: 2020-09-06 Release date: 2021-09-22 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.52 Å) Cite: Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain. J.Med.Chem., 65, 2022
7K03	Crystal structure of the tandem bromodomain (BD1 and BD2) of human TAF1 bound to ATR kinase inhibitor AZD6738 Descriptor: 1,2-ETHANEDIOL, 4-(4-{1-[(R)-amino(hydroxy)methyl-lambda~4~-sulfanyl]cyclopropyl}-6-[(3R)-3-methylmorpholin-4-yl]pyrimidin-2-yl)-1H-pyrrolo[2,3-b]pyridine, Transcription initiation factor TFIID subunit 1 Authors: Karim, M.R, Schonbrunn, E. Deposit date: 2020-09-03 Release date: 2021-09-22 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain. J.Med.Chem., 65, 2022
7K1P	Crystal structure of the second bromodomain (BD2) of human TAF1 bound to bromosporine Descriptor: 1,2-ETHANEDIOL, Bromosporine, Transcription initiation factor TFIID subunit 1 Authors: Karim, M.R, Schonbrunn, E. Deposit date: 2020-09-08 Release date: 2021-09-22 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain. J.Med.Chem., 65, 2022
7K27	Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to ATR inhibitor AZ20 Descriptor: 1,2-ETHANEDIOL, 4-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole, DIMETHYL SULFOXIDE, ... Authors: Karim, M.R, Schonbrunn, E. Deposit date: 2020-09-08 Release date: 2021-09-22 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain. J.Med.Chem., 65, 2022
7K3O	Crystal structure of the unliganded second bromodomain (BD2) of human TAF1 Descriptor: 1,2-ETHANEDIOL, SULFATE ION, Transcription initiation factor TFIID subunit 1 Authors: Karim, M.R, Schonbrunn, E. Deposit date: 2020-09-12 Release date: 2021-09-22 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain. J.Med.Chem., 65, 2022
7K6F	Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 in complex with MES (2-(N-morpholino)ethanesulfonic acid) Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACETATE ION, ... Authors: Karim, M.R, Bikowitz, M.J, Schonbrunn, E. Deposit date: 2020-09-20 Release date: 2021-09-22 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain. J.Med.Chem., 65, 2022
7K42	Crystal structure of the second bromodomain (BD2) of human TAF1 bound to dioxane Descriptor: 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, SULFATE ION, ... Authors: Karim, M.R, Schonbrunn, E. Deposit date: 2020-09-14 Release date: 2021-09-22 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain. J.Med.Chem., 65, 2022
5IOK	Crystal structure of Taf14 YEATS domain in complex with histone H3K9cr Descriptor: (ACE)QTAR(KCR)ST, DI(HYDROXYETHYL)ETHER, Transcription initiation factor TFIID subunit 14 Authors: Andrews, F.H, Kuateladze, T.G. Deposit date: 2016-03-08 Release date: 2016-04-20 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.22 Å) Cite: The Taf14 YEATS domain is a reader of histone crotonylation. Nat.Chem.Biol., 12, 2016
6H7X	First X-ray structure of full-length human RuvB-Like 2. Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ... Authors: Silva, S, Brito, J.A, Matias, P, Bandeiras, T. Deposit date: 2018-07-31 Release date: 2018-08-08 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.892 Å) Cite: X-ray structure of full-length human RuvB-Like 2 - mechanistic insights into coupling between ATP binding and mechanical action. Sci Rep, 8, 2018
5L4G	The human 26S proteasome at 3.9 A Descriptor: 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ... Authors: Schweitzer, A, Aufderheide, A, Rudack, T, Beck, F. Deposit date: 2016-05-25 Release date: 2016-09-07 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structure of the human 26S proteasome at a resolution of 3.9 angstrom. Proc.Natl.Acad.Sci.USA, 113, 2016
1UBD	CO-CRYSTAL STRUCTURE OF HUMAN YY1 ZINC FINGER DOMAIN BOUND TO THE ADENO-ASSOCIATED VIRUS P5 INITIATOR ELEMENT Descriptor: DNA (5'-D(*AP*GP*GP*GP*TP*CP*TP*CP*CP*AP*TP*TP*TP*TP*GP*AP*A P*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*TP*TP*CP*AP*AP*AP*AP*TP*GP*GP*AP*GP*AP*C P*CP*CP*T)-3'), PROTEIN (YY1 ZINC FINGER DOMAIN), ... Authors: Houbaviy, H.B, Usheva, A, Shenk, T, Burley, S.K. Deposit date: 1996-10-04 Release date: 1996-12-23 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator. Proc.Natl.Acad.Sci.USA, 93, 1996
5MG2	Crystal structure of the second bromodomain of human TAF1 in complex with BAY-299 chemical probe Descriptor: 1,2-ETHANEDIOL, 6-(3-oxidanylpropyl)-2-(1,3,6-trimethyl-2-oxidanylidene-benzimidazol-5-yl)benzo[de]isoquinoline-1,3-dione, Transcription initiation factor TFIID subunit 1 Authors: Tallant, C, Bouche, L, Holton, S.J, Fedorov, O, Siejka, P, Picaud, S, Krojer, T, Srikannathasan, V, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hartung, I.V, Haendler, B, Muller, S, Huber, K.V.M, Structural Genomics Consortium (SGC) Deposit date: 2016-11-20 Release date: 2017-05-03 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains. J. Med. Chem., 60, 2017
5LN3	The human 26S Proteasome at 6.8 Ang. Descriptor: 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ... Authors: Schweitzer, A, Beck, F, Sakata, E, Unverdorben, P. Deposit date: 2016-08-03 Release date: 2017-03-22 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (6.8 Å) Cite: Molecular Details Underlying Dynamic Structures and Regulation of the Human 26S Proteasome. Mol. Cell Proteomics, 16, 2017
5M32	Human 26S proteasome in complex with Oprozomib Descriptor: 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ... Authors: Haselbach, D, Schrader, J, Lambrecht, F, Henneberg, F, Chari, A, Stark, H. Deposit date: 2016-10-14 Release date: 2017-07-05 Last modified: 2019-12-11 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs. Nat Commun, 8, 2017
7W3B	Structure of USP14-bound human 26S proteasome in substrate-engaged state ED5_USP14 Descriptor: 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... Authors: Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. Deposit date: 2021-11-25 Release date: 2022-05-04 Last modified: 2022-06-01 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
7W3J	Structure of USP14-bound human 26S proteasome in substrate-inhibited state SC_USP14 Descriptor: 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... Authors: Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. Deposit date: 2021-11-25 Release date: 2022-05-04 Last modified: 2022-06-01 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
7W3G	Structure of USP14-bound human 26S proteasome in substrate-engaged state ED2.0_USP14 Descriptor: 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... Authors: Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. Deposit date: 2021-11-25 Release date: 2022-05-04 Last modified: 2022-06-01 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
7W3A	Structure of USP14-bound human 26S proteasome in substrate-engaged state ED4_USP14 Descriptor: 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... Authors: Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. Deposit date: 2021-11-25 Release date: 2022-05-04 Last modified: 2022-06-01 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022

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