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8GKO	Crystal Structure Analysis of Aspergillus fumigatus alkaline protease Descriptor: 1,2-ETHANEDIOL, Alkaline protease 1, FORMYL GROUP, ... Authors: Fernandez, D, Diec, D.D.L, Guo, W, Russi, S. Deposit date: 2023-03-20 Release date: 2023-11-01 Method: X-RAY DIFFRACTION (1.06 Å) Cite: Targeting Aspergillus allergen oryzin with a chemical probe at atomic precision. Sci Rep, 13, 2023
8GKQ	Crystal Structure Analysis of Aspergillus fumigatus alkaline protease Descriptor: 1,2-ETHANEDIOL, Alkaline protease 1, CALCIUM ION, ... Authors: Fernandez, D, Diec, D.D.L, Guo, W, Russi, S. Deposit date: 2023-03-20 Release date: 2023-11-01 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Targeting Aspergillus allergen oryzin with a chemical probe at atomic precision. Sci Rep, 13, 2023
8GKP	Crystal Structure Analysis of Aspergillus fumigatus alkaline protease Descriptor: Alkaline protease 1, DI(HYDROXYETHYL)ETHER, FORMIC ACID, ... Authors: Fernandez, D, Diec, D.D.L, Guo, W, Russi, S. Deposit date: 2023-03-20 Release date: 2023-11-01 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Targeting Aspergillus allergen oryzin with a chemical probe at atomic precision. Sci Rep, 13, 2023
6EQW	X-ray structure of the proprotein convertase furin bound with the competitive inhibitor 4-aminomethyl-phenylacetyl-Arg-Val-Arg-Amba Descriptor: AMA-ARG-TBG-ARG-00S, CALCIUM ION, CHLORIDE ION, ... Authors: Dahms, S.O, Than, M.E. Deposit date: 2017-10-16 Release date: 2018-02-28 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.994 Å) Cite: X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket. Biochemistry, 57, 2018
6EQV	X-ray structure of the proprotein convertase furin bound with the competitive inhibitor Phac-Cit-Val-Arg-Amba Descriptor: CALCIUM ION, CHLORIDE ION, Furin, ... Authors: Dahms, S.O, Than, M.E. Deposit date: 2017-10-16 Release date: 2018-02-28 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.895 Å) Cite: X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket. Biochemistry, 57, 2018
1LW6	Crystal Structure of the Complex of Subtilisin BPN' with Chymotrypsin Inhibitor 2 at 1.5 Angstrom Resolution Descriptor: CALCIUM ION, SUBTILISIN BPN', SUBTILISIN-CHYMOTRYPSIN INHIBITOR-2A, ... Authors: Radisky, E.S, Koshland JR, D.E. Deposit date: 2002-05-30 Release date: 2002-08-21 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.5 Å) Cite: A clogged gutter mechanism for protease inhibitors. Proc.Natl.Acad.Sci.USA, 99, 2002
6EQX	X-ray structure of the proprotein convertase furin bound with the competitive inhibitor Arg-Arg-Arg-Val-Arg-Amba Descriptor: Arg-Arg-Arg-Val-Arg-00S, CALCIUM ION, CHLORIDE ION, ... Authors: Dahms, S.O, Than, M.E. Deposit date: 2017-10-16 Release date: 2018-02-28 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.994 Å) Cite: X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket. Biochemistry, 57, 2018
1MEE	THE COMPLEX BETWEEN THE SUBTILISIN FROM A MESOPHILIC BACTERIUM AND THE LEECH INHIBITOR EGLIN-C Descriptor: CALCIUM ION, EGLIN C, MESENTERICOPEPTIDASE Authors: Dauter, Z, Betzel, C, Wilson, K.S. Deposit date: 1991-04-15 Release date: 1992-10-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2 Å) Cite: Complex between the subtilisin from a mesophilic bacterium and the leech inhibitor eglin-C. Acta Crystallogr.,Sect.B, 47, 1991
7O1U	X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 1 (BEV241) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ... Authors: Dahms, S.O, Brandstetter, H. Deposit date: 2021-03-30 Release date: 2021-09-01 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.7 Å) Cite: OFF-State-Specific Inhibition of the Proprotein Convertase Furin. Acs Chem.Biol., 16, 2021
7O1W	X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 2 (mi307) soaked at 1 M NaCl Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ... Authors: Dahms, S.O, Brandstetter, H. Deposit date: 2021-03-30 Release date: 2021-09-01 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.8 Å) Cite: OFF-State-Specific Inhibition of the Proprotein Convertase Furin. Acs Chem.Biol., 16, 2021
7O22	X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 4 (mi359) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ... Authors: Dahms, S.O, Brandstetter, H. Deposit date: 2021-03-30 Release date: 2021-09-01 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.8 Å) Cite: OFF-State-Specific Inhibition of the Proprotein Convertase Furin. Acs Chem.Biol., 16, 2021
7O1Y	X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 2 (mi307) soaked at 0.25 M NaCl Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ... Authors: Dahms, S.O, Brandstetter, H. Deposit date: 2021-03-30 Release date: 2021-09-01 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.7 Å) Cite: OFF-State-Specific Inhibition of the Proprotein Convertase Furin. Acs Chem.Biol., 16, 2021
7O20	X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 3 (mi300) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ... Authors: Dahms, S.O, Brandstetter, H. Deposit date: 2021-03-30 Release date: 2021-09-01 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.8 Å) Cite: OFF-State-Specific Inhibition of the Proprotein Convertase Furin. Acs Chem.Biol., 16, 2021
2ID4	The 1.9 A structure of Kex2 in complex with an Ac-R-E-R-K-chloromethyl ketone inhibitor. Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, Ac-RERK-CMK inhibitor, ... Authors: Wheatley, J.L, Holyoak, T. Deposit date: 2006-09-14 Release date: 2007-05-01 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Differential P1 arginine and lysine recognition in the prototypical proprotein convertase Kex2. Proc.Natl.Acad.Sci.Usa, 104, 2007
6HLD	X-ray structure of furin in complex with the cyclic peptide c[succinyl-Phe-2-Nal-(Arg)3-Lys]-Lys-4-Amba Descriptor: ALN-ARG-ARG-ARG-SLL-LYS-00S, CALCIUM ION, CHLORIDE ION, ... Authors: Dahms, S.O. Deposit date: 2018-09-11 Release date: 2019-02-06 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin. Chemmedchem, 14, 2019
6HZA	X-ray structure of furin in complex with the cyclic peptide c[glutaryl-Arg-Arg-Lys]-Arg-4-Amba Descriptor: ARG-ARG-LYS-ARG-00S, CALCIUM ION, CHLORIDE ION, ... Authors: Dahms, S.O. Deposit date: 2018-10-23 Release date: 2019-02-06 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin. Chemmedchem, 14, 2019
6HLB	X-ray structure of furin in complex with the cyclic peptide c[succinyl-Phe-2-Nal-(Arg)4-Lys]-Arg-4-Amba Descriptor: CALCIUM ION, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: Dahms, S.O. Deposit date: 2018-09-11 Release date: 2019-02-06 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2 Å) Cite: Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin. Chemmedchem, 14, 2019
6XIB	PCSK9(deltaCRD) in complex with cyclic peptide 30 Descriptor: GLYCEROL, Peptide 30, Proprotein convertase subtilisin/kexin type 9 Authors: Orth, P. Deposit date: 2020-06-19 Release date: 2020-11-18 Last modified: 2024-04-24 Method: X-RAY DIFFRACTION (1.546 Å) Cite: Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design. J.Med.Chem., 63, 2020
6HLE	X-ray structure of furin in complex with the P6-P2-cyclized peptide H-Lys-Arg-Arg-Tle-Lys-4-Amba Descriptor: 3-[4-(3-oxidanylidenepropyl)piperazin-1-yl]propanal, CALCIUM ION, CHLORIDE ION, ... Authors: Dahms, S.O. Deposit date: 2018-09-11 Release date: 2019-02-06 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.994 Å) Cite: Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin. Chemmedchem, 14, 2019
6XIC	PCSK9(deltaCRD) in complex with cyclic peptide 40 Descriptor: GLYCEROL, Peptide 40, Proprotein convertase subtilisin/kexin type 9 Authors: Orth, P. Deposit date: 2020-06-19 Release date: 2020-11-18 Last modified: 2024-04-24 Method: X-RAY DIFFRACTION (1.377 Å) Cite: Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design. J.Med.Chem., 63, 2020
6XID	PCSK9(deltaCRD) in complex with cyclic peptide 51 Descriptor: GLYCEROL, Peptide 51, Proprotein convertase subtilisin/kexin type 9 Authors: Orth, P. Deposit date: 2020-06-19 Release date: 2020-11-18 Last modified: 2024-04-24 Method: X-RAY DIFFRACTION (1.482 Å) Cite: Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design. J.Med.Chem., 63, 2020
6HZD	X-ray structure of furin in complex with the cyclic inhibitor c[glutaryl-Arg-Arg-Arg-Lys]-Arg-4-Amba Descriptor: ARG-ARG-ARG-LYS-ARG-00S, CALCIUM ION, CHLORIDE ION, ... Authors: Dahms, S.O. Deposit date: 2018-10-23 Release date: 2019-02-06 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin. Chemmedchem, 14, 2019
6XIE	PCSK9(deltaCRD) in complex with cyclic peptide 77 Descriptor: GLYCEROL, Peptide 77, Proprotein convertase subtilisin/kexin type 9 Authors: Orth, P. Deposit date: 2020-06-19 Release date: 2020-11-18 Last modified: 2024-04-24 Method: X-RAY DIFFRACTION (1.43 Å) Cite: Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design. J.Med.Chem., 63, 2020
5VLK	Short PCSK9 delta-P' complex with shrunken peptide bearing homo-Arginine Descriptor: ACE-THR-VAL-PHE-THR-SER-TRP-GLU-GLU-TYR-LEU-ASP-TRP-VAL-NH2 peptide, ACE-TRP-ASN-LEU-VAL-HRG-ILE-GLY-LEU-LEU peptide, CALCIUM ION, ... Authors: Eigenbrot, C, Ultsch, M. Deposit date: 2017-04-25 Release date: 2017-08-16 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists. Nat. Struct. Mol. Biol., 24, 2017
5VLP	PCSK9 complex with LDLR antagonist peptide and Fab7G7 Descriptor: Fab7G7 heavy chain, Fab7G7 light chain, LDLR antagonist peptide, ... Authors: Eigenbrot, C, Ultsch, M. Deposit date: 2017-04-25 Release date: 2017-08-16 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists. Nat. Struct. Mol. Biol., 24, 2017

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