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9ICP	DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SIX BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF PYROPHOSPHATE (1 MILLIMOLAR) AND MGCL2 (5 MILLIMOLAR) Descriptor: DNA (5'-D(*CP*AP*GP*AP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*CP*TP*GP*T)-3'), PROTEIN (DNA POLYMERASE BETA (E.C.2.7.7.7)), ... Authors: Pelletier, H, Sawaya, M.R. Deposit date: 1995-12-16 Release date: 1996-11-15 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (3.1 Å) Cite: A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta Biochemistry, 35, 1996
9EU6	The FK1 domain of FKBP51 in complex with SAFit-analog 23j Descriptor: (1,5-dimethylpyrazol-4-yl)methyl (2~{S})-1-[(2~{S})-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)ethanoyl]piperidine-2-carboxylate, Peptidyl-prolyl cis-trans isomerase FKBP5 Authors: Meyners, C, Buffa, V, Hausch, F. Deposit date: 2024-03-27 Release date: 2024-06-12 Last modified: 2024-09-11 Method: X-RAY DIFFRACTION (1.54 Å) Cite: 1,4-Pyrazolyl-Containing SAFit-Analogues are Selective FKBP51 Inhibitors With Improved Ligand Efficiency and Drug-Like Profile. Chemmedchem, 19, 2024
9B6A	GluA2 flip Q in complex with TARPgamma2 at pH8, class12, structure of LBD-TMD-TARPgamma2 Descriptor: Isoform Flip of Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit Authors: Nakagawa, T, Greger, I.H. Deposit date: 2024-03-23 Release date: 2024-07-31 Last modified: 2024-09-04 Method: ELECTRON MICROSCOPY (3.35 Å) Cite: Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization. Nat.Struct.Mol.Biol., 2024
9CHR	Cryo-EM structure of the human ether-a-go-go related K+ channel (hERG) in 300 mM K+ without symmetry Descriptor: Potassium voltage-gated channel subfamily H member 2 Authors: Lau, C.H.Y, Hunter, M.J, Vandenberg, J.I. Deposit date: 2024-07-01 Release date: 2024-08-21 Last modified: 2024-09-11 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Potassium dependent structural changes in the selectivity filter of HERG potassium channels. Nat Commun, 15, 2024
9ICQ	DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SIX BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DATP (1 MILLIMOLAR) AND MNCL2 (5 MILLIMOLAR) Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*GP*AP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*CP*TP*GP*T)-3'), ... Authors: Pelletier, H, Sawaya, M.R. Deposit date: 1996-01-04 Release date: 1996-11-15 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.9 Å) Cite: A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta Biochemistry, 35, 1996
9ICF	DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX + 2'-DEOXYADENOSINE-5'-TRIPHOSPHATE, SOAKED IN THE PRESENCE OF DATP AND ZNCL2 Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*TP*TP*AP*GP*AP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*AP*TP*GP*A)-3'), ... Authors: Pelletier, H, Sawaya, M.R. Deposit date: 1995-12-15 Release date: 1995-12-15 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (3 Å) Cite: A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta Biochemistry, 35, 1996
9CHP	Cryo-EM structure of the human ether-a-go-go related K+ channel (hERG) in 300 mM K+ Descriptor: Potassium voltage-gated channel subfamily H member 2 Authors: Lau, C.H.Y, Hunter, M.J, Vandenberg, J.I. Deposit date: 2024-07-01 Release date: 2024-08-21 Last modified: 2024-09-11 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Potassium dependent structural changes in the selectivity filter of HERG potassium channels. Nat Commun, 15, 2024
9B64	GluA2 flip Q in complex with TARPgamma2 at pH5, class23, structure of LBD-TMD-TARPgamma2 Descriptor: Isoform Flip of Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit Authors: Nakagawa, T, Greger, I.H. Deposit date: 2024-03-23 Release date: 2024-07-31 Last modified: 2024-09-04 Method: ELECTRON MICROSCOPY (3.56 Å) Cite: Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization. Nat.Struct.Mol.Biol., 2024
8YHE	Cryo-EM structure of CTR-bound type VII CRISPR-Cas complex at post-state II Descriptor: RNA (29-MER), RNA (46-MER), ZINC ION, ... Authors: Zhang, H, Deng, Z, Li, X. Deposit date: 2024-02-28 Release date: 2024-08-21 Last modified: 2024-09-25 Method: ELECTRON MICROSCOPY (3.07 Å) Cite: Structural basis for the activity of the type VII CRISPR-Cas system. Nature, 633, 2024
9ICJ	DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA Descriptor: DNA (5'-D(*CP*AP*TP*TP*AP*GP*AP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*AP*TP*G)-3'), PROTEIN (DNA POLYMERASE BETA (E.C.2.7.7.7)), ... Authors: Pelletier, H, Sawaya, M.R. Deposit date: 1995-12-15 Release date: 1996-11-15 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Characterization of the metal ion binding helix-hairpin-helix motifs in human DNA polymerase beta by X-ray structural analysis Biochemistry, 35, 1996
9ICH	DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DGTP (1 MILLIMOLAR) AND ZNCL2 (1 MILLIMOLAR) Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*TP*TP*AP*GP*AP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*AP*TP*G)-3'), ... Authors: Pelletier, H, Sawaya, M.R. Deposit date: 1995-12-15 Release date: 1996-11-15 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Characterization of the metal ion binding helix-hairpin-helix motifs in human DNA polymerase beta by X-ray structural analysis. Biochemistry, 35, 1996
9EUE	The FK1 domain of FKBP51 in complex with SAFit-analog 23a Descriptor: (1-methylpyrazol-4-yl)methyl (2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)ethanoyl]piperidine-2-carboxylate, Peptidyl-prolyl cis-trans isomerase FKBP5 Authors: Meyners, C, Buffa, V, Hausch, F. Deposit date: 2024-03-27 Release date: 2024-06-12 Last modified: 2024-09-11 Method: X-RAY DIFFRACTION (2 Å) Cite: 1,4-Pyrazolyl-Containing SAFit-Analogues are Selective FKBP51 Inhibitors With Improved Ligand Efficiency and Drug-Like Profile. Chemmedchem, 19, 2024
9ICI	DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DTTP (1 MILLIMOLAR) AND ZNCL2 (1 MILLIMOLAR) Descriptor: DNA (5'-D(*CP*AP*TP*TP*AP*GP*AP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*AP*TP*GP*T)-3'), PROTEIN (DNA POLYMERASE BETA (E.C.2.7.7.7)), ... Authors: Pelletier, H, Sawaya, M.R. Deposit date: 1995-12-15 Release date: 1996-11-15 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Characterization of the metal ion binding helix-hairpin-helix motifs in human DNA polymerase beta by X-ray structural analysis. Biochemistry, 35, 1996
5WDA	Structure of the PulG pseudopilus Descriptor: CALCIUM ION, General secretion pathway protein G Authors: Lopez-Castilla, A, Thomassin, J.L, Bardiaux, B, Zheng, W, Nivaskumar, M, Yu, X, Nilges, M, Egelman, E.H, Izadi-Pruneyre, N, Francetic, O. Deposit date: 2017-07-04 Release date: 2017-10-25 Last modified: 2020-01-01 Method: ELECTRON MICROSCOPY (5 Å) Cite: Structure of the calcium-dependent type 2 secretion pseudopilus. Nat Microbiol, 2, 2017
9AVL	Structure of human calcium-sensing receptor in complex with Gi3 protein in nanodiscs Descriptor: (19R,22S,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Zuo, H, Park, J, Frangaj, A, Ye, J, Lu, G, Manning, J.J, Asher, W.B, Lu, Z, Hu, G, Wang, L, Mendez, J, Eng, E, Zhang, Z, Lin, X, Grasucci, R, Hendrickson, W.A, Clarke, O.B, Javitch, J.A, Conigrave, A.D, Fan, Q.R. Deposit date: 2024-03-04 Release date: 2024-04-17 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Promiscuous G-protein activation by the calcium-sensing receptor. Nature, 629, 2024
9B0Z	Structure of Optineurin bound to HOIP NZF1 domain and M1-linked diubiquitin, crystal form 2 Descriptor: E3 ubiquitin-protein ligase RNF31, Optineurin, Ubiquitin, ... Authors: Michel, M.A, Scutts, S, Komander, D. Deposit date: 2024-03-12 Release date: 2024-07-31 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Linkage and substrate specificity conferred by NZF ubiquitin binding domains To Be Published
9ICO	DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX, SOAKED IN THE PRESENCE OF DTTP AND MGCL2 Descriptor: DNA (5'-D(*CP*AP*GP*AP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*CP*TP*GP*T)-3'), PROTEIN (DNA POLYMERASE BETA (E.C.2.7.7.7)), ... Authors: Pelletier, H, Sawaya, M.R. Deposit date: 1995-12-16 Release date: 1995-12-16 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.9 Å) Cite: A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta Biochemistry, 35, 1996
9ICU	DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SIX BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DTTP (1 MILLIMOLAR) AND MNCL2 (5 MILLIMOLAR) Descriptor: DNA (5'-D(*CP*AP*GP*AP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*CP*TP*GP*T)-3'), MANGANESE (II) ION, ... Authors: Pelletier, H, Sawaya, M.R. Deposit date: 1995-12-16 Release date: 1996-11-15 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.9 Å) Cite: A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta Biochemistry, 35, 1996
9EWN	Mpro from SARS-CoV-2 with 4Q mutation Descriptor: Non-structural protein 11 Authors: Plewka, J, Lis, K, Czarna, A, Kantyka, T, Pyrc, K. Deposit date: 2024-04-04 Release date: 2024-04-17 Last modified: 2024-04-24 Method: X-RAY DIFFRACTION (2.113 Å) Cite: SARS-CoV-2 M pro oligomerization as a potential target for therapy. Int.J.Biol.Macromol., 267, 2024
9BRZ	V0-only V-ATPase and synaptophysin complex in mouse brain isolated synaptic vesicles Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Wang, C, Jiang, W, Yang, K, Wang, X, Guo, Q, Brunger, A.T. Deposit date: 2024-05-12 Release date: 2024-06-19 Last modified: 2024-08-07 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Structure and topography of the synaptic V-ATPase-synaptophysin complex. Nature, 631, 2024
9ICT	DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX + 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, SOAKED IN THE PRESENCE OF DGTP AND MNCL2 Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*GP*AP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*CP*TP*GP*T)-3'), ... Authors: Pelletier, H, Sawaya, M.R. Deposit date: 1995-12-16 Release date: 1996-11-15 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (3 Å) Cite: A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta Biochemistry, 35, 1996
9EOF	Structure of the human INTS5/8/10/15 subcomplex Descriptor: Integrator complex subunit 10, Integrator complex subunit 15, Integrator complex subunit 5, ... Authors: Razew, M, Galej, W.P. Deposit date: 2024-03-14 Release date: 2024-06-12 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (7.7 Å) Cite: Structural basis of the Integrator complex assembly and association with transcription factors. Mol.Cell, 84, 2024
9RNT	RIBONUCLEASE T1 WITH FREE RECOGNITION AND CATALYTIC SITE: CRYSTAL STRUCTURE ANALYSIS AT 1.5 ANGSTROMS RESOLUTION Descriptor: CALCIUM ION, RIBONUCLEASE T1 Authors: Martinez-Oyanedel, J, Heinemann, U, Saenger, W. Deposit date: 1991-09-25 Release date: 1993-01-15 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Ribonuclease T1 with free recognition and catalytic site: crystal structure analysis at 1.5 A resolution. J.Mol.Biol., 222, 1991
8Z4L	Cryo-EM structure of CTR-bound type VII CRISPR-Cas complex at substrate-engaged state I Descriptor: RNA (40-MER), RNA (49-MER), ZINC ION, ... Authors: Zhang, H, Deng, Z, Li, X. Deposit date: 2024-04-17 Release date: 2024-08-21 Last modified: 2024-09-25 Method: ELECTRON MICROSCOPY (2.85 Å) Cite: Structural basis for the activity of the type VII CRISPR-Cas system. Nature, 633, 2024
9ICR	DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX + 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, SOAKED IN THE PRESENCE OF DCTP AND MNCL2 Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*GP*AP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*CP*TP*GP*T)-3'), ... Authors: Pelletier, H, Sawaya, M.R. Deposit date: 1996-01-04 Release date: 1996-01-04 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (3 Å) Cite: A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta Biochemistry, 35, 1996

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