PDB: 225399 resultsInfo pagesStatus searchChemie searchBIRD

---

6O2W	Crystal structure of the SARAF luminal domain Cys-lock mutant dimer Descriptor: GLYCEROL, Store-operated calcium entry-associated regulatory factor Authors: Kimberlin, C.R, Minor, D.L. Deposit date: 2019-02-24 Release date: 2019-05-29 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.101 Å) Cite: SARAF Luminal Domain Structure Reveals a Novel Domain-Swapped beta-Sandwich Fold Important for SOCE Modulation. J.Mol.Biol., 431, 2019
6HKU	Trichodysplasia spinulosa-associated polyomavirus (TSPyV) VP1 in complex with sialylated precision glycooligomers Descriptor: Capsid protein VP1, GLYCEROL, N-acetyl-alpha-neuraminic acid, ... Authors: Rustmeier, N.H, Stehle, T. Deposit date: 2018-09-08 Release date: 2019-03-27 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Divalent Sialylated Precision Glycooligomers Binding to Polyomaviruses and the Effect of Different Linkers. Macromol Biosci, 19, 2019
8SIC	Crystal structure of Epstein-Barr virus glycoprotein 350 (gp350) in complex with Cy137C02, a monoclonal antibody isolated from macaques immunized with a gp350 nanoparticle vaccine Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cy137C02 Fab heavy chain, Cy137C02 Fab light chain, ... Authors: Joyce, M.G, Jensen, J.L, Chen, W.H, Kanekiyo, M. Deposit date: 2023-04-14 Release date: 2024-04-17 Method: X-RAY DIFFRACTION (2.76 Å) Cite: Crystal structure of Epstein-Barr virus glycoprotein 350 (gp350) in complex with Cy137C02, a monoclonal antibody isolated from macaques immunized with a gp350 nanoparticle vaccine To Be Published
6EJ7	Human Xylosyltransferase 1 in complex with UDP-xylose and peptide QEEEGAGGGQGG Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ... Authors: Briggs, D.C, Hohenester, E. Deposit date: 2017-09-20 Release date: 2018-05-02 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Basis for the Initiation of Glycosaminoglycan Biosynthesis by Human Xylosyltransferase 1. Structure, 26, 2018
6NVT	Crystal structure of TLA-1 extended spectrum Beta-lactamase Descriptor: ACETATE ION, Beta-lactamase, CHLORIDE ION, ... Authors: Rudino-Pinera, E, Cifuentes-Castro, V.H, Rodriguez-Almazan, C. Deposit date: 2019-02-05 Release date: 2019-12-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The crystal structure of ESBL TLA-1 in complex with clavulanic acid reveals a second acylation site. Biochem.Biophys.Res.Commun., 522, 2020
8JVA	Cryo-EM structure of the N-terminal domain of Omicron BA.1 in complex with nanobody N235 and S2L20 Fab Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, S2L20 heavy chain, S2L20 light chain, ... Authors: Liu, B, Liu, H.H, Han, P, Qi, J.X. Deposit date: 2023-06-28 Release date: 2024-05-22 Method: ELECTRON MICROSCOPY (2.81 Å) Cite: Enhanced potency of an IgM-like nanobody targeting conserved epitope in SARS-CoV-2 spike N-terminal domain. Signal Transduct Target Ther, 9, 2024
6NYW	Structure of spastin AAA domain N527C mutant in complex with 8-fluoroquinazoline-based inhibitor Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, N-(5-tert-butyl-1H-pyrazol-3-yl)-8-fluoro-2-[(2R)-2-methylpiperazin-1-yl]quinazolin-4-amine, ... Authors: Pisa, R, Cupido, T, Kapoor, T.M. Deposit date: 2019-02-12 Release date: 2019-03-27 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.189 Å) Cite: Designing Allele-Specific Inhibitors of Spastin, a Microtubule-Severing AAA Protein. J. Am. Chem. Soc., 141, 2019
6NZQ	CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_29 AKA 6-[(5-FLUORO-4-METH YLPYRIDIN-2-YL)AMINO]-4-({2-METHOXY-3-[(PYRIDIN-2-YLMETHYL )CARBAMOYL]PHENYL}AMINO)-N-METHYLPYRIDINE-3-CARBOXAMIDE Descriptor: 6-[(5-fluoro-4-methylpyridin-2-yl)amino]-4-[(2-methoxy-3-{[(pyridin-2-yl)methyl]carbamoyl}phenyl)amino]-N-methylpyridine-3-carboxamide, Non-receptor tyrosine-protein kinase TYK2 Authors: Khan, J.A. Deposit date: 2019-02-14 Release date: 2019-07-31 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.11 Å) Cite: Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165. J.Med.Chem., 62, 2019
6NW5	Crystal structure of TmPep1050 aminopeptidase with its metal cofactors Descriptor: Aminopeptidase, COBALT (II) ION, HYDROXIDE ION, ... Authors: Dutoit, R. Deposit date: 2019-02-06 Release date: 2019-10-23 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.7 Å) Cite: How metal cofactors drive dimer-dodecamer transition of the M42 aminopeptidase TmPep1050 ofThermotoga maritima. J.Biol.Chem., 294, 2019
8K5O	Cryo-EM structure of the RC-LH core comples from Halorhodospira halochloris Descriptor: (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 2-O-octyl-beta-D-glucopyranose, ... Authors: Wang, G.-L, Qi, C.-H, Yu, L.-J. Deposit date: 2023-07-22 Release date: 2024-05-22 Method: ELECTRON MICROSCOPY (2.42 Å) Cite: Structural insights into the unusual core photocomplex from a triply extremophilic purple bacterium, Halorhodospira halochloris. J Integr Plant Biol, 2024
5K9O	Crystal structure of multidonor HV1-18+HD3-9 class broadly neutralizing Influenza A antibody 31.b.09 in complex with Hemagglutinin H1 A/California/04/2009 Descriptor: 31.b.09 Heavy Fv, 31.b.09 Light Fv, Hemagglutinin, ... Authors: Joyce, M.G, Thomas, P.V, Wheatley, A.K, McDermott, A.B, Mascola, J.R, Kwong, P.D. Deposit date: 2016-06-01 Release date: 2016-12-28 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.387 Å) Cite: Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses. Cell, 166, 2016
6NZF	CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_5 AKA 4-[(2-CARBAMOYLPHEN YL)AMINO]-6-[(5-FLUOROPYRIDIN-2-YL)AMINO]-N-METHYLPYRIDINE -3-CARBOXAMIDE Descriptor: 6-[(5-fluoropyridin-2-yl)amino]-N-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide, Non-receptor tyrosine-protein kinase TYK2, SULFATE ION Authors: Muckelbauer, J.M. Deposit date: 2019-02-13 Release date: 2019-07-24 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Identification ofN-Methyl Nicotinamide andN-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2). J.Med.Chem., 62, 2019
6YSX	Thrombin in complex with 4-amino-N-(5-methylisoxazol-3-yl)benzenesulfonamide (j80) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, Hirudin variant-2, ... Authors: Scanlan, W, Heine, A, Klebe, G, Abazi, N. Deposit date: 2020-04-23 Release date: 2021-05-12 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.48 Å) Cite: Thrombin in complex with 4-amino-N-(5-methylisoxazol-3-yl)benzenesulfonamide (j80) To be published
6YWA	Human REF STING in complex with 3',3'-c-[2'FdAMP-2'FdAM(PS)] Descriptor: 3',3'-c-[2'FdAMP-2'FdAM(PS)], GLYCEROL, Stimulator of interferon genes protein Authors: Boura, E, Smola, M. Deposit date: 2020-04-29 Release date: 2021-05-12 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.311 Å) Cite: Human REF STING in complex with 3',3'-c-[2'FdAMP-2'FdAM(PS)] To Be Published
6YWB	Human wtSTING in complex with 3',3'-c-[2'FdAMP-2'FdAM(PS)] Descriptor: 3',3'-c-[2'FdAMP-2'FdAM(PS)], Stimulator of interferon protein Authors: Boura, E, Smola, M. Deposit date: 2020-04-29 Release date: 2021-05-12 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.503 Å) Cite: Human wtSTING in complex with 3',3'-c-[2'FdAMP-2'FdAM(PS)] To Be Published
6NXS	Crystal structure of Arabidopsis thaliana cytosolic triosephosphate isomerase C218Y mutant Descriptor: SODIUM ION, Triosephosphate isomerase, cytosolic Authors: Jimenez-Sandoval, P, Diaz-Quezada, C, Torres-Larios, A, Brieba, L.G. Deposit date: 2019-02-09 Release date: 2020-02-12 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.52 Å) Cite: Structural basis for the modulation of plant cytosolic triosephosphate isomerase activity by mimicry of redox-based modifications. Plant J., 99, 2019
6YSJ	Thrombin in complex with 2-amino-1-(4-bromophenyl)ethan-1-one (j10) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-1-(4-bromophenyl)ethanone, DIMETHYL SULFOXIDE, ... Authors: Scanlan, W, Heine, A, Klebe, G, Abazi, N, Paulus, A. Deposit date: 2020-04-22 Release date: 2021-05-12 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Thrombin in complex with 2-amino-1-(4-bromophenyl)ethan-1-one (j10) To be published
6NZE	CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_5 AKA 4-[(2-CARBAMOYLPHEN YL)AMINO]-6-[(5-FLUOROPYRIDIN-2-YL)AMINO]-N-METHYLPYRIDINE -3-CARBOXAMIDE Descriptor: 4-[(2-carbamoylphenyl)amino]-6-[(5-fluoropyridin-2-yl)amino]-N-methylpyridine-3-carboxamide, Non-receptor tyrosine-protein kinase TYK2, SULFATE ION Authors: Muckelbauer, J.M. Deposit date: 2019-02-13 Release date: 2019-07-24 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Identification ofN-Methyl Nicotinamide andN-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2). J.Med.Chem., 62, 2019
6NZP	CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH COMPOUND-11 AKA 6-CYCLOPROPANEAMIDO-4-{[2-METHOXY-3-(1-METHYL-1H-1,2,4-TRI AZOL-3-YL)PHENYL]AMINO}-N-(?H?)METHYLPYRIDAZINE-3-CARBOXAMIDE Descriptor: 6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]amino}-N-methylpyridazine-3-carboxamide, CHLORIDE ION, Non-receptor tyrosine-protein kinase TYK2 Authors: Khan, J.A. Deposit date: 2019-02-14 Release date: 2019-07-31 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165. J.Med.Chem., 62, 2019
8S7C	Ternary Complex of Cachd1, FZD5 and LRP6 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Frizzled-5, ... Authors: Zhao, Y, Ren, J, Jones, E.Y. Deposit date: 2024-02-29 Release date: 2024-04-24 Last modified: 2024-05-15 Method: X-RAY DIFFRACTION (4.7 Å) Cite: Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain. Science, 384, 2024
6Z0Z	Human wtSTING in complex with 3',3'-c-(2'FdAMP-2'FdAMP) Descriptor: 2'-fluoro-,3',3'-c-di-AMP, Stimulator of interferon protein Authors: Boura, E, Smola, M. Deposit date: 2020-05-11 Release date: 2021-05-19 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.499 Å) Cite: Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein. Angew.Chem.Int.Ed.Engl., 60, 2021
6O0N	M.tb MenD with Inhibitor Descriptor: 1,4-dihydroxy-2-naphthoic acid, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase Authors: Johnston, J.M, Ho, N.A.T, Bashiri, G, Bulloch, E.M, Nigon, L.V, Jirgis, E.M.N, Baker, E.N. Deposit date: 2019-02-16 Release date: 2020-02-19 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.03 Å) Cite: Allosteric regulation of menaquinone (vitamin K2) biosynthesis in the human pathogenMycobacterium tuberculosis. J.Biol.Chem., 295, 2020
8S0L	Crystal structure of the TMPRSS2 zymogen in complex with the nanobody A07 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Nanobody A07, ... Authors: Duquerroy, S, Fernandez, I, Rey, F. Deposit date: 2024-02-14 Release date: 2024-06-26 Last modified: 2024-09-04 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirus. Cell, 187, 2024
6O2V	Crystal structure of the SARAF luminal domain Cys-lock mutant monomer Descriptor: FORMIC ACID, GLYCEROL, Store-operated calcium entry-associated regulatory factor Authors: Kimberlin, C.R, Minor, D.L. Deposit date: 2019-02-24 Release date: 2019-05-29 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.58 Å) Cite: SARAF Luminal Domain Structure Reveals a Novel Domain-Swapped beta-Sandwich Fold Important for SOCE Modulation. J.Mol.Biol., 431, 2019
7R85	Structure of mouse Bai1 (ADGRB1) TSR3 domain Descriptor: Vasculostatin-120, alpha-D-mannopyranose, beta-D-glucopyranose-(1-3)-alpha-L-fucopyranose Authors: Miao, Y, Jude, K.M, Garcia, K.C. Deposit date: 2021-06-26 Release date: 2021-11-10 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.45 Å) Cite: RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development. Cell, 184, 2021

<825826827828829830831832833834835836837838839840>