7R7D
| Structure of human SHP2 in complex with compound 22 | Descriptor: | 4-[6-(4-amino-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl]-3-chloro-N-methylpyridin-2-amine, TETRAETHYLENE GLYCOL, Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Leonard, P.G, Cross, J. | Deposit date: | 2021-06-24 | Release date: | 2021-10-27 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Discovery of 6-[(3 S ,4 S )-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor. J.Med.Chem., 64, 2021
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6GLW
| Structure of galectin-10 in complex with the Fab fragment of a Charcot-Leyden crystal solubilizing antibody, 1D11 | Descriptor: | ACETATE ION, Fab 1D11 - Heavy chain, Fab 1D11 - Light chain, ... | Authors: | Verstraete, K, Verschueren, K, Savvides, S.N. | Deposit date: | 2018-05-23 | Release date: | 2019-06-05 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Protein crystallization promotes type 2 immunity and is reversible by antibody treatment. Science, 364, 2019
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7RP0
| Structural Snapshots of Intermediates in the Gating of a K+ Channel | Descriptor: | DIACYL GLYCEROL, KcsA Fab chain A, KcsA Fab chain B, ... | Authors: | Reddi, R, Matulef, K, Riederer, E.A, Valiyaveetil, F.I. | Deposit date: | 2021-08-02 | Release date: | 2021-10-27 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Structures of Gating Intermediates in a K + channell. J.Mol.Biol., 433, 2021
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8BHH
| The crystal structure of a feruloyl esterase C from Fusarium oxysporum in complex with p-coumaric acid | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4'-HYDROXYCINNAMIC ACID, ... | Authors: | Dimarogona, M, Topakas, E, Kosinas, C, Ferousi, C, Nikolaivits, E. | Deposit date: | 2022-10-31 | Release date: | 2023-07-05 | Last modified: | 2024-01-03 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Crystal structure of the Fusarium oxysporum tannase-like feruloyl esterase FaeC in complex with p-coumaric acid provides insight into ligand binding. Febs Lett., 597, 2023
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4YD7
| Endothiapepsin in complex with fragment 255 | Descriptor: | 2-(imidazo[1,2-a]pyridin-2-yl)-N-phenylacetamide, ACETATE ION, Endothiapepsin, ... | Authors: | Stieler, M, Heine, A, Klebe, G. | Deposit date: | 2015-02-21 | Release date: | 2016-03-02 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.419 Å) | Cite: | Crystallographic Fragment Screening of an Entire Library To Be Published
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7R86
| Structure of mouse BAI1 (ADGRB1) in complex with mouse Nogo receptor (RTN4R) | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-AMINOBENZOIC ACID, ... | Authors: | Miao, Y, Jude, K.M, Garcia, K.C. | Deposit date: | 2021-06-26 | Release date: | 2021-11-10 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development. Cell, 184, 2021
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5KGA
| X-ray structure of a glucosamine N-Acetyltransferase from Clostridium acetobutylicum, mutant D287N, in complex with N-acetylglucosamine | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYL COENZYME *A, ... | Authors: | Dopkins, B.J, Thoden, J.B, Tipton, P.A, Holden, H.M. | Deposit date: | 2016-06-13 | Release date: | 2016-07-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Studies on a Glucosamine/Glucosaminide N-Acetyltransferase. Biochemistry, 55, 2016
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6GKH
| CryoEM structure of the MDA5-dsRNA filament in complex with ADP-AlF4 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Interferon-induced helicase C domain-containing protein 1, MAGNESIUM ION, ... | Authors: | Yu, Q, Qu, K, Modis, Y. | Deposit date: | 2018-05-21 | Release date: | 2018-11-21 | Last modified: | 2020-11-18 | Method: | ELECTRON MICROSCOPY (4.06 Å) | Cite: | Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis. Mol. Cell, 72, 2018
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7VPL
| Cryo-EM structure of the human ATP13A2 (SPM-bound E2Pi state) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Polyamine-transporting ATPase 13A2, ... | Authors: | Tomita, A, Yamashita, K, Nishizawa, T, Nureki, O. | Deposit date: | 2021-10-17 | Release date: | 2021-12-29 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM reveals mechanistic insights into lipid-facilitated polyamine export by human ATP13A2. Mol.Cell, 81, 2021
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6GKT
| X-ray structure of a non-autocrystallizing galectin-10 variant, Gal10-Tyr69Glu | Descriptor: | Galectin-10, HEXAETHYLENE GLYCOL, TETRAETHYLENE GLYCOL, ... | Authors: | Verstraete, K, Verschueren, K, Savvides, S.N. | Deposit date: | 2018-05-21 | Release date: | 2019-06-05 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Protein crystallization promotes type 2 immunity and is reversible by antibody treatment. Science, 364, 2019
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7VSH
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7VPJ
| Cryo-EM structure of the human ATP13A2 (E1P-ADP state) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Tomita, A, Yamashita, K, Nishizawa, T, Nureki, O. | Deposit date: | 2021-10-17 | Release date: | 2021-12-29 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM reveals mechanistic insights into lipid-facilitated polyamine export by human ATP13A2. Mol.Cell, 81, 2021
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6H30
| The crystal structure of SBD1-SBD2 tandem of GlnPQ transporter | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, DI(HYDROXYETHYL)ETHER, ... | Authors: | Schuurman-Wolters, G.K, Guskov, A, Poolman, B. | Deposit date: | 2018-07-17 | Release date: | 2019-08-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The crystal structure of SBD1-SBD2 tandem of GlnPQ transporter To Be Published
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8B4C
| ToxR bacterial transcriptional regulator bound to 20 bp toxT promoter DNA | Descriptor: | Cholera toxin transcriptional activator, DNA (20-MER) | Authors: | Canals, A, Pieretti, S, Muriel, M, El Yaman, N, Fabrega-Ferrer, M, Perez-Luque, R, Krukonis, E.S, Coll, M. | Deposit date: | 2022-09-20 | Release date: | 2023-08-09 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | ToxR activates the Vibrio cholerae virulence genes by tethering DNA to the membrane through versatile binding to multiple sites. Proc.Natl.Acad.Sci.USA, 120, 2023
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8B4B
| ToxR bacterial transcriptional regulator bound to 19 bp ompU promoter DNA | Descriptor: | AMMONIUM ION, CADMIUM ION, Cholera toxin transcriptional activator, ... | Authors: | Canals, A, Pieretti, S, Muriel, M, El Yaman, N, Fabrega-Ferrer, M, Perez-Luque, R, Krukonis, E.S, Coll, M. | Deposit date: | 2022-09-20 | Release date: | 2023-08-09 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | ToxR activates the Vibrio cholerae virulence genes by tethering DNA to the membrane through versatile binding to multiple sites. Proc.Natl.Acad.Sci.USA, 120, 2023
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8B4D
| ToxR bacterial transcriptional regulator bound to 40 bp toxT promoter DNA | Descriptor: | Cholera toxin transcriptional activator, DNA (40-MER) | Authors: | Canals, A, Pieretti, S, Muriel, M, El Yaman, N, Fabrega-Ferrer, M, Perez-Luque, R, Krukonis, E.S, Coll, M. | Deposit date: | 2022-09-20 | Release date: | 2023-08-09 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.64 Å) | Cite: | ToxR activates the Vibrio cholerae virulence genes by tethering DNA to the membrane through versatile binding to multiple sites. Proc.Natl.Acad.Sci.USA, 120, 2023
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8BJJ
| ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo MARTX toxin, bound to ATP-Mg-actin, human profilin 1 and a sulfate ion | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | Authors: | Teixeira-Nunes, M, Renault, L, Retailleau, P. | Deposit date: | 2022-11-04 | Release date: | 2023-09-20 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.699 Å) | Cite: | Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin. Plos Pathog., 19, 2023
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6H5X
| Crystal structure of human Angiotensin-1 converting enzyme N-domain in complex with Omapatrilat. | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Cozier, G.E, Acharya, K.R. | Deposit date: | 2018-07-25 | Release date: | 2018-11-07 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Molecular Basis for Multiple Omapatrilat Binding Sites within the ACE C-Domain: Implications for Drug Design. J. Med. Chem., 61, 2018
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6HPE
| Crystal structure of glutathione transferase Omega 3S from Trametes versicolor in complex with the glutathione adduct of phenethyl-isothiocyanate | Descriptor: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Schwartz, M, Favier, F, Didierjean, C. | Deposit date: | 2018-09-20 | Release date: | 2019-04-24 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | The structure of Trametes versicolor glutathione transferase Omega 3S bound to its conjugation product glutathionyl-phenethylthiocarbamate reveals plasticity of its active site. Protein Sci., 28, 2019
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6HTV
| Crystal structure of Leuconostoc citreum NRRL B-1299 N-terminally truncated dextransucrase DSR-M in complex with isomaltotetraose | Descriptor: | Alternansucrase, CALCIUM ION, alpha-D-glucopyranose-(1-6)-alpha-D-glucopyranose-(1-6)-alpha-D-glucopyranose-(1-6)-alpha-D-glucopyranose | Authors: | Claverie, M, Cioci, G, Remaud-Simeon, M, Moulis, C, Lippens, G. | Deposit date: | 2018-10-04 | Release date: | 2019-09-11 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.9 Å) | Cite: | Futile Encounter Engineering of the DSR-M Dextransucrase Modifies the Resulting Polymer Length. Biochemistry, 58, 2019
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8B9I
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8B9G
| Cryo-EM structure of MLE in complex with ADP:AlF4 and U10 RNA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Dosage compensation regulator, RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3'), ... | Authors: | Jagtap, P.K.A, Hennig, J. | Deposit date: | 2022-10-06 | Release date: | 2023-10-18 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.86 Å) | Cite: | Structural basis of RNA-induced autoregulation of the DExH-type RNA helicase maleless. Mol.Cell, 83, 2023
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8B9K
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8B9J
| Cryo-EM structure of MLE in complex with ADP:AlF4 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Dosage compensation regulator, MAGNESIUM ION, ... | Authors: | Jagtap, P.K.A, Hennig, J. | Deposit date: | 2022-10-06 | Release date: | 2023-10-18 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | Structural basis of RNA-induced autoregulation of the DExH-type RNA helicase maleless. Mol.Cell, 83, 2023
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8QDO
| Crystal structure of the tegument protein UL82 (pp71) from Human Cytomegalovirus | Descriptor: | Protein pp71, TETRAETHYLENE GLYCOL | Authors: | Bresch, I.P, Eberhage, J, Reubold, T.F, Eschenburg, S. | Deposit date: | 2023-08-30 | Release date: | 2024-02-28 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of the tegument protein UL82 (pp71) from human cytomegalovirus. Protein Sci., 33, 2024
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