9B37
 
 | | Open state of kainate receptor GluK2 in complex with agonist glutamate and positive allosteric modulator BPAM344 bound to one concanavalin A dimer. Composite map. | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Nadezhdin, K.D, Gangwar, S.P, Sobolevsky, A.I. | | Deposit date: | 2024-03-18 | | Release date: | 2024-05-22 | | Last modified: | 2024-06-26 | | Method: | ELECTRON MICROSCOPY (6.66 Å) | | Cite: | Kainate receptor channel opening and gating mechanism.
Nature, 630, 2024
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9B36
 | | Open state of kainate receptor GluK2 in complex with agonist glutamate and positive allosteric modulator BPAM344 bound to two concanavalin A dimers. Composite map. | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Nadezhdin, K.D, Gangwar, S.P, Sobolevsky, A.I. | | Deposit date: | 2024-03-18 | | Release date: | 2024-05-22 | | Last modified: | 2024-06-26 | | Method: | ELECTRON MICROSCOPY (4.29 Å) | | Cite: | Kainate receptor channel opening and gating mechanism.
Nature, 630, 2024
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9B35
 | | Ligand-binding and transmembrane domains of kainate receptor GluK2 in the open state, a complex with agonist glutamate and positive allosteric modulator BPAM344 | | Descriptor: | GLUTAMIC ACID, Glutamate receptor ionotropic, kainate 2 | | Authors: | Nadezhdin, K.D, Gangwar, S.P, Sobolevsky, A.I. | | Deposit date: | 2024-03-18 | | Release date: | 2024-05-22 | | Last modified: | 2024-06-26 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Kainate receptor channel opening and gating mechanism.
Nature, 630, 2024
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9B34
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9B33
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9B2H
 | | HIV-1 wild type protease with GRL-072-17A, a substituted tetrahydrofuran derivative based on Darunavir as P2 group | | Descriptor: | 2,5:6,9-dianhydro-1,3,7,8-tetradeoxy-4-O-({(2S,3R)-3-hydroxy-4-[(4-methoxybenzene-1-sulfonyl)(2-methylpropyl)amino]-1-phenylbutan-2-yl}carbamoyl)-L-gluco-nonitol, CHLORIDE ION, FORMIC ACID, ... | | Authors: | Wang, Y.-F, Agniswamy, J, Ghosh, A.K, Weber, I.T. | | Deposit date: | 2024-03-15 | | Release date: | 2024-07-24 | | Method: | X-RAY DIFFRACTION (1.32 Å) | | Cite: | Design of substituted tetrahydrofuran derivatives for HIV-1 protease inhibitors: synthesis, biological evaluation, and X-ray structural studies.
Org.Biomol.Chem., 2024
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9B27
 | | Dia1 at the Barbed End of F-Actin | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | | Authors: | Palmer, N.J, Barrie, K.R, Dominguez, R. | | Deposit date: | 2024-03-14 | | Release date: | 2024-05-29 | | Last modified: | 2024-08-21 | | Method: | ELECTRON MICROSCOPY (3.51 Å) | | Cite: | Mechanisms of actin filament severing and elongation by formins.
Nature, 632, 2024
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9B22
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9B21
 | | Crystal structure of ADP-ribose diphosphatase from Klebsiella pneumoniae (ADP Ribose bound, Orthorhombic P form) | | Descriptor: | ADP-ribose pyrophosphatase, MAGNESIUM ION, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | | Authors: | Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | | Deposit date: | 2024-03-14 | | Release date: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal structure of ADP-ribose diphosphatase from Klebsiella pneumoniae (ADP Ribose bound, Orthorhombic P form)
To be published
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9B20
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9B1Z
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9B1V
 | | Crystal structure of PqqT with PQQ and Gd3+ bound | | Descriptor: | 1,2-ETHANEDIOL, GADOLINIUM ION, PYRROLOQUINOLINE QUINONE, ... | | Authors: | Boggs, G.D, Bruchs, A.T, Thompson, P.J, Olshansky, L, Bridwell-Rabb, J. | | Deposit date: | 2024-03-13 | | Release date: | 2024-08-21 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Structure-driven development of a biomimetic rare earth artificial metalloprotein.
Proc.Natl.Acad.Sci.USA, 121, 2024
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9B1U
 | | Crystal structure of PqqT with PQQ bound | | Descriptor: | PYRROLOQUINOLINE QUINONE, Putative ABC transporter periplasmic solute-binding protein, SODIUM ION | | Authors: | Boggs, D, Bruchs, A, Thompson, P, Olshansky, L, Bridwell-Rabb, J. | | Deposit date: | 2024-03-13 | | Release date: | 2024-08-21 | | Method: | X-RAY DIFFRACTION (1.46 Å) | | Cite: | Structure-driven development of a biomimetic rare earth artificial metalloprotein.
Proc.Natl.Acad.Sci.USA, 121, 2024
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9B1R
 | | Functional implication of the homotrimeric multidomain vacuolar sorting receptor 1 from Arabidopsis thaliana | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Vacuolar-sorting receptor 1 | | Authors: | Park, H, Youn, B, Park, D.J, Puthanveettil, S.V, Kang, C. | | Deposit date: | 2024-03-13 | | Release date: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Functional implication of the homotrimeric multidomain vacuolar sorting receptor 1 (VSR1) from Arabidopsis thaliana.
Sci Rep, 14, 2024
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9B1Q
 | | Crystal Structure of human Tryptophan 2,3-dioxygenase in complex with PYN1 inhibitor | | Descriptor: | (5P)-1-[(imidazolidin-1-yl)methyl]-5-(1H-indol-3-yl)-1H-1,2,3-benzotriazole, PROTOPORPHYRIN IX CONTAINING FE, Tryptophan 2,3-dioxygenase, ... | | Authors: | Geeraerts, Z, Yeh, S.-R. | | Deposit date: | 2024-03-13 | | Release date: | 2024-08-21 | | Last modified: | 2024-09-11 | | Method: | X-RAY DIFFRACTION (2.624 Å) | | Cite: | Structural Insights into Protein-Inhibitor Interactions in Human Tryptophan Dioxygenase.
J.Med.Chem., 67, 2024
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9B1O
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9B1N
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9B1M
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9B1L
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9B1K
 | | Urate bound human URAT1 in the occluded state | | Descriptor: | Solute carrier family 22 member 12, URIC ACID | | Authors: | Dai, Y, Lee, C.H. | | Deposit date: | 2024-03-13 | | Release date: | 2024-09-18 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Transport mechanism and structural pharmacology of human urate transporter URAT1.
Cell Res., 2024
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9B1J
 | | Urate bound human URAT1 in the inward-facing state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, PHOSPHATE ION, Solute carrier family 22 member 12, ... | | Authors: | Dai, Y, Lee, C.H. | | Deposit date: | 2024-03-13 | | Release date: | 2024-09-18 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Transport mechanism and structural pharmacology of human urate transporter URAT1.
Cell Res., 2024
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9B1I
 | | Human urate transporter 1 URAT1 in complex with verinurad | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Solute carrier family 22 member 12, verinurad | | Authors: | Dai, Y, Lee, C.H. | | Deposit date: | 2024-03-13 | | Release date: | 2024-09-18 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Transport mechanism and structural pharmacology of human urate transporter URAT1.
Cell Res., 2024
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9B1H
 | | Human urate transporter 1 URAT1 in complex with lesinurad | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Solute carrier family 22 member 12, lesinurad | | Authors: | Dai, Y, Lee, C.H. | | Deposit date: | 2024-03-13 | | Release date: | 2024-09-18 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Transport mechanism and structural pharmacology of human urate transporter URAT1.
Cell Res., 2024
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9B1G
 | | Human urate transporter 1 URAT1 in complex with dotinurad | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Solute carrier family 22 member 12, dotinurad | | Authors: | Dai, Y, Lee, C.H. | | Deposit date: | 2024-03-13 | | Release date: | 2024-09-18 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Transport mechanism and structural pharmacology of human urate transporter URAT1.
Cell Res., 2024
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9B1F
 | | Human urate transporter 1 URAT1 in apo state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Solute carrier family 22 member 12 | | Authors: | Dai, Y, Lee, C.H. | | Deposit date: | 2024-03-13 | | Release date: | 2024-09-18 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Transport mechanism and structural pharmacology of human urate transporter URAT1.
Cell Res., 2024
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