7BYM
 
 | | Cryo-EM structure of human KCNQ4 with retigabine | | Descriptor: | Calmodulin-3, Green fluorescent protein,Potassium voltage-gated channel subfamily KQT member 4, POTASSIUM ION, ... | | Authors: | Shen, H, Li, T, Yue, Z. | | Deposit date: | 2020-04-23 | | Release date: | 2020-12-02 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs.
Mol.Cell, 81, 2021
|
|
7ON3
 | | SaFtsZ complexed with GDP (soak 10 mM EGTA) | | Descriptor: | 1,2-ETHANEDIOL, Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Fernandez-Tornero, C, Ruiz, F.M, Andreu, J.M. | | Deposit date: | 2021-05-25 | | Release date: | 2022-03-02 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.32 Å) | | Cite: | FtsZ filament structures in different nucleotide states reveal the mechanism of assembly dynamics.
Plos Biol., 20, 2022
|
|
1A99
 | | PUTRESCINE RECEPTOR (POTF) FROM E. COLI | | Descriptor: | 1,4-DIAMINOBUTANE, PUTRESCINE-BINDING PROTEIN | | Authors: | Vassylyev, D.G, Tomitori, H, Kashiwagi, K, Morikawa, K, Igarashi, K. | | Deposit date: | 1998-04-17 | | Release date: | 1998-10-21 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure and mutational analysis of the Escherichia coli putrescine receptor. Structural basis for substrate specificity.
J.Biol.Chem., 273, 1998
|
|
7BQ1
 | | X-ray structure of human PPARalpha ligand binding domain-intrinsic fatty acid (E. coli origin)-SRC1 coactivator peptide co-crystals obtained by co-crystallization | | Descriptor: | 15-meric peptide from Nuclear receptor coactivator 1, GLYCEROL, PALMITIC ACID, ... | | Authors: | Kamata, S, Ishikawa, R, Akahane, M, Oyama, T, Ishii, I. | | Deposit date: | 2020-03-23 | | Release date: | 2020-11-11 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.521 Å) | | Cite: | PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates.
Iscience, 23, 2020
|
|
7ON4
 | | SaFtsZ complexed with GDP (co-crystalization with 1mM EDTA) | | Descriptor: | 1,2-ETHANEDIOL, Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Fernandez-Tornero, C, Ruiz, F.M, Andreu, J.M. | | Deposit date: | 2021-05-25 | | Release date: | 2022-03-02 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | FtsZ filament structures in different nucleotide states reveal the mechanism of assembly dynamics.
Plos Biol., 20, 2022
|
|
7BQF
 | | Dimerization of SAV1 WW tandem | | Descriptor: | 1,4-DIETHYLENE DIOXIDE, Protein salvador homolog 1 | | Authors: | Lin, Z, Zhang, M. | | Deposit date: | 2020-03-24 | | Release date: | 2020-09-23 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.70037615 Å) | | Cite: | A WW Tandem-Mediated Dimerization Mode of SAV1 Essential for Hippo Signaling.
Cell Rep, 32, 2020
|
|
8UD8
 | | Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution | | Descriptor: | (4S,5aS,8S,8aR)-4-(2-methylpropyl)-N-[(1R,5Z,7R,8R,9R,10R,11S,12R)-10,11,12-trihydroxy-7-methyl-13-oxa-2-thiabicyclo[7.3.1]tridec-5-en-8-yl]octahydro-2H-oxepino[2,3-c]pyrrole-8-carboxamide (non-preferred name), 16S Ribosomal RNA, 23S Ribosomal RNA, ... | | Authors: | Aleksandrova, E.V, Syroegin, E.A, Wu, K.J.Y, Tresco, B.I.C, Ramkissoon, A, See, D.N.Y, Liow, P, Dittemore, G.A, Yu, M, Testolin, G, Mitcheltree, M.J, Liu, R.Y, Svetlov, M.S, Myers, A.G, Polikanov, Y.S. | | Deposit date: | 2023-09-28 | | Release date: | 2024-02-21 | | Last modified: | 2025-02-12 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | An antibiotic preorganized for ribosomal binding overcomes antimicrobial resistance.
Science, 383, 2024
|
|
5HDJ
 | | Structure of B. megaterium NfrA1 | | Descriptor: | 1,2-ETHANEDIOL, FLAVIN MONONUCLEOTIDE, NfrA1 | | Authors: | Vigouroux, A, Morera, S. | | Deposit date: | 2016-01-05 | | Release date: | 2016-04-06 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | Functional and structural characterization of two Bacillus megaterium nitroreductases biotransforming the herbicide mesotrione.
Biochem.J., 473, 2016
|
|
5J6Y
 | | Crystal structure of PA14 domain of MpAFP Antifreeze protein | | Descriptor: | Antifreeze protein, CALCIUM ION, alpha-D-glucopyranose, ... | | Authors: | Guo, S. | | Deposit date: | 2016-04-05 | | Release date: | 2017-06-07 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.03 Å) | | Cite: | Structure of a 1.5-MDa adhesin that binds its Antarctic bacterium to diatoms and ice.
Sci Adv, 3, 2017
|
|
8Z2G
 | | MHET bound form of PET-degrading cutinase mutant Cut190*SS_S176A | | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-(2-hydroxyethyloxycarbonyl)benzoic acid, AMMONIUM ION, ... | | Authors: | Numoto, N, Kondo, F, Bekker, G.J, Liao, Z, Yamashita, M, Iida, A, Ito, N, Kamiya, N, Oda, M. | | Deposit date: | 2024-04-12 | | Release date: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural dynamics of the Ca 2+ -regulated cutinase towards structure-based improvement of PET degradation activity.
Int.J.Biol.Macromol., 281, 2024
|
|
7T3P
 | | IP3 and ATP bound type 3 IP3 receptor in the pre-active A state | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Inositol 1,4,5-trisphosphate receptor type 3, ... | | Authors: | Schmitz, E.A, Takahashi, H, Karakas, E. | | Deposit date: | 2021-12-08 | | Release date: | 2022-03-23 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural basis for activation and gating of IP 3 receptors.
Nat Commun, 13, 2022
|
|
7T3Q
 | | IP3 and ATP bound type 3 IP3 receptor in the pre-active B state | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Inositol 1,4,5-trisphosphate receptor type 3, ... | | Authors: | Schmitz, E.A, Takahashi, H, Karakas, E. | | Deposit date: | 2021-12-08 | | Release date: | 2022-03-23 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural basis for activation and gating of IP 3 receptors.
Nat Commun, 13, 2022
|
|
7T3T
 | | IP3, ATP, and Ca2+ bound type 3 IP3 receptor in the active state | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ... | | Authors: | Schmitz, E.A, Takahashi, H, Karakas, E. | | Deposit date: | 2021-12-08 | | Release date: | 2022-03-23 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structural basis for activation and gating of IP 3 receptors.
Nat Commun, 13, 2022
|
|
7T3U
 | | IP3, ATP, and Ca2+ bound type 3 IP3 receptor in the inactive state | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ... | | Authors: | Schmitz, E.A, Takahashi, H, Karakas, E. | | Deposit date: | 2021-12-08 | | Release date: | 2022-03-23 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structural basis for activation and gating of IP 3 receptors.
Nat Commun, 13, 2022
|
|
7T3R
 | | IP3 and ATP bound type 3 IP3 receptor in the pre-active C state | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Inositol 1,4,5-trisphosphate receptor type 3, ... | | Authors: | Schmitz, E.A, Takahashi, H, Karakas, E. | | Deposit date: | 2021-12-08 | | Release date: | 2022-03-23 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural basis for activation and gating of IP 3 receptors.
Nat Commun, 13, 2022
|
|
6ZEL
 | | CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX with compound F5 | | Descriptor: | 1,2-ETHANEDIOL, 3,5-dimethyl-4-[(6-methylpyrimidin-4-yl)sulfanylmethyl]-1,2-oxazole, Bromodomain-containing protein 4 | | Authors: | Krojer, T, Martinez-Cartro, M, Picaud, S, Filippakopoulos, P, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Barril, X, von Delft, F. | | Deposit date: | 2020-06-16 | | Release date: | 2020-07-29 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.12 Å) | | Cite: | CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX with compound F5
To Be Published
|
|
6Z6S
 | | Crystal structure of Uba4-Urm1 from Chaetomium thermophilum | | Descriptor: | Adenylyltransferase and sulfurtransferase uba4, Ubiquitin-related modifier 1, ZINC ION | | Authors: | Grudnik, P, Pabis, M, Ethiraju Ravichandran, K, Glatt, S. | | Deposit date: | 2020-05-29 | | Release date: | 2020-07-22 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (3.153 Å) | | Cite: | Molecular basis for the bifunctional Uba4-Urm1 sulfur-relay system in tRNA thiolation and ubiquitin-like conjugation.
Embo J., 39, 2020
|
|
8F49
 | |
6Z8W
 | | X-ray structure of the complex between human alpha thrombin and a thrombin binding aptamer variant (TBA-3G), which contains 1-beta-D-glucopyranosyl residue in the side chain of Thy3 at N3. | | Descriptor: | D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, POTASSIUM ION, Prothrombin, ... | | Authors: | Troisi, R, Timofeev, E.N, Sica, F. | | Deposit date: | 2020-06-02 | | Release date: | 2021-01-27 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | Expanding the recognition interface of the thrombin-binding aptamer HD1 through modification of residues T3 and T12.
Mol Ther Nucleic Acids, 23, 2021
|
|
8KB5
 | | Cryo-EM structure of the human nucleosome containing H3.8 | | Descriptor: | DNA (145-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | Authors: | Hirai, H, Kujirai, T, Takizawa, Y, Kurumizaka, H. | | Deposit date: | 2023-08-03 | | Release date: | 2023-10-18 | | Last modified: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (2.26133 Å) | | Cite: | Cryo-EM and biochemical analyses of the nucleosome containing the human histone H3 variant H3.8.
J.Biochem., 174, 2023
|
|
4TMP
 | | Crystal structure of AF9 YEATS bound to H3K9ac peptide | | Descriptor: | 1,2-ETHANEDIOL, ALA-ARG-THR-LYS-GLN-THR-ALA-ARG-ALY-SER-THR, Protein AF-9 | | Authors: | Li, H, Li, Y, Wang, H, Ren, Y. | | Deposit date: | 2014-06-02 | | Release date: | 2014-11-05 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | AF9 YEATS Domain Links Histone Acetylation to DOT1L-Mediated H3K79 Methylation.
Cell, 159, 2014
|
|
6UAO
 | | Imidazole-triggered RAS-specific subtilisin SUBT_BACAM complexed with the peptide EEYSAM | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Peptide EEYSAM, ... | | Authors: | Toth, E.A, Bryan, P.N, Orban, J. | | Deposit date: | 2019-09-11 | | Release date: | 2020-09-16 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.63 Å) | | Cite: | Engineering subtilisin proteases that specifically degrade active RAS.
Commun Biol, 4, 2021
|
|
5K0H
 | |
8ZTN
 | | AtALMT9 with LMNG (trans2 class) | | Descriptor: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, Aluminum-activated malate transporter 9 | | Authors: | Lee, Y, Lee, S. | | Deposit date: | 2024-06-07 | | Release date: | 2025-03-12 | | Method: | ELECTRON MICROSCOPY (2.77 Å) | | Cite: | Structural basis for malate-driven, pore lipid-regulated activation of the Arabidopsis vacuolar anion channel ALMT9.
Nat Commun, 16, 2025
|
|
6PZJ
 | |
