7MEX
 
 | | Structure of yeast Ubr1 in complex with Ubc2 and N-degron | | Descriptor: | E3 ubiquitin-protein ligase UBR1, N-degron, Ubiquitin, ... | | Authors: | Pan, M, Zheng, Q, Wang, T, Liang, L, Yu, Y, Liu, L, Zhao, M. | | Deposit date: | 2021-04-08 | | Release date: | 2021-11-24 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.35 Å) | | Cite: | Structural insights into Ubr1-mediated N-degron polyubiquitination.
Nature, 600, 2021
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7LN1
 | | Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and Ub6 (Class 3) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Hexa-ubiquitin, ... | | Authors: | Pan, M, Yu, Y, Liu, L, Zhao, M. | | Deposit date: | 2021-02-06 | | Release date: | 2021-09-15 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Mechanistic insight into substrate processing and allosteric inhibition of human p97.
Nat.Struct.Mol.Biol., 28, 2021
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7LN3
 | | Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and polyubiquitinated Ub-Eos (FOM, Class 2) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Pan, M, Yu, Y, Liu, L, Zhao, M. | | Deposit date: | 2021-02-06 | | Release date: | 2021-09-15 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.45 Å) | | Cite: | Mechanistic insight into substrate processing and allosteric inhibition of human p97.
Nat.Struct.Mol.Biol., 28, 2021
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1CK0
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1DUI
 | | Subtilisin BPN' from Bacillus amyloliquefaciens, crystal growth mutant | | Descriptor: | DIISOPROPYL PHOSPHONATE, PROTEIN (SUBTILISIN BPN'), SODIUM ION | | Authors: | Pan, Q, Gallagher, D.T. | | Deposit date: | 2000-01-17 | | Release date: | 2000-01-28 | | Last modified: | 2021-11-03 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Probing Protein Interaction Chemistry Through Crystal Growth: Structure, Mutation, and Mechanism in Subtilisin s88
J.Cryst.Growth, 212, 2000
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4N9L
 | | crystal structure of beta-lactamse PenP_E166S in complex with meropenem | | Descriptor: | (2S,3R,4S)-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, Beta-lactamase | | Authors: | Pan, X, Wong, W, Zhao, Y. | | Deposit date: | 2013-10-21 | | Release date: | 2014-09-10 | | Last modified: | 2022-02-09 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Perturbing the General Base Residue Glu166 in the Active Site of Class A beta-Lactamase Leads to Enhanced Carbapenem Binding and Acylation
Biochemistry, 53, 2014
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4N9K
 | | crystal structure of beta-lactamse PenP_E166S in complex with cephaloridine | | Descriptor: | 5-METHYL-2-[2-OXO-1-(2-THIOPHEN-2-YL-ACETYLAMINO)-ETHYL]-3,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID, Beta-lactamase | | Authors: | Pan, X, Wong, W, Zhao, Y. | | Deposit date: | 2013-10-21 | | Release date: | 2014-09-10 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Perturbing the General Base Residue Glu166 in the Active Site of Class A beta-Lactamase Leads to Enhanced Carbapenem Binding and Acylation
Biochemistry, 53, 2014
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4N92
 | | Crystal structure of beta-lactamse PenP_E166S | | Descriptor: | Beta-lactamase | | Authors: | Pan, X, Wong, W, Zhao, Y. | | Deposit date: | 2013-10-19 | | Release date: | 2014-09-10 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Perturbing the General Base Residue Glu166 in the Active Site of Class A beta-Lactamase Leads to Enhanced Carbapenem Binding and Acylation
Biochemistry, 53, 2014
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1P79
 | | Crystal structure of a bulged RNA tetraplex: implications for a novel binding site in RNA tetraplex | | Descriptor: | 5'-R(*UP*GP*UP*GP*GP*U)-3', POTASSIUM ION | | Authors: | Pan, B, Xiong, Y, Shi, K, Sundaralingam, M. | | Deposit date: | 2003-04-30 | | Release date: | 2003-11-04 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | Crystal Structure of a Bulged RNA Tetraplex at 1.1 A Resolution: Implications for a Novel Binding Site in RNA Tetraplex
STRUCTURE, 11, 2003
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2F9T
 | | Structure of the type III CoaA from Pseudomonas aeruginosa | | Descriptor: | Pantothenate Kinase | | Authors: | Leonardi, R, Yun, M.K, Chohnan, S, White, S.W, Rock, C.O, Jackowski, S. | | Deposit date: | 2005-12-06 | | Release date: | 2006-08-22 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Prokaryotic Type II and Type III Pantothenate Kinases: The Same Monomer Fold Creates Dimers with Distinct Catalytic Properties.
Structure, 14, 2006
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1R3E
 | | Crystal Structure of tRNA Pseudouridine Synthase TruB and Its RNA Complex: RNA-protein Recognition Through a Combination of Rigid Docking and Induced Fit | | Descriptor: | 5'-R(*CP*UP*GP*UP*GP*UP*(FHU)P*CP*GP*AP*UP*CP*CP*AP*CP*AP*G)-3', 5'-R(*CP*UP*GP*UP*GP*UP*UP*CP*GP*AP*UP*CP*CP*AP*CP*AP*G)-3', tRNA pseudouridine synthase B | | Authors: | Pan, H, Agarwalla, S, Moustakas, D.T, Finer-Moore, J, Stroud, R.M. | | Deposit date: | 2003-10-01 | | Release date: | 2003-11-04 | | Last modified: | 2018-02-07 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal Structure of tRNA Pseudouridine Synthase TruB and Its RNA Complex: RNA Recognition Through a Combination of Rigid Docking and Induced Fit
Proc.Natl.Acad.Sci.USA, 100, 2003
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1R3F
 | | Crystal Structure of tRNA Pseudouridine Synthase TruB and Its RNA Complex: RNA-protein Recognition Through a Combination of Rigid Docking and Induced Fit | | Descriptor: | tRNA pseudouridine synthase B | | Authors: | Pan, H, Agarwalla, S, Moustakas, D.T, Finer-Moore, J, Stroud, R.M. | | Deposit date: | 2003-10-01 | | Release date: | 2003-11-04 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structure of tRNA Pseudouridine Synthase TruB and Its RNA Complex: RNA Recognition Through a Combination of Rigid Docking and Induced Fit
Proc.Natl.Acad.Sci.USA, 100, 2003
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7XCA
 | | Crystal structure of the porcine astrovirus capsid spike domain | | Descriptor: | CHLORIDE ION, Capsid protein spike domain, MAGNESIUM ION | | Authors: | Pan, L.X, Zhang, W.C, Yang, D.F, Yang, L.Y, Liu, H. | | Deposit date: | 2022-03-23 | | Release date: | 2023-03-29 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure analysis of porcine astrovirus capsid spike and spike/neutralizing antibody complexes.
To Be Published
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6Z20
 | | Structure of the EC2 domain of CD9 in complex with nanobody 4C8 | | Descriptor: | CD9 antigen, CHLORIDE ION, GLYCEROL, ... | | Authors: | Oosterheert, W, Manshande, J, Pearce, N.M, Lutz, M, Gros, P. | | Deposit date: | 2020-05-14 | | Release date: | 2020-09-23 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.68 Å) | | Cite: | Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F.
Life Sci Alliance, 3, 2020
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1MDG
 | | An Alternating Antiparallel Octaplex in an RNA Crystal Structure | | Descriptor: | 5'-R(*UP*(BGM)GP*AP*GP*GP*U)-3', COBALT HEXAMMINE(III), SODIUM ION | | Authors: | Pan, B.C, Xiong, Y, Shi, K, Sundaralingam, M. | | Deposit date: | 2002-08-07 | | Release date: | 2003-08-12 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | An Eight-Stranded Helical Fragment in RNA Crystal Structure: Implications for Tetraplex Interaction
Structure, 11, 2003
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331D
 | | CRYSTAL STRUCTURE OF D(GCGCGCG) WITH 5'-OVERHANG G'S | | Descriptor: | COBALT HEXAMMINE(III), DNA (5'-D(*GP*CP*GP*CP*GP*CP*G)-3') | | Authors: | Pan, B, Ban, C, Wahl, M, Sundaralingam, M. | | Deposit date: | 1997-05-13 | | Release date: | 1997-09-24 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Crystal structure of d(GCGCGCG) with 5'-overhang G residues.
Biophys.J., 73, 1997
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8B9Y
 | | Cysteine Synthase from Trypanosoma cruzi with PLP and OAS | | Descriptor: | Cysteine synthase, putative, GLYCEROL, ... | | Authors: | Sowerby, K.V, Pohl, E. | | Deposit date: | 2022-10-10 | | Release date: | 2023-05-31 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Cysteine synthase: multiple structures of a key enzyme in cysteine synthesis and a potential drug target for Chagas disease and leishmaniasis.
Acta Crystallogr D Struct Biol, 79, 2023
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8B9W
 | | Cysteine Synthase from Trypanosoma theileri with PLP bound | | Descriptor: | CHLORIDE ION, GLYCEROL, PYRIDOXAL-5'-PHOSPHATE, ... | | Authors: | Sowerby, K.V, Pohl, E. | | Deposit date: | 2022-10-10 | | Release date: | 2023-05-31 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Cysteine synthase: multiple structures of a key enzyme in cysteine synthesis and a potential drug target for Chagas disease and leishmaniasis.
Acta Crystallogr D Struct Biol, 79, 2023
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3JQF
 | | Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 1,3,5-triazine-2,4,6-triamine (AX2) | | Descriptor: | (4S,5S)-1,2-DITHIANE-4,5-DIOL, 1,3,5-triazine-2,4,6-triamine, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ... | | Authors: | Tulloch, L.B, Hunter, W.N. | | Deposit date: | 2009-09-06 | | Release date: | 2009-12-08 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structure-based design of pteridine reductase inhibitors targeting african sleeping sickness and the leishmaniases.
J.Med.Chem., 53, 2010
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2PGG
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2OLW
 | | Crystal Structure of E. coli pseudouridine synthase RluE | | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ACETIC ACID, Ribosomal large subunit pseudouridine synthase E, ... | | Authors: | Pan, H, Ho, J.D, Stroud, R.M, Finer-Moore, J. | | Deposit date: | 2007-01-19 | | Release date: | 2007-03-13 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | The Crystal Structure of E. coli rRNA Pseudouridine Synthase RluE.
J.Mol.Biol., 367, 2007
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4RXC
 | | T. Brucei Farnesyl Diphosphate Synthase Complexed with Homorisedronate BPH-6 | | Descriptor: | Farnesyl pyrophosphate synthase, MAGNESIUM ION, [1-hydroxy-3-(pyridin-3-yl)propane-1,1-diyl]bis(phosphonic acid) | | Authors: | Cao, R, Liu, Y.-L, Oldfield, E. | | Deposit date: | 2014-12-09 | | Release date: | 2015-04-15 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometries.
ACS Med Chem Lett, 6, 2015
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2OML
 | | crystal structure of E. coli pseudouridine synthase RluE | | Descriptor: | Ribosomal large subunit pseudouridine synthase E, SULFATE ION | | Authors: | Pan, H, Ho, J.D, Stroud, R.M, Finer-Moore, J. | | Deposit date: | 2007-01-22 | | Release date: | 2007-03-13 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | The Crystal Structure of E. coli rRNA Pseudouridine Synthase RluE.
J.Mol.Biol., 367, 2007
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2PKU
 | | Solution structure of PICK1 PDZ in complex with the carboxyl tail peptide of GluR2 | | Descriptor: | PRKCA-binding protein, peptide (GLU)(SER)(VAL)(LYS)(ILE) | | Authors: | Pan, L, Wu, H, Shen, C, Shi, Y, Xia, J, Zhang, M. | | Deposit date: | 2007-04-18 | | Release date: | 2007-11-20 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes
Embo J., 26, 2007
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3CKL
 | | Crystal structure of human cytosolic sulfotransferase SULT1B1 in complex with PAP and resveratrol | | Descriptor: | ADENOSINE-3'-5'-DIPHOSPHATE, RESVERATROL, Sulfotransferase family cytosolic 1B member 1 | | Authors: | Pan, P.W, Tempel, W, Dong, A, Loppnau, P, Kozieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Bountra, C, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) | | Deposit date: | 2008-03-16 | | Release date: | 2008-04-01 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of human cytosolic sulfotransferase SULT1B1 in complex with PAP and resveratrol.
To be Published
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