8E3W
| BRD4-D1 in complex with BET inhibitor | Descriptor: | (4P)-4-[2-(cyclopropylmethoxy)-5-(methanesulfonyl)phenyl]-2-methylisoquinolin-1(2H)-one, 1,2-ETHANEDIOL, Bromodomain-containing protein 4 | Authors: | Gorman, M.A, Fitzgerald, C.G.D, White, J.M, Parker, M.W. | Deposit date: | 2022-08-17 | Release date: | 2023-03-29 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Bromodomain and extraterminal protein-targeted probe enables tumour visualisation in vivo using positron emission tomography. Chem.Commun.(Camb.), 59, 2023
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8DYR
| BRD4-D1 in complex with BET inhibitor | Descriptor: | (4P,6P)-4-[2-(cyclopropylmethoxy)-5-(methanesulfonyl)phenyl]-6-[1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl]-2-methylisoquinolin-1(2H)-one, 1,2-ETHANEDIOL, Bromodomain-containing protein 4 | Authors: | Gorman, M.A, Fitzgerald, C.G.D, White, J.M, Parker, M.W. | Deposit date: | 2022-08-04 | Release date: | 2023-03-29 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Bromodomain and extraterminal protein-targeted probe enables tumour visualisation in vivo using positron emission tomography. Chem.Commun.(Camb.), 59, 2023
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8E84
| Human PCNA mutant- C148S | Descriptor: | Proliferating cell nuclear antigen | Authors: | Magrino, J, Page, B, Gaubitz, C, Kelch, B.A. | Deposit date: | 2022-08-25 | Release date: | 2023-04-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | A thermosensitive PCNA allele underlies an ataxia-telangiectasia-like disorder. J.Biol.Chem., 299, 2023
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3B0F
| Crystal structure of the UBA domain of p62 and its interaction with ubiquitin | Descriptor: | SULFATE ION, Sequestosome-1 | Authors: | Isogai, S, Morimoto, D, Arita, K, Unzai, S, Tenno, T, Hasegawa, J, Sou, Y, Komatsu, M, Tanaka, K, Shirakawa, M, Tochio, H. | Deposit date: | 2011-06-09 | Release date: | 2011-06-29 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Crystal structure of the ubiquitin-associated (UBA) domain of p62 and its interaction with ubiquitin. J.Biol.Chem., 286, 2011
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2YEL
| Crystal Structure of the First Bromodomain of Human Brd4 with the inhibitor GW841819X | Descriptor: | 1,2-ETHANEDIOL, BENZYL [(4R)-1-METHYL-6-PHENYL-4H-[1,2,4]TRIAZOLO[4,3-A][1,4]BENZODIAZEPIN-4-YL]CARBAMATE, HUMAN BRD4 | Authors: | Chung, C.W. | Deposit date: | 2011-03-25 | Release date: | 2011-06-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Discovery and Characterization of Small Molecule Inhibitors of the Bet Family Bromodomains. J.Med.Chem., 54, 2011
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8E67
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8E66
| ETV6 H396Y variant bound to DNA containing the sequence GGAA | Descriptor: | CACODYLATE ION, Complementary 15 bp strand, GGAA-containing 15 bp DNA, ... | Authors: | Scheu, K, Chan, A.C, Murphy, M.E, McIntosh, L.P. | Deposit date: | 2022-08-22 | Release date: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | The functional role of histidine within the ETV6 ETS domain to be published
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3AV4
| Crystal structure of mouse DNA methyltransferase 1 | Descriptor: | DNA (cytosine-5)-methyltransferase 1, ZINC ION | Authors: | Takeshita, K, Suetake, I, Yamashita, E, Suga, M, Narita, H, Nakagawa, A, Tajima, S. | Deposit date: | 2011-02-22 | Release date: | 2011-05-04 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1). Proc.Natl.Acad.Sci.USA, 108, 2011
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8EAD
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8D7W
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8CVP
| Cereblon-DDB1 in the Apo form | Descriptor: | DNA damage-binding protein 1, Protein cereblon, ZINC ION | Authors: | Watson, E.R, Lander, G.C. | Deposit date: | 2022-05-18 | Release date: | 2022-07-20 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Molecular glue CELMoD compounds are regulators of cereblon conformation. Science, 378, 2022
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8D7X
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8D7V
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8DP5
| Structure of the PEAK3/14-3-3 complex | Descriptor: | 14-3-3 protein beta/alpha, 14-3-3 protein epsilon, Protein PEAK3, ... | Authors: | Torosyan, H, Paul, M, Jura, N, Verba, K.A. | Deposit date: | 2022-07-14 | Release date: | 2023-06-28 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3. Nat Commun, 14, 2023
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3B6Y
| Crystal Structure of the Second HIN-200 Domain of Interferon-Inducible Protein 16 | Descriptor: | Gamma-interferon-inducible protein Ifi-16, SULFATE ION | Authors: | Liao, J.C.C, Lam, R, Ravichandran, M, Duan, S, Tempel, W, Chirgadze, N.Y, Arrowsmith, C.H, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2007-10-29 | Release date: | 2007-11-13 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Crystal Structure Analysis of the Second HIN Domain of IFI16. To be Published
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8EJM
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8EHG
| Rabbit muscle aldolase determined using single-particle cryo-EM with Apollo camera. | Descriptor: | Fructose-bisphosphate aldolase A | Authors: | Peng, R, Fu, X, Mendez, J.H, Randolph, P.H, Bammes, B, Stagg, S.M. | Deposit date: | 2022-09-14 | Release date: | 2022-12-21 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.24 Å) | Cite: | Characterizing the resolution and throughput of the Apollo direct electron detector. J Struct Biol X, 7, 2023
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8D7U
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8D81
| Cereblon~DDB1 bound to Pomalidomide | Descriptor: | DNA damage-binding protein 1, Protein cereblon, S-Pomalidomide, ... | Authors: | Watson, E.R, Lander, G.C. | Deposit date: | 2022-06-07 | Release date: | 2022-07-20 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Molecular glue CELMoD compounds are regulators of cereblon conformation. Science, 378, 2022
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8D7Y
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8EW2
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8EOM
| TUDOR DOMAIN OF TUMOR SUPPRESSOR P53BP1 WITH MFP-5973 | Descriptor: | 4-(4-methylpiperazine-1-sulfonyl)benzamide, SULFATE ION, TP53-binding protein 1, ... | Authors: | The, J, Hong, Z, Headey, S, Gunzburg, M, Doak, B, James, L.I, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC) | Deposit date: | 2022-10-03 | Release date: | 2023-01-18 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | TUDOR DOMAIN OF TUMOR SUPPRESSOR P53BP1 WITH MFP-5973 to be published
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8F1G
| Crystal structure of human WDR5 in complex with compound WM662 | Descriptor: | (2S)-2-({(2S)-3-(3'-chloro[1,1'-biphenyl]-4-yl)-1-oxo-1-[(1H-tetrazol-5-yl)amino]propan-2-yl}oxy)propanoic acid, GLYCEROL, SULFATE ION, ... | Authors: | Liu, H. | Deposit date: | 2022-11-05 | Release date: | 2023-01-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction. Acs Chem.Biol., 18, 2023
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8EQ8
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8EQH
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