2IC3
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2IEJ
| Human Protein Farnesyltransferase Complexed with Inhibitor Compound STN-48 And FPP Analog at 1.8A Resolution | Descriptor: | ACETATE ION, METHYL N-{(3S)-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-6-PHENYL-1,2,3,4-TETRAHYDROQUINOLIN-3-YL}-N-[(1-METHYL-1H-IMIDAZOL-4-YL)SULFONYL]GLYCINATE, Protein farnesyltransferase subunit beta, ... | Authors: | Hast, M.A, Beese, L.S. | Deposit date: | 2006-09-19 | Release date: | 2007-01-23 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase. Mol.Biochem.Parasitol., 152, 2007
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2GT4
| Crystal Structure of the Y103F mutant of the GDP-mannose mannosyl hydrolase in complex with GDP-mannose and MG+2 | Descriptor: | GDP-mannose mannosyl hydrolase, GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE, MAGNESIUM ION, ... | Authors: | Gabelli, S.B, Bianchet, M.A, Azurmendi, H.F, Mildvan, A.S, Amzel, L.A. | Deposit date: | 2006-04-27 | Release date: | 2006-12-12 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | X-ray, NMR, and mutational studies of the catalytic cycle of the GDP-mannose mannosyl hydrolase reaction. Biochemistry, 45, 2006
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2GTN
| Mutated MAP kinase P38 (Mus Musculus) in complex with Inhbitor PG-951717 | Descriptor: | 2-(2,6-DIFLUOROPHENOXY)-N-(2-FLUOROPHENYL)-9-ISOPROPYL-9H-PURIN-8-AMINE, Mitogen-activated protein kinase 14, SULFATE ION | Authors: | Walter, R.L, Mekel, M.J, Evdokimov, A.G, Pokross, M.E, Sabat, M. | Deposit date: | 2006-04-28 | Release date: | 2006-07-11 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The development of novel C-2, C-8, and N-9 trisubstituted purines as inhibitors of TNF-alpha production. Bioorg.Med.Chem.Lett., 16, 2006
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2GX6
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2GWS
| Crystal Structure of human DNA Polymerase lambda with a G/G mismatch in the primer terminus | Descriptor: | 1,2-ETHANEDIOL, 5'-D(*CP*GP*GP*CP*AP*GP*CP*GP*CP*AP*C)-3', 5'-D(*GP*TP*GP*CP*GP*G)-3', ... | Authors: | Garcia-Diaz, M, Picher, A.J, Bebenek, K, Pedersen, L.C, Kunkel, T.A, Blanco, L. | Deposit date: | 2006-05-05 | Release date: | 2006-09-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Promiscuous mismatch extension by human DNA polymerase lambda. Nucleic Acids Res., 34, 2006
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2GYK
| Crystal structure of the complex of the Colicin E9 DNase domain with a mutant immunity protein, IMME9 (D51A) | Descriptor: | Colicin-E9, Colicin-E9 immunity protein, PHOSPHATE ION, ... | Authors: | Santi, P.S, Kolade, O.O, Kuhlmann, U.C, Hemmings, A.M. | Deposit date: | 2006-05-09 | Release date: | 2007-05-15 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal structures of the complexes of the Colicin E9 DNase domain with mutant immunity proteins To be Published
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2GZJ
| Crystal Structure of the E9 DNase Domain with a Mutant Immunity Protein IM9 (D51A) | Descriptor: | Colicin-E9, Colicin-E9 immunity protein, PHOSPHATE ION, ... | Authors: | Santi, P.S, Kolade, O.O, Kuhlmann, U.C, Kleanthous, C, Hemmings, A.M. | Deposit date: | 2006-05-11 | Release date: | 2008-03-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal Structure of the Complex of
the Colicin E9 DNase Domain with a Mutant Immunity Protein, IM9 (D51A) To be Published
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2H1Y
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2H4P
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2H2Q
| Crystal structure of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate synthase | Descriptor: | 2'-DEOXYURIDINE-5'-MONOPHOSPHATE, Bifunctional dihydrofolate reductase-thymidylate synthase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Senkovich, O, Schormann, N, Chattopadhyay, D. | Deposit date: | 2006-05-19 | Release date: | 2008-04-08 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function. Proteins, 73, 2008
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2HBN
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2HC8
| Structure of the A. fulgidus CopA A-domain | Descriptor: | Cation-transporting ATPase, P-type | Authors: | Sazinsky, M.H, Agawal, S, Arguello, J.M, Rosenzweig, A.C. | Deposit date: | 2006-06-15 | Release date: | 2006-09-05 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structure of the Actuator Domain from the Archaeoglobus fulgidus Cu(+)-ATPase(,). Biochemistry, 45, 2006
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2HDS
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6XEY
| Cryo-EM structure of the SARS-CoV-2 spike glycoprotein bound to Fab 2-4 | Descriptor: | 2-4 Heavy Chain, 2-4 Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Rapp, M, Shapiro, L, Ho, D.D. | Deposit date: | 2020-06-14 | Release date: | 2020-07-22 | Last modified: | 2021-01-27 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike. Nature, 584, 2020
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2GNA
| Crystal structure of UDP-GlcNAc inverting 4,6-dehydratase in complex with NADP and UDP-Gal | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GALACTOSE-URIDINE-5'-DIPHOSPHATE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Ishiyama, N, Creuzenet, C, Lam, J.S, Berghuis, A.M. | Deposit date: | 2006-04-09 | Release date: | 2006-05-09 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural Studies of FlaA1 from Helicobacter pylori Reveal the Mechanism for Inverting 4,6-Dehydratase Activity. J.Biol.Chem., 281, 2006
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2GP7
| Estrogen Related Receptor-gamma ligand binding domain | Descriptor: | CALCIUM ION, Estrogen-related receptor gamma | Authors: | Wang, L, Zuercher, W.J, Consler, T.G, Lambert, M.H, Miller, A.B, Osband-miller, L.A, McKee, D.D, Willson, T.M, Nolte, R.T. | Deposit date: | 2006-04-17 | Release date: | 2006-09-26 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation. J.Biol.Chem., 281, 2006
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2HE7
| FERM domain of EPB41L3 (DAL-1) | Descriptor: | Band 4.1-like protein 3 | Authors: | Hallberg, B.M, Busam, R.D, Arrowsmith, C, Berglund, H, Collins, R, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Schiavone, L.H, Johansson, I, Hogbom, M, Karlberg, T, Kotenyova, T, Nilvebrandt, J, Norberg, P, Stenmark, P, Nordlund, P, Nilsson-ehle, P, Nyman, T, Ogg, D, Sagemark, J, Sundstrom, M, Uppenberg, J, Van den berg, S, Weigelt, J, Persson, C, Thorsell, A.G, Structural Genomics Consortium (SGC) | Deposit date: | 2006-06-21 | Release date: | 2006-07-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis of tumor suppressor in lung cancer 1 (TSLC1) binding to differentially expressed in adenocarcinoma of the lung (DAL-1/4.1B). J.Biol.Chem., 286, 2011
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2GQS
| SAICAR Synthetase Complexed with CAIR-Mg2+ and ADP | Descriptor: | 5-AMINO-1-(5-O-PHOSPHONO-BETA-D-RIBOFURANOSYL)-1H-IMIDAZOLE-4-CARBOXYLIC ACID, ADENOSINE-5'-DIPHOSPHATE, FORMIC ACID, ... | Authors: | Ginder, N.D, Honzatko, R.B. | Deposit date: | 2006-04-21 | Release date: | 2006-05-16 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Nucleotide Complexes of Escherichia coli Phosphoribosylaminoimidazole Succinocarboxamide Synthetase. J.Biol.Chem., 281, 2006
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6XKY
| Caulobacter crescentus FljK filament, straightened | Descriptor: | Flagellin | Authors: | Montemayor, E.J, Ploscariu, N.T, Sanchez, J.C, Parrell, D, Dillard, R.S, Shebelut, C.W, Ke, Z, Guerrero-Ferreira, R.C, Wright, E.R. | Deposit date: | 2020-06-27 | Release date: | 2020-12-23 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Flagellar Structures from the Bacterium Caulobacter crescentus and Implications for Phage phi CbK Predation of Multiflagellin Bacteria J.Bacteriol., 203, 2021
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2GZE
| Crystal structure of the E9 DNase domain with a mutant immunity protein IM9 (Y55A) | Descriptor: | Colicin-E9, Colicin-E9 immunity protein, PHOSPHATE ION, ... | Authors: | Santi, P.S, Kolade, O.O, Kuhlmann, U.C, Kleanthous, C, Hemmings, A.M. | Deposit date: | 2006-05-11 | Release date: | 2008-03-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structure of the Complex of
the Colicin E9 DNase Domain with a Mutant Immunity Protein, IM9 (Y55A) To be Published
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2GTM
| Mutated Mouse P38 MAP Kinase Domain in complex with Inhibitor PG-892579 | Descriptor: | 8-(2-CHLOROPHENYLAMINO)-2-(2,6-DIFLUOROPHENYLAMINO)-9-ETHYL-9H-PURINE-1,7-DIIUM, Mitogen-activated protein kinase 14 | Authors: | Walter, R.L, Mekel, M.J, Evdokimov, A.G, Pokross, M.E, Sabat, M. | Deposit date: | 2006-04-28 | Release date: | 2006-05-23 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The development of novel C-2, C-8, and N-9 trisubstituted purines as inhibitors of TNF-alpha production. Bioorg.Med.Chem.Lett., 16, 2006
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2GZM
| Crystal Structure of the Glutamate Racemase from Bacillus anthracis | Descriptor: | D-GLUTAMIC ACID, Glutamate racemase | Authors: | May, M, Santarsiero, B.D, Johnson, M.E, Mesecar, A.D. | Deposit date: | 2006-05-11 | Release date: | 2007-05-29 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Structural and functional analysis of two glutamate racemase isozymes from Bacillus anthracis and implications for inhibitor design. J.Mol.Biol., 371, 2007
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2GVI
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6CRX
| SARS Spike Glycoprotein, Stabilized variant, two S1 CTDs in the upwards conformation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Fibritin, ... | Authors: | Kirchdoerfer, R.N, Wang, N, Pallesen, J, Turner, H.L, Cottrell, C.A, McLellan, J.S, Ward, A.B. | Deposit date: | 2018-03-19 | Release date: | 2018-04-11 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis. Sci Rep, 8, 2018
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