4GQQ
| Human pancreatic alpha-amylase with bound ethyl caffeate | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ... | Authors: | Williams, L.K, Brayer, G.D. | Deposit date: | 2012-08-23 | Release date: | 2012-10-24 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Order and disorder: differential structural impacts of myricetin and ethyl caffeate on human amylase, an antidiabetic target. J.Med.Chem., 55, 2012
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8AKF
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4WI3
| Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation I253A | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region | Authors: | Farrugia, W, Burvenich, I.J.G, Scott, A.M, Ramsland, P.A. | Deposit date: | 2014-09-25 | Release date: | 2015-09-30 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.703 Å) | Cite: | Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice To Be Published
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4WI6
| Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation N434A | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region | Authors: | Farrugia, W, Burvenich, I.J.G, Scott, A.M, Ramsland, P.A. | Deposit date: | 2014-09-25 | Release date: | 2015-09-30 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.201 Å) | Cite: | Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice To Be Published
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8AK6
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8AK9
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4WJV
| Crystal structure of Rsa4 in complex with the Nsa2 binding peptide | Descriptor: | Maltose-binding periplasmic protein, Ribosome assembly protein 4, Ribosome biogenesis protein NSA2, ... | Authors: | Holdermann, I, Paternoga, H, Bassler, J, Hurt, E, Sinning, I. | Deposit date: | 2014-10-01 | Release date: | 2014-11-19 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation. J.Cell Biol., 207, 2014
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8AK7
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8AKA
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4WSR
| The crystal structure of hemagglutinin form A/chicken/New York/14677-13/1998 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin | Authors: | Yang, H, Carney, P.J, Chang, J.C, Villanueva, J.M, Stevens, J. | Deposit date: | 2014-10-28 | Release date: | 2015-02-25 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure and receptor binding preferences of recombinant hemagglutinins from avian and human h6 and h10 influenza a virus subtypes. J.Virol., 89, 2015
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8AKE
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8AK8
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8AKG
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4X12
| JC Polyomavirus genotype 3 VP1 in complex with GD1b oligosaccharide | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, Major capsid protein, ... | Authors: | Stroh, L.J, Stehle, T. | Deposit date: | 2014-11-24 | Release date: | 2015-04-22 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The Greater Affinity of JC Polyomavirus Capsid for alpha 2,6-Linked Lactoseries Tetrasaccharide c than for Other Sialylated Glycans Is a Major Determinant of Infectivity. J.Virol., 89, 2015
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8BL0
| Human Sirt6 in complex with the inhibitor S6023 and ADP-ribose | Descriptor: | 3-[4-[[5-(2-fluorophenyl)thiophen-2-yl]methyl]piperazin-1-yl]sulfonylbenzenesulfonamide, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | You, W, Steegborn, C. | Deposit date: | 2022-11-09 | Release date: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen To Be Published
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8BL1
| Human Sirt6 in complex with the inhibitor S6039 and ADP-ribose | Descriptor: | 2-azanyl-5-[4-[[5-(2-fluorophenyl)thiophen-2-yl]methyl]piperazin-1-yl]sulfonyl-benzenesulfonamide, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | You, W, Steegborn, C. | Deposit date: | 2022-11-09 | Release date: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen To Be Published
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5YST
| RanM189D in complex with RanBP1-CRM1 | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1,Exportin-1, ... | Authors: | Sun, Q, Zhang, Y. | Deposit date: | 2017-11-15 | Release date: | 2018-11-21 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | RanM189D in complex with RanBP1-CRM1 To Be Published
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5YSU
| Plumbagin in complex with CRM1-RanM189D-RanBP1 | Descriptor: | (2~{R})-2-methyl-5-oxidanyl-2,3-dihydronaphthalene-1,4-dione, CHLORIDE ION, Exportin-1,Exportin-1, ... | Authors: | Sun, Q, Zhang, Y. | Deposit date: | 2017-11-15 | Release date: | 2018-11-21 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | RanL182A in complex with RanBP1-CRM1 To Be Published
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5YRO
| RanL182A in complex with RanBP1-CRM1 | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1,Exportin-1, ... | Authors: | Sun, Q, Zhang, Y. | Deposit date: | 2017-11-09 | Release date: | 2018-11-21 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.396 Å) | Cite: | RanL182A in complex with RanBP1-CRM1 To Be Published
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5YTB
| RanY197A in complex with RanBP1-CRM1 | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... | Authors: | Sun, Q, Zhang, Y. | Deposit date: | 2017-11-17 | Release date: | 2018-11-21 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | RanY197A in complex with RanBP1-CRM1 To Be Published
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9BOO
| Crystal structure of MERS-CoV Nsp5 in complex with PF-07817883 | Descriptor: | 3C-like proteinase nsp5, N-(methoxycarbonyl)-3-methyl-L-valyl-(4R)-N-{(1Z,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-4-(trifluoromethyl)-L-prolinamide | Authors: | Chen, P, Arutyunova, E, Lemieux, M.J. | Deposit date: | 2024-05-05 | Release date: | 2024-08-07 | Last modified: | 2024-09-18 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | A Structural Comparison of Oral SARS-CoV-2 Drug Candidate Ibuzatrelvir Complexed with the Main Protease (M pro ) of SARS-CoV-2 and MERS-CoV. Jacs Au, 4, 2024
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9D2C
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4V6X
| Structure of the human 80S ribosome | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | Authors: | Anger, A.M, Armache, J.-P, Berninghausen, O, Habeck, M, Subklewe, M, Wilson, D.N, Beckmann, R. | Deposit date: | 2013-02-27 | Release date: | 2014-07-09 | Last modified: | 2023-02-01 | Method: | ELECTRON MICROSCOPY (5 Å) | Cite: | Structures of the human and Drosophila 80S ribosome. Nature, 497, 2013
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9GDK
| Jumonji domain-containing protein 1C with crystallization epitope mutations L2440Y:G2444H | Descriptor: | Probable JmjC domain-containing histone demethylation protein 2C | Authors: | Fairhead, M, Strain-Damerell, C, Ye, M, Mackinnon, S.R, Pinkas, D, MacLean, E.M, Koekemoer, L, Damerell, D, Krojer, T, Arrowsmith, C.H, Edwards, A, Bountra, C, Yue, W, Burgess-Brown, N, Marsden, B, von Delft, F, Structural Genomics Consortium (SGC) | Deposit date: | 2024-08-05 | Release date: | 2024-08-21 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | A fast, parallel method for efficiently exploring crystallization behaviour of large numbers of protein variants To Be Published
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9FZK
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