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6O0H	Cryo-EM structure of human ATP-citrate lyase in complex with inhibitor NDI-091143 Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase, methyl 3-chloro-5-[(4,6-difluoro[1,1'-biphenyl]-3-yl)sulfamoyl]-4-hydroxybenzoate Authors: Wei, J, Tong, L. Deposit date: 2019-02-16 Release date: 2019-04-17 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.67 Å) Cite: An allosteric mechanism for potent inhibition of human ATP-citrate lyase. Nature, 568, 2019
7LLA	Structure of human ATP citrate lyase in complex with acetyl-CoA and oxaloacetate (EM map was generated in Cryosparc with non-uniform refinement) Descriptor: ACETYL COENZYME *A, ATP-citrate synthase, OXALOACETATE ION Authors: Wei, X, Marmorstein, R. Deposit date: 2021-02-03 Release date: 2021-03-03 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (2.97 Å) Cite: Reply to: Acetyl-CoA is produced by the citrate synthase homology module of ATP-citrate lyase. Nat.Struct.Mol.Biol., 28, 2021
7LJ9	Structure of human ATP citrate lyase in complex with acetyl-CoA and oxaloacetate Descriptor: ACETYL COENZYME *A, ATP-citrate synthase, OXALOACETATE ION Authors: Wei, X, Marmorstein, R. Deposit date: 2021-01-28 Release date: 2021-03-31 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3 Å) Cite: Reply to: Acetyl-CoA is produced by the citrate synthase homology module of ATP-citrate lyase. Nat.Struct.Mol.Biol., 28, 2021
7RIG	Structure of ACLY-D1026A-substrates Descriptor: (3S)-citryl-Coenzyme A, ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase, ... Authors: Wei, X, Marmorstein, R. Deposit date: 2021-07-19 Release date: 2023-05-10 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (2.2 Å) Cite: Allosteric role of the citrate synthase homology domain of ATP citrate lyase. Nat Commun, 14, 2023
7RKZ	Structure of ACLY D1026A-substrates-asym-int Descriptor: (3S)-citryl-Coenzyme A, ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase, ... Authors: Wei, X, Marmorstein, R. Deposit date: 2021-07-22 Release date: 2023-05-10 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (2.6 Å) Cite: Allosteric role of the citrate synthase homology domain of ATP citrate lyase. Nat Commun, 14, 2023
7RMP	Structure of ACLY D1026A - substrates-asym Descriptor: (3S)-citryl-Coenzyme A, ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase, ... Authors: Wei, X, Marmorstein, R. Deposit date: 2021-07-28 Release date: 2023-05-10 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Allosteric role of the citrate synthase homology domain of ATP citrate lyase. Nat Commun, 14, 2023
7LIW	Local refinement of human ATP citrate lyase E599Q mutant ASH domain Descriptor: (2S)-2-hydroxy-2-[2-oxo-2-(phosphonooxy)ethyl]butanedioic acid, ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase, ... Authors: Wei, X, Marmorstein, R. Deposit date: 2021-01-28 Release date: 2021-05-19 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (2.85 Å) Cite: Reply to: Acetyl-CoA is produced by the citrate synthase homology module of ATP-citrate lyase. Nat.Struct.Mol.Biol., 28, 2021
6ZNW	Methanosaeta concilii ATP citrate lyase (D541A mutant) in complex with (3S)-citryl-CoA. Descriptor: (3S)-citryl-Coenzyme A, CITRATE ANION, Citrate lyase, ... Authors: Verschueren, K.H.G, Verstraete, K. Deposit date: 2020-07-06 Release date: 2021-07-14 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.121 Å) Cite: Acetyl-CoA is produced by the citrate synthase homology module of ATP-citrate lyase. Nat.Struct.Mol.Biol., 28, 2021
6POF	Structure of human ATP citrate lyase Descriptor: ATP-citrate synthase Authors: Wei, X, Marmorstein, R. Deposit date: 2019-07-03 Release date: 2020-01-01 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (4.3 Å) Cite: Molecular basis for acetyl-CoA production by ATP-citrate lyase. Nat.Struct.Mol.Biol., 27, 2020
6UIA	Structure of ATP citrate lyase with CoA in a partially open conformation Descriptor: ATP-citrate synthase, COENZYME A Authors: Wei, X, Marmorstein, R. Deposit date: 2019-09-30 Release date: 2019-12-25 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (4.3 Å) Cite: Molecular basis for acetyl-CoA production by ATP-citrate lyase. Nat.Struct.Mol.Biol., 27, 2020
6UUZ	Structure of ACLY in the presence of citrate and CoA Descriptor: ATP-citrate synthase, COENZYME A Authors: Xuepeng, W, Ronen, M. Deposit date: 2019-11-01 Release date: 2020-01-01 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3 Å) Cite: Molecular basis for acetyl-CoA production by ATP-citrate lyase. Nat.Struct.Mol.Biol., 27, 2020
6UI9	Structure of human ATP citrate lyase in complex with acetyl-CoA and oxaloacetate Descriptor: ACETYL COENZYME *A, ACLY, OXALOACETATE ION Authors: Wei, X, Marmorstein, R. Deposit date: 2019-09-30 Release date: 2019-12-25 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Molecular basis for acetyl-CoA production by ATP-citrate lyase Nat.Struct.Mol.Biol., 27, 2020
6QFB	Structure of the human ATP citrate lyase holoenzyme in complex with citrate, coenzyme A and Mg.ADP Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase, CITRATE ANION, ... Authors: Verstraete, K, Verschueren, K. Deposit date: 2019-01-09 Release date: 2019-04-10 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (3.25 Å) Cite: Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle. Nature, 568, 2019
6UV5	Structure of human ATP citrate lyase in complex with acetyl-CoA and oxaloacetate Descriptor: ACETYL COENZYME *A, ATP citrate lyase, OXALOACETATE ION Authors: Wei, X, Marmorstein, R. Deposit date: 2019-11-01 Release date: 2019-12-25 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Molecular basis for acetyl-CoA production by ATP-citrate lyase. Nat.Struct.Mol.Biol., 27, 2020
6UUW	Structure of human ATP citrate lyase E599Q mutant in complex with Mg2+, citrate, ATP and CoA Descriptor: (2S)-2-hydroxy-2-[2-oxo-2-(phosphonooxy)ethyl]butanedioic acid, ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase, ... Authors: Wei, X, Marmorstein, R. Deposit date: 2019-11-01 Release date: 2019-12-25 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (2.85 Å) Cite: Molecular basis for acetyl-CoA production by ATP-citrate lyase Nat.Struct.Mol.Biol., 27, 2020
6HXJ	Structure of ATP citrate lyase from Chlorobium limicola in complex with citrate and coenzyme A. Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ATP-citrate lyase alpha-subunit, ATP-citrate lyase beta-subunit, ... Authors: Verstraete, K, Verschueren, K. Deposit date: 2018-10-17 Release date: 2019-04-10 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.58 Å) Cite: Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle. Nature, 568, 2019
6HXH	Structure of the human ATP citrate lyase holoenzyme in complex with citrate, coenzyme A and Mg.ADP Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase,Human ATP citrate lyase, CITRATE ANION, ... Authors: Verstraete, K, Verschueren, K. Deposit date: 2018-10-17 Release date: 2019-04-10 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle. Nature, 568, 2019
6HXI	Structure of ATP citrate lyase from Methanothrix soehngenii in complex with citrate and coenzyme A Descriptor: ACETATE ION, CITRATE ANION, COENZYME A, ... Authors: Verstraete, K, Verschueren, K. Deposit date: 2018-10-17 Release date: 2019-04-10 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle. Nature, 568, 2019
8GRE	F-box protein in complex with skp1(FL) and substrate Descriptor: Citrate synthase, E3 ubiquitin ligase complex SCF subunit, F-box protein UCC1, ... Authors: Nishio, K, Nakatsukasa, K, Kamura, T, Mizushima, T. Deposit date: 2022-09-01 Release date: 2023-04-26 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Defective import of mitochondrial metabolic enzyme elicits ectopic metabolic stress. Sci Adv, 9, 2023
8GRF	Crystal structure of F-box protein in the ternary complex with adaptor protein Skp1(DL) and its substrate Descriptor: 1,2-ETHANEDIOL, Citrate synthase, E3 ubiquitin ligase complex SCF subunit, ... Authors: Nishio, K, Nakatsukasa, K, Kamura, T, Mizushima, T. Deposit date: 2022-09-01 Release date: 2023-04-26 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (2.53 Å) Cite: Defective import of mitochondrial metabolic enzyme elicits ectopic metabolic stress. Sci Adv, 9, 2023
8G5C	Structure of ACLY-D1026A-substrates, local refinement of ASH domain Descriptor: (3S)-citryl-Coenzyme A, ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase, ... Authors: Xuepeng, W, Ronen, M. Deposit date: 2023-02-12 Release date: 2023-05-10 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (2.2 Å) Cite: Allosteric role of the citrate synthase homology domain of ATP citrate lyase. Nat Commun, 14, 2023
8G1F	Structure of ACLY-D1026A-products Descriptor: (3S)-citryl-Coenzyme A, ACETYL COENZYME *A, ADENOSINE-5'-DIPHOSPHATE, ... Authors: Wei, X, Marmorstein, R. Deposit date: 2023-02-02 Release date: 2023-05-10 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (2.4 Å) Cite: Allosteric role of the citrate synthase homology domain of ATP citrate lyase. Nat Commun, 14, 2023
8G5D	Structure of ACLY-D1026A-products, local refinement of ASH domain Descriptor: (3S)-citryl-Coenzyme A, ACETYL COENZYME *A, ADENOSINE-5'-DIPHOSPHATE, ... Authors: Wei, X, Marmorstein, R. Deposit date: 2023-02-13 Release date: 2023-05-10 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (2.5 Å) Cite: Allosteric role of the citrate synthase homology domain of ATP citrate lyase. Nat Commun, 14, 2023
8G1E	Structure of ACLY-D1026A-products-asym Descriptor: (3S)-citryl-Coenzyme A, ACETYL COENZYME *A, ADENOSINE-5'-DIPHOSPHATE, ... Authors: Wei, X, Marmorstein, R. Deposit date: 2023-02-02 Release date: 2023-05-10 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Allosteric role of the citrate synthase homology domain of ATP citrate lyase. Nat Commun, 14, 2023

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