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1CSR	Alpha-fluoro acid and alpha-fluoro amide analogs of acetyl-coa as inhibitors of of citrate synthase: effect of pka matching on binding affinity and hydrogen bond length Descriptor: ALPHA-FLUORO-AMIDOCARBOXYMETHYLDETHIA COENZYME A COMPLEX, CITRATE SYNTHASE, OXALOACETATE ION Authors: Usher, K.C, Remington, S.J. Deposit date: 1995-08-04 Release date: 1995-10-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.7 Å) Cite: alpha-Fluoro acid and alpha-fluoro amide analogs of acetyl-CoA as inhibitors of citrate synthase: effect of pKa matching on binding affinity and hydrogen bond length. Biochemistry, 34, 1995
1AMZ	CHICKEN CITRATE SYNTHASE COMPLEX WITH NITROMETHYLDE-COA AND MALATE Descriptor: CITRATE SYNTHASE, D-MALATE, NITROMETHYLDETHIA COENZYME A Authors: Usher, K.C, Remington, S.J. Deposit date: 1997-06-19 Release date: 1997-12-24 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Mechanisms of Enzyme-Catalyzed Deprotonation of Acetyl-Coenzyme A To be Published
1A59	COLD-ACTIVE CITRATE SYNTHASE Descriptor: CITRATE SYNTHASE, CITRIC ACID, COENZYME A Authors: Russell, R.J.M, Gerike, U, Danson, M.J, Hough, D.W, Taylor, G.L. Deposit date: 1998-02-20 Release date: 1999-03-30 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.09 Å) Cite: Structural adaptations of the cold-active citrate synthase from an Antarctic bacterium. Structure, 6, 1998
1AL6	CHICKEN CITRATE SYNTHASE COMPLEX WITH N-HYDROXYAMIDO-COA AND OXALOACETATE Descriptor: CITRATE SYNTHASE, N-HYDROXYAMIDOCARBOXYMETHYLDETHIA COENZYME *A, OXALOACETATE ION Authors: Usher, K.C, Remington, S.J. Deposit date: 1997-06-12 Release date: 1997-12-24 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Mechanisms of Enzyme-Catalyzed Deprotonation of Acetyl-Coenzyme A To be Published
6BOO	Crystal structure of 2-methylcitrate synthase from Aspergillus fumigatus with oxaloacetate and coenzyme-A. Descriptor: 2-methylcitrate synthase, mitochondrial, COENZYME A, ... Authors: Schlachter, C, Chruszcz, M. Deposit date: 2017-11-20 Release date: 2018-11-28 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Comparative studies of Aspergillus fumigatus 2-methylcitrate synthase and human citrate synthase. Biol.Chem., 400, 2019
1CSH	A very short hydrogen bond provides only moderate stabilization of an enzyme: inhibitor complex of citrate synthase Descriptor: AMIDOCARBOXYMETHYLDETHIA COENZYME *A, CITRATE SYNTHASE, OXALOACETATE ION Authors: Usher, K.C, Remington, S.J. Deposit date: 1994-03-07 Release date: 1994-04-30 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.65 Å) Cite: A very short hydrogen bond provides only moderate stabilization of an enzyme-inhibitor complex of citrate synthase. Biochemistry, 33, 1994
6BOL	Crystal structure of mutant 2-methylcitrate synthase mcsAG419A from Aspergillus fumigatus. Descriptor: 2-methylcitrate synthase, mitochondrial, CHLORIDE ION, ... Authors: Schlachter, C, Chruszcz, M. Deposit date: 2017-11-20 Release date: 2018-11-28 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Comparative studies of Aspergillus fumigatus 2-methylcitrate synthase and human citrate synthase. Biol.Chem., 400, 2019
6BON	Crystal structure of 2-methylcitrate synthase from Aspergillus fumigatus with oxaloacetate and coenzyme-A. Descriptor: 2-methylcitrate synthase, mitochondrial, COENZYME A, ... Authors: Schlachter, C, Chruszcz, M. Deposit date: 2017-11-20 Release date: 2018-11-28 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Comparative studies of Aspergillus fumigatus 2-methylcitrate synthase and human citrate synthase. Biol.Chem., 400, 2019
6BOP	Crystal structure of 2-methylcitrate synthase from Aspergillus fumigatus Descriptor: 2-methylcitrate synthase, mitochondrial Authors: Schlachter, C, Chruszcz, M. Deposit date: 2017-11-20 Release date: 2018-11-28 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.71 Å) Cite: Comparative studies of Aspergillus fumigatus 2-methylcitrate synthase and human citrate synthase. Biol.Chem., 400, 2019
6BOM	Crystal structure of mutant 2-methylcitrate synthase mcsAG306A from Aspergillus fumigatus. Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-methylcitrate synthase, mitochondrial Authors: Schlachter, C, Chruszcz, M. Deposit date: 2017-11-20 Release date: 2018-11-28 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Comparative studies of Aspergillus fumigatus 2-methylcitrate synthase and human citrate synthase. Biol.Chem., 400, 2019
6ABV	Crystal structure of citrate synthase (Msed_0281) from Metallosphaera sedula Descriptor: Citrate synthase, GLYCEROL Authors: Lee, S.-H, Kim, K.-J. Deposit date: 2018-07-24 Release date: 2019-01-16 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure and biochemical properties of msed_0281, the citrate synthase from Metallosphaera sedula. Biochem. Biophys. Res. Commun., 509, 2019
6CTS	PROPOSED MECHANISM FOR THE CONDENSATION REACTION OF CITRATE SYNTHASE. 1.9-ANGSTROMS STRUCTURE OF THE TERNARY COMPLEX WITH OXALOACETATE AND CARBOXYMETHYL COENZYME A Descriptor: CITRATE SYNTHASE, CITRYL-THIOETHER-COENZYME *A Authors: Karpusas, M, Branchaud, B, Remington, S.J. Deposit date: 1989-11-16 Release date: 1990-10-15 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Proposed mechanism for the condensation reaction of citrate synthase: 1.9-A structure of the ternary complex with oxaloacetate and carboxymethyl coenzyme A. Biochemistry, 29, 1990
1CSS	ALPHA-FLUORO ACID AND ALPHA-FLUORO AMIDE ANALOGS OF ACETYL-COA AS INHIBITORS OF OF CITRATE SYNTHASE: EFFECT OF PKA MATCHING ON BINDING AFFINITY AND HYDROGEN BOND LENGTH Descriptor: ALPHA-FLUORO-CARBOXYMETHYLDETHIA COENZYME A COMPLEX, CITRATE SYNTHASE, OXALOACETATE ION Authors: Usher, K.C, Remington, S.J. Deposit date: 1995-08-04 Release date: 1995-10-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.7 Å) Cite: alpha-Fluoro acid and alpha-fluoro amide analogs of acetyl-CoA as inhibitors of citrate synthase: effect of pKa matching on binding affinity and hydrogen bond length. Biochemistry, 34, 1995
8GR9	Crystal structure of peroxisomal citrate synthase (Cit2) from Saccharomyces cerevisiae in complex with oxaloacetate and coenzyme-A Descriptor: CHLORIDE ION, COENZYME A, Citrate synthase, ... Authors: Nishio, K, Nakatsukasa, K, Kamura, T, Mizushima, T. Deposit date: 2022-09-01 Release date: 2023-04-26 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (1.48 Å) Cite: Defective import of mitochondrial metabolic enzyme elicits ectopic metabolic stress. Sci Adv, 9, 2023
8GR8	Crystal structure of peroxisomal citrate synthase (Cit2) from Saccharomycescerevisiae Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, Citrate synthase, ... Authors: Nishio, K, Nakatsukasa, K, Kamura, T, Mizushima, T. Deposit date: 2022-09-01 Release date: 2023-04-26 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Defective import of mitochondrial metabolic enzyme elicits ectopic metabolic stress. Sci Adv, 9, 2023
8GQZ	Crystal structure of mitochondrial citrate synthase (Cit1) from Saccharomyces cerevisiae Descriptor: ACETATE ION, CHLORIDE ION, Citrate synthase, ... Authors: Nishio, K, Nakatsukasa, K, Kamura, T, Mizushima, T. Deposit date: 2022-08-31 Release date: 2023-04-26 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (1.42 Å) Cite: Defective import of mitochondrial metabolic enzyme elicits ectopic metabolic stress. Sci Adv, 9, 2023
8GLB	Selenomethionine Derivatized Citrate Synthase (CitA) in Mycobacterium tuberculosis with Pyruvate Descriptor: 1,2-ETHANEDIOL, PYRUVIC ACID, citrate synthase Authors: Pathirage, R, Ronning, D, Favrot, L. Deposit date: 2023-03-21 Release date: 2023-06-07 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Mycobacterium tuberculosis CitA activity is modulated by cysteine oxidation and pyruvate binding. Rsc Med Chem, 14, 2023
8GMI	Citrate Synthase (CitA) in Mycobacterium tuberculosis modified by Ebselen at C143 residue Descriptor: CITRATE ANION, N-phenyl-2-selanylbenzamide, citrate synthase Authors: Pathirage, R, Ronning, D. Deposit date: 2023-03-25 Release date: 2023-06-07 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Mycobacterium tuberculosis CitA activity is modulated by cysteine oxidation and pyruvate binding. Rsc Med Chem, 14, 2023
8GI7	C143A variant of Citrate Synthase (CitA) in Mycobacterium tuberculosis Descriptor: 1,2-ETHANEDIOL, CITRATE ANION, citrate synthase (unknown stereospecificity) Authors: Pathirage, R, Ronning, D. Deposit date: 2023-03-13 Release date: 2023-06-07 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Mycobacterium tuberculosis CitA activity is modulated by cysteine oxidation and pyruvate binding. Rsc Med Chem, 14, 2023
8GMK	Pyruvate bound structure of Citrate Synthase (CitA) in Mycobacterium Tuberculosis Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, PYRUVIC ACID, ... Authors: Pathirage, R, Ronning, D, Yamsek, M. Deposit date: 2023-03-26 Release date: 2023-06-07 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.81 Å) Cite: Mycobacterium tuberculosis CitA activity is modulated by cysteine oxidation and pyruvate binding. Rsc Med Chem, 14, 2023
8GM9	Structure of Citrate Synthase(CitA) in Mycobacterium Tuberculosis Descriptor: 1,2-ETHANEDIOL, ACRYLIC ACID, DI(HYDROXYETHYL)ETHER, ... Authors: Pathirage, R, Ronning, D, Favrot, L. Deposit date: 2023-03-24 Release date: 2023-06-07 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Mycobacterium tuberculosis CitA activity is modulated by cysteine oxidation and pyruvate binding. Rsc Med Chem, 14, 2023
8GLL	R149E variant of Citrate Synthase (CitA) in Mycobacterium tuberculosis Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, SULFATE ION, ... Authors: Pathirage, R, Ronning, D, Petit, C. Deposit date: 2023-03-22 Release date: 2023-06-07 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Mycobacterium tuberculosis CitA activity is modulated by cysteine oxidation and pyruvate binding. Rsc Med Chem, 14, 2023
8GIW	C143K variant of Citrate Synthase (CitA) in Mycobacterium tuberculosis Descriptor: 1,2-ETHANEDIOL, CITRATE ANION, DI(HYDROXYETHYL)ETHER, ... Authors: Pathirage, R, Ronning, D. Deposit date: 2023-03-14 Release date: 2023-06-07 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3.15 Å) Cite: Mycobacterium tuberculosis CitA activity is modulated by cysteine oxidation and pyruvate binding. Rsc Med Chem, 14, 2023
8GMF	R153M variant of Citrate Synthase (CitA) in Mycobacterium tuberculosis Descriptor: citrate synthase Authors: Pathirage, R, Ronning, D. Deposit date: 2023-03-25 Release date: 2023-06-07 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.96 Å) Cite: Mycobacterium tuberculosis CitA activity is modulated by cysteine oxidation and pyruvate binding. Rsc Med Chem, 14, 2023
6POE	Structure of ACLY in complex with CoA Descriptor: ATP-citrate synthase, COENZYME A Authors: Wei, X, Marmorstein, R. Deposit date: 2019-07-03 Release date: 2019-12-25 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Molecular basis for acetyl-CoA production by ATP-citrate lyase. Nat.Struct.Mol.Biol., 27, 2020

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