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4PM1	Human transthyretin (TTR) complexed with 16-alpha-bromo-estradiol Descriptor: (14beta,16alpha,17alpha)-16-bromoestra-1,3,5(10)-triene-3,17-diol, 1,2-ETHANEDIOL, Transthyretin Authors: Stura, E.A, Ciccone, L. Deposit date: 2014-05-20 Release date: 2014-10-08 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.23 Å) Cite: Transthyretin complexes with curcumin and bromo-estradiol: evaluation of solubilizing multicomponent mixtures. N Biotechnol, 32, 2014
4PMF	Human transthyretin (TTR) complexed with curcumin Descriptor: (1Z,4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one, 1,2-ETHANEDIOL, SODIUM ION, ... Authors: Stura, E.A, Ciccone, L. Deposit date: 2014-05-21 Release date: 2014-10-08 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Transthyretin complexes with curcumin and bromo-estradiol: evaluation of solubilizing multicomponent mixtures. N Biotechnol, 32, 2014
5OQ0	Crystal structure of transthyretin mutant 87-110-117 Descriptor: Transthyretin Authors: Zanotti, G, Vallese, F, Berni, R. Deposit date: 2017-08-10 Release date: 2017-12-27 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Structural and dynamics evidence for scaffold asymmetric flexibility of the human transthyretin tetramer. PLoS ONE, 12, 2017
5IHH	Crystal structure of human transthyretin in complex with luteolin-MeO at 1.35 A resolution Descriptor: 2-(3,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-4H-1-chromen-4-one, SODIUM ION, Transthyretin Authors: Begum, A, Nilsson, L, Olofsson, A, Sauer-Eriksson, A.E. Deposit date: 2016-02-29 Release date: 2016-04-20 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Modifications of the 7-Hydroxyl Group of the Transthyretin Ligand Luteolin Provide Mechanistic Insights into Its Binding Properties and High Plasma Specificity. Plos One, 11, 2016
4WCD	Trypanosoma brucei PTR1 in complex with inhibitor 10 Descriptor: 5-(1H-benzotriazol-6-yl)-1,3,4-thiadiazol-2-amine, ACETATE ION, GLYCEROL, ... Authors: Mangani, S, Di Pisa, F, Pozzi, C. Deposit date: 2014-09-04 Release date: 2015-09-30 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.68 Å) Cite: Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery. ACS Omega, 2, 2017
5A6I	V122I Transthyretin structure in complex with Tolcalpone Descriptor: TRANSTHYRETIN, Tolcapone Authors: Reverter, D, Gallego, P, Santana, R, Ventura, S. Deposit date: 2015-06-26 Release date: 2016-02-24 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Repositioning Tolcapone as a Potent Inhibitor of Transthyretin Amyloidogenesis and its Associated Cellular Toxicity Nat.Commun., 7, 2016
5AL8	Transthyretin binding heterogeneity and anti-amyloidogenic activity of natural polyphenols and their metabolites: daidzein-7-O- glucuronide Descriptor: DAIDZEIN-7-O-GLUCURONIDE, TRANSTHYRETIN Authors: Florio, P, Foll, C, Cianci, M, Del Rio, D, Zanotti, G, Berni, R. Deposit date: 2015-03-06 Release date: 2015-10-21 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Transthyretin Binding Heterogeneity and Anti-Amyloidogenic Activity of Natural Polyphenols and Their Metabolites J.Biol.Chem., 290, 2015
5AKS	Transthyretin binding heterogeneity and anti-amyloidogenic activity of natural polyphenols and their metabolites: resveratrol-3-O- glucuronide Descriptor: DIMETHYL SULFOXIDE, Resveratrol-3-O-glucuronide, SULFATE ION, ... Authors: Florio, P, Foll, C, Cianci, M, Del Rio, D, Zanotti, G, Berni, R. Deposit date: 2015-03-05 Release date: 2015-10-21 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.25 Å) Cite: Transthyretin Binding Heterogeneity and Anti-Amyloidogenic Activity of Natural Polyphenols and Their Metabolites J.Biol.Chem., 290, 2015
5AKT	Transthyretin binding heterogeneity and anti-amyloidogenic activity of natural polyphenols and their metabolites: resveratrol-4'-O- glucuronide Descriptor: Resveratrol-4'-O-glucuronide, SULFATE ION, TRANSTHYRETIN Authors: Florio, P, Folli, C, Cianci, M, Del Rio, D, Zanotti, G, Berni, R. Deposit date: 2015-03-05 Release date: 2015-10-21 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Transthyretin Binding Heterogeneity and Anti-Amyloidogenic Activity of Natural Polyphenols and Their Metabolites J.Biol.Chem., 290, 2015
5AL0	Transthyretin binding heterogeneity and anti-amyloidogenic activity of natural polyphenols and their metabolites: resveratrol-3-O-sulfate Descriptor: DIMETHYL SULFOXIDE, RESVERATROL-3-O-SULFATE, SULFATE ION, ... Authors: Florio, P, Foll, C, Cianci, M, Del Rio, D, Zanotti, G, Berni, R. Deposit date: 2015-03-05 Release date: 2015-10-21 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.388 Å) Cite: Transthyretin Binding Heterogeneity and Anti-Amyloidogenic Activity of Natural Polyphenols and Their Metabolites J.Biol.Chem., 290, 2015
5AKV	Transthyretin binding heterogeneity and anti-amyloidogenic activity of natural polyphenols and their metabolites: genistein-7-O- glucuronide Descriptor: Genistein-7-O-glucuronide, TRANSTHYRETIN Authors: Florio, P, Foll, C, Cianci, M, Del Rio, D, Zanotti, G, Berni, R. Deposit date: 2015-03-05 Release date: 2015-10-21 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.52 Å) Cite: Transthyretin Binding Heterogeneity and Anti-Amyloidogenic Activity of Natural Polyphenols and Their Metabolites J.Biol.Chem., 290, 2015
7ACU	Crystal structure of human transthyretin in complex with Benzbromarone Descriptor: Transthyretin, [3,5-bis(bromanyl)-4-oxidanyl-phenyl]-(2-ethyl-1-benzofuran-3-yl)methanone Authors: Leite, J.P, Gales, L. Deposit date: 2020-09-11 Release date: 2020-10-28 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.541 Å) Cite: Repurposing Benzbromarone for Familial Amyloid Polyneuropathy: A New Transthyretin Tetramer Stabilizer. Int J Mol Sci, 21, 2020
7ZIR	Cryo-EM structure of hnRNPDL amyloid fibrils Descriptor: Heterogeneous nuclear ribonucleoprotein D-like Authors: Garcia-Pardo, J, Chaves-Sanjuan, A, Bartolome-Nafria, A, Gil-Garcia, M, Visentin, C, Bolognesi, M, Ricagno, S, Ventura, S. Deposit date: 2022-04-08 Release date: 2022-12-28 Last modified: 2023-12-13 Method: ELECTRON MICROSCOPY (2.5 Å) Cite: Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid associated with limb-girdle muscular dystrophy D3. Nat Commun, 14, 2023
7THA	Crystal structure of human transthyretin variant C10A/M13V Descriptor: CALCIUM ION, Transthyretin Authors: Jaeger, M, Mortenson, D.E, Yan, N.L, Kelly, J.W. Deposit date: 2022-01-10 Release date: 2023-04-12 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Lysine carbamylation competes with urea unfolding of human transthyretin introducing kinetic heterogeneity To Be Published
6XTK	Y114C Transthyretin structure in complex with Tolcalpone Descriptor: Tolcapone, Transthyretin Authors: Varejao, N, Reverter, D, Pinheiro, F, Pallares, I, Ventura, S. Deposit date: 2020-01-16 Release date: 2020-05-13 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Tolcapone, a potent aggregation inhibitor for the treatment of familial leptomeningeal amyloidosis. Febs J., 288, 2021
3CN2	Human transthyretin (TTR) in complex with 3,5-Dibromo-4-hydroxybiphenyl Descriptor: 3,5-dibromobiphenyl-4-ol, Transthyretin Authors: Connelly, S, Wilson, I.A. Deposit date: 2008-03-24 Release date: 2008-10-28 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.52 Å) Cite: Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. J.Med.Chem., 51, 2008
3CFN	Crystal structure of human transthyretin in complex with 1-anilino-8-naphthalene sulfonate Descriptor: 8-ANILINO-1-NAPHTHALENE SULFONATE, Transthyretin Authors: Lima, L.-M.T.R, Foguel, D, Polikarpov, I. Deposit date: 2008-03-04 Release date: 2009-03-03 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.87 Å) Cite: Identification of a novel ligand binding motif in the transthyretin channel. Bioorg.Med.Chem., 18, 2010
9B1R	Functional implication of the homotrimeric multidomain vacuolar sorting receptor 1 from Arabidopsis thaliana Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Vacuolar-sorting receptor 1 Authors: Park, H, Youn, B, Park, D.J, Puthanveettil, S.V, Kang, C. Deposit date: 2024-03-13 Release date: 2024-05-15 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Functional implication of the homotrimeric multidomain vacuolar sorting receptor 1 (VSR1) from Arabidopsis thaliana. Sci Rep, 14, 2024
3CFT	Crystal structure of human transthyretin in complex with 1-amino-5-naphthalene sulfonate Descriptor: 5-aminonaphthalene-1-sulfonic acid, Transthyretin Authors: Lima, L.-M.T.R, Foguel, D, Polikarpov, I. Deposit date: 2008-03-04 Release date: 2009-03-03 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.87 Å) Cite: Identification of a novel ligand binding motif in the transthyretin channel. Bioorg.Med.Chem., 18, 2010
3CN0	Human transthyretin (TTR) in complex with 3,5-Dimethyl-4-hydroxystilbene Descriptor: 2,6-dimethyl-4-[(E)-2-phenylethenyl]phenol, Transthyretin Authors: Connelly, S, Wilson, I.A. Deposit date: 2008-03-24 Release date: 2008-10-28 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.52 Å) Cite: Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. J.Med.Chem., 51, 2008
7OB4	Cryo-EM structure of a twisted-dimer transthyretin amyloid fibril from vitreous body of the eye Descriptor: Transthyretin Authors: Iakovleva, I, Sauer-Eriksson, A.E. Deposit date: 2021-04-21 Release date: 2021-12-15 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (3.22 Å) Cite: Structural basis for transthyretin amyloid formation in vitreous body of the eye. Nat Commun, 12, 2021
3CFM	Crystal structure of the apo form of human wild-type transthyretin Descriptor: Transthyretin Authors: Lima, L.-M.T.R, Foguel, D, Polikarpov, I. Deposit date: 2008-03-04 Release date: 2009-03-03 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Identification of a novel ligand binding motif in the transthyretin channel. Bioorg.Med.Chem., 18, 2010
3D2T	Human transthyretin (ttr) complexed with diflunisal Descriptor: 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID, Transthyretin Authors: Palaninathan, S.K, Kelly, J.W, Sacchettini, J.C. Deposit date: 2008-05-08 Release date: 2008-05-20 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis. J.Med.Chem., 47, 2004
3CN1	Human transthyretin (TTR) in complex with 3,5-Dibromo-4-hydroxystilbene Descriptor: 2,6-dibromo-4-[(E)-2-phenylethenyl]phenol, Transthyretin Authors: Connelly, S, Wilson, I.A. Deposit date: 2008-03-24 Release date: 2008-10-28 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.52 Å) Cite: Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. J.Med.Chem., 51, 2008
3DGD	Crystal structure of the F87M/L110M mutant of human transthyretin at pH 4.6 Descriptor: ACETATE ION, GLYCEROL, Transthyretin, ... Authors: Palmieri, L.C, Freire, J.B.B, Foguel, D, Lima, L.M.T.R. Deposit date: 2008-06-13 Release date: 2008-07-22 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.383 Å) Cite: Novel Zn2+-binding sites in human transthyretin: implications for amyloidogenesis and retinol-binding protein recognition. J.Biol.Chem., 285, 2010

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