7MEW
 
 | | E. coli MsbA in complex with G247 | | Descriptor: | (2E)-3-{1-cyclopropyl-7-[(1S)-1-(3,6-dichloro-2-fluorophenyl)ethoxy]naphthalen-2-yl}prop-2-enoic acid, ATP-dependent lipid A-core flippase | | Authors: | Thelot, F, Liao, M. | | Deposit date: | 2021-04-08 | | Release date: | 2021-10-06 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Distinct allosteric mechanisms of first-generation MsbA inhibitors.
Science, 374, 2021
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7MET
 | | A. baumannii MsbA in complex with TBT1 decoupler | | Descriptor: | 2-(4-chlorobenzamido)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid, ATP-dependent lipid A-core flippase | | Authors: | Thelot, F, Liao, M. | | Deposit date: | 2021-04-07 | | Release date: | 2021-10-06 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.97 Å) | | Cite: | Distinct allosteric mechanisms of first-generation MsbA inhibitors.
Science, 374, 2021
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7MJP
 | | Vascular KATP channel: Kir6.1 SUR2B propeller-like conformation 2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Sung, M.W, Shyng, S.L. | | Deposit date: | 2021-04-20 | | Release date: | 2021-10-13 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Vascular K ATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7MJQ
 | | Vascular KATP channel: Kir6.1 SUR2B quatrefoil-like conformation 2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ATP-sensitive inward rectifier potassium channel 8, ... | | Authors: | Sung, M.W, Shyng, S.L. | | Deposit date: | 2021-04-20 | | Release date: | 2021-10-13 | | Last modified: | 2022-10-26 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Vascular K ATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7MJO
 | | Vascular KATP channel: Kir6.1 SUR2B quatrefoil-like conformation 1 | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ... | | Authors: | Sung, M.W, Shyng, S.L. | | Deposit date: | 2021-04-20 | | Release date: | 2021-10-13 | | Last modified: | 2022-10-26 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Vascular K ATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7M33
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7MPE
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7M69
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7M68
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8RQ4
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8RQ3
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8T46
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8PMD
 | | Nucleotide-bound BSEP in nanodiscs | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Bile salt export pump, MAGNESIUM ION | | Authors: | Liu, H, Irobalieva, R.N, Kowal, J, Ni, D, Nosol, K, Bang-Sorensen, R, Lancien, L, Stahlberg, H, Stieger, B, Locher, K.P. | | Deposit date: | 2023-06-28 | | Release date: | 2023-11-22 | | Method: | ELECTRON MICROSCOPY (2.95 Å) | | Cite: | Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP.
Nat Commun, 14, 2023
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8PMJ
 | | Vanadate-trapped BSEP in nanodiscs | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Bile salt export pump, ... | | Authors: | Liu, H, Irobalieva, R.N, Kowal, J, Ni, D, Nosol, K, Bang-Sorensen, R, Lancien, L, Stahlberg, H, Stieger, B, Locher, K.P. | | Deposit date: | 2023-06-28 | | Release date: | 2023-11-29 | | Method: | ELECTRON MICROSCOPY (2.81 Å) | | Cite: | Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP.
Nat Commun, 14, 2023
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8PEE
 | | ABCB1 L335C mutant (mABCB1) in the inward facing state bound to AAC | | Descriptor: | (4S,11S,18S)-4-[[(2,4-dinitrophenyl)disulfanyl]methyl]-11,18-dimethyl-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione, (4~{S},11~{S},18~{S})-4,11-dimethyl-18-(sulfanylmethyl)-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione, ATP-dependent translocase ABCB1, ... | | Authors: | Parey, K, Januliene, D, Gewering, T, Moeller, A. | | Deposit date: | 2023-06-13 | | Release date: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Tracing the substrate translocation mechanism in P-glycoprotein.
Elife, 12, 2024
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8SG4
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7MIT
 | | Vascular KATP channel: Kir6.1 SUR2B propeller-like conformation 1 | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ... | | Authors: | Sung, M.W, Shyng, S.L. | | Deposit date: | 2021-04-17 | | Release date: | 2021-10-13 | | Last modified: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Vascular K ATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides.
Proc.Natl.Acad.Sci.USA, 118, 2021
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8QOE
 | | Inward-facing conformation of the ABC transporter BmrA | | Descriptor: | Multidrug resistance ABC transporter ATP-binding/permease protein BmrA | | Authors: | Di Cesare, M, Kaplan, E, Valimehr, S, Hanssen, E, Orelle, C, Jault, J.M. | | Deposit date: | 2023-09-28 | | Release date: | 2023-12-20 | | Last modified: | 2024-01-24 | | Method: | ELECTRON MICROSCOPY (3.16 Å) | | Cite: | The transport activity of the multidrug ABC transporter BmrA does not require a wide separation of the nucleotide-binding domains.
J.Biol.Chem., 300, 2023
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8T1P
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8SZC
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8T3K
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8SX9
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8SX8
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8SXB
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8SX7
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