PDB: 234 件ウェブページステータス検索Chemie searchBIRD

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3VMK	3-isopropylmalate dehydrogenase from Shewanella benthica DB21 MT-2 分子名称: 3-ISOPROPYLMALIC ACID, 3-isopropylmalate dehydrogenase, CHLORIDE ION, ... 著者 Nagae, T, Watanabe, N. 登録日 2011-12-13 公開日 2012-02-29 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 Structural analysis of 3-isopropylmalate dehydrogenase from the obligate piezophile Shewanella benthica DB21MT-2 and the nonpiezophile Shewanella oneidensis MR-1 Acta Crystallogr.,Sect.F, 68, 2012
5I95	Crystal Structure of Human Mitochondrial Isocitrate Dehydrogenase R140Q Mutant Homodimer bound to NADPH and alpha-Ketoglutaric acid 分子名称: 2-OXOGLUTARIC ACID, ACETATE ION, CALCIUM ION, ... 著者 Zhang, B, Jin, L, Wu, W, Jiang, F, DeLaBarre, B, Travins, J.A, Padyana, A.K. 登録日 2016-02-19 公開日 2017-03-01 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations. Cancer Discov, 7, 2017
5I96	Crystal Structure of Human Mitochondrial Isocitrate Dehydrogenase (IDH2) R140Q Mutant Homodimer in Complex with AG-221 (Enasidenib) Inhibitor. 分子名称: 2-methyl-1-[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol, ACETATE ION, CALCIUM ION, ... 著者 Wei, W, Zhang, B, Jin, L, Jiang, F, DeLaBarre, B, Travins, J.A, Padyana, A.K. 登録日 2016-02-19 公開日 2017-03-08 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations. Cancer Discov, 7, 2017
3WZY	S266A mutant 3-isopropylmalate dehydrogenase from Shewanella oneidensis MR-1 at 580MPa - complex with IPM and Mg 分子名称: 3-ISOPROPYLMALIC ACID, 3-isopropylmalate dehydrogenase, MAGNESIUM ION 著者 Nagae, T, Watanabe, N. 登録日 2014-10-08 公開日 2015-10-14 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Pressure Adaptation of 3-Isopropylmalate Dehydrogenase from the Extremely Piezophilic Bacterium Shewanella benthica is Attributed to just One Amino Acid Substitution To be Published
4JA8	Complex of Mitochondrial Isocitrate Dehydrogenase R140Q Mutant with AGI-6780 Inhibitor 分子名称: 1-[5-(cyclopropylsulfamoyl)-2-thiophen-3-yl-phenyl]-3-[3-(trifluoromethyl)phenyl]urea, CALCIUM ION, GLYCEROL, ... 著者 Wei, W, Chen, L, Wu, M, Jiang, F, Travins, J, Qian, K, DeLaBarre, B. 登録日 2013-02-18 公開日 2013-04-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science, 340, 2013
1HQS	CRYSTAL STRUCTURE OF ISOCITRATE DEHYDROGENASE FROM BACILLUS SUBTILIS 分子名称: CITRIC ACID, ISOCITRATE DEHYDROGENASE, R-1,2-PROPANEDIOL, ... 著者 Singh, S.K, Matsuno, K, LaPorte, D.C, Banaszak, L.J. 登録日 2000-12-19 公開日 2001-07-25 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Crystal structure of Bacillus subtilis isocitrate dehydrogenase at 1.55 A. Insights into the nature of substrate specificity exhibited by Escherichia coli isocitrate dehydrogenase kinase/phosphatase. J.Biol.Chem., 276, 2001
3TY4	Crystal structure of homoisocitrate dehydrogenase from Schizosaccharomyces pombe 分子名称: GLYCEROL, Probable homoisocitrate dehydrogenase 著者 Bulfer, S.L, Hendershot, J.M, Trievel, R.C. 登録日 2011-09-23 公開日 2011-11-09 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Crystal structure of homoisocitrate dehydrogenase from Schizosaccharomyces pombe. Proteins, 80, 2012
3VMJ	3-isopropylmalate dehydrogenase from Shewanella oneidensis MR-1 分子名称: 3-ISOPROPYLMALIC ACID, 3-isopropylmalate dehydrogenase, CHLORIDE ION, ... 著者 Nagae, T, Watanabe, N. 登録日 2011-12-13 公開日 2012-02-29 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 Structural analysis of 3-isopropylmalate dehydrogenase from the obligate piezophile Shewanella benthica DB21MT-2 and the nonpiezophile Shewanella oneidensis MR-1 Acta Crystallogr.,Sect.F, 68, 2012
3VML	Chimera 3-isopropylmalate dehydrogenase between Shewanella oneidensis MR-1 (O) and Shewanella benthica DB21 MT-2 (M) from N-terminal: 20% O middle 70% M residual 10% O 分子名称: 3-ISOPROPYLMALIC ACID, 3-isopropylmalate dehydrogenase, CHLORIDE ION, ... 著者 Nagae, T, Watanabe, N. 登録日 2011-12-13 公開日 2012-12-26 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 Structure analysis of chimeric 3-isopropylmalate dehydrogenase between the obligate piezophile Shewanella benthica DB21MT-2 and the nonpiezophile Shewanella oneidensis MR-1 To be Published
6LTF	Dimeric isocitrate dehydrogenase from Xanthomonas campestris pv. campestris 8004 分子名称: BENZOIC ACID, Isocitrate dehydrogenase 著者 Zhu, G.P. 登録日 2020-01-22 公開日 2021-02-10 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 Dimeric isocitrate dehydrogenase from Xanthomonas campestris pv. campestris 8004 To Be Published
3DMS	1.65A crystal structure of isocitrate dehydrogenase from Burkholderia pseudomallei 分子名称: Isocitrate dehydrogenase [NADP] 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2008-07-01 公開日 2008-07-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structural basis of the substrate specificity of bifunctional isocitrate dehydrogenase kinase/phosphatase. Biochemistry, 50, 2011
1W0D	The high resolution structure of Mycobacterium tuberculosis LeuB (Rv2995c) 分子名称: 3-ISOPROPYLMALATE DEHYDROGENASE, SULFATE ION 著者 Singh, R.K, Kefala, G, Janowski, R, Mueller-Dieckmann, C, Weiss, M.S, TB Structural Genomics Consortium (TBSGC) 登録日 2004-06-03 公開日 2004-12-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 The High Resolution Structure of Leub (Rv2995C) from Mycobacterium Tuberculosis J.Mol.Biol., 346, 2005
6BKX	Novel Modes of Inhibition of Wild-Type IDH1: Direct Covalent Modification of His315 with Cmpd1 分子名称: (6aS,7S,9R,10aS)-7,10a-dimethyl-8-oxo-2-(phenylamino)-5,6,6a,7,8,9,10,10a-octahydrobenzo[h]quinazoline-9-carbonitrile, CALCIUM ION, ISOCITRIC ACID, ... 著者 Jakob, C.G, Qiu, W. 登録日 2017-11-09 公開日 2018-07-25 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315. J. Med. Chem., 61, 2018
5HN3	Crystal structure of beta-decarboxylating dehydrogenase (TK0280) from Thermococcus kodakarensis (apo form) 分子名称: Homoisocitrate dehydrogenase, IMIDAZOLE, SODIUM ION 著者 Shimizu, T, Tomita, T, Nishiyama, M. 登録日 2016-01-18 公開日 2016-12-07 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure and function of an ancestral-type beta-decarboxylating dehydrogenase from Thermococcus kodakarensis Biochem. J., 474, 2017
1PB1	A four location model to explain the stereospecificity of proteins. 分子名称: GLYCEROL, ISOCITRIC ACID, Isocitrate dehydrogenase [NADP], ... 著者 Mesecar, A.D, Koshland Jr, D.E. 登録日 2003-05-14 公開日 2003-06-17 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural Biology: A New Model for Protein Stereospecificity. Nature, 403, 2000
1PB3	Sites of binding and orientation in a four location model for protein stereospecificity. 分子名称: GLYCEROL, Isocitrate dehydrogenase [NADP], SULFATE ION 著者 Mesecar, A.D, Koshland Jr, D.E. 登録日 2003-05-14 公開日 2003-06-17 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Sites of Binding and Orientation in a Four-Location Model for Protein Stereospecificity. IUBMB Life, 49, 2000
4XXV	Crystal structure of 3-isopropylmalate dehydrogenase from Burkholderia thailandensis in complex with NAD 分子名称: 3-isopropylmalate dehydrogenase, GLYCEROL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2015-01-31 公開日 2015-02-25 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of 3-isopropylmalate dehydrogenase from Burkholderia thailandensis in complex with NAD to be published
6C0E	Crystal Structure of Isocitrate Dehydrogenase from Legionella pneumophila with bound NADPH with an alpha-ketoglutarate adduct 分子名称: (3~{S})-3-[(4~{S})-3-aminocarbonyl-1-[(2~{R},3~{R},4~{S},5~{R})-5-[[[[(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-3,4-bis(oxidanyl)oxolan-2-yl]-4~{H}-pyridin-4-yl]-2-oxidanylidene-pentanedioic acid, CHLORIDE ION, GLYCINE, ... 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2017-12-29 公開日 2018-02-07 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal Structure of Isocitrate Dehydrogenase from Legionella pneumophila with bound NADPH with an ??-ketoglutarate adduct to be published
8KIB	NADP+-dependent cytosolic isocitrate dehydrogenase complexed with oxaloacetate 分子名称: ISOPROPYL ALCOHOL, Isocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Kang, B.S, Cho, H.Y. 登録日 2023-08-23 公開日 2024-09-04 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 NADP+-dependent cytosolic isocitrate dehydrogenase complexed with oxaloacetate To Be Published
6IXL	Crystal structure of isocitrate dehydrogenase from Ostreococcus tauri 分子名称: GLYCEROL, Isocitrate dehydrogenase, SULFATE ION 著者 Zhu, G.P, Tang, W.G, Wang, P. 登録日 2018-12-11 公開日 2019-12-18 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Crystal structures of NAD + -linked isocitrate dehydrogenase from the green alga Ostreococcus tauri and its evolutionary relationship with eukaryotic NADP + -linked homologs. Arch.Biochem.Biophys., 708, 2021
2UXQ	Isocitrate dehydrogenase from the psychrophilic bacterium Desulfotalea psychrophila: biochemical properties and crystal structure analysis 分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, ISOCITRATE DEHYDROGENASE NATIVE, ... 著者 Fedoy, A.-E, Yang, N, Martinez, A, Leiros, H.-K.S, Steen, I.H. 登録日 2007-03-29 公開日 2008-02-05 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structural and Functional Properties of Isocitrate Dehydrogenase from the Psychrophilic Bacterium Desulfotalea Psychrophila Reveal a Cold -Active Enzyme with an Unusual High Thermal J.Mol.Biol., 372, 2007
4IWH	Crystal structure of a 3-isopropylmalate dehydrogenase from Burkholderia pseudomallei 分子名称: 3-isopropylmalate dehydrogenase, MAGNESIUM ION 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2013-01-23 公開日 2013-02-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Crystal structure of a 3-isopropylmalate dehydrogenase from Burkholderia pseudomallei TO BE PUBLISHED
1CNZ	3-ISOPROPYLMALATE DEHYDROGENASE (IPMDH) FROM SALMONELLA TYPHIMURIUM 分子名称: MANGANESE (II) ION, PROTEIN (3-ISOPROPYLMALATE DEHYDROGENASE), SULFATE ION 著者 Wallon, G, Kryger, G, Lovett, S.T, Oshima, T, Ringe, D, Petsko, G.A. 登録日 1999-05-24 公開日 1999-06-01 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Crystal Structures of Eschericia Coli and Salmonella Typhimurium 3- Isopropylmalate Dehydrogenase and Comparison with Their Thermophilic Counterpart from Thermus Thermophilus J.Mol.Biol., 266, 1997
8W49	mouse isocitrate dehydrogenase with isocitrate and magnesium 分子名称: ISOCITRIC ACID, ISOPROPYL ALCOHOL, Isocitrate dehydrogenase [NADP] cytoplasmic, ... 著者 Kang, B.S, Cho, H.Y. 登録日 2023-08-23 公開日 2024-09-04 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 mouse isocitrate dehydrogenase with isocitrate and magnesium To Be Published
6IXT	Crystal structure of isocitrate dehydrogenase from Ostreococcus tauri in complex with NAD+ and Mg2+ 分子名称: GLYCEROL, Isocitrate dehydrogenase, MAGNESIUM ION, ... 著者 Zhu, G.P, Tang, W.G, Wang, P. 登録日 2018-12-12 公開日 2019-12-18 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Crystal structures of NAD + -linked isocitrate dehydrogenase from the green alga Ostreococcus tauri and its evolutionary relationship with eukaryotic NADP + -linked homologs. Arch.Biochem.Biophys., 708, 2021

 

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