1NAU
| NMR Solution Structure of the Glucagon Antagonist [desHis1, desPhe6, Glu9]Glucagon Amide in the Presence of Perdeuterated Dodecylphosphocholine Micelles | 分子名称: | Glucagon | 著者 | Ying, J, Ahn, J.-M, Jacobsen, N.E, Brown, M.F, Hruby, V.J. | 登録日 | 2002-11-28 | 公開日 | 2003-03-18 | 最終更新日 | 2021-10-27 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR Solution Structure of the Glucagon Antagonist [desHis1, desPhe6, Glu9]Glucagon Amide in the Presence of Perdeuterated Dodecylphosphocholine Micelles Biochemistry, 42, 2003
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6NZN
| Dimer-of-dimer amyloid fibril structure of glucagon | 分子名称: | Glucagon | 著者 | Gelenter, M.D, Smith, K.J, Liao, S.Y, Mandala, V.S, Dregni, A.J, Lamm, M.S, Tian, Y, Wei, X, Pochan, D.J, Tucker, T.J, Su, Y, Hong, M. | 登録日 | 2019-02-14 | 公開日 | 2019-06-05 | 最終更新日 | 2024-05-15 | 実験手法 | SOLID-STATE NMR | 主引用文献 | The peptide hormone glucagon forms amyloid fibrils with two coexisting beta-strand conformations. Nat.Struct.Mol.Biol., 26, 2019
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7D68
| Cryo-EM structure of the human glucagon-like peptide-2 receptor-Gs protein complex | 分子名称: | Glucagon-like peptide 2 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Sun, W, Chen, L, Zhou, Q, Zhao, L, Zhang, H, Cong, Z, Shen, D, Zhao, F, Zhou, F, Cai, X, Chen, Y, Zhou, Y, Gadgaard, S, van der Velden, W.J, Zhao, S, Jiang, Y, Rosenkilde, M.M, Yang, D, Xu, H.E, Zhang, Y, Wang, M. | 登録日 | 2020-09-29 | 公開日 | 2020-12-16 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor. Cell Res., 30, 2020
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1BH0
| STRUCTURE OF A GLUCAGON ANALOG | 分子名称: | GLUCAGON | 著者 | Sturm, N.S, Lin, Y, Burley, S.K, Krstenansky, J.L, Ahn, J.-M, Azizeh, B.Y, Trivedi, D, Hruby, V.J. | 登録日 | 1998-06-11 | 公開日 | 1998-11-04 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structure-function studies on positions 17, 18, and 21 replacement analogues of glucagon: the importance of charged residues and salt bridges in glucagon biological activity. J.Med.Chem., 41, 1998
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1GCN
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1KX6
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3IOL
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6LMK
| Cryo-EM structure of the human glucagon receptor in complex with Gs | 分子名称: | Glucagon, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Qiao, A, Han, S, Tai, L, Sun, F, Zhao, Q, Wu, B. | 登録日 | 2019-12-26 | 公開日 | 2020-04-01 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural basis of Gsand Girecognition by the human glucagon receptor. Science, 367, 2020
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6LML
| Cryo-EM structure of the human glucagon receptor in complex with Gi1 | 分子名称: | Glucagon, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Qiao, A, Han, S, Li, X, Sun, F, Zhao, Q, Wu, B. | 登録日 | 2019-12-26 | 公開日 | 2020-04-01 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structural basis of Gsand Girecognition by the human glucagon receptor. Science, 367, 2020
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5EE7
| Crystal structure of the human glucagon receptor (GCGR) in complex with the antagonist MK-0893 | 分子名称: | 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, 3-[[4-[(1~{S})-1-[3-[3,5-bis(chloranyl)phenyl]-5-(6-methoxynaphthalen-2-yl)pyrazol-1-yl]ethyl]phenyl]carbonylamino]propanoic acid, Glucagon receptor,Endolysin,Glucagon receptor, ... | 著者 | Jazayeri, A, Dore, A.S, Lamb, D, Krishnamurthy, H, Southall, S.M, Baig, A.H, Bortolato, A, Koglin, M, Robertson, N.J, Errey, J.C, Andrews, S.P, Brown, A.J.H, Cooke, R.M, Weir, M, Marshall, F.H. | 登録日 | 2015-10-22 | 公開日 | 2016-04-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Extra-helical binding site of a glucagon receptor antagonist. Nature, 533, 2016
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7RTB
| Peptide-19 bound to the Glucagon-Like Peptide-1 Receptor (GLP-1R) | 分子名称: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Johnson, R.M, Danev, R, Sexton, P.M, Wootten, D. | 登録日 | 2021-08-12 | 公開日 | 2021-10-06 | 実験手法 | ELECTRON MICROSCOPY (2.14 Å) | 主引用文献 | Cryo-EM structure of the dual incretin receptor agonist, peptide-19, in complex with the glucagon-like peptide-1 receptor. Biochem.Biophys.Res.Commun., 578, 2021
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7XM8
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5E94
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5YQZ
| Structure of the glucagon receptor in complex with a glucagon analogue | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glucagon analogue, ... | 著者 | Zhang, H, Qiao, A, Yang, L, VAN EPS, N, Frederiksen, K, Yang, D, Dai, A, Cai, X, Zhang, H, Yi, C, Can, C, He, L, Yang, H, Lau, J, Ernst, O, Hanson, M, Stevens, R, Wang, M, Seedtz-Runge, S, Jiang, H, Zhao, Q, Wu, B. | 登録日 | 2017-11-08 | 公開日 | 2018-01-17 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structure of the glucagon receptor in complex with a glucagon analogue. Nature, 553, 2018
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5XF1
| Structure of the Full-length glucagon class B G protein-coupled receptor | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhang, H, Qiao, A, Yang, D, Yang, L, Dai, A, de Graaf, C, Reedtz-Runge, S, Dharmarajan, V, Zhang, H, Han, G.W, Grant, T, Sierra, R, Weierstall, U, Nelson, G, Liu, W, Wu, Y, Ma, L, Cai, X, Lin, G, Wu, X, Geng, Z, Dong, Y, Song, G, Griffin, P, Lau, J, Cherezov, V, Yang, H, Hanson, M, Stevens, R, Jiang, H, Wang, M, Zhao, Q, Wu, B. | 登録日 | 2017-04-06 | 公開日 | 2017-05-24 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | 主引用文献 | Structure of the full-length glucagon class B G-protein-coupled receptor. Nature, 546, 2017
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8JRV
| Cryo-EM structure of the glucagon receptor bound to glucagon and beta-arrestin 1 | 分子名称: | Beta-arrestin 1 and single-chain fragment variable 30 (scFv30), Glucagon, HA signal peptide,HPC4 purification tag,Glucagon receptor,C-terminal tail of Vasopressin V2 receptor, ... | 著者 | Chen, K, Zhang, C, Lin, S, Zhao, Q, Wu, B. | 登録日 | 2023-06-17 | 公開日 | 2023-08-16 | 最終更新日 | 2023-09-13 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Tail engagement of arrestin at the glucagon receptor. Nature, 620, 2023
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6WHC
| CryoEM Structure of the glucagon receptor with a dual-agonist peptide | 分子名称: | Dual-agonist peptide, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Belousoff, M.J, Sexton, P, Danev, R. | 登録日 | 2020-04-07 | 公開日 | 2020-05-27 | 最終更新日 | 2020-07-22 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide. J.Biol.Chem., 295, 2020
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5XEZ
| Structure of the Full-length glucagon class B G protein-coupled receptor | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-{[(4-cyclohexylphenyl){[3-(methylsulfonyl)phenyl]carbamoyl}amino]methyl}-N-(1H-tetrazol-5-yl)benzamide, ... | 著者 | Zhang, H, Qiao, A, Yang, D, Yang, L, Dai, A, de Graaf, C, Reedtz-Runge, S, Dharmarajan, V, Zhang, H, Han, G.W, Grant, T, Sierra, R, Weierstall, U, Nelson, G, Liu, W, Wu, Y, Ma, L, Cai, X, Lin, G, Wu, X, Geng, Z, Dong, Y, Song, G, Griffin, P, Lau, J, Cherezov, V, Yang, H, Hanson, M, Stevens, R, Jiang, H, Wang, M, Zhao, Q, Wu, B. | 登録日 | 2017-04-06 | 公開日 | 2017-05-24 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structure of the full-length glucagon class B G-protein-coupled receptor. Nature, 546, 2017
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3C59
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8JRU
| Cryo-EM structure of the glucagon receptor bound to beta-arrestin 1 in ligand-free state | 分子名称: | Beta-arrestin 1 and single-chain fragment variable 30 (scFv30), HA signal peptide,HPC4 purification tag,Glucagon receptor,C-terminal tail of Vasopressin V2 receptor, Nanobody 32, ... | 著者 | Chen, K, Zhang, C, Lin, S, Zhao, Q, Wu, B. | 登録日 | 2023-06-17 | 公開日 | 2023-08-16 | 最終更新日 | 2023-09-13 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Tail engagement of arrestin at the glucagon receptor. Nature, 620, 2023
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3C5T
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4ERS
| A Molecular Basis for Negative Regulation of the Glucagon Receptor | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab heavy chain, Fab light chain, ... | 著者 | Murray, J.M, Koth, C.M, Mukund, S. | 登録日 | 2012-04-20 | 公開日 | 2012-08-29 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.637 Å) | 主引用文献 | Molecular basis for negative regulation of the glucagon receptor. Proc.Natl.Acad.Sci.USA, 109, 2012
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4L6R
| Structure of the class B human glucagon G protein coupled receptor | 分子名称: | DI(HYDROXYETHYL)ETHER, Soluble cytochrome b562 and Glucagon receptor chimera | 著者 | Siu, F.Y, He, M, de Graaf, C, Han, G.W, Yang, D, Zhang, Z, Zhou, C, Xu, Q, Wacker, D, Joseph, J.S, Liu, W, Lau, J, Cherezov, V, Katritch, V, Wang, M.W, Stevens, R.C, GPCR Network (GPCR) | 登録日 | 2013-06-12 | 公開日 | 2013-07-24 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structure of the human glucagon class B G-protein-coupled receptor. Nature, 499, 2013
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2L63
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2L64
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