PDB: 30867 件ウェブページステータス検索Chemie searchBIRD

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8TOO	Crystal structure of Epstein-Barr virus gp42 in complex with antibody 4C12 分子名称: 4C12 heavy chain, 4C12 light chain, Glycoprotein 42 著者 Bu, W, Kumar, A, Board, N, Kim, J, Dowdell, K, Zhang, S, Lei, Y, Hostal, A, Krogmann, T, Wang, Y, Pittaluga, S, Marcotrigiano, J, Cohen, J.I. 登録日 2023-08-03 公開日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Epstein-Barr virus gp42 antibodies reveal sites of vulnerability for receptor binding and fusion to B cells. Immunity, 57, 2024
7R2E	Structure of human Senp7 with SUMO2 分子名称: Sentrin-specific protease 7, Small ubiquitin-related modifier 3, prop-2-en-1-amine 著者 Reverter, D, Li, Y. 登録日 2022-02-04 公開日 2022-12-07 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Structural Basis for the SUMO2 Isoform Specificity of SENP7. J.Mol.Biol., 434, 2022
7M5U	Crystal structure of human MPP8 chromodomain in complex with peptidomimetic ligand UNC5246 分子名称: M-phase phosphoprotein 8, UNC5246 著者 Budziszewski, G.R, McGinty, R.K, Waybright, J.M, Norris, J.L, James, L.I. 登録日 2021-03-24 公開日 2021-09-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 A Peptidomimetic Ligand Targeting the Chromodomain of MPP8 Reveals HRP2's Association with the HUSH Complex. Acs Chem.Biol., 16, 2021
6DNO	Crystal structure of Protein Phosphatase 1 (PP1) bound to the muscle glycogen-targeting subunit (Gm) 分子名称: Microcystin-LR, Protein phosphatase 1 regulatory subunit 3A, Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 著者 Choy, M.S, Kumar, G.S, Peti, W, Page, R. 登録日 2018-06-07 公開日 2019-01-23 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Identification of the substrate recruitment mechanism of the muscle glycogen protein phosphatase 1 holoenzyme. Sci Adv, 4, 2018
8BOL	X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with an inhibitor P18 分子名称: (2~{S})-2-[[(2~{S})-1-oxidanyl-1-oxidanylidene-6-[[(~{E},2~{S})-5-phenyl-2-[[4-[[2-[4,7,10-tris(2-hydroxy-2-oxoethyl)-1,4,7,10-tetrazacyclododec-1-yl]ethanoylamino]methyl]cyclohexyl]carbonylamino]pent-4-enoyl]amino]hexan-2-yl]carbamoylamino]pentanedioic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Motlova, L, Barinka, C, Benesova, M. 登録日 2022-11-15 公開日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with an inhibitor P18 To Be Published
6FTQ	Crystal structure of human beta-ureidopropionase (beta-alanine synthase) - mutant T299C 分子名称: Beta-ureidopropionase 著者 Dobritzsch, D, Maurer, D. 登録日 2018-02-23 公開日 2018-11-21 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Crystal structure and pH-dependent allosteric regulation of human beta-ureidopropionase, an enzyme involved in anticancer drug metabolism. Biochem. J., 475, 2018
5VGY	Identification of a New Zinc Binding Chemotype by Fragment Screening 分子名称: (5S)-5-[(2,4-dimethoxyphenyl)methyl]-5-hydroxy-2-sulfanylideneimidazolidin-4-one, Carbonic anhydrase 2, SODIUM ION, ... 著者 Peat, T.S. 登録日 2017-04-11 公開日 2017-08-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.39 Å) 主引用文献 Identification of a New Zinc Binding Chemotype by Fragment Screening. J. Med. Chem., 60, 2017
7R3G	PROSS optimitzed variant of RhlR (75 mutations) in complex with the synthetic antagonist mBTL 分子名称: 4-(3-bromophenoxy)-N-[(3S)-2-oxothiolan-3-yl]butanamide, Regulatory protein RhlR 著者 Henke, S, Blankenfeldt, W. 登録日 2022-02-07 公開日 2022-12-14 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Moonlighting chaperone activity of the enzyme PqsE contributes to RhlR-controlled virulence of Pseudomonas aeruginosa. Nat Commun, 13, 2022
8BJY	Engineered Fructosyl Peptide Oxidase - X02B mutant 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Fructosyl Peptide Oxidase mutant (X02B), GLYCEROL 著者 Estiri, H, Bhattacharya, S, Rodriguez-Buitrago, J.A, Parisini, E. 登録日 2022-11-08 公開日 2023-11-22 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.475 Å) 主引用文献 Tailoring FPOX enzymes for enhanced stability and expanded substrate recognition. Sci Rep, 13, 2023
6DTE	GlcNAc-inspired cyclophellitol bound to NagZ 分子名称: 2,2,2-trifluoro-N-[(1R,2R,3R,4R,5R,6R)-2,3,5,6-tetrahydroxy-4-(hydroxymethyl)cyclohexyl]acetamide, Beta-hexosaminidase 著者 Mark, B.L, Winogrodzki, J.L. 登録日 2018-06-15 公開日 2019-04-24 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.929 Å) 主引用文献 A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to beta-lactams in Pseudomonas aeruginosa. Chem. Commun. (Camb.), 54, 2018
6DPD	Crystal Structure of Bacillus Halodurans Ribonuclease H1 in Complex with an RNA/DNA Hybrid: Reaction in 16 mM Mn2+ and 200 mM K+ for 40 s at 21 C 分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*CP*GP*AP*TP*GP*T)-3'), GLYCEROL, ... 著者 Samara, N.L, Yang, W. 登録日 2018-06-09 公開日 2018-08-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 Cation trafficking propels RNA hydrolysis. Nat. Struct. Mol. Biol., 25, 2018
8BLX	Engineered Fructosyl Peptide Oxidase - X02A mutant 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, Fructosyl Peptide Oxidase mutant (X02A), ... 著者 Estiri, H, Bhattacharya, S, Rodriguez-Buitrago, J.A, Parisini, E. 登録日 2022-11-10 公開日 2023-11-22 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Tailoring FPOX enzymes for enhanced stability and expanded substrate recognition. Sci Rep, 13, 2023
8BO8	X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with an inhibitor P17 分子名称: (2~{S})-2-[[(2~{S})-1-oxidanyl-1-oxidanylidene-6-[[(~{E},2~{S})-5-phenyl-2-[[4-[[2-[4,7,10-tris(2-hydroxy-2-oxoethyl)-1,4,7,10-tetrazacyclododec-1-yl]ethanoylamino]methyl]cyclohexyl]carbonylamino]pent-4-enoyl]amino]hexan-2-yl]carbamoylamino]pentanedioic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Motlova, L, Barinka, C, Benesova, M. 登録日 2022-11-15 公開日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with an inhibitor P17 To Be Published
6FVI	ASH / PapD-like domain of human CEP192 (PapD-like domain 7) 分子名称: CHLORIDE ION, Centrosomal protein of 192 kDa 著者 Kovalevskiy, O.V, van Breugel, M. 登録日 2018-03-02 公開日 2019-03-20 実験手法 X-RAY DIFFRACTION (1 Å) 主引用文献 ASH / PapD-like domain of human CEP192 (PapD-like domain 7) To Be Published
8BQ7	Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH2829 分子名称: GLYCEROL, N-glycosylase/DNA lyase, NICKEL (II) ION, ... 著者 Scaletti, E, Stenmark, P. 登録日 2022-11-19 公開日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH2829 To Be Published
6KAV	Carbonmonoxy human hemoglobin A in the R2 quaternary structure at 140 K: Light 分子名称: CARBON MONOXIDE, Hemoglobin subunit alpha, Hemoglobin subunit beta, ... 著者 Shibayama, N, Park, S.Y, Ohki, M, Sato-Tomita, A. 登録日 2019-06-24 公開日 2020-02-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Direct observation of ligand migration within human hemoglobin at work. Proc.Natl.Acad.Sci.USA, 117, 2020
6DQQ	Crystal structure of Haemophilus influenzae OppA complex with endogenous peptide 分子名称: ACETATE ION, ALA-ALA-ALA-ALA, Periplasmic oligopeptide-binding protein, ... 著者 Tanaka, K.J, Pinkett, H.W. 登録日 2018-06-11 公開日 2018-11-28 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Oligopeptide-binding protein from nontypeableHaemophilus influenzaehas ligand-specific sites to accommodate peptides and heme in the binding pocket. J. Biol. Chem., 294, 2019
8BNB	Crystal structure of Trichoplax Scribble PDZ2 domain 分子名称: Leucine-rich repeat-containing protein 1 著者 Maddumage, J.C, Kvansakul, M. 登録日 2022-11-14 公開日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 Crystal structure of Trichoplax Scribble PDZ2 domain To be published
6KB2	X-ray structure of human PPARalpha ligand binding domain-Wy14643 co-crystals obtained by soaking 分子名称: 2-({4-CHLORO-6-[(2,3-DIMETHYLPHENYL)AMINO]PYRIMIDIN-2-YL}SULFANYL)ACETIC ACID, Peroxisome proliferator-activated receptor alpha 著者 Kamata, S, Suda, K, Saito, K, Oyama, T, Ishii, I. 登録日 2019-06-24 公開日 2020-11-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates. Iscience, 23, 2020
8TR4	Crystal Structure of Mtb Pks13 Thioesterase domain in complex with inhibitor X20404 分子名称: 4-(2-{(4M)-4-[(6M)-6-(2,5-dimethoxyphenyl)pyridin-3-yl]-1H-1,2,3-triazol-1-yl}ethyl)-N,N-dimethylbenzamide, Polyketide synthase Pks13, SULFATE ION 著者 Krieger, I.V, Sacchettini, J.C. 登録日 2023-08-09 公開日 2024-04-24 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Inhibitors of the Thioesterase Activity of Mycobacterium tuberculosis Pks13 Discovered Using DNA-Encoded Chemical Library Screening. Acs Infect Dis., 10, 2024
5VDR	Human cyclic GMP-AMP synthase (cGAS) in complex with 3',3'-cdIMP 分子名称: 3',3'-cdIMP, Cyclic GMP-AMP synthase, ZINC ION 著者 Byrnes, L.J, Hall, J.D. 登録日 2017-04-03 公開日 2017-09-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.042 Å) 主引用文献 The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition. Protein Sci., 26, 2017
8BMU	Engineered Fructosyl Peptide Oxidase - X04 mutant 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, Fructosyl Peptide Oxidase mutant (X04), ... 著者 Estiri, H, Bhattacharya, S, Rodriguez-Buitrago, J.A, Parisini, E. 登録日 2022-11-11 公開日 2023-11-22 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Tailoring FPOX enzymes for enhanced stability and expanded substrate recognition. Sci Rep, 13, 2023
6KB9	X-ray structure of human PPARalpha ligand binding domain-pemafibrate co-crystals obtained by cross-seeding 分子名称: (2~{R})-2-[3-[[1,3-benzoxazol-2-yl-[3-(4-methoxyphenoxy)propyl]amino]methyl]phenoxy]butanoic acid, GLYCEROL, Peroxisome proliferator-activated receptor alpha 著者 Kamata, S, Saito, K, Honda, A, Ishikawa, R, Oyama, T, Ishii, I. 登録日 2019-06-24 公開日 2020-11-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates. Iscience, 23, 2020
6FXR	Crystal Structure of full-length Human Lysyl Hydroxylase LH3 - Cocrystal with Fe2+, Mn2+, UDP-Gal 分子名称: 2-OXOGLUTARIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Scietti, L, Chiapparino, A, De Giorgi, F, Fumagalli, M, Khoriauli, L, Nergadze, S, Basu, S, Olieric, V, Banushi, B, Giulotto, E, Gissen, P, Forneris, F. 登録日 2018-03-09 公開日 2018-08-22 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3. Nat Commun, 9, 2018
8BOS	Transition state analogue complex of small G protein and its GAP effector 分子名称: GTPase HRas, GUANIDINE, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Baumann, P, Jin, Y. 登録日 2022-11-15 公開日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 A small G protein with MgF3 TSA complex To Be Published

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