PDB: 30867 件ウェブページステータス検索Chemie searchBIRD

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7RPD	X-ray crystal structure of OXA-24/40 V130D in complex with ertapenem 分子名称: (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, BICARBONATE ION, Beta-lactamase, ... 著者 Powers, R.A, Mitchell, J.M, June, C.M. 登録日 2021-08-03 公開日 2022-07-06 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Conformational flexibility in carbapenem hydrolysis drives substrate specificity of the class D carbapenemase OXA-24/40. J.Biol.Chem., 298, 2022
5U6U	The crystal structure of 4-ethylthiobenzoate-bound CYP199A4 分子名称: 4-(ethylsulfanyl)benzoic acid, CHLORIDE ION, Cytochrome P450, ... 著者 Coleman, T, Bruning, J.B, Bell, S.G. 登録日 2016-12-08 公開日 2018-06-13 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.786 Å) 主引用文献 Cytochrome P450 CYP199A4 from Rhodopseudomonas palustris Catalyzes Heteroatom Dealkylations, Sulfoxidation, and Amide and Cyclic Hemiacetal Formation Acs Catalysis, 8, 2018
7A1Z	Crystal structure of human protein kinase CK2alpha' (CSNK2A2 gene product) in complex with the ATP-competitive inhibitor 6-bromo-5-chloro-1H-triazolo[4,5-b]pyridine 分子名称: 1,2-ETHANEDIOL, 6-bromanyl-5-chloranyl-1~{H}-[1,2,3]triazolo[4,5-b]pyridine, CHLORIDE ION, ... 著者 Niefind, K, Lindenblatt, D, Toelzer, C, Bretner, M, Chojnacki, K, Wielechowska, M, Winska, P. 登録日 2020-08-14 公開日 2020-12-09 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.024 Å) 主引用文献 Synthesis, biological properties and structural study of new halogenated azolo[4,5-b]pyridines as inhibitors of CK2 kinase. Bioorg.Chem., 106, 2021
5HNL	In-house X-ray single crystal diffraction from protein microcrystals via magnetically oriented microcrystal arrays in gels 分子名称: Lysozyme C 著者 Tsukui, S, Kimura, F, Kusaka, K, Baba, S, Mizuno, N, Kimura, T. 登録日 2016-01-18 公開日 2016-07-20 実験手法 X-RAY DIFFRACTION (2.424 Å) 主引用文献 Neutron and X-ray single-crystal diffraction from protein microcrystals via magnetically oriented microcrystal arrays in gels. Acta Crystallogr D Struct Biol, 72, 2016
7RPE	X-ray crystal structure of OXA-24/40 in complex with ertapenem 分子名称: (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, BICARBONATE ION, Beta-lactamase, ... 著者 Powers, R.A, Mitchell, J.M, June, C.M. 登録日 2021-08-03 公開日 2022-07-06 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Conformational flexibility in carbapenem hydrolysis drives substrate specificity of the class D carbapenemase OXA-24/40. J.Biol.Chem., 298, 2022
6CE6	Structure of HDAC6 zinc-finger ubiquitin binding domain soaked with 3,3'-(benzo[1,2-d:5,4-d']bis(thiazole)-2,6-diyl)dipropionic acid 分子名称: 3,3'-(benzo[1,2-d:5,4-d']bis[1,3]thiazole-2,6-diyl)dipropanoic acid, Histone deacetylase 6, UNKNOWN ATOM OR ION, ... 著者 Harding, R.J, Halabelian, L, Ferreira de Freitas, R, Ravichandran, M, Santhakumar, V, Schapira, M, Bountra, C, Edwards, A.M, Arrowsmith, C.M, Structural Genomics Consortium (SGC) 登録日 2018-02-11 公開日 2018-02-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors. J. Med. Chem., 61, 2018
5U78	Crystal structure of ORP8 PH domain in P1211 space group 分子名称: Oxysterol-binding protein-related protein 8 著者 Ghai, R, Yang, H. 登録日 2016-12-12 公開日 2017-10-18 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.978 Å) 主引用文献 ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane. Nat Commun, 8, 2017
7A5C	Crystal structure of spin labelled VcSiaP R125A bound to an artificial peptide ligand. 分子名称: GLYCEROL, Sialic acid-binding periplasmic protein SiaP 著者 Peter, M.F, Glaenzer, J, Hagelueken, G. 登録日 2020-08-21 公開日 2020-12-30 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Triggering Closure of a Sialic Acid TRAP Transporter Substrate Binding Protein through Binding of Natural or Artificial Substrates. J.Mol.Biol., 433, 2020
6IVO	Crystal structure of a membrane protein P208A 分子名称: 1,2-ETHANEDIOL, ACETIC ACID, CHLORIDE ION, ... 著者 Kittredge, A, Fukuda, F, Zhang, Y, Yang, T. 登録日 2018-12-04 公開日 2019-11-06 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations. Commun Biol, 2, 2019
7R5Q	Escherichia coli type II Asparaginase N24S mutant in complex with GLU 分子名称: GLUTAMIC ACID, L-asparaginase 2 著者 Maggi, M, Scotti, C. 登録日 2022-02-11 公開日 2022-09-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Aspects of E. coli Type II Asparaginase in Complex with Its Secondary Product L-Glutamate. Int J Mol Sci, 23, 2022
5UA0	Dimeric crystal structure of HTPA reductase from arabidopsis thaliana 分子名称: 4-hydroxy-tetrahydrodipicolinate reductase 2, chloroplastic, SULFATE ION 著者 Keown, J.K, Pearce, F.G, Goldstone, D.C. 登録日 2016-12-18 公開日 2017-12-13 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Plant DHDPR forms a dimer with unique secondary structure features that preclude higher-order assembly. Biochem. J., 475, 2018
7ZJ3	Structure of TRIM2 RING domain in complex with UBE2D1~Ub conjugate 分子名称: Polyubiquitin-C, Tripartite motif-containing protein 2, Ubiquitin-conjugating enzyme E2 D1, ... 著者 Esposito, D, Garza-Garcia, A, Dudley-Fraser, J, Rittinger, K. 登録日 2022-04-08 公開日 2022-11-30 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.53 Å) 主引用文献 Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity. Nat Commun, 13, 2022
6G10	Complex of rice blast (Magnaporthe oryzae) effector protein AVR-PikD with the HMA domain of Pikp-1 from rice (Oryza sativa) 分子名称: AVR-Pik protein, CHLORIDE ION, Resistance protein Pikp-1 著者 De la Concepcion, J.C, Franceschetti, M, Banfield, M.J. 登録日 2018-03-20 公開日 2018-06-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Polymorphic residues in rice NLRs expand binding and response to effectors of the blast pathogen. Nat Plants, 4, 2018
7QZ2	Crystal structure of GacS D1 domain in complex with BeF3- 分子名称: BERYLLIUM TRIFLUORIDE ION, CADMIUM ION, Histidine kinase, ... 著者 Fadel, F, Bassim, V, Botzanowski, T, Francis, V.I, Legrand, P, Porter, S.L, Bourne, Y, Cianferani, S, Vincent, F. 登録日 2022-01-30 公開日 2022-07-06 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Insights into the atypical autokinase activity of the Pseudomonas aeruginosa GacS histidine kinase and its interaction with RetS. Structure, 30, 2022
5UAU	Structure of human PYCR-1 complexed with proline 分子名称: PROLINE, Pyrroline-5-carboxylate reductase 1, mitochondrial, ... 著者 Tanner, J.J. 登録日 2016-12-20 公開日 2017-03-15 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Resolving the cofactor-binding site in the proline biosynthetic enzyme human pyrroline-5-carboxylate reductase 1. J. Biol. Chem., 292, 2017
8BJJ	ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo MARTX toxin, bound to ATP-Mg-actin, human profilin 1 and a sulfate ion 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... 著者 Teixeira-Nunes, M, Renault, L, Retailleau, P. 登録日 2022-11-04 公開日 2023-09-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.699 Å) 主引用文献 Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin. Plos Pathog., 19, 2023
5HOO	Crystal structure of the Mos1 Strand Transfer Complex 分子名称: MAGNESIUM ION, Mariner Mos1 transposase, Mos1 IR DNA NTS, ... 著者 Richardson, J.M, Morris, E.R. 登録日 2016-01-19 公開日 2016-06-01 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 A bend, flip and trap mechanism for transposon integration. Elife, 5, 2016
6I3A	Crystal structure of v22Pizza6-AYW, a circularly permuted designer protein 分子名称: BROMIDE ION, v22Pizza6-AYW 著者 Mylemans, B, Noguchi, H, Deridder, E, Voet, A.R.D. 登録日 2018-11-05 公開日 2019-11-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Influence of circular permutations on the structure and stability of a six-fold circular symmetric designer protein. Protein Sci., 2020
7MIC	Maize rayado fino virus protease in complex with Ubiquitin 分子名称: 3-AMINOPROPANE, GLYCEROL, RNA replication protein, ... 著者 Patel, A, Mark, B.L. 登録日 2021-04-16 公開日 2021-07-21 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 The endopeptidase of the maize-affecting Marafivirus type member maize rayado fino virus doubles as a deubiquitinase. J.Biol.Chem., 297, 2021
6I3F	Crystal structure of the complex of human angiotensinogen and renin at 2.55 Angstrom 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensinogen, ... 著者 Yan, Y, Read, R.J. 登録日 2018-11-06 公開日 2018-12-26 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Structural basis for the specificity of renin-mediated angiotensinogen cleavage. J. Biol. Chem., 294, 2019
7MWL	The TAM domain of BAZ2A in complex with a 12mer mCG DNA 分子名称: Bromodomain adjacent to zinc finger domain protein 2A, DNA (5'-D(*GP*CP*CP*AP*AP*(5CM)P*GP*TP*TP*GP*GP*C)-3'), GLYCEROL 著者 Liu, K, Dong, A, Li, Y, Loppnau, P, Edwards, A.M, Arrowsmith, C.H, Min, J, Structural Genomics Consortium (SGC) 登録日 2021-05-17 公開日 2021-07-21 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 The TAM domain of BAZ2A in complex with a 12mer mCG DNA To Be Published
8QA9	Crystal structure of the RK2 plasmid encoded co-complex of the C-terminally truncated transcriptional repressor protein KorB complexed with the partner repressor protein KorA bound to OA-DNA 分子名称: DNA (5'-D(*TP*GP*TP*TP*TP*AP*GP*CP*TP*AP*AP*AP*CP*A)-3'), SULFATE ION, Transcriptional repressor protein KorB, ... 著者 McLean, T.C, Mundy, J.E.A, Lawson, D.M, Le, T.B.K. 登録日 2023-08-22 公開日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of the RK2 plasmid encoded co-complex of the C-terminally truncated transcriptional repressor protein KorB complexed with the partner repressor protein KorA bound to OA-DNA To Be Published
7R4M	Crystal structure of mitochondrial NAD kinase 分子名称: CALCIUM ION, NAD kinase 2, mitochondrial, ... 著者 Labesse, G, Mary, C, Gelin, M, Lionne, C. 登録日 2022-02-08 公開日 2022-07-06 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Crystal structure of human NADK2 reveals a dimeric organization and active site occlusion by lysine acetylation. Mol.Cell, 82, 2022
6I3U	Optimization of potent and selective ATM inhibitors suitable for a proof-of-concept study in Huntington's disease models 分子名称: 2-morpholin-4-yl-6-[7-[(2~{R})-1-morpholin-4-ylpropan-2-yl]oxy-9~{H}-thioxanthen-4-yl]pyran-4-one, Phosphatidylinositol 3-kinase catalytic subunit type 3 著者 Leonard, P.M. 登録日 2018-11-07 公開日 2019-03-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Optimization of Potent and Selective Ataxia Telangiectasia-Mutated Inhibitors Suitable for a Proof-of-Concept Study in Huntington's Disease Models. J.Med.Chem., 62, 2019
7RPB	X-ray crystal structure of OXA-24/40 V130D in complex with meropenem 分子名称: (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid, BICARBONATE ION, Beta-lactamase 著者 Powers, R.A, Mitchell, J.M, June, C.M. 登録日 2021-08-03 公開日 2022-07-06 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Conformational flexibility in carbapenem hydrolysis drives substrate specificity of the class D carbapenemase OXA-24/40. J.Biol.Chem., 298, 2022

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