7RPD
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![BU of 7rpd by Molmil](/molmil-images/mine/7rpd) | X-ray crystal structure of OXA-24/40 V130D in complex with ertapenem | 分子名称: | (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, BICARBONATE ION, Beta-lactamase, ... | 著者 | Powers, R.A, Mitchell, J.M, June, C.M. | 登録日 | 2021-08-03 | 公開日 | 2022-07-06 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Conformational flexibility in carbapenem hydrolysis drives substrate specificity of the class D carbapenemase OXA-24/40. J.Biol.Chem., 298, 2022
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5U6U
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![BU of 5u6u by Molmil](/molmil-images/mine/5u6u) | The crystal structure of 4-ethylthiobenzoate-bound CYP199A4 | 分子名称: | 4-(ethylsulfanyl)benzoic acid, CHLORIDE ION, Cytochrome P450, ... | 著者 | Coleman, T, Bruning, J.B, Bell, S.G. | 登録日 | 2016-12-08 | 公開日 | 2018-06-13 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.786 Å) | 主引用文献 | Cytochrome P450 CYP199A4 from Rhodopseudomonas palustris Catalyzes Heteroatom Dealkylations, Sulfoxidation, and Amide and Cyclic Hemiacetal Formation Acs Catalysis, 8, 2018
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7A1Z
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![BU of 7a1z by Molmil](/molmil-images/mine/7a1z) | Crystal structure of human protein kinase CK2alpha' (CSNK2A2 gene product) in complex with the ATP-competitive inhibitor 6-bromo-5-chloro-1H-triazolo[4,5-b]pyridine | 分子名称: | 1,2-ETHANEDIOL, 6-bromanyl-5-chloranyl-1~{H}-[1,2,3]triazolo[4,5-b]pyridine, CHLORIDE ION, ... | 著者 | Niefind, K, Lindenblatt, D, Toelzer, C, Bretner, M, Chojnacki, K, Wielechowska, M, Winska, P. | 登録日 | 2020-08-14 | 公開日 | 2020-12-09 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.024 Å) | 主引用文献 | Synthesis, biological properties and structural study of new halogenated azolo[4,5-b]pyridines as inhibitors of CK2 kinase. Bioorg.Chem., 106, 2021
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5HNL
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![BU of 5hnl by Molmil](/molmil-images/mine/5hnl) | In-house X-ray single crystal diffraction from protein microcrystals via magnetically oriented microcrystal arrays in gels | 分子名称: | Lysozyme C | 著者 | Tsukui, S, Kimura, F, Kusaka, K, Baba, S, Mizuno, N, Kimura, T. | 登録日 | 2016-01-18 | 公開日 | 2016-07-20 | 実験手法 | X-RAY DIFFRACTION (2.424 Å) | 主引用文献 | Neutron and X-ray single-crystal diffraction from protein microcrystals via magnetically oriented microcrystal arrays in gels. Acta Crystallogr D Struct Biol, 72, 2016
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7RPE
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![BU of 7rpe by Molmil](/molmil-images/mine/7rpe) | X-ray crystal structure of OXA-24/40 in complex with ertapenem | 分子名称: | (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, BICARBONATE ION, Beta-lactamase, ... | 著者 | Powers, R.A, Mitchell, J.M, June, C.M. | 登録日 | 2021-08-03 | 公開日 | 2022-07-06 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | 主引用文献 | Conformational flexibility in carbapenem hydrolysis drives substrate specificity of the class D carbapenemase OXA-24/40. J.Biol.Chem., 298, 2022
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6CE6
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![BU of 6ce6 by Molmil](/molmil-images/mine/6ce6) | Structure of HDAC6 zinc-finger ubiquitin binding domain soaked with 3,3'-(benzo[1,2-d:5,4-d']bis(thiazole)-2,6-diyl)dipropionic acid | 分子名称: | 3,3'-(benzo[1,2-d:5,4-d']bis[1,3]thiazole-2,6-diyl)dipropanoic acid, Histone deacetylase 6, UNKNOWN ATOM OR ION, ... | 著者 | Harding, R.J, Halabelian, L, Ferreira de Freitas, R, Ravichandran, M, Santhakumar, V, Schapira, M, Bountra, C, Edwards, A.M, Arrowsmith, C.M, Structural Genomics Consortium (SGC) | 登録日 | 2018-02-11 | 公開日 | 2018-02-28 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors. J. Med. Chem., 61, 2018
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5U78
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![BU of 5u78 by Molmil](/molmil-images/mine/5u78) | |
7A5C
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![BU of 7a5c by Molmil](/molmil-images/mine/7a5c) | |
6IVO
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![BU of 6ivo by Molmil](/molmil-images/mine/6ivo) | Crystal structure of a membrane protein P208A | 分子名称: | 1,2-ETHANEDIOL, ACETIC ACID, CHLORIDE ION, ... | 著者 | Kittredge, A, Fukuda, F, Zhang, Y, Yang, T. | 登録日 | 2018-12-04 | 公開日 | 2019-11-06 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations. Commun Biol, 2, 2019
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7R5Q
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5UA0
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![BU of 5ua0 by Molmil](/molmil-images/mine/5ua0) | |
7ZJ3
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![BU of 7zj3 by Molmil](/molmil-images/mine/7zj3) | Structure of TRIM2 RING domain in complex with UBE2D1~Ub conjugate | 分子名称: | Polyubiquitin-C, Tripartite motif-containing protein 2, Ubiquitin-conjugating enzyme E2 D1, ... | 著者 | Esposito, D, Garza-Garcia, A, Dudley-Fraser, J, Rittinger, K. | 登録日 | 2022-04-08 | 公開日 | 2022-11-30 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | 主引用文献 | Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity. Nat Commun, 13, 2022
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6G10
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7QZ2
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![BU of 7qz2 by Molmil](/molmil-images/mine/7qz2) | Crystal structure of GacS D1 domain in complex with BeF3- | 分子名称: | BERYLLIUM TRIFLUORIDE ION, CADMIUM ION, Histidine kinase, ... | 著者 | Fadel, F, Bassim, V, Botzanowski, T, Francis, V.I, Legrand, P, Porter, S.L, Bourne, Y, Cianferani, S, Vincent, F. | 登録日 | 2022-01-30 | 公開日 | 2022-07-06 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | 主引用文献 | Insights into the atypical autokinase activity of the Pseudomonas aeruginosa GacS histidine kinase and its interaction with RetS. Structure, 30, 2022
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5UAU
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![BU of 5uau by Molmil](/molmil-images/mine/5uau) | Structure of human PYCR-1 complexed with proline | 分子名称: | PROLINE, Pyrroline-5-carboxylate reductase 1, mitochondrial, ... | 著者 | Tanner, J.J. | 登録日 | 2016-12-20 | 公開日 | 2017-03-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Resolving the cofactor-binding site in the proline biosynthetic enzyme human pyrroline-5-carboxylate reductase 1. J. Biol. Chem., 292, 2017
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8BJJ
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![BU of 8bjj by Molmil](/molmil-images/mine/8bjj) | ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo MARTX toxin, bound to ATP-Mg-actin, human profilin 1 and a sulfate ion | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | 著者 | Teixeira-Nunes, M, Renault, L, Retailleau, P. | 登録日 | 2022-11-04 | 公開日 | 2023-09-20 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.699 Å) | 主引用文献 | Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin. Plos Pathog., 19, 2023
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5HOO
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6I3A
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![BU of 6i3a by Molmil](/molmil-images/mine/6i3a) | Crystal structure of v22Pizza6-AYW, a circularly permuted designer protein | 分子名称: | BROMIDE ION, v22Pizza6-AYW | 著者 | Mylemans, B, Noguchi, H, Deridder, E, Voet, A.R.D. | 登録日 | 2018-11-05 | 公開日 | 2019-11-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Influence of circular permutations on the structure and stability of a six-fold circular symmetric designer protein. Protein Sci., 2020
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7MIC
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6I3F
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![BU of 6i3f by Molmil](/molmil-images/mine/6i3f) | Crystal structure of the complex of human angiotensinogen and renin at 2.55 Angstrom | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensinogen, ... | 著者 | Yan, Y, Read, R.J. | 登録日 | 2018-11-06 | 公開日 | 2018-12-26 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Structural basis for the specificity of renin-mediated angiotensinogen cleavage. J. Biol. Chem., 294, 2019
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7MWL
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![BU of 7mwl by Molmil](/molmil-images/mine/7mwl) | The TAM domain of BAZ2A in complex with a 12mer mCG DNA | 分子名称: | Bromodomain adjacent to zinc finger domain protein 2A, DNA (5'-D(*GP*CP*CP*AP*AP*(5CM)P*GP*TP*TP*GP*GP*C)-3'), GLYCEROL | 著者 | Liu, K, Dong, A, Li, Y, Loppnau, P, Edwards, A.M, Arrowsmith, C.H, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2021-05-17 | 公開日 | 2021-07-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | The TAM domain of BAZ2A in complex with a 12mer mCG DNA To Be Published
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8QA9
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![BU of 8qa9 by Molmil](/molmil-images/mine/8qa9) | Crystal structure of the RK2 plasmid encoded co-complex of the C-terminally truncated transcriptional repressor protein KorB complexed with the partner repressor protein KorA bound to OA-DNA | 分子名称: | DNA (5'-D(*TP*GP*TP*TP*TP*AP*GP*CP*TP*AP*AP*AP*CP*A)-3'), SULFATE ION, Transcriptional repressor protein KorB, ... | 著者 | McLean, T.C, Mundy, J.E.A, Lawson, D.M, Le, T.B.K. | 登録日 | 2023-08-22 | 公開日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal structure of the RK2 plasmid encoded co-complex of the C-terminally truncated transcriptional repressor protein KorB complexed with the partner repressor protein KorA bound to OA-DNA To Be Published
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7R4M
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![BU of 7r4m by Molmil](/molmil-images/mine/7r4m) | Crystal structure of mitochondrial NAD kinase | 分子名称: | CALCIUM ION, NAD kinase 2, mitochondrial, ... | 著者 | Labesse, G, Mary, C, Gelin, M, Lionne, C. | 登録日 | 2022-02-08 | 公開日 | 2022-07-06 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Crystal structure of human NADK2 reveals a dimeric organization and active site occlusion by lysine acetylation. Mol.Cell, 82, 2022
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6I3U
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7RPB
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![BU of 7rpb by Molmil](/molmil-images/mine/7rpb) | X-ray crystal structure of OXA-24/40 V130D in complex with meropenem | 分子名称: | (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid, BICARBONATE ION, Beta-lactamase | 著者 | Powers, R.A, Mitchell, J.M, June, C.M. | 登録日 | 2021-08-03 | 公開日 | 2022-07-06 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Conformational flexibility in carbapenem hydrolysis drives substrate specificity of the class D carbapenemase OXA-24/40. J.Biol.Chem., 298, 2022
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