8HW4
| Cryo-EM structure of dehydroepiandrosterone sulfate-bound human ABC transporter ABCC3 in nanodiscs | 分子名称: | 17-oxoandrost-5-en-3beta-yl hydrogen sulfate, ATP-binding cassette sub-family C member 3 | 著者 | Wang, J, Wang, F.F, Chen, Y.X, Zhou, C.Z. | 登録日 | 2022-12-28 | 公開日 | 2023-06-07 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | 主引用文献 | Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate-binding pocket. Embo J., 42, 2023
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8HVH
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8HW2
| Cryo-EM structure of beta-estradiol 17-(beta-D-glucuronide)-bound human ABC transporter ABCC3 in nanodiscs | 分子名称: | ATP-binding cassette sub-family C member 3, Estradiol-17beta-glucuronide | 著者 | Wang, J, Wang, F.F, Chen, Y.X, Zhou, C.Z. | 登録日 | 2022-12-28 | 公開日 | 2023-06-07 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (3.65 Å) | 主引用文献 | Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate-binding pocket. Embo J., 42, 2023
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6BAA
| Cryo-EM structure of the pancreatic beta-cell KATP channel bound to ATP and glibenclamide | 分子名称: | 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | 著者 | Martin, G.M, Yoshioka, C, Shyng, S.L. | 登録日 | 2017-10-12 | 公開日 | 2017-11-01 | 最終更新日 | 2019-12-25 | 実験手法 | ELECTRON MICROSCOPY (3.63 Å) | 主引用文献 | Anti-diabetic drug binding site in a mammalian KATPchannel revealed by Cryo-EM. Elife, 6, 2017
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6C3P
| Cryo-EM structure of human KATP bound to ATP and ADP in propeller form | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | 著者 | Lee, K.P.K, Chen, J, MacKinnon, R. | 登録日 | 2018-01-10 | 公開日 | 2018-01-24 | 実験手法 | ELECTRON MICROSCOPY (5.6 Å) | 主引用文献 | Molecular structure of human KATP in complex with ATP and ADP. Elife, 6, 2017
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6C0V
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6A6N
| Crystal structure of an inward-open apo state of the eukaryotic ABC multidrug transporter CmABCB1 | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ATP-binding cassette, sub-family B, ... | 著者 | Kato, H, Nakatsu, T, Kodan, A. | 登録日 | 2018-06-28 | 公開日 | 2019-01-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.02 Å) | 主引用文献 | Inward- and outward-facing X-ray crystal structures of homodimeric P-glycoprotein CmABCB1. Nat Commun, 10, 2019
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6C3O
| Cryo-EM structure of human KATP bound to ATP and ADP in quatrefoil form | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | 著者 | Lee, K.P.K, Chen, J, MacKinnon, R. | 登録日 | 2018-01-10 | 公開日 | 2018-01-31 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Molecular structure of human KATP in complex with ATP and ADP Elife, 6, 2017
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6D3S
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7PQX
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7PSD
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7PRO
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7PR1
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7PRU
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7QKS
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7QKR
| Cryo-EM structure of ABC transporter STE6-2p from Pichia pastoris with Verapamil at 3.2 A resolution | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, Dexverapamil, MAGNESIUM ION, ... | 著者 | Schleker, E.S.M, Reinhart, C. | 登録日 | 2021-12-18 | 公開日 | 2022-10-26 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural and functional investigation of ABC transporter STE6-2p from Pichia pastoris reveals unexpected interaction with sterol molecules. Proc.Natl.Acad.Sci.USA, 119, 2022
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7RIT
| Drug-free A. baumannii MsbA | 分子名称: | ATP-dependent lipid A-core flippase | 著者 | Thelot, F, Liao, M. | 登録日 | 2021-07-20 | 公開日 | 2021-10-06 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (5.2 Å) | 主引用文献 | Distinct allosteric mechanisms of first-generation MsbA inhibitors. Science, 374, 2021
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7S5X
| Human KATP channel in open conformation, focused on Kir and one SUR, position 1 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | 著者 | Zhao, C, MacKinnon, R. | 登録日 | 2021-09-12 | 公開日 | 2021-12-01 | 最終更新日 | 2021-12-08 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Molecular structure of an open human K ATP channel. Proc.Natl.Acad.Sci.USA, 118, 2021
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7S5V
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7S5Y
| Human KATP channel in open conformation, focused on Kir and one SUR, position 2 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | 著者 | Zhao, C, MacKinnon, R. | 登録日 | 2021-09-12 | 公開日 | 2021-12-01 | 最終更新日 | 2021-12-08 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Molecular structure of an open human K ATP channel. Proc.Natl.Acad.Sci.USA, 118, 2021
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7S61
| Human KATP channel in open conformation, focused on Kir and one SUR, position 5 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | 著者 | Zhao, C, MacKinnon, R. | 登録日 | 2021-09-12 | 公開日 | 2021-12-01 | 最終更新日 | 2021-12-08 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Molecular structure of an open human K ATP channel. Proc.Natl.Acad.Sci.USA, 118, 2021
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7S60
| Human KATP channel in open conformation, focused on Kir and one SUR, position 4 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | 著者 | Zhao, C, MacKinnon, R. | 登録日 | 2021-09-12 | 公開日 | 2021-12-01 | 最終更新日 | 2021-12-08 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Molecular structure of an open human K ATP channel. Proc.Natl.Acad.Sci.USA, 118, 2021
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7S5Z
| Human KATP channel in open conformation, focused on Kir and one SUR, position 3 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | 著者 | Zhao, C, MacKinnon, R. | 登録日 | 2021-09-12 | 公開日 | 2021-12-01 | 最終更新日 | 2021-12-08 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Molecular structure of an open human K ATP channel. Proc.Natl.Acad.Sci.USA, 118, 2021
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7SEL
| E. coli MsbA in complex with LPS and inhibitor G7090 (compound 3) | 分子名称: | (2E)-3-{7-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1-methylnaphthalen-2-yl}prop-2-enoic acid, (2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[(2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-carboxy-2-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{R})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]-5-oxidanyl-oxan-4-yl]oxy-4,5-bis(oxidanyl)oxane-2-carboxylic acid, ATP-dependent lipid A-core flippase | 著者 | Payandeh, J, Koth, C.M, Verma, V.A. | 登録日 | 2021-09-30 | 公開日 | 2022-03-09 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.978 Å) | 主引用文献 | Discovery of Inhibitors of the Lipopolysaccharide Transporter MsbA: From a Screening Hit to Potent Wild-Type Gram-Negative Activity. J.Med.Chem., 65, 2022
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7SGR
| Structure of hemolysin A secretion system HlyB/D complex | 分子名称: | Alpha-hemolysin translocation ATP-binding protein HlyB, Membrane fusion protein (MFP) family protein,Hemolysin secretion protein D, chromosomal, ... | 著者 | Zhao, H, Chen, J. | 登録日 | 2021-10-07 | 公開日 | 2022-09-14 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | The hemolysin A secretion system is a multi-engine pump containing three ABC transporters. Cell, 185, 2022
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