9F7F
 
 | | UP1 in complex with Z1491353358 | | 分子名称: | (3S)-1-(phenylsulfonyl)pyrrolidin-3-amine, Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed | | 著者 | Dunnett, L, Prischi, F. | | 登録日 | 2024-05-03 | | 公開日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Enhanced identification of small molecules binding to hnRNP A1 via in silico hotspot and cryptic pockets mapping coupled with X-Ray fragment screening
To Be Published
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8ZHF
 | | SARS-CoV-2 spike trimer (6P) in complex with R1-26 Fab, head-to-head aggregate | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of R1-26 Fab, ... | | 著者 | Yan, Q, Gao, X, Liu, B, Hou, R, He, P, Li, Z, Chen, Q, Wang, J, He, J, Chen, L, Zhao, J, Xiong, X. | | 登録日 | 2024-05-10 | | 公開日 | 2024-08-21 | | 実験手法 | ELECTRON MICROSCOPY (5.26 Å) | | 主引用文献 | Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein helping to drive the genesis of Omicron variants
To Be Published
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9EY4
 | | The FK1 domain of FKBP51 in complex with (3S,11S)-12-((3,5-dichlorophenyl)sulfonyl)-5-oxo-11-vinyldecahydro-1H-6,10-epiminopyrrolo[1,2-a]azonine-3-carboxamide | | 分子名称: | (1~{S},4~{S},7~{S},8~{S},9~{R})-13-[3,5-bis(chloranyl)phenyl]sulfonyl-8-ethenyl-2-oxidanylidene-3,13-diazatricyclo[7.3.1.0^{3,7}]tridecane-4-carboxamide, Peptidyl-prolyl cis-trans isomerase FKBP5 | | 著者 | Meyners, C, Krajczy, P, Hausch, F. | | 登録日 | 2024-04-09 | | 公開日 | 2024-06-12 | | 最終更新日 | 2024-08-28 | | 実験手法 | X-RAY DIFFRACTION (1.16 Å) | | 主引用文献 | Structure-Based Design of Ultrapotent Tricyclic Ligands for FK506-Binding Proteins.
Chemistry, 30, 2024
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9C54
 | | Crystal structure of human PTPN2 catalytic domain | | 分子名称: | Tyrosine-protein phosphatase non-receptor type 2 | | 著者 | Bester, S.M, Linwood, R, Wu, W.-I, Mou, T.-C. | | 登録日 | 2024-06-05 | | 公開日 | 2024-09-04 | | 最終更新日 | 2024-09-25 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Enhancing the apo protein tyrosine phosphatase non-receptor type 2 crystal soaking strategy through inhibitor-accessible binding sites.
Acta Crystallogr.,Sect.F, 80, 2024
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9B60
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8YMJ
 | | Cryo-EM structure of Hepatitis B virus surface antigen subviral particle with D2 symmetry | | 分子名称: | Isoform S of Large envelope protein | | 著者 | Wang, T, Cao, L, Mu, A, Wang, Q, Rao, Z.H. | | 登録日 | 2024-03-09 | | 公開日 | 2024-09-18 | | 最終更新日 | 2024-09-25 | | 実験手法 | ELECTRON MICROSCOPY (6.6 Å) | | 主引用文献 | Inherent symmetry and flexibility in hepatitis B virus subviral particles.
Science, 385, 2024
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9B61
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9C61
 | | Crystal structure of the human LRRK2 WDR domain in complex with CACHE1193-26 | | 分子名称: | (4R)-4-[4-(5-fluoro-1H-indol-3-yl)piperidine-1-carbonyl]piperidin-2-one, Non-specific serine/threonine protein kinase, UNKNOWN ATOM OR ION | | 著者 | Zeng, H, Dong, A, Kutera, M, Ilyassov, O, Seitova, A, Loppnau, P, Schapira, M, Arrowsmith, C.H, Edwards, A.M, Halabelian, L. | | 登録日 | 2024-06-07 | | 公開日 | 2024-07-03 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Crystal structure of the human LRRK2 WDR domain in complex with CACHE1193-26
To be published
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9FZ4
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9EMC
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9CWS
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9CIA
 | | T cell receptor complex | | 分子名称: | CHOLESTEROL, T cell receptor delta constant, T cell receptor gamma constant 1, ... | | 著者 | Gully, B.S, Rossjohn, J. | | 登録日 | 2024-07-03 | | 公開日 | 2024-07-31 | | 実験手法 | ELECTRON MICROSCOPY (3.39 Å) | | 主引用文献 | T cell receptor complex
To Be Published
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8Y6Q
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9EY8
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8ZYN
 | | Cryo-EM Structure of inhibitor-free hERG Channel | | 分子名称: | Potassium voltage-gated channel subfamily H member 2 | | 著者 | Miyashita, Y, Moriya, T, Kato, T, Kawasaki, M, Yasuda, Y, Adachi, N, Suzuki, K, Ogasawara, S, Saito, T, Senda, T, Murata, T. | | 登録日 | 2024-06-18 | | 公開日 | 2024-09-18 | | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | | 主引用文献 | Improved higher resolution Cryo-EM structures reveal the binding modes of hERG Channel Inhibitors
To Be Published
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5X0Q
 | | OxyR2 E204G variant (Cl-bound) from Vibrio vulnificus | | 分子名称: | CHLORIDE ION, CITRIC ACID, LysR family transcriptional regulator | | 著者 | Jo, I, Ha, N.-C. | | 登録日 | 2017-01-23 | | 公開日 | 2017-03-15 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | The hydrogen peroxide hypersensitivity of OxyR2 in Vibrio vulnificus depends on conformational constraints
J. Biol. Chem., 292, 2017
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9F7H
 | | UP1 in complex with Z45617795 | | 分子名称: | Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed, N-(2-phenylethyl)methanesulfonamide | | 著者 | Dunnett, L, Prischi, F. | | 登録日 | 2024-05-03 | | 公開日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | | 主引用文献 | Enhanced identification of small molecules binding to hnRNP A1 via in silico hotspot and cryptic pockets mapping coupled with X-Ray fragment screening
To Be Published
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9CHW
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8ZYQ
 | | Cryo-EM Structure of pimozide-bound hERG Channel | | 分子名称: | 3-[1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl]-1~{H}-benzimidazol-2-one, Potassium voltage-gated channel subfamily H member 2 | | 著者 | Miyashita, Y, Moriya, T, Kato, T, Kawasaki, M, Yasuda, Y, Adachi, N, Suzuki, K, Ogasawara, S, Saito, T, Senda, T, Murata, T. | | 登録日 | 2024-06-18 | | 公開日 | 2024-09-18 | | 実験手法 | ELECTRON MICROSCOPY (3.18 Å) | | 主引用文献 | Improved higher resolution Cryo-EM structures reveal the binding modes of hERG Channel Inhibitors
To Be Published
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9F1S
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9CGI
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9CEY
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5X2G
 | | Crystal structure of Campylobacter jejuni Cas9 in complex with sgRNA and target DNA (AGAAACC PAM) | | 分子名称: | 1,2-ETHANEDIOL, CRISPR-associated endonuclease Cas9, Non-target DNA strand, ... | | 著者 | Yamada, M, Watanabe, Y, Hirano, H, Nakane, T, Ishitani, R, Nishimasu, H, Nureki, O. | | 登録日 | 2017-01-31 | | 公開日 | 2017-03-29 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal Structure of the Minimal Cas9 from Campylobacter jejuni Reveals the Molecular Diversity in the CRISPR-Cas9 Systems
Mol. Cell, 65, 2017
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9BA4
 | | Full-length cross-linked Contactin 2 (CNTN2) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Contactin-2 | | 著者 | Liu, J.L, Fan, S.F, Ren, G.R, Rudenko, G.R. | | 登録日 | 2024-04-03 | | 公開日 | 2024-07-17 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | | 主引用文献 | Molecular mechanism of contactin 2 homophilic interaction.
Structure, 2024
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9F8G
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