PDB: 225399 件ウェブページステータス検索Chemie searchBIRD

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6O2W	Crystal structure of the SARAF luminal domain Cys-lock mutant dimer 分子名称: GLYCEROL, Store-operated calcium entry-associated regulatory factor 著者 Kimberlin, C.R, Minor, D.L. 登録日 2019-02-24 公開日 2019-05-29 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.101 Å) 主引用文献 SARAF Luminal Domain Structure Reveals a Novel Domain-Swapped beta-Sandwich Fold Important for SOCE Modulation. J.Mol.Biol., 431, 2019
6HKU	Trichodysplasia spinulosa-associated polyomavirus (TSPyV) VP1 in complex with sialylated precision glycooligomers 分子名称: Capsid protein VP1, GLYCEROL, N-acetyl-alpha-neuraminic acid, ... 著者 Rustmeier, N.H, Stehle, T. 登録日 2018-09-08 公開日 2019-03-27 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Divalent Sialylated Precision Glycooligomers Binding to Polyomaviruses and the Effect of Different Linkers. Macromol Biosci, 19, 2019
8SIC	Crystal structure of Epstein-Barr virus glycoprotein 350 (gp350) in complex with Cy137C02, a monoclonal antibody isolated from macaques immunized with a gp350 nanoparticle vaccine 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cy137C02 Fab heavy chain, Cy137C02 Fab light chain, ... 著者 Joyce, M.G, Jensen, J.L, Chen, W.H, Kanekiyo, M. 登録日 2023-04-14 公開日 2024-04-17 実験手法 X-RAY DIFFRACTION (2.76 Å) 主引用文献 Crystal structure of Epstein-Barr virus glycoprotein 350 (gp350) in complex with Cy137C02, a monoclonal antibody isolated from macaques immunized with a gp350 nanoparticle vaccine To Be Published
6EJ7	Human Xylosyltransferase 1 in complex with UDP-xylose and peptide QEEEGAGGGQGG 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ... 著者 Briggs, D.C, Hohenester, E. 登録日 2017-09-20 公開日 2018-05-02 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Basis for the Initiation of Glycosaminoglycan Biosynthesis by Human Xylosyltransferase 1. Structure, 26, 2018
6NVT	Crystal structure of TLA-1 extended spectrum Beta-lactamase 分子名称: ACETATE ION, Beta-lactamase, CHLORIDE ION, ... 著者 Rudino-Pinera, E, Cifuentes-Castro, V.H, Rodriguez-Almazan, C. 登録日 2019-02-05 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The crystal structure of ESBL TLA-1 in complex with clavulanic acid reveals a second acylation site. Biochem.Biophys.Res.Commun., 522, 2020
8JVA	Cryo-EM structure of the N-terminal domain of Omicron BA.1 in complex with nanobody N235 and S2L20 Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, S2L20 heavy chain, S2L20 light chain, ... 著者 Liu, B, Liu, H.H, Han, P, Qi, J.X. 登録日 2023-06-28 公開日 2024-05-22 実験手法 ELECTRON MICROSCOPY (2.81 Å) 主引用文献 Enhanced potency of an IgM-like nanobody targeting conserved epitope in SARS-CoV-2 spike N-terminal domain. Signal Transduct Target Ther, 9, 2024
6NYW	Structure of spastin AAA domain N527C mutant in complex with 8-fluoroquinazoline-based inhibitor 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, N-(5-tert-butyl-1H-pyrazol-3-yl)-8-fluoro-2-[(2R)-2-methylpiperazin-1-yl]quinazolin-4-amine, ... 著者 Pisa, R, Cupido, T, Kapoor, T.M. 登録日 2019-02-12 公開日 2019-03-27 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.189 Å) 主引用文献 Designing Allele-Specific Inhibitors of Spastin, a Microtubule-Severing AAA Protein. J. Am. Chem. Soc., 141, 2019
6NZQ	CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_29 AKA 6-[(5-FLUORO-4-METH YLPYRIDIN-2-YL)AMINO]-4-({2-METHOXY-3-[(PYRIDIN-2-YLMETHYL )CARBAMOYL]PHENYL}AMINO)-N-METHYLPYRIDINE-3-CARBOXAMIDE 分子名称: 6-[(5-fluoro-4-methylpyridin-2-yl)amino]-4-[(2-methoxy-3-{[(pyridin-2-yl)methyl]carbamoyl}phenyl)amino]-N-methylpyridine-3-carboxamide, Non-receptor tyrosine-protein kinase TYK2 著者 Khan, J.A. 登録日 2019-02-14 公開日 2019-07-31 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165. J.Med.Chem., 62, 2019
6NW5	Crystal structure of TmPep1050 aminopeptidase with its metal cofactors 分子名称: Aminopeptidase, COBALT (II) ION, HYDROXIDE ION, ... 著者 Dutoit, R. 登録日 2019-02-06 公開日 2019-10-23 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 How metal cofactors drive dimer-dodecamer transition of the M42 aminopeptidase TmPep1050 ofThermotoga maritima. J.Biol.Chem., 294, 2019
8K5O	Cryo-EM structure of the RC-LH core comples from Halorhodospira halochloris 分子名称: (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 2-O-octyl-beta-D-glucopyranose, ... 著者 Wang, G.-L, Qi, C.-H, Yu, L.-J. 登録日 2023-07-22 公開日 2024-05-22 実験手法 ELECTRON MICROSCOPY (2.42 Å) 主引用文献 Structural insights into the unusual core photocomplex from a triply extremophilic purple bacterium, Halorhodospira halochloris. J Integr Plant Biol, 2024
5K9O	Crystal structure of multidonor HV1-18+HD3-9 class broadly neutralizing Influenza A antibody 31.b.09 in complex with Hemagglutinin H1 A/California/04/2009 分子名称: 31.b.09 Heavy Fv, 31.b.09 Light Fv, Hemagglutinin, ... 著者 Joyce, M.G, Thomas, P.V, Wheatley, A.K, McDermott, A.B, Mascola, J.R, Kwong, P.D. 登録日 2016-06-01 公開日 2016-12-28 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.387 Å) 主引用文献 Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses. Cell, 166, 2016
6NZF	CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_5 AKA 4-[(2-CARBAMOYLPHEN YL)AMINO]-6-[(5-FLUOROPYRIDIN-2-YL)AMINO]-N-METHYLPYRIDINE -3-CARBOXAMIDE 分子名称: 6-[(5-fluoropyridin-2-yl)amino]-N-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide, Non-receptor tyrosine-protein kinase TYK2, SULFATE ION 著者 Muckelbauer, J.M. 登録日 2019-02-13 公開日 2019-07-24 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Identification ofN-Methyl Nicotinamide andN-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2). J.Med.Chem., 62, 2019
6YSX	Thrombin in complex with 4-amino-N-(5-methylisoxazol-3-yl)benzenesulfonamide (j80) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, Hirudin variant-2, ... 著者 Scanlan, W, Heine, A, Klebe, G, Abazi, N. 登録日 2020-04-23 公開日 2021-05-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 Thrombin in complex with 4-amino-N-(5-methylisoxazol-3-yl)benzenesulfonamide (j80) To be published
6YWA	Human REF STING in complex with 3',3'-c-[2'FdAMP-2'FdAM(PS)] 分子名称: 3',3'-c-[2'FdAMP-2'FdAM(PS)], GLYCEROL, Stimulator of interferon genes protein 著者 Boura, E, Smola, M. 登録日 2020-04-29 公開日 2021-05-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.311 Å) 主引用文献 Human REF STING in complex with 3',3'-c-[2'FdAMP-2'FdAM(PS)] To Be Published
6YWB	Human wtSTING in complex with 3',3'-c-[2'FdAMP-2'FdAM(PS)] 分子名称: 3',3'-c-[2'FdAMP-2'FdAM(PS)], Stimulator of interferon protein 著者 Boura, E, Smola, M. 登録日 2020-04-29 公開日 2021-05-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.503 Å) 主引用文献 Human wtSTING in complex with 3',3'-c-[2'FdAMP-2'FdAM(PS)] To Be Published
6NXS	Crystal structure of Arabidopsis thaliana cytosolic triosephosphate isomerase C218Y mutant 分子名称: SODIUM ION, Triosephosphate isomerase, cytosolic 著者 Jimenez-Sandoval, P, Diaz-Quezada, C, Torres-Larios, A, Brieba, L.G. 登録日 2019-02-09 公開日 2020-02-12 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Structural basis for the modulation of plant cytosolic triosephosphate isomerase activity by mimicry of redox-based modifications. Plant J., 99, 2019
6YSJ	Thrombin in complex with 2-amino-1-(4-bromophenyl)ethan-1-one (j10) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-1-(4-bromophenyl)ethanone, DIMETHYL SULFOXIDE, ... 著者 Scanlan, W, Heine, A, Klebe, G, Abazi, N, Paulus, A. 登録日 2020-04-22 公開日 2021-05-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Thrombin in complex with 2-amino-1-(4-bromophenyl)ethan-1-one (j10) To be published
6NZE	CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_5 AKA 4-[(2-CARBAMOYLPHEN YL)AMINO]-6-[(5-FLUOROPYRIDIN-2-YL)AMINO]-N-METHYLPYRIDINE -3-CARBOXAMIDE 分子名称: 4-[(2-carbamoylphenyl)amino]-6-[(5-fluoropyridin-2-yl)amino]-N-methylpyridine-3-carboxamide, Non-receptor tyrosine-protein kinase TYK2, SULFATE ION 著者 Muckelbauer, J.M. 登録日 2019-02-13 公開日 2019-07-24 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Identification ofN-Methyl Nicotinamide andN-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2). J.Med.Chem., 62, 2019
6NZP	CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH COMPOUND-11 AKA 6-CYCLOPROPANEAMIDO-4-{[2-METHOXY-3-(1-METHYL-1H-1,2,4-TRI AZOL-3-YL)PHENYL]AMINO}-N-(?H?)METHYLPYRIDAZINE-3-CARBOXAMIDE 分子名称: 6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]amino}-N-methylpyridazine-3-carboxamide, CHLORIDE ION, Non-receptor tyrosine-protein kinase TYK2 著者 Khan, J.A. 登録日 2019-02-14 公開日 2019-07-31 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165. J.Med.Chem., 62, 2019
8S7C	Ternary Complex of Cachd1, FZD5 and LRP6 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Frizzled-5, ... 著者 Zhao, Y, Ren, J, Jones, E.Y. 登録日 2024-02-29 公開日 2024-04-24 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (4.7 Å) 主引用文献 Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain. Science, 384, 2024
6Z0Z	Human wtSTING in complex with 3',3'-c-(2'FdAMP-2'FdAMP) 分子名称: 2'-fluoro-,3',3'-c-di-AMP, Stimulator of interferon protein 著者 Boura, E, Smola, M. 登録日 2020-05-11 公開日 2021-05-19 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.499 Å) 主引用文献 Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein. Angew.Chem.Int.Ed.Engl., 60, 2021
6O0N	M.tb MenD with Inhibitor 分子名称: 1,4-dihydroxy-2-naphthoic acid, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase 著者 Johnston, J.M, Ho, N.A.T, Bashiri, G, Bulloch, E.M, Nigon, L.V, Jirgis, E.M.N, Baker, E.N. 登録日 2019-02-16 公開日 2020-02-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.03 Å) 主引用文献 Allosteric regulation of menaquinone (vitamin K2) biosynthesis in the human pathogenMycobacterium tuberculosis. J.Biol.Chem., 295, 2020
8S0L	Crystal structure of the TMPRSS2 zymogen in complex with the nanobody A07 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Nanobody A07, ... 著者 Duquerroy, S, Fernandez, I, Rey, F. 登録日 2024-02-14 公開日 2024-06-26 最終更新日 2024-09-04 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirus. Cell, 187, 2024
6O2V	Crystal structure of the SARAF luminal domain Cys-lock mutant monomer 分子名称: FORMIC ACID, GLYCEROL, Store-operated calcium entry-associated regulatory factor 著者 Kimberlin, C.R, Minor, D.L. 登録日 2019-02-24 公開日 2019-05-29 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 SARAF Luminal Domain Structure Reveals a Novel Domain-Swapped beta-Sandwich Fold Important for SOCE Modulation. J.Mol.Biol., 431, 2019
7R85	Structure of mouse Bai1 (ADGRB1) TSR3 domain 分子名称: Vasculostatin-120, alpha-D-mannopyranose, beta-D-glucopyranose-(1-3)-alpha-L-fucopyranose 著者 Miao, Y, Jude, K.M, Garcia, K.C. 登録日 2021-06-26 公開日 2021-11-10 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development. Cell, 184, 2021

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