PDB: 47902 件ウェブページステータス検索Chemie searchBIRD

---

6PR4	D262N/S128A S. typhimurium siroheme synthase 分子名称: S-ADENOSYL-L-HOMOCYSTEINE, Siroheme synthase 著者 Pennington, J.M, Stroupe, M.E. 登録日 2019-07-10 公開日 2020-02-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Siroheme synthase orients substrates for dehydrogenase and chelatase activities in a common active site. Nat Commun, 11, 2020
5OGQ	Structure of cathepsin B1 from Schistosoma mansoni in complex with WRR391 inhibitor 分子名称: ACETATE ION, Cathepsin B-like peptidase (C01 family), ethyl 1-[[(2~{S})-3-(4-hydroxyphenyl)-1-oxidanylidene-1-[[(3~{S})-1-phenyl-5-pyridin-2-ylsulfonyl-pentan-3-yl]amino]propan-2-yl]carbamoyl]piperidine-4-carboxylate 著者 Jilkova, A, Rezacova, P, Brynda, J, Mares, M. 登録日 2017-07-13 公開日 2018-11-21 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors. Acs Infect Dis., 2020
6PRO	MnSOD from Geobacillus stearothermophilus 分子名称: MANGANESE (II) ION, Superoxide dismutase 著者 Adams, J.J, Morton, C.J, Parker, M.W. 登録日 2019-07-10 公開日 2020-05-20 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.263 Å) 主引用文献 The Crystal Structure of the Manganese Superoxide Dismutase from Geobacillus stearothermophilus: Parker and Blake (1988) Revisited Aust.J.Chem., 73, 2020
6P8H	Crystal structure of CDK4 in complex with CyclinD1 and P21 分子名称: Cyclin-dependent kinase 4, Cyclin-dependent kinase inhibitor 1, G1/S-specific cyclin-D1 著者 Guiley, K.Z, Stevenson, J.W, Lou, K, Barkovich, K.J, Bunch, K, Tripathi, S.M, Shokat, K.M, Rubin, S.M. 登録日 2019-06-07 公開日 2019-12-25 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.19 Å) 主引用文献 p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition. Science, 366, 2019
6P8P	Structure of P. aeruginosa ATCC27853 HORMA1 分子名称: CALCIUM ION, Uncharacterized protein 著者 Ye, Q, Corbett, K.D. 登録日 2019-06-07 公開日 2019-12-25 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.635 Å) 主引用文献 HORMA Domain Proteins and a Trip13-like ATPase Regulate Bacterial cGAS-like Enzymes to Mediate Bacteriophage Immunity. Mol.Cell, 77, 2020
6OYW	ASK1 kinase domain in complex with Compound 11 分子名称: (19S)-19-methyl-16,17,18,19-tetrahydro-8,4-(azeno)[1,2,4]triazolo[4,3-f][1,6,13]benzoxadiazacyclohexadecin-10(9H)-one, MAGNESIUM ION, Mitogen-activated protein kinase kinase kinase 5 著者 Marcotte, D.J. 登録日 2019-05-15 公開日 2019-11-27 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.603 Å) 主引用文献 Rational Design and Optimization of a Novel Class of Macrocyclic Apoptosis Signal-Regulating Kinase 1 Inhibitors. J.Med.Chem., 62, 2019
6P07	Spastin hexamer in complex with substrate 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Sandate, C.R, Szyk, A, Zehr, E, Roll-Mecak, A, Lander, G.C. 登録日 2019-05-16 公開日 2019-06-12 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 An allosteric network in spastin couples multiple activities required for microtubule severing. Nat.Struct.Mol.Biol., 26, 2019
6P00	RebH Variant 8F, Tryptamine 6-halogenase 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Flavin-dependent tryptophan halogenase RebH 著者 Andorfer, M.C, Sukumar, N, Lewis, J.C. 登録日 2019-05-16 公開日 2020-05-27 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.249 Å) 主引用文献 Structural and Computational Analysis of Laboratory-Evolved Halogenases Reveals Molecular Details of Site-Selectivity To Be Published
6P1C	Transcription antitermination factor Q21, SeMet-derivative 分子名称: CHLORIDE ION, Q protein 著者 Yin, Z, Ebright, R.H. 登録日 2019-05-19 公開日 2019-06-26 最終更新日 2019-12-18 実験手法 X-RAY DIFFRACTION (2.005 Å) 主引用文献 Structural basis of Q-dependent antitermination. Proc.Natl.Acad.Sci.USA, 116, 2019
7WOW	The state 6 of Omicron Spike with bispecific antibody FD01 分子名称: 16L9 Fv, GW01 Fv, Spike glycoprotein 著者 Zhang, X, Zhan, W.Q, Chen, Z.G, Sun, L. 登録日 2022-01-22 公開日 2022-11-30 実験手法 ELECTRON MICROSCOPY (6.11 Å) 主引用文献 Combating the SARS-CoV-2 Omicron (BA.1) and BA.2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies Cell Discov, 8, 2022
6P0L	Crystal structure of GDP-bound human RalA in a covalent complex with aryl sulfonyl fluoride compounds. 分子名称: 4-[(2-methoxypyridin-3-yl)sulfamoyl]benzene-1-sulfonic acid, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Bum-Erdene, K, Gonzalez-Gutierrez, G, Liu, D, Ghozayel, M.K, Xu, D, Meroueh, S.O. 登録日 2019-05-17 公開日 2020-03-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Small-molecule covalent bond formation at tyrosine creates a binding site and inhibits activation of Ral GTPases. Proc.Natl.Acad.Sci.USA, 117, 2020
6P16	Cu-bound PCuAC domain from PmoF1 分子名称: COPPER (II) ION, PmoF1 著者 Sendzik, M.R, Fisher, O.S, Rosenzweig, A.C. 登録日 2019-05-19 公開日 2019-09-25 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.913 Å) 主引用文献 PCuAC domains from methane-oxidizing bacteria use a histidine brace to bind copper. J.Biol.Chem., 294, 2019
7W97	Crystal Structure of the CYP102A1 (P450BM3) Heme Domain with N-Hexadecanoyl-L-Homoserine 分子名称: (2~{S})-2-(hexadecanoylamino)-4-oxidanyl-butanoic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, GLYCEROL, ... 著者 Karasawa, M, Stanfield, J.K, Kasai, C, Sugimoto, H, Shoji, O. 登録日 2021-12-09 公開日 2022-12-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Crystal Structure of the CYP102A1 (P450BM3) Heme Domain with N-Hexadecanoyl-L-Homoserine To Be Published
5O8R	The crystal structure of DfoA bound to FAD and NADP; the desferrioxamine biosynthetic pathway cadaverine monooxygenase from the fire blight disease pathogen Erwinia amylovora 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, L-lysine 6-monooxygenase involved in desferrioxamine biosynthesis, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Salomone-Stagni, M, Bartho, J.D, Polsinelli, I, Bellini, D, Walsh, M.A, Demitri, N, Benini, S. 登録日 2017-06-14 公開日 2018-02-28 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 A complete structural characterization of the desferrioxamine E biosynthetic pathway from the fire blight pathogen Erwinia amylovora. J. Struct. Biol., 202, 2018
6P38	Crystal Structure Analysis of TAF1 Bromodomain 分子名称: 4-{[(3R)-4-cyclopentyl-1,3-dimethyl-2-oxo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-6-yl]amino}-N-(1-methylpiperidin-4-yl)-3-[(propan-2-yl)oxy]benzamide, Transcription initiation factor TFIID subunit 1 著者 Seo, H.-S, Dhe-Paganon, S. 登録日 2019-05-23 公開日 2020-05-27 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Dual Inhibition of TAF1 and BET Bromodomains from the BI-2536 Kinase Inhibitor Scaffold. Acs Med.Chem.Lett., 10, 2019
5O96	Structure of the putative methyltransferase Lpg2936 from Legionella pneumophila in complex with the bound cofactor SAM 分子名称: Ribosomal RNA small subunit methyltransferase E, S-ADENOSYLMETHIONINE 著者 Pinotsis, N, Waksman, G. 登録日 2017-06-15 公開日 2017-11-08 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of the Legionella pneumophila Lpg2936 in complex with the cofactor S-adenosyl-L-methionine reveals novel insights into the mechanism of RsmE family methyltransferases. Protein Sci., 26, 2017
5O3O	Pronase-treated paired helical filament in Alzheimer's disease brain 分子名称: Microtubule-associated protein tau 著者 Fitzpatrick, A.W.P, Falcon, B, He, S, Murzin, A.G, Murshudov, G, Garringer, H.G, Crowther, R.A, Ghetti, B, Goedert, M, Scheres, S.H.W. 登録日 2017-05-24 公開日 2017-07-26 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Cryo-EM structures of tau filaments from Alzheimer's disease. Nature, 547, 2017
6P43	Yeast cytochrome c peroxidase in complex with iso-1 cytochrome c (Y48K) 分子名称: Cytochrome c iso-1, Cytochrome c peroxidase, mitochondrial, ... 著者 Yee, E.F, Crane, B.R. 登録日 2019-05-25 公開日 2019-10-23 最終更新日 2019-11-20 実験手法 X-RAY DIFFRACTION (1.913 Å) 主引用文献 Tuning Radical Relay Residues by Proton Management Rescues Protein Electron Hopping. J.Am.Chem.Soc., 141, 2019
6P23	Structure of a nested set of N-terminally extended MHC I-peptides provide novel insights into antigen processing presentation 分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, B-8 alpha chain, ... 著者 Li, L, Batliwala, M, Bouvier, M. 登録日 2019-05-20 公開日 2019-10-16 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.595 Å) 主引用文献 ERAP1 enzyme-mediated trimming and structural analyses of MHC I-bound precursor peptides yield novel insights into antigen processing and presentation. J.Biol.Chem., 294, 2019
5OAI	Structure of MDM2 with low molecular weight inhibitor 分子名称: 3-[(1~{R})-2-(~{tert}-butylamino)-1-[methanoyl-[[3,4,5-tris(fluoranyl)phenyl]methyl]amino]-2-oxidanylidene-ethyl]-6-chloranyl-1~{H}-indole-2-carboxylic acid, E3 ubiquitin-protein ligase Mdm2 著者 Twarda-Clapa, A, Neochoritis, C.G, Grudnik, P, Dubin, G, Domling, A, Holak, T.A. 登録日 2017-06-22 公開日 2019-02-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A fluorinated indole-based MDM2 antagonist selectively inhibits the growth of p53wtosteosarcoma cells. Febs J., 286, 2019
5O66	Asymmetric AcrABZ-TolC 分子名称: Multidrug efflux pump accessory protein AcrZ, Multidrug efflux pump subunit AcrA, Multidrug efflux pump subunit AcrB, ... 著者 Du, D, Luisi, B.F. 登録日 2017-06-05 公開日 2017-06-14 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (5.9 Å) 主引用文献 An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump. Elife, 6, 2017
5O7W	Crystal structure of the 4-FLUORO RSL lectin in complex with Lewis x tetrasaccharide 分子名称: 1,2-ETHANEDIOL, CALCIUM ION, Putative fucose-binding lectin protein, ... 著者 Varrot, A. 登録日 2017-06-09 公開日 2018-06-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Effect of Noncanonical Amino Acids on Protein-Carbohydrate Interactions: Structure, Dynamics, and Carbohydrate Affinity of a Lectin Engineered with Fluorinated Tryptophan Analogs. ACS Chem. Biol., 13, 2018
5O84	Glutathione S-transferase Tau 23 (partially oxidized) 分子名称: 1,2-ETHANEDIOL, ACETATE ION, FORMIC ACID, ... 著者 Young, D.R, Van Molle, I, Tossounian, M, Messens, J. 登録日 2017-06-12 公開日 2017-10-25 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Disulfide bond formation protects Arabidopsis thaliana glutathione transferase tau 23 from oxidative damage. Biochim. Biophys. Acta, 1862, 2018
6P40	Crystal Structure of Full Length APOBEC3G FKL 分子名称: Apolipoprotein B mRNA editing enzyme, catalytic peptide-like 3G, ZINC ION 著者 Yang, H.J, Li, S.X, Chen, X.S. 登録日 2019-05-25 公開日 2020-02-12 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.452 Å) 主引用文献 Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G. Nat Commun, 11, 2020
7W9D	Crystal Structure of the Oxomolybdenum Mesoporphyrin IX-Reconstituted CYP102A1 (P450BM3) Heme Domain with N-Hexadecanoyl-L-Homoserine 分子名称: (2~{S})-2-(hexadecanoylamino)-4-oxidanyl-butanoic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, GLYCEROL, ... 著者 Karasawa, M, Stanfield, J.K, Kasai, C, Sugimoto, H, Shoji, O. 登録日 2021-12-09 公開日 2022-12-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Crystal Structure of the Oxomolybdenum Mesoporphyrin IX-Reconstituted CYP102A1 (P450BM3) Heme Domain with N-Hexadecanoyl-L-Homoserine To Be Published

<812813814815816817818819820821822823824825826827>