PDB: 22592 件ウェブページステータス検索Chemie searchBIRD

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8I68	Crystal structure of Mycobacterium tuberculosis Uracil-DNA glycosylase in complex with Uric acid, Form III 分子名称: 1,2-ETHANEDIOL, URIC ACID, Uracil-DNA glycosylase 著者 Raj, P, Paul, A, Gopal, B. 登録日 2023-01-27 公開日 2023-07-12 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Crystal structures of non-uracil ring fragments in complex with Mycobacterium tuberculosis uracil DNA glycosylase (MtUng) as a starting point for novel inhibitor design: A case study with the barbituric acid fragment. Eur.J.Med.Chem., 258, 2023
4G2R	Crystal Structure of the carboxyltransferase subunit of ACC (AccD6) in complex with inhibitor haloxyfop from Mycobacterium tuberculosis 分子名称: (2R)-2-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid, AccD6, Carboxyltransferase beta-subunit of Acyl-CoA Carboxylase 著者 Reddy, M.C.M, Bruning, J.B, Thurman, C, Sherekar, M, Valluru, S, Ehrenfeld, H, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) 登録日 2012-07-12 公開日 2014-02-19 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Structure, Activity, and Inhibition of the Carboxyltransferase beta-Subunit of Acetyl Coenzyme A Carboxylase (AccD6) from Mycobacterium tuberculosis. Antimicrob.Agents Chemother., 58, 2014
5IEU	Crystal Structure of Mycobacterium Tuberculosis ATP-independent Proteasome Activator Tetramer 分子名称: Bacterial proteasome activator 著者 Bai, L, Hu, K, Wang, T, Jastrab, J.B, Darwin, K.H, Li, H. 登録日 2016-02-25 公開日 2016-03-30 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural analysis of the dodecameric proteasome activator PafE in Mycobacterium tuberculosis. Proc.Natl.Acad.Sci.USA, 113, 2016
6T0G	Crystal structure of CYP124 in complex with vitamin D3 分子名称: (1S,3Z)-3-[(2E)-2-[(1R,3AR,7AS)-7A-METHYL-1-[(2R)-6-METHYLHEPTAN-2-YL]-2,3,3A,5,6,7-HEXAHYDRO-1H-INDEN-4-YLIDENE]ETHYLI DENE]-4-METHYLIDENE-CYCLOHEXAN-1-OL, MAGNESIUM ION, Methyl-branched lipid omega-hydroxylase, ... 著者 Bukhdruker, S, Marin, E, Varaksa, T, Gilep, A, Strushkevich, N, Borshchevskiy, V. 登録日 2019-10-03 公開日 2020-10-14 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Metabolic Fate of Human Immunoactive Sterols in Mycobacterium tuberculosis. J.Mol.Biol., 433, 2021
6PCM	Crystal Structure of Mycobacterium smegmatis Topoisomerase I with ssDNA bound to both N- and C-terminal domains 分子名称: DNA (5'-D(P*AP*GP*TP*GP*AP*GP*CP*GP*AP*GP*CP*TP*TP*CP*CP*GP*CP*TP*TP*GP*AP*CP*TP*T)-3'), DNA topoisomerase 1, SULFATE ION 著者 Tan, K, Cao, N, Tse-Dinh, Y.C. 登録日 2019-06-17 公開日 2020-03-25 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.107 Å) 主引用文献 Mechanistic insights from structure of Mycobacterium smegmatis topoisomerase I with ssDNA bound to both N- and C-terminal domains. Nucleic Acids Res., 48, 2020
6T0K	Crystal structure of CYP124 in complex with inhibitor carbethoxyhexyl imidazole 分子名称: CHLORIDE ION, CYP124 in complex with inhibitor carbethoxyhexyl imidazole, GLYCEROL, ... 著者 Bukhdruker, S, Marin, E, Varaksa, T, Gilep, A, Strushkevich, N, Borshchevskiy, V. 登録日 2019-10-03 公開日 2020-10-14 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.18 Å) 主引用文献 Metabolic Fate of Human Immunoactive Sterols in Mycobacterium tuberculosis. J.Mol.Biol., 433, 2021
5O0A	Crystal structure of Phosphopantetheine adenylyltransferase from Mycobacterium abcessus in complex with 5-methyl-1-phenyl-pyrazole-4-carboxylic acid (Fragment 1) 分子名称: 5-methyl-1-phenyl-pyrazole-4-carboxylic acid, Phosphopantetheine adenylyltransferase 著者 Thomas, S.E, Kim, S.Y, Mendes, V, Blaszczyk, M, Blundell, T.L. 登録日 2017-05-16 公開日 2017-06-28 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.805 Å) 主引用文献 Structural Biology and the Design of New Therapeutics: From HIV and Cancer to Mycobacterial Infections: A Paper Dedicated to John Kendrew. J. Mol. Biol., 429, 2017
5O0C	Crystal structure of Phosphopantetheine adenylyltransferase from Mycobacterium abcessus in complex with 3-(3-methyl-1H-indol-1-yl)propanoic acid (Fragment 3) 分子名称: 3-(3-methylindol-1-yl)propanoic acid, Phosphopantetheine adenylyltransferase 著者 Thomas, S.E, Kim, S.Y, Mendes, V, Blaszczyk, M, Blundell, T.L. 登録日 2017-05-16 公開日 2017-06-28 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.642 Å) 主引用文献 Structural Biology and the Design of New Therapeutics: From HIV and Cancer to Mycobacterial Infections: A Paper Dedicated to John Kendrew. J. Mol. Biol., 429, 2017
4XGQ	Crystal structure of addiction module from Mycobacterial species 分子名称: Antitoxin VapB30, MAGNESIUM ION, Ribonuclease VapC30 著者 Lee, B.-J, Lee, I.-G, Lee, S.J. 登録日 2015-01-02 公開日 2015-08-12 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural and functional studies of the Mycobacterium tuberculosis VapBC30 toxin-antitoxin system: implications for the design of novel antimicrobial peptides Nucleic Acids Res., 43, 2015
4XGR	Crystal structure of addiction module from Mycobacterial species 分子名称: Antitoxin VapB30, MAGNESIUM ION, Ribonuclease VapC30 著者 Lee, B.-J, Lee, I.-G, Lee, S.J. 登録日 2015-01-02 公開日 2015-08-12 最終更新日 2015-09-16 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural and functional studies of the Mycobacterium tuberculosis VapBC30 toxin-antitoxin system: implications for the design of novel antimicrobial peptides Nucleic Acids Res., 43, 2015
6DRQ	The crystal structure of SatS c-terminal domain in complex with bromine 分子名称: BROMIDE ION, Primosomal protein 著者 Hughes, R.C, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) 登録日 2018-06-12 公開日 2019-01-23 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Mycobacterium tuberculosisSatS is a chaperone for the SecA2 protein export pathway. Elife, 8, 2019
3NXS	Crystal structure of LAO/AO transport system from Mycobacterium smegmatis bound to GDP 分子名称: CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, LAO/AO transport system ATPase 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2010-07-14 公開日 2010-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structures of Mycobacterial MeaB and MMAA-like GTPases J.Struct.Funct.Genom., 16, 2015
4WS6	Crystal structure of Mycobacterium tuberculosis uracil-DNA glycosylase in complex with 5-aminouracil, Form I 分子名称: 1,2-ETHANEDIOL, 5-AMINO-1H-PYRIMIDINE-2,4-DIONE, CHLORIDE ION, ... 著者 Arif, S.M, Geethanandan, K, Mishra, P, Surolia, A, Varshney, U, Vijayan, M. 登録日 2014-10-25 公開日 2015-07-15 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Structural plasticity in Mycobacterium tuberculosis uracil-DNA glycosylase (MtUng) and its functional implications. Acta Crystallogr.,Sect.D, 71, 2015
5U94	Crystal structure of the Mycobacterium tuberculosis PASTA kinase PknB in complex with the potential theraputic kinase inhibitor GSK690693. 分子名称: 4-{2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-piperidin-3-ylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl}-2-methylbut-3 -yn-2-ol, GLYCEROL, MAGNESIUM ION, ... 著者 Wlodarchak, N, Satyshur, K, Striker, R. 登録日 2016-12-15 公開日 2017-12-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 In Silico Screen and Structural Analysis Identifies Bacterial Kinase Inhibitors which Act with beta-Lactams To Inhibit Mycobacterial Growth. Mol. Pharm., 15, 2018
4WNB	Crystal structure of the ChsH1-ChsH2 complex from Mycobacterium tuberculosis bound to 3-OPC-CoA 分子名称: 3-oxo-4-pregnene-20-carboxyl-Coenzyme A, CADMIUM ION, CALCIUM ION, ... 著者 Guja, K.E, Yang, M, Sampson, N, Garcia-Diaz, M. 登録日 2014-10-11 公開日 2014-10-29 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 A Distinct MaoC-like Enoyl-CoA Hydratase Architecture Mediates Cholesterol Catabolism in Mycobacterium tuberculosis. Acs Chem.Biol., 9, 2014
4V1F	Crystal structure of a mycobacterial ATP synthase rotor ring in complex with Bedaquiline 分子名称: Bedaquiline, F0F1 ATP SYNTHASE SUBUNIT C, octyl beta-D-glucopyranoside 著者 Preiss, L, Yildiz, O, Meier, T. 登録日 2014-09-26 公開日 2015-05-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.697 Å) 主引用文献 Structure of the mycobacterial ATP synthase Fo rotor ring in complex with the anti-TB drug bedaquiline. Sci Adv, 1, 2015
4W78	Crystal structure of the ChsH1-ChsH2 complex from Mycobacterium tuberculosis 分子名称: CADMIUM ION, CALCIUM ION, CHLORIDE ION, ... 著者 Guja, K.E, Yang, M, Sampson, N, Garcia-Diaz, M. 登録日 2014-08-21 公開日 2014-10-08 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.541 Å) 主引用文献 A Distinct MaoC-like Enoyl-CoA Hydratase Architecture Mediates Cholesterol Catabolism in Mycobacterium tuberculosis. Acs Chem.Biol., 9, 2014
4V1G	Crystal structure of a mycobacterial ATP synthase rotor ring 分子名称: F0F1 ATP SYNTHASE SUBUNIT C, octyl beta-D-glucopyranoside 著者 Preiss, L, Yildiz, O, Meier, T. 登録日 2014-09-26 公開日 2015-05-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structure of the Mycobacterial ATP Synthase Fo Rotor Ring in Complex with the Anti-Tb Drug Bedaquiline. Sci.Adv., 1, 2015
6H59	Crystal structure of Mycobacterium tuberculosis phosphatidylinositol phosphate synthase (PgsA1) with CDP-DAG bound 分子名称: (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CDP-diacylglycerol--inositol 3-phosphatidyltransferase, MAGNESIUM ION, ... 著者 Grave, K, Hogbom, M. 登録日 2018-07-24 公開日 2019-05-15 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure ofMycobacterium tuberculosisphosphatidylinositol phosphate synthase reveals mechanism of substrate binding and metal catalysis. Commun Biol, 2, 2019
6T0F	Crystal structure of CYP124 in complex with cholest-4-en-3-one 分子名称: (8ALPHA,9BETA)-CHOLEST-4-EN-3-ONE, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, GLYCEROL, ... 著者 Bukhdruker, S, Marin, E, Varaksa, T, Gilep, A, Strushkevich, N, Borshchevskiy, V. 登録日 2019-10-03 公開日 2020-10-14 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Metabolic Fate of Human Immunoactive Sterols in Mycobacterium tuberculosis. J.Mol.Biol., 433, 2021
6H5A	Crystal structure of Mycobacterium tuberculosis phosphatidylinositol phosphate synthase (PgsA1) in complex with manganese and citrate 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CDP-diacylglycerol--inositol 3-phosphatidyltransferase, CITRATE ANION, ... 著者 Grave, K, Hogbom, M. 登録日 2018-07-24 公開日 2019-05-15 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Structure ofMycobacterium tuberculosisphosphatidylinositol phosphate synthase reveals mechanism of substrate binding and metal catalysis. Commun Biol, 2, 2019
6T0H	Crystal structure of CYP124 in complex with 1-alpha-hydroxy-vitamin D3 分子名称: 1-alpha-hydroxy-vitamin D3, CHLORIDE ION, CYP124 in complex with inhibitor carbethoxyhexyl imidazole, ... 著者 Bukhdruker, S, Marin, E, Varaksa, T, Gilep, A, Strushkevich, N, Borshchevskiy, V. 登録日 2019-10-03 公開日 2020-10-14 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.18 Å) 主引用文献 Metabolic Fate of Human Immunoactive Sterols in Mycobacterium tuberculosis. J.Mol.Biol., 433, 2021
6T0L	Crystal structure of CYP124 in complex with inhibitor compound 5' 分子名称: CHLORIDE ION, CYP124 in complex with inhibitor compound 5', DI(HYDROXYETHYL)ETHER, ... 著者 Bukhdruker, S, Marin, E, Varaksa, T, Gilep, A, Strushkevich, N, Borshchevskiy, V. 登録日 2019-10-03 公開日 2020-10-14 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Metabolic Fate of Human Immunoactive Sterols in Mycobacterium tuberculosis. J.Mol.Biol., 433, 2021
5D1R	Crystal structure of Mycobacterium tuberculosis Rv1816 transcriptional regulator. 分子名称: MAGNESIUM ION, NICKEL (II) ION, Rv1816 transcriptional regulator, ... 著者 Chou, T.-H, Delmar, J, Su, C.-C, Yu, E. 登録日 2015-08-04 公開日 2015-09-30 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Basis for the Regulation of the MmpL Transporters of Mycobacterium tuberculosis. J.Biol.Chem., 290, 2015
5IET	Crystal Structure of Mycobacterium Tuberculosis ATP-independent Proteasome activator 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Bacterial proteasome activator, SULFATE ION 著者 Bai, L, Hu, K, Wang, T, Jastrab, J.B, Darwin, K.H, Li, H. 登録日 2016-02-25 公開日 2016-03-30 最終更新日 2019-12-11 実験手法 X-RAY DIFFRACTION (2.88 Å) 主引用文献 Structural analysis of the dodecameric proteasome activator PafE in Mycobacterium tuberculosis. Proc.Natl.Acad.Sci.USA, 113, 2016

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