7EGB
 
 | | TFIID-based holo PIC on SCP promoter | | 分子名称: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | | 著者 | Chen, X, Wu, Z, Hou, H, Qi, Y, Wang, X, Li, J, Xu, Y. | | 登録日 | 2021-03-24 | | 公開日 | 2021-05-05 | | 最終更新日 | 2023-07-26 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural insights into preinitiation complex assembly on core promoters.
Science, 372, 2021
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3JUH
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7EG9
 | | TFIID-based intermediate PIC on SCP promoter | | 分子名称: | DNA (79-MER), DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... | | 著者 | Chen, X, Qi, Y, Wang, X, Wu, Z, Li, J, Xu, Y. | | 登録日 | 2021-03-24 | | 公開日 | 2021-05-05 | | 最終更新日 | 2021-05-19 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural insights into preinitiation complex assembly on core promoters.
Science, 372, 2021
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7EG8
 | | TFIID-based core PIC on PUMA promoter | | 分子名称: | DNA (85-MER), DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... | | 著者 | Chen, X, Qi, Y, Hou, H, Wang, X, Wu, Z, Li, J, Xu, Y. | | 登録日 | 2021-03-24 | | 公開日 | 2021-05-05 | | 最終更新日 | 2021-05-19 | | 実験手法 | ELECTRON MICROSCOPY (7.4 Å) | | 主引用文献 | Structural insights into preinitiation complex assembly on core promoters.
Science, 372, 2021
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6I4P
 | | Crystal structure of the disease-causing G194C mutant of the human dihydrolipoamide dehydrogenase | | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Dihydrolipoyl dehydrogenase, mitochondrial, ... | | 著者 | Szabo, E, Wilk, P, Torocsik, B, Weiss, M.S, Adam-Vizi, V, Ambrus, A. | | 登録日 | 2018-11-10 | | 公開日 | 2019-11-20 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Underlying molecular alterations in human dihydrolipoamide dehydrogenase deficiency revealed by structural analyses of disease-causing enzyme variants.
Hum.Mol.Genet., 28, 2019
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6IV9
 | | the Cas13d binary complex | | 分子名称: | Cas13d, MAGNESIUM ION, crRNA (50-MER) | | 著者 | Zhang, B, Ye, Y.M, Ye, W.W, OuYang, S.Y. | | 登録日 | 2018-12-02 | | 公開日 | 2019-06-19 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Two HEPN domains dictate CRISPR RNA maturation and target cleavage in Cas13d.
Nat Commun, 10, 2019
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6DU8
 | | Human Polycsytin 2-l1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Polycystic kidney disease 2-like 1 protein | | 著者 | Hulse, R.E, Clapham, D.E, Li, Z, Huang, R.K, Zhang, J. | | 登録日 | 2018-06-20 | | 公開日 | 2018-07-25 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | | 主引用文献 | Cryo-EM structure of the polycystin 2-l1 ion channel.
Elife, 7, 2018
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1B7V
 | | Structure of the C-553 cytochrome from Bacillus pasteruii to 1.7 A resolution | | 分子名称: | HEME C, PROTEIN (CYTOCHROME C-553) | | 著者 | Gonzalez, A, Benini, S, Rypniewski, W.R, Wilson, K.S, Ciurli, S. | | 登録日 | 1999-01-22 | | 公開日 | 2000-03-27 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Crystal structure of oxidized Bacillus pasteurii cytochrome c553 at 0.97-A resolution.
Biochemistry, 39, 2000
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6IBJ
 | | Copper binding protein from Laetisaria arvalis (LaX325) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Auxiliary activity CAZyme, COPPER (II) ION | | 著者 | Frandsen, K.E.H, Tandrup, T, Labourel, A, Haon, M, Berrin, J.-G, Lo Leggio, L. | | 登録日 | 2018-11-30 | | 公開日 | 2019-11-13 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | A fungal family of lytic polysaccharide monooxygenase-like copper proteins.
Nat.Chem.Biol., 16, 2020
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7EGC
 | | p53-bound TFIID-based holo PIC on HDM2 promoter | | 分子名称: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | | 著者 | Chen, X, Wu, Z, Hou, H, Qi, Y, Wang, X, Li, J, Xu, Y. | | 登録日 | 2021-03-24 | | 公開日 | 2021-05-12 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structural insights into preinitiation complex assembly on core promoters.
Science, 372, 2021
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6B5H
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6IBH
 | | Copper binding protein from Laetisaria arvalis (LaX325) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Auxiliary activity CAZyme, COPPER (II) ION, ... | | 著者 | Frandsen, K.E.H, Tandrup, T, Labourel, A, Haon, M, Berrin, J.-G, Lo Leggio, L. | | 登録日 | 2018-11-30 | | 公開日 | 2019-11-13 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | A fungal family of lytic polysaccharide monooxygenase-like copper proteins.
Nat.Chem.Biol., 16, 2020
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1ICG
 | | STRUCTURE OF THE HYBRID RNA/DNA R-GCUUCGGC-D[F]U IN PRESENCE OF IR(NH3)6+++ | | 分子名称: | 5'-R(*GP*CP*UP*UP*CP*GP*GP*C)-D(P*(UFP))-3', CHLORIDE ION, IRIDIUM HEXAMMINE ION | | 著者 | Cruse, W, Saludjian, P, Neuman, A, Prange, T. | | 登録日 | 2001-03-31 | | 公開日 | 2001-04-09 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | | 主引用文献 | Destabilizing effect of a fluorouracil extra base in a hybrid RNA duplex compared with bromo and chloro analogues.
Acta Crystallogr.,Sect.D, 57, 2001
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3O24
 | | Crystal structure of the brevianamide F prenyltransferase FtmPT1 from Aspergillus fumigatus | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Brevianamide F prenyltransferase, CHLORIDE ION, ... | | 著者 | Jost, M, Zocher, G.E, Stehle, T. | | 登録日 | 2010-07-22 | | 公開日 | 2010-12-08 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure-function analysis of an enzymatic prenyl transfer reaction identifies a reaction chamber with modifiable specificity.
J.Am.Chem.Soc., 132, 2010
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1KFU
 | | Crystal Structure of Human m-Calpain Form II | | 分子名称: | M-CALPAIN LARGE SUBUNIT, M-CALPAIN SMALL SUBUNIT | | 著者 | Strobl, S, Fernandez-Catalan, C, Braun, M, Huber, R, Masumoto, H, Nakagawa, K, Irie, A, Sorimachi, H, Bourenkow, G, Bartunik, H, Suzuki, K, Bode, W. | | 登録日 | 2001-11-23 | | 公開日 | 2001-12-07 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium.
Proc.Natl.Acad.Sci.USA, 97, 2000
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7WU7
 | | Prefoldin-tubulin-TRiC complex | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Prefoldin subunit 1, Prefoldin subunit 2, ... | | 著者 | Gestaut, D, Zhao, Y, Park, J, Ma, B, Leitner, A, Collier, M, Pintilie, G, Roh, S.-H, Chiu, W, Frydman, J. | | 登録日 | 2022-02-07 | | 公開日 | 2022-12-21 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (3.85 Å) | | 主引用文献 | Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT.
Cell, 185, 2022
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1KJ1
 | | MANNOSE-SPECIFIC AGGLUTININ (LECTIN) FROM GARLIC (ALLIUM SATIVUM) BULBS COMPLEXED WITH ALPHA-D-MANNOSE | | 分子名称: | alpha-D-mannopyranose, lectin I, lectin II | | 著者 | Ramachandraiah, G, Chandra, N.R, Surolia, A, Vijayan, M. | | 登録日 | 2001-12-04 | | 公開日 | 2002-02-22 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Re-refinement using reprocessed data to improve the quality of the structure: a case study involving garlic lectin.
Acta Crystallogr.,Sect.D, 58, 2002
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6HHH
 | | Crystal Structure of AKT1 in Complex with Covalent-Allosteric AKT Inhibitor 31 | | 分子名称: | RAC-alpha serine/threonine-protein kinase, ~{N}-[4-[4-[[4-(5-oxidanylidene-3-phenyl-6~{H}-1,6-naphthyridin-2-yl)phenyl]methyl]piperazin-1-yl]phenyl]propanamide | | 著者 | Landel, I, Weisner, J, Mueller, M.P, Scheinpflug, R, Rauh, D. | | 登録日 | 2018-08-28 | | 公開日 | 2019-02-20 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt.
Chem Sci, 10, 2019
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8PH9
 | | E. coli RNA polymerase paused at ops site (non-complementary scaffold) | | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | 著者 | Zuber, P.K, Said, N, Hilal, T, Loll, B, Wahl, M.C, Knauer, S.H. | | 登録日 | 2023-06-19 | | 公開日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Concerted transformation of a hyper-paused transcription complex and its reinforcing protein.
Nat Commun, 15, 2024
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7EEB
 | | Structure of the CatSpermasome | | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Wu, J.P, Ke, M. | | 登録日 | 2021-03-18 | | 公開日 | 2021-07-28 | | 最終更新日 | 2021-08-11 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structure of a mammalian sperm cation channel complex.
Nature, 595, 2021
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1HM6
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8EO2
 | | Lufaxin a bifunctional inhibitor of complement and coagulation | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BROMIDE ION, ... | | 著者 | Andersen, J.F, Strayer, E.C. | | 登録日 | 2022-10-01 | | 公開日 | 2023-08-09 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | | 主引用文献 | A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism.
Blood, 141, 2023
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6FD0
 | | Human KIBRA C2 domain mutant M734I S735A | | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Protein KIBRA | | 著者 | Crennell, S.J, Posner, M.G, Bagby, S. | | 登録日 | 2017-12-21 | | 公開日 | 2018-05-16 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.64215851 Å) | | 主引用文献 | Distinctive phosphoinositide- and Ca2+-binding properties of normal and cognitive performance-linked variant forms of KIBRA C2 domain.
J. Biol. Chem., 293, 2018
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5O3L
 | | Paired helical filament in Alzheimer's disease brain | | 分子名称: | Microtubule-associated protein tau | | 著者 | Fitzpatrick, A.W.P, Falcon, B, He, S, Murzin, A.G, Murshudov, G, Garringer, H.G, Crowther, R.A, Ghetti, B, Goedert, M, Scheres, S.H.W. | | 登録日 | 2017-05-24 | | 公開日 | 2017-07-26 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Cryo-EM structures of tau filaments from Alzheimer's disease.
Nature, 547, 2017
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6IPU
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