3HQY
 
 | | Discovery of novel inhibitors of PDE10A | | 分子名称: | 2-({4-[4-(pyridin-4-ylmethyl)-1H-pyrazol-3-yl]phenoxy}methyl)quinoline, MAGNESIUM ION, SULFATE ION, ... | | 著者 | Pandit, J, Marr, E.S. | | 登録日 | 2009-06-08 | | 公開日 | 2009-08-04 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia
J.Med.Chem., 52, 2009
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3IT5
 | | Crystal Structure of the LasA Virulence Factor from Pseudomonas aeruginosa | | 分子名称: | Protease lasA, ZINC ION | | 著者 | Spencer, J, Murphy, L.M, Conners, R, Sessions, R.B, Gamblin, S.J. | | 登録日 | 2009-08-27 | | 公開日 | 2009-11-17 | | 最終更新日 | 2017-11-01 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of the LasA virulence factor from Pseudomonas aeruginosa: substrate specificity and mechanism of M23 metallopeptidases.
J.Mol.Biol., 396, 2010
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3IMJ
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3IMR
 | | Transthyretin in complex with (E)-2,6-dibromo-4-(2,6-dichlorostyryl)phenol | | 分子名称: | 2,6-dibromo-4-[(E)-2-(2,6-dichlorophenyl)ethenyl]phenol, Transthyretin | | 著者 | Connelly, S, Wilson, I.A. | | 登録日 | 2009-08-11 | | 公開日 | 2010-01-12 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity.
J.Am.Chem.Soc., 132, 2010
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3INM
 | | Crystal structure of human cytosolic NADP(+)-dependent isocitrate dehydrogenase R132H mutant in complex with NADPH, ALPHA-KETOGLUTARATE and CALCIUM(2+) | | 分子名称: | 2-OXOGLUTARIC ACID, CALCIUM ION, GLYCEROL, ... | | 著者 | Fontano, E, Brown, R.S, Suto, R.K, Bhyravbhatla, B. | | 登録日 | 2009-08-12 | | 公開日 | 2009-11-24 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.
Nature, 462, 2009
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3IW6
 | | Human p38 MAP Kinase in Complex with a Benzylpiperazin-Pyrrol | | 分子名称: | Mitogen-activated protein kinase 14, ethyl 4-[(4-benzylpiperazin-1-yl)carbonyl]-1-ethyl-3,5-dimethyl-1H-pyrrole-2-carboxylate, octyl beta-D-glucopyranoside | | 著者 | Gruetter, C, Simard, J.R, Rauh, D. | | 登録日 | 2009-09-02 | | 公開日 | 2009-11-17 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | High-Throughput Screening To Identify Inhibitors Which Stabilize Inactive Kinase Conformations in p38alpha
J.Am.Chem.Soc., 131, 2009
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3IWG
 | | Acetyltransferase from GNAT family from Colwellia psychrerythraea. | | 分子名称: | Acetyltransferase, GNAT family, CHLORIDE ION, ... | | 著者 | Osipiuk, J, Stein, A, Shackelford, G, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2009-09-02 | | 公開日 | 2009-09-15 | | 最終更新日 | 2017-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | X-ray crystal structure of Acetyltransferase from GNAT family from Colwellia psychrerythraea.
To be Published
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3I6V
 | | Crystal structure of a periplasmic His/Glu/Gln/Arg/opine family-binding protein from Silicibacter pomeroyi in complex with lysine | | 分子名称: | GLYCEROL, LYSINE, SODIUM ION, ... | | 著者 | Bonanno, J.B, Rutter, M, Bain, K.T, Miller, S, Romero, R, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | | 登録日 | 2009-07-07 | | 公開日 | 2009-07-21 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of a periplasmic His/Glu/Gln/Arg/opine family-binding protein from Silicibacter pomeroyi in complex with lysine
To be Published
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3I73
 | | Structural characterization for the nucleotide binding ability of subunit A with ADP of the A1AO ATP synthase | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, A-TYPE ATP SYNTHASE CATALYTIC SUBUNIT A, ... | | 著者 | Manimekalai, S.M.S, Kumar, A, Balakrishna, A.M, Gruber, G. | | 登録日 | 2009-07-08 | | 公開日 | 2010-01-12 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Nucleotide binding states of subunit A of the A-ATP synthase and the implication of P-loop switch in evolution.
J.Mol.Biol., 396, 2010
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3I7C
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3I74
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3I7Z
 | | Protein Tyrosine Phosphatase 1B - Transition state analog for the first catalytic step | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, EGFR receptor fragment, GLYCEROL, ... | | 著者 | Brandao, T.A.S, Johnson, S.J, Hengge, A.C. | | 登録日 | 2009-07-09 | | 公開日 | 2010-03-16 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Insights into the reaction of protein-tyrosine phosphatase 1B: crystal structures for transition state analogs of both catalytic steps.
J.Biol.Chem., 285, 2010
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3I90
 | | Crystal structure of human chromobox homolog 6 (CBX6) with H3K27 peptide | | 分子名称: | Chromobox protein homolog 6, H3K27 peptide | | 著者 | Amaya, M.F, Ravichandran, M, Loppnau, P, Kozieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Bountra, C, Bochkarev, A, Min, J, Ouyang, H, Structural Genomics Consortium (SGC) | | 登録日 | 2009-07-10 | | 公開日 | 2009-09-08 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Recognition and specificity determinants of the human cbx chromodomains.
J.Biol.Chem., 286, 2011
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3I8Z
 | | Crystal structure of human chromobox homolog 4 (CBX4) | | 分子名称: | E3 SUMO-protein ligase CBX4 | | 著者 | Amaya, M.F, Zhihong, L, Loppnau, P, Kozieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Bountra, C, Bochkarev, A, Min, J, Ouyang, H, Structural Genomics Consortium (SGC) | | 登録日 | 2009-07-10 | | 公開日 | 2009-08-25 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | | 主引用文献 | Crystal structure of human chromobox homolog 4 (CBX4)
To be Published
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3I94
 | | Crystal structure of PcyA-biliverdin XIII alpha complex | | 分子名称: | 3-[2-[(Z)-[3-(2-carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-2-ylidene]methy l]-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid, Phycocyanobilin:ferredoxin oxidoreductase, SULFATE ION | | 著者 | Hagiwara, Y, Sugishima, M, Fukuyama, K. | | 登録日 | 2009-07-10 | | 公開日 | 2009-10-27 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.04 Å) | | 主引用文献 | Structural insights into vinyl reduction regiospecificity of phycocyanobilin:ferredoxin oxidoreductase (PcyA).
to be published
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3IA0
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3IB6
 | | Crystal structure of an uncharacterized protein from Listeria monocytogenes serotype 4b | | 分子名称: | Uncharacterized protein | | 著者 | Bonanno, J.B, Gilmore, M, Bain, K.T, Do, J, Ozyurt, S, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | | 登録日 | 2009-07-15 | | 公開日 | 2009-07-28 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of an uncharacterized protein from Listeria monocytogenes serotype 4b
To be Published
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3IBE
 | | Crystal Structure of a Pyrazolopyrimidine Inhibitor Bound to PI3 Kinase Gamma | | 分子名称: | 1-(4-{4-morpholin-4-yl-1-[1-(pyridin-3-ylcarbonyl)piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}phenyl)-3-pyridin-4-ylurea, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION | | 著者 | Bard, J, Svenson, K. | | 登録日 | 2009-07-15 | | 公開日 | 2009-09-01 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.798 Å) | | 主引用文献 | ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin: Design and Synthesis of Highly Potent and Selective Pyrazolopyrimidines.
J.Med.Chem., 52, 2009
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3IC2
 | | Crystal Structure of liganded hemoglobin in complex with a potent antisickling agent, INN-266 | | 分子名称: | 4-[(5-methoxy-2-methylphenoxy)methyl]pyridine, Hemoglobin subunit alpha, Hemoglobin subunit beta, ... | | 著者 | Safo, M.K, Musayev, F.N, Gandhi, A.K, Jorge, P. | | 登録日 | 2009-07-17 | | 公開日 | 2009-07-28 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural and in Vitro Chracterization of Pyridyl Derivatives of Benzaldehydes: Highly Potent Antisickling Agents
To be Published
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3IEK
 | | Crystal Structure of native TTHA0252 from Thermus thermophilus HB8 | | 分子名称: | CITRATE ANION, Ribonuclease TTHA0252, SULFATE ION, ... | | 著者 | Ishikawa, H, Nakagawa, N, Kuramitsu, S, Yokoyama, S, Masui, R. | | 登録日 | 2009-07-22 | | 公開日 | 2010-07-28 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Crystal Structure of native TTHA0252 from Thermus thermophilus HB8
To be Published
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3ICE
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3IHI
 | | Crystal structure of mouse thymidylate synthase | | 分子名称: | SULFATE ION, Thymidylate synthase | | 著者 | Dowiercial, A, Jarmula, A, Rypniewski, W.R, Sokolowska, M, Fraczyk, T, Ciesla, J, Rode, W. | | 登録日 | 2009-07-30 | | 公開日 | 2010-02-02 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Mouse thymidylate synthase does not show the inactive conformation, observed for the human enzyme
Struct Chem, 2016
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3IF8
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3IJY
 | | Structure of S67-27 in Complex with Kdo(2.8)Kdo | | 分子名称: | 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-8)-prop-2-en-1-yl 3-deoxy-alpha-D-manno-oct-2-ulopyranosidonic acid, Immunoglobulin heavy chain (IGG3), Immunoglobulin light chain (IGG3), ... | | 著者 | Brooks, C.L, Blackler, R.J, Evans, S.V. | | 登録日 | 2009-08-05 | | 公開日 | 2009-10-06 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | The role of CDR H3 in antibody recognition of a synthetic analog of a lipopolysaccharide antigen.
Glycobiology, 20, 2010
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3IHA
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