8J7E
 
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8CJL
 | | Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor TPT-004 | | 分子名称: | 3-ethyl-8-[(2-methyl-5~{H}-imidazo[2,1-b][1,3]thiazol-6-yl)methyl]-7-(oxetan-3-ylmethyl)purine-2,6-dione, FE (III) ION, Tryptophan 5-hydroxylase 1 | | 著者 | Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U. | | 登録日 | 2023-02-13 | | 公開日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors.
J.Med.Chem., 66, 2023
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8CJM
 | | Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-07-047 | | 分子名称: | 7-(cyclobutylmethyl)-3-ethyl-8-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-ylmethyl)purine-2,6-dione, FE (III) ION, Tryptophan 5-hydroxylase 1 | | 著者 | Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U. | | 登録日 | 2023-02-13 | | 公開日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors.
J.Med.Chem., 66, 2023
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8CJI
 | | Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-07-052 | | 分子名称: | FE (III) ION, Tryptophan 5-hydroxylase 1, methyl (2~{S})-2-azanyl-3-[[3-[[3-ethyl-2,6-bis(oxidanylidene)-8-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-ylmethyl)purin-7-yl]methyl]phenyl]carbonylamino]propanoate | | 著者 | Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U. | | 登録日 | 2023-02-13 | | 公開日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors.
J.Med.Chem., 66, 2023
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1RE8
 | | Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 2 | | 分子名称: | 3-[(4-HYDROXYBENZOYL)AMINO]AZEPAN-4-YL 4-(2-HYDROXYBENZOYL)BENZOATE, N-OCTANE, cAMP-dependent protein kinase, ... | | 著者 | Akamine, P, Madhusudan, Brunton, L.L, Ou, H.D, Canaves, J.M, Xuong, N.H, Taylor, S.S. | | 登録日 | 2003-11-06 | | 公開日 | 2004-02-24 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Balanol analogues probe specificity determinants and the conformational malleability of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase catalytic subunit
Biochemistry, 43, 2004
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7V90
 | | Telomeric mononucleosome | | 分子名称: | DNA (145-mer), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | | 著者 | Soman, A. | | 登録日 | 2021-08-24 | | 公開日 | 2022-07-27 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Columnar structure of human telomeric chromatin.
Nature, 609, 2022
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7X58
 | | Cryo-EM structure of human subnucleosome (open form) | | 分子名称: | Histone H3.1, Histone H4, Widom601 DNA FW (145-MER), ... | | 著者 | Nozawa, K, Takizawa, Y, Kurumizaka, H. | | 登録日 | 2022-03-04 | | 公開日 | 2022-11-16 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (3.93 Å) | | 主引用文献 | Cryo-electron microscopy structure of the H3-H4 octasome: A nucleosome-like particle without histones H2A and H2B.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7VA4
 | | Telomeric tetranucleosome in open state | | 分子名称: | DNA (539-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | | 著者 | Soman, A. | | 登録日 | 2021-08-27 | | 公開日 | 2022-07-27 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (14 Å) | | 主引用文献 | Columnar structure of human telomeric chromatin.
Nature, 609, 2022
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7V9J
 | | Telomeric trinucleosome | | 分子名称: | DNA (408-mer), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | | 著者 | Soman, A. | | 登録日 | 2021-08-25 | | 公開日 | 2022-07-27 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (8 Å) | | 主引用文献 | Columnar structure of human telomeric chromatin.
Nature, 609, 2022
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7V9S
 | | Telomeric trinucleosome in open state | | 分子名称: | DNA (408-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | | 著者 | Soman, A. | | 登録日 | 2021-08-26 | | 公開日 | 2022-07-27 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (11 Å) | | 主引用文献 | Columnar structure of human telomeric chromatin.
Nature, 609, 2022
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7V9C
 | | Telomeric Dinucleosome in open state | | 分子名称: | DNA (275-mer), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | | 著者 | Soman, A. | | 登録日 | 2021-08-24 | | 公開日 | 2022-07-27 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Columnar structure of human telomeric chromatin.
Nature, 609, 2022
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7X57
 | | Cryo-EM structure of human subnucleosome (closed form) | | 分子名称: | Histone H3.1, Histone H4, Widom601 DNA FW (145-MER), ... | | 著者 | Nozawa, K, Takizawa, Y, Kurumizaka, H. | | 登録日 | 2022-03-04 | | 公開日 | 2022-11-16 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (3.63 Å) | | 主引用文献 | Cryo-electron microscopy structure of the H3-H4 octasome: A nucleosome-like particle without histones H2A and H2B.
Proc.Natl.Acad.Sci.USA, 119, 2022
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1KX8
 | | Antennal Chemosensory Protein A6 from Mamestra brassicae, tetragonal form | | 分子名称: | CHEMOSENSORY PROTEIN A6 | | 著者 | Lartigue, A, Campanacci, V, Roussel, A, Larsson, A.M, Jones, T.A, Tegoni, M, Cambillau, C. | | 登録日 | 2002-01-31 | | 公開日 | 2002-12-04 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | X-Ray Structure and Ligand Binding Study of a Chemosensory Protein
J.Biol.Chem., 277, 2002
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7V96
 | | Telomeric Dinucleosome | | 分子名称: | DNA (275-mer), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | | 著者 | Soman, A. | | 登録日 | 2021-08-24 | | 公開日 | 2022-07-27 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.92 Å) | | 主引用文献 | Columnar structure of human telomeric chromatin.
Nature, 609, 2022
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7V9K
 | | Telomeric tetranucleosome | | 分子名称: | DNA (539-mer), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | | 著者 | Soman, A. | | 登録日 | 2021-08-25 | | 公開日 | 2022-07-27 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (8.1 Å) | | 主引用文献 | Columnar structure of human telomeric chromatin.
Nature, 609, 2022
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3KUH
 | | Crystal structure of E. coli HPPK(H115A) in complex with AMPCPP and HP | | 分子名称: | 2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, ACETATE ION, ... | | 著者 | Blaszczyk, J, Li, Y, Yan, H, Ji, X. | | 登録日 | 2009-11-27 | | 公開日 | 2010-11-24 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Roles of residues E77 and H115 in E. coli HPPK
To be Published
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8Q2D
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8Q2C
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1PM6
 | | Solution Structure of Full-Length Excisionase (Xis) from Bacteriophage HK022 | | 分子名称: | Excisionase | | 著者 | Rogov, V.V, Luecke, C, Muresanu, L, Wienk, H, Kleinhaus, I, Werner, K, Loehr, F, Pristovsek, P, Rueterjans, H. | | 登録日 | 2003-06-10 | | 公開日 | 2003-12-30 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure and stability of the full-length excisionase from bacteriophage HK022.
Eur.J.Biochem., 270, 2003
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6QKL
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8OMM
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1PVG
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5B24
 | | The crystal structure of the nucleosome containing cyclobutane pyrimidine dimer | | 分子名称: | DNA (145-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Horikoshi, N, Tachiwana, H, Kagawa, W, Osakabe, A, Kurumizaka, H. | | 登録日 | 2015-12-31 | | 公開日 | 2016-03-02 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | Crystal structure of the nucleosome containing ultraviolet light-induced cyclobutane pyrimidine dimer
Biochem.Biophys.Res.Commun., 471, 2016
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8ONV
 | | KRAS-G13D in complex with BI-2493 | | 分子名称: | (7~{S})-2'-azanyl-3-[2-[(2~{S})-2-methylpiperazin-1-yl]pyrimidin-4-yl]spiro[5,6-dihydro-4~{H}-1,2-benzoxazole-7,4'-6,7-dihydro-5~{H}-1-benzothiophene]-3'-carbonitrile, 1,2-ETHANEDIOL, GTPase KRas, ... | | 著者 | Boettcher, J, Herdeis, L. | | 登録日 | 2023-04-04 | | 公開日 | 2023-06-07 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.01 Å) | | 主引用文献 | Pan-KRAS inhibitor disables oncogenic signalling and tumour growth.
Nature, 619, 2023
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8OYS
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