PDB: 98041 件ウェブページステータス検索Chemie searchBIRD

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5HU0	BACE1 in complex with 4-(3-(furan-2-carboxamido)phenyl)-1-methyl-5-oxo-4-phenylimidazolidin-2-iminium 分子名称: Beta-secretase 1, L(+)-TARTARIC ACID, N-{3-[(2E,4R)-2-imino-1-methyl-5-oxo-4-phenylimidazolidin-4-yl]phenyl}furan-2-carboxamide 著者 Orth, P. 登録日 2016-01-27 公開日 2016-11-09 最終更新日 2017-01-04 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer's Disease. J. Med. Chem., 59, 2016
5HXO	Crystal Structure of Z,Z-Farnesyl Diphosphate Synthase with D71M, E75A and H103Y Mutants 分子名称: (2Z,6Z)-farnesyl diphosphate synthase, chloroplastic 著者 Lee, C.C, Chan, Y.T, Wang, A.H.J. 登録日 2016-01-31 公開日 2017-04-05 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Crystal Structure and Potential Head-to-Middle Condensation Function of aZ,Z-Farnesyl Diphosphate Synthase. Acs Omega, 2, 2017
1ON6	Crystal structure of mouse alpha-1,4-N-acetylhexosaminotransferase (EXTL2) in complex with UDPGlcNAc 分子名称: 1,2-ETHANEDIOL, Alpha-1,4-N-acetylhexosaminyltransferase EXTL2, MANGANESE (II) ION, ... 著者 Pedersen, L.C, Dong, J, Taniguchi, F, Kitagawa, H, Krahn, J.M, Pedersen, L.G, Sugahara, K, Negishi, M. 登録日 2003-02-27 公開日 2003-04-22 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal Structure of an alpha-1,4-N-acetylhexosaminyltransferase (EXTL2), a member of the exostosin gene family involved in heparan sulfate biosynthesis J.Biol.Chem., 278, 2003
5HCT	Endothiapepsin in complex with biacylhydrazone 分子名称: 1,2-ETHANEDIOL, 2-amino-N'-{3-[(E)-{2-[(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]hydrazinylidene}methyl]benzylidene}-3-(1H-indol-2-yl)propanehydrazide (non-preferred name), ACETATE ION, ... 著者 Radeva, N, Heine, A, Klebe, G. 登録日 2016-01-04 公開日 2016-07-20 実験手法 X-RAY DIFFRACTION (1.36 Å) 主引用文献 Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin: Fragment-Based Drug Design Facilitated by Dynamic Combinatorial Chemistry. Angew.Chem.Int.Ed.Engl., 55, 2016
5HHP	Crystal Structure of HLA-A*0201 in complex with M1-G4E 分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, A-2 alpha chain, ... 著者 Gras, S, Josephs, T.M, Rossjohn, J. 登録日 2016-01-11 公開日 2016-03-23 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Molecular basis for universal HLA-A*0201-restricted CD8+ T-cell immunity against influenza viruses. Proc.Natl.Acad.Sci.USA, 113, 2016
5HHQ	Crystal Structure of HLA-A*0201 in complex with M1-L3W 分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, A-2 alpha chain, ... 著者 Gras, S, Josephs, T.M, Rossjohn, J. 登録日 2016-01-11 公開日 2016-03-23 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Molecular basis for universal HLA-A*0201-restricted CD8+ T-cell immunity against influenza viruses. Proc.Natl.Acad.Sci.USA, 113, 2016
5HJR	Murine endoplasmic reticulum alpha-glucosidase II with bound covalent intermediate 分子名称: 1,2-ETHANEDIOL, 5-fluoro-beta-D-glucopyranose, CALCIUM ION, ... 著者 Caputo, A.T, Roversi, P, Alonzi, D.S, Kiappes, J.L, Zitzmann, N. 登録日 2016-01-13 公開日 2016-07-27 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structures of mammalian ER alpha-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals. Proc.Natl.Acad.Sci.USA, 113, 2016
1IQZ	OXIDIZED [4Fe-4S] FERREDOXIN FROM BACILLUS THERMOPROTEOLYTICUS (FORM I) 分子名称: Ferredoxin, IRON/SULFUR CLUSTER, SULFATE ION 著者 Fukuyama, K, Okada, T, Kakuta, Y, Takahashi, Y. 登録日 2001-08-30 公開日 2002-02-13 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (0.92 Å) 主引用文献 Atomic resolution structures of oxidized [4Fe-4S] ferredoxin from Bacillus thermoproteolyticus in two crystal forms: systematic distortion of [4Fe-4S] cluster in the protein. J.Mol.Biol., 315, 2002
7ZJW	Rabbit 80S ribosome as it decodes the Sec-UGA codon 分子名称: 18S rRNA, 28S rRNA, 40S Ribosomal protein eS19, ... 著者 Hilal, T, Simonovic, M, Spahn, C.M.T. 登録日 2022-04-12 公開日 2022-10-19 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structure of the mammalian ribosome as it decodes the selenocysteine UGA codon. Science, 376, 2022
5DRJ	Crystal Structure of the ER-alpha Ligand-binding Domain in complex with a dichloro-substituted, 3-methyl 2,5-diarylthiophene-core ligand 4,4'-(3-methylthiene-2,5-diyl)bis(3-chlorophenol) 分子名称: 4,4'-(3-methylthiene-2,5-diyl)bis(3-chlorophenol), Estrogen receptor, Nuclear receptor coactivator 2 著者 Nwachukwu, J.C, Srinivasan, S, Zheng, Y, Wang, S, Min, J, Dong, C, Liao, Z, Cavett, V, Nowak, J, Houtman, R, Carlson, K.E, Josan, J.S, Elemento, O, Katzenellenbogen, J.A, Zhou, H.B, Nettles, K.W. 登録日 2015-09-15 公開日 2016-05-04 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Predictive features of ligand-specific signaling through the estrogen receptor. Mol.Syst.Biol., 12, 2016
4B2A	Structure of the factor Xa-like trypsin variant triple-Ala (TGA) in complex with eglin C 分子名称: 1,2-ETHANEDIOL, CALCIUM ION, CATIONIC TRYPSIN, ... 著者 Menzel, A, Neumann, P, Stubbs, M.T. 登録日 2012-07-13 公開日 2012-08-01 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Thermodynamic signatures in macromolecular interactions involving conformational flexibility. Biol.Chem., 395, 2014
4B2C	Structure of the factor Xa-like trypsin variant triple-Ala (TPA) in complex with eglin C 分子名称: 1,2-ETHANEDIOL, CALCIUM ION, CATIONIC TRYPSIN, ... 著者 Menzel, A, Neumann, P, Stubbs, M.T. 登録日 2012-07-13 公開日 2012-08-01 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.43 Å) 主引用文献 Thermodynamic signatures in macromolecular interactions involving conformational flexibility. Biol.Chem., 395, 2014
3U3W	Crystal Structure of Bacillus thuringiensis PlcR in complex with the peptide PapR7 and DNA 分子名称: 5'-D(P*AP*TP*AP*TP*GP*AP*AP*AP*TP*AP*TP*TP*GP*CP*AP*TP*AP*G)-3', 5'-D(P*CP*TP*AP*TP*GP*CP*AP*AP*TP*AP*TP*TP*TP*CP*AP*TP*AP*T)-3', C-terminus heptapeptide from PapR protein, ... 著者 Grenha, R, Slamti, L, Bouillaut, L, Lereclus, D, Nessler, S. 登録日 2011-10-06 公開日 2013-01-09 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural basis for the activation mechanism of the PlcR virulence regulator by the quorum-sensing signal peptide PapR. Proc.Natl.Acad.Sci.USA, 110, 2013
1RFB	CRYSTAL STRUCTURE OF RECOMBINANT BOVINE INTERFERON-GAMMA AT 3.0 ANGSTROMS RESOLUTION 分子名称: INTERFERON-GAMMA 著者 Samudzi, C.T, Rubin, J.R. 登録日 1993-06-30 公開日 1994-01-31 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure of recombinant bovine interferon-gamma at 3.0 A resolution. Acta Crystallogr.,Sect.D, 49, 1993
3OJM	Crystal Structure of FGF1 complexed with the ectodomain of FGFR2b harboring P253R Apert mutation 分子名称: Fibroblast growth factor receptor 2, Heparin-binding growth factor 1, SULFATE ION 著者 Beenken, A, Mohammadi, M. 登録日 2010-08-23 公開日 2011-08-31 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Plasticity in Interactions of Fibroblast Growth Factor 1 (FGF1) N Terminus with FGF Receptors Underlies Promiscuity of FGF1. J.Biol.Chem., 287, 2012
1IFG	CRYSTAL STRUCTURE OF A MONOMERIC FORM OF GENERAL PROTEASE INHIBITOR, ECOTIN IN ABSENCE OF A PROTEASE 分子名称: ECOTIN 著者 Eggers, C.T, Wang, S.X, Fletterick, R.J, Craik, C.S. 登録日 2001-04-12 公開日 2001-05-18 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The role of ecotin dimerization in protease inhibition. J.Mol.Biol., 308, 2001
4IVS	Crystal structure of BACE1 with its inhibitor 分子名称: Beta-secretase 1, N-{N-[4-(acetylamino)-3,5-dichlorobenzyl]carbamimidoyl}-2-(6-cyano-1H-indol-1-yl)acetamide 著者 Chen, T.T, Li, L, Chen, W.Y, Xu, Y.C. 登録日 2013-01-23 公開日 2013-11-13 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.636 Å) 主引用文献 Virtual screening and structure-based discovery of indole acylguanidines as potent beta-secretase (BACE1) inhibitors Molecules, 18, 2013
1XDJ	Crystal Structure of T. maritima Cobalamin-Independent Methionine Synthase complexed with Zn2+ and Homocysteine 分子名称: 2-AMINO-4-MERCAPTO-BUTYRIC ACID, 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, MESO-ERYTHRITOL, ... 著者 Pejchal, R, Ludwig, M.L. 登録日 2004-09-06 公開日 2005-03-01 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Cobalamin-independent methionine synthase (MetE): a face-to-face double barrel that evolved by gene duplication Plos Biol., 3, 2005
1MI6	Docking of the modified RF2 X-ray structure into the Low Resolution Cryo-EM map of RF2 E.coli 70S Ribosome 分子名称: peptide chain release factor RF-2 著者 Rawat, U.B.S, Zavialov, A.V, Sengupta, J, Valle, M, Grassucci, R.A, Linde, J, Vestergaard, B, Ehrenberg, M, Frank, J. 登録日 2002-08-22 公開日 2003-01-14 最終更新日 2024-02-14 実験手法 ELECTRON MICROSCOPY (12.8 Å) 主引用文献 A cryo-electron microscopic study of ribosome-bound termination factor RF2 Nature, 421, 2003
1MSA	MANNOSE-SPECIFIC AGGLUTININ (LECTIN) FROM SNOWDROP (GALANTHUS NIVALIS) BULBS COMPLEXED WITH METHYL-ALPHA-D-MANNOSIDE 分子名称: AGGLUTININ, methyl alpha-D-mannopyranoside 著者 Wright, C.S, Hester, G. 登録日 1995-03-06 公開日 1995-09-15 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Structure of mannose-specific snowdrop (Galanthus nivalis) lectin is representative of a new plant lectin family. Nat.Struct.Biol., 2, 1995
2QR0	Structure of VEGF complexed to a Fab containing TYR and SER in the CDRs 分子名称: Fab-Fragment Heavy Chain, Fab-Fragment Light Chain, Vascular endothelial growth factor A 著者 Wiesmann, C. 登録日 2007-07-27 公開日 2007-08-14 最終更新日 2017-10-25 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries J.Mol.Biol., 373, 2007
4EMZ	HIV-1 Nef in complex with MHC-I cytoplasmic domain and Mu1 adaptin subunit of AP1 adaptor (second domain) 分子名称: AP-1 complex subunit mu-1, MHC-I, Protein Nef 著者 Jia, X, Xiong, Y. 登録日 2012-04-12 公開日 2012-06-20 最終更新日 2012-07-25 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef. Nat.Struct.Mol.Biol., 19, 2012
1UIP	ADENOSINE DEAMINASE (HIS 238 GLU MUTANT) 分子名称: ADENOSINE DEAMINASE, PURINE RIBOSIDE, ZINC ION 著者 Wilson, D.K, Quiocho, F.A. 登録日 1996-08-30 公開日 1997-06-24 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Site-directed mutagenesis of histidine 238 in mouse adenosine deaminase: substitution of histidine 238 does not impede hydroxylate formation. Biochemistry, 35, 1996
1RNI	Bifunctional DNA primase/polymerase domain of ORF904 from the archaeal plasmid pRN1 分子名称: ORF904, ZINC ION 著者 Lipps, G, Weinzierl, A.O, von Scheven, G, Buchen, C, Cramer, P. 登録日 2003-12-01 公開日 2004-01-27 最終更新日 2011-11-16 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structure of a bifunctional DNA primase-polymerase Nat.Struct.Mol.Biol., 11, 2004
1IR0	OXIDIZED [4Fe-4S] FERREDOXIN FROM BACILLUS THERMOPROTEOLYTICUS (FORM II) 分子名称: Ferredoxin, IRON/SULFUR CLUSTER, SULFATE ION 著者 Fukuyama, K, Okada, T, Kakuta, Y, Takahashi, Y. 登録日 2001-08-30 公開日 2002-02-13 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1 Å) 主引用文献 Atomic resolution structures of oxidized [4Fe-4S] ferredoxin from Bacillus thermoproteolyticus in two crystal forms: systematic distortion of [4Fe-4S] cluster in the protein. J.Mol.Biol., 315, 2002

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